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A) Hematoxilina-eosina. Arteria epineural con infiltrado inflamatorio y destrucción de la pared arterial. B) Inmunohistoquímica con anticuerpo frente a CD45. Las células inflamatorias en la arteria epineural muestran positividad frente a CD45.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Í. Corral, M.M. Kawiorski, C. Moreno, H. Pian" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Í." "apellidos" => "Corral" ] 1 => array:2 [ "nombre" => "M.M." "apellidos" => "Kawiorski" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Moreno" ] 3 => array:2 [ "nombre" => "H." "apellidos" => "Pian" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S217358082030167X" "doi" => "10.1016/j.nrleng.2019.09.001" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217358082030167X?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485319301112?idApp=UINPBA00004N" "url" => "/02134853/0000003500000008/v1_202009180744/S0213485319301112/v1_202009180744/es/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S2173580820301668" "issn" => "21735808" "doi" => "10.1016/j.nrleng.2019.06.005" "estado" => "S300" "fechaPublicacion" => "2020-10-01" "aid" => "1343" "copyright" => "Sociedad Española de Neurología" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Neurologia. 2020;35:618-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "The use of botulinum toxin type A in nervus intermedius neuralgia" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "618" "paginaFinal" => "619" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Toxina botulínica tipo A en la neuralgia del nervio intermediario" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 667 "Ancho" => 1800 "Tamanyo" => 174754 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Brain MRI scan (3T scanner) showing compression of the right glossopharyngeal nerve by the anterior inferior cerebellar artery.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Erdocia-Goñi, I. Hernando de la Bárcena" "autores" => array:2 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Erdocia-Goñi" ] 1 => array:2 [ "nombre" => "I." 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"apellidos" => "González de la Aleja" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0213485319301100" "doi" => "10.1016/j.nrl.2019.09.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485319301100?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580820301711?idApp=UINPBA00004N" "url" => "/21735808/0000003500000008/v1_202010030617/S2173580820301711/v1_202010030617/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Vasculitic mononeuritis multiplex associated with livedoid vasculopathy" "tieneTextoCompleto" => true "saludo" => "Dear Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "616" "paginaFinal" => "617" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Í. Corral, M.M. Kawiorski, C. Moreno, H. Pian" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Í." "apellidos" => "Corral" "email" => array:1 [ 0 => "inigo.corral@salud.madrid.org" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M.M." "apellidos" => "Kawiorski" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Moreno" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "H." "apellidos" => "Pian" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Neurología, Hospital Universitario Ramón y Cajal, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital UniversitarioRamón yCajal, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Mononeuritis múltiple vasculítica asociada a vasculopatía livedoide" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 674 "Ancho" => 900 "Tamanyo" => 168019 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Skin biopsy (haematoxylin-eosin staining). Occlusive vasculopathy in superficial and deep dermal arteries. Dermal blood vessels present focal thrombosis and mural hyalinisation, with no inflammatory infiltrate. The epidermis is preserved.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Livedoid vasculopathy (LV) is a chronic, painful skin disorder affecting the distal segment of the lower limbs. From a histopathological viewpoint, it is characterised by thrombosis of the dermal arteries, with no leukocytoclastic vasculitis. Patients typically present purple-coloured macules, which may progress to ulcers and leave white scars after healing (atrophie blanche).<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> In some cases, LV has been associated with mononeuritis multiplex (MM) secondary to thrombosis of the vasa nervorum. We present the first reported case of vasculitic MM associated with LV.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Our patient was a 58-year-old man with no relevant medical history, who presented 2 months’ progression of pain and progressive loss of strength and sensitivity in both feet, associated with erythematous lesions on the tops of the feet. He also reported loss of sensitivity in the fourth and fifth fingers of the right hand. He presented no constitutional symptoms and had no history of systemic disease.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The examination detected confluent erythematous macules in both feet, compatible with livedo racemosa, and no ulcers or atrophie blanche. Muscle strength was 3/5 in plantar flexion and 2/5 in dorsiflexion. Patellar and Achilles reflexes were absent in the left limb and hypoactive in the right. The patient also displayed reduced tactile and pain sensitivity below the knees and in the fourth and fifth fingers of the right hand. The remaining results of the neurological examination were normal.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Laboratory analyses yielded normal results, including normal levels of homocysteine, cryoglobulins, lupus anticoagulant, and rheumatoid factor. Tests for antinuclear, antineutrophil cytoplasmic, anti-®2 microglobulin, anticardiolipin, antiganglioside, and antineuronal antibodies returned negative results; results from serology tests for syphilis, hepatitis B and C viruses, and HIV were also negative. CSF analysis yielded normal results, with no oligoclonal bands. Screening tests for hereditary thrombophilia and occult cancer yielded negative results.</p><p id="par0025" class="elsevierStylePara elsevierViewall">A neurophysiological study detected increased distal latencies and low-amplitude motor evoked potentials in the peroneal and tibial nerves. Somatosensory evoked potentials were not detected in the sural nerves. Low-amplitude motor evoked potentials were detected in the right ulnar nerve. Electrical activity was normal in both median nerves and the left ulnar nerve.