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Letter to the Editor
Isolated bilateral abducens nerve palsy secondary to clivus metastasis of prostate adenocarcinoma undetected by magnetic resonance imaging
Paresia del nervio abducens bilateral aislada secundaria a metástasis en clivus de adenocarcinoma de próstata inadvertida en resonancia magnética
G. Mayà-Casalprima, E. Serranob, H.K Oberoic, L. Llulla,
Corresponding author
BLLLULL@clinic.cat

Corresponding author.
a Servicio de Neurología, Hospital Clínic, Barcelona, Spain
b Servicio de Radiodiagnóstico, Hospital Sagrat Cor, Barcelona, Spain
c Servicio de Oncología, Hospital Clínic, Barcelona, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Bilateral abducens nerve palsy has numerous causes&#44; including cerebrovascular diseases&#44; intracranial hypertension&#44; carotid-cavernous fistulas&#44; infection&#44; trauma&#44; Guillain&#8211;Barr&#233; syndrome&#44; Wernicke&#8211;Korsakoff syndrome&#44; and tumours&#46; The condition rarely presents in isolation&#59; when it does&#44; presence of a tumour in the clivus should be ruled out&#46; We present a case of bilateral abducens nerve palsy secondary to clival metastasis of prostate cancer&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Our patient was a 72-year-old man with 6-year history of prostate adenocarcinoma and bone metastases who visited our emergency department in March 2018 due to diplopia of 2 months&#8217; progression&#59; he was receiving sixth-line treatment with radium-223 and had already completed 4 cycles&#44; showing good tolerance&#46; He initially reported difficulty with left eye abduction&#44; developing difficulty with right eye abduction 2 weeks later&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The most recent imaging studies available&#44; performed a month previously&#44; were bone scintigraphy&#44; which revealed bone lesions in multiple sites&#44; including the skull and the left superior maxillary bone &#40;see online supplementary material&#41;&#44; and a chest and abdominal axial CT scan&#44; which revealed no visceral anomalies&#46; A week previously&#44; the patient had undergone a brain MRI study&#44; which was initially interpreted as normal&#59; however&#44; a later evaluation of MR images detected contrast uptake in the left abducens nerve &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; An electromyography study conducted the previous day had yielded normal results&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The neurological examination detected isolated bilateral abducens nerve palsy &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; A blood analysis detected no abnormalities&#59; acute-phase reactants were within normal ranges&#46; A head CT bone window study revealed diffuse hyperdensities in the clivus and sphenoid bones&#44; suggestive of bone metastases &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">We started outpatient treatment with dexamethasone dosed at 4&#8239;mg&#47;24&#8239;h&#44; which was later down-titrated&#44; and skull base radiation therapy &#40;total dose of 30&#8239;Gy&#41;&#59; given the progression of the cancer&#44; treatment was switched to a new line of chemotherapy with cabazitaxel&#46; Diplopia resolved within 4 weeks&#44; and has not reappeared after 6 months of follow-up&#46; No follow-up neuroimages are available&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The abducens nerve innervates the lateral rectus muscle&#44; responsible for eye abduction&#46; Its trajectory is subdivided into 5 segments<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a>&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1</span><p id="par0035" class="elsevierStylePara elsevierViewall">Intra-axial&#58; the abducens nucleus is located in the posterior&#44; caudal portion of the pons&#46; It projects axons anteriorly through the medial lemniscus&#44; which is medial to the fascicles of the facial nerve&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2</span><p id="par0040" class="elsevierStylePara elsevierViewall">Cisternal&#58; the abducens nerve emerges at the pontomedullary sulcus&#44; lateral to the bundles of the corticospinal tract&#44; and courses upwards along the prepontine cistern until reaching the posterior&#44; dural surface of the clivus&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3</span><p id="par0045" class="elsevierStylePara elsevierViewall">Dorello canal&#58; after perforating the clival dura mater&#44; the abducens nerve enters the Dorello canal to reach the cavernous sinus&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4</span><p id="par0050" class="elsevierStylePara elsevierViewall">Cavernous sinus&#58; the abducens nerve runs immediately lateral to the internal carotid artery&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">5</span><p id="par0055" class="elsevierStylePara elsevierViewall">Extracranial&#58; the abducens nerve enters the orbit through the superior orbital fissure and reaches the lateral rectus muscle&#46;</p></li></ul></p><p id="par0060" class="elsevierStylePara elsevierViewall">A clival lesion may therefore damage the abducens nerve bilaterally at the level of the Dorello canal&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The literature includes only 12 cases of isolated bilateral abducens nerve palsy secondary to tumours of varying aetiology&#46; In 7 patients &#40;3 with primary tumours and 4 with metastases&#41;&#44; the clivus was the main structure involved&#58; clivus chordoma &#40;2&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> multiple myeloma of the clivus &#40;1&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> clivus diffuse large B cell lymphoma &#40;1&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> clivus metastasis of Ewing&#8217;s sarcoma &#40;1&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> clivus metastasis of small-cell lung carcinoma &#40;1&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> and clivus metastasis of lung adenocarcinoma &#40;1&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> The remaining 5 patients had pituitary adenoma &#40;3&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10-12</span></a> primary non-Hodgkin&#8217;s lymphoma of the sphenoid sinus &#40;1&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> and nasopharyngeal carcinoma &#40;1&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> The primary tumour was previously unknown in only one of the 3 patients presenting metastasis&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> In some patients&#44; abducens nerve palsy was bilateral from diagnosis&#44; whereas other patients initially presented unilateral symptoms&#44; with bilateral palsy developing over the course of several days or weeks&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Our case shows that bone metastases may go undetected in contrast brain MRI scans&#59; head CT scans&#44; particularly bone window images&#44; may be extremely helpful for diagnosis&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">To our knowledge&#44; this is the first reported case of isolated bilateral abducens nerve palsy secondary to clival metastasis of prostate adenocarcinoma&#46; Clivus tumours should be included in the differential diagnosis of bilateral abducens nerve palsy&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0080" class="elsevierStylePara elsevierViewall">The authors have received no funding for this study&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; May&#224;-Casalprim G&#44; Serrano E&#44; Oberoi HK&#44; Llull L&#46; Paresia del nervio abducens bilateral aislada secundaria a met&#225;stasis en clivus de adenocarcinoma de pr&#243;stata inadvertida en resonancia magn&#233;tica&#46; Neurolog&#237;a&#46; 2020&#59;35&#58;599&#8211;601&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A and B&#41; Brain MRI&#46; Contrast T1-weighted sequences&#58; A&#41; axial plane&#59; B&#41; sagittal plane&#46; Red arrow&#58; the left abducens nerve&#44; emerging from the prepontine cistern&#44; shows increased contrast uptake&#44; probably due to involvement of the Dorello canal&#46; Green arrow&#58; trigeminal nerve&#44; with no contrast uptake&#46; C and D&#41; Head CT scan &#40;bone window&#41;&#44; axial plane&#46; C&#41; Diffuse hyperdensities in the clivus and sphenoid bone &#40;red asterisk&#41;&#44; suggesting bone metastases&#46; D&#