</p><p id="par0030" class="elsevierStylePara elsevierViewall">A skin biopsy revealed occlusive vasculopathy in the superficial and deep dermal arteries, with areas of mural hyalinisation, no inflammatory infiltrate, and preserved epidermis; these findings are consistent with LV (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). A sural nerve biopsy revealed intense loss of myelinated fibres. An epineurial artery showed CD45+ inflammatory infiltrate, with arterial wall infiltration and destruction (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). No thrombosis was observed in other arteries.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">The patient was treated with acetylsalicylic acid at 100 mg/day, prednisone at 1 mg/kg/day, and amitriptyline and tramadol as rescue medications; treatment relieved pain and strength and sensitivity progressively improved. Skin lesions improved progressively, leaving no atrophie blanche. A year after the first consultation, the patient presented deep vein thrombosis in the right leg, which was attributed to immobilisation and treated with acenocoumarol for 6 months. Again, tests for thrombophilia and occult cancer yielded negative results. The dose of prednisone was gradually reduced, and the drug was suspended at 19 months. The patient remains asymptomatic after 6 years of follow-up.</p><p id="par0040" class="elsevierStylePara elsevierViewall">LV was diagnosed based on the characteristic skin biopsy findings.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The condition is not always associated with atrophie blanche.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> The pathogenesis of LV is unclear. In many cases, the condition is associated with acquired or hereditary thrombophilia, neoplasia, or systemic diseases.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> However, it may also appear in isolation, as in our patient; in this case, coagulopathy and systemic disease could not be confirmed, despite extensive testing and a long follow-up period.</p><p id="par0045" class="elsevierStylePara elsevierViewall">The literature includes cases of peripheral neuropathy as an extracutaneous manifestation of LV, usually with a clinical and electrophysiological pattern of mononeuritis multiplex.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3–9</span></a> In a retrospective series of 70 patients with LV, 9% presented peripheral neuropathy.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> In some patients, biopsy studies reveal ischaemic neuropathy secondary to thrombosis of the vasa nervorum, with no signs of vasculitis.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,6,7,9</span></a> To our knowledge, this is the first reported case of vasculitic MM associated with LV. We should consider this diagnostic possibility and perform a nerve biopsy in these patients, as immunosuppressive treatment may resolve the symptoms.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Our patient met the diagnostic criteria for non-systemic vasculitic neuropathy (NSVN), as the nerve biopsy revealed inflammatory infiltrate in the vessel wall and signs of vascular damage, with no evidence of systemic vasculitis.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> Copresence of NSVN and LV, and the simultaneous improvement of both conditions after initiation of corticosteroid treatment, suggest a pathogenic association between the 2, although the nature of this association is unclear. LV may be associated with other inflammatory diseases, such as connective tissue disorders, and may therefore be associated with NSVN.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0055" class="elsevierStylePara elsevierViewall">This study has received no specific funding from any public, commercial, or non-profit organisation.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-07-08" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Corral Í, Kawiorski MM, Moreno C, Pian H. Mononeuritis múltiple vasculítica asociada a vasculopatía livedoide. Neurología. 2020;35:616–617.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 674 "Ancho" => 900 "Tamanyo" => 168019 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Skin biopsy (haematoxylin-eosin staining). Occlusive vasculopathy in superficial and deep dermal arteries. Dermal blood vessels present focal thrombosis and mural hyalinisation, with no inflammatory infiltrate. The epidermis is preserved.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1155 "Ancho" => 750 "Tamanyo" => 214657 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Sural nerve biopsy. A) Haematoxylin-eosin staining: epineurial artery shows inflammatory infiltrate and destruction of the arterial wall. B) Immunohistochemical study with anti-CD45 antibodies: CD45+ inflammatory cells in the epineurial artery.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Livedoid vasculopathy: An in-depth analysis using a modified Delphi approach" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Alavi" 1 => "J. Hafner" 2 => "J.P. Dutz" 3 => "D. Mayer" 4 => "G. Sibbald" 5 => "P.R. 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Year/Month | Html | Total | |
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2024 November | 4 | 1 | 5 |
2024 October | 35 | 9 | 44 |
2024 September | 45 | 15 | 60 |
2024 August | 52 | 11 | 63 |
2024 July | 37 | 7 | 44 |
2024 June | 43 | 9 | 52 |
2024 May | 21 | 3 | 24 |
2024 April | 29 | 2 | 31 |
2024 March | 44 | 3 | 47 |
2024 February | 56 | 3 | 59 |
2024 January | 70 | 3 | 73 |
2023 December | 68 | 5 | 73 |
2023 November | 75 | 8 | 83 |
2023 October | 102 | 24 | 126 |
2023 September | 63 | 14 | 77 |
2023 August | 54 | 14 | 68 |
2023 July | 97 | 11 | 108 |
2023 June | 78 | 3 | 81 |
2023 May | 101 | 2 | 103 |
2023 April | 68 | 2 | 70 |
2023 March | 52 | 3 | 55 |
2023 February | 52 | 1 | 53 |
2023 January | 55 | 10 | 65 |
2022 December | 52 | 16 | 68 |
2022 November | 39 | 7 | 46 |
2022 October | 48 | 8 | 56 |
2022 September | 40 | 15 | 55 |
2022 August | 45 | 9 | 54 |
2022 July | 32 | 8 | 40 |
2022 June | 30 | 6 | 36 |
2022 May | 42 | 12 | 54 |
2022 April | 62 | 9 | 71 |
2022 March | 64 | 11 | 75 |
2022 February | 57 | 7 | 64 |
2022 January | 79 | 10 | 89 |
2021 December | 43 | 10 | 53 |
2021 November | 45 | 9 | 54 |
2021 October | 43 | 13 | 56 |
2021 September | 20 | 12 | 32 |
2021 August | 32 | 18 | 50 |
2021 July | 12 | 12 | 24 |
2021 June | 19 | 5 | 24 |
2021 May | 40 | 9 | 49 |
2021 April | 80 | 21 | 101 |
2021 March | 41 | 6 | 47 |
2021 February | 22 | 8 | 30 |
2021 January | 17 | 3 | 20 |
2020 December | 14 | 7 | 21 |
2020 November | 8 | 9 | 17 |
2020 October | 4 | 6 | 10 |
2020 September | 0 | 6 | 6 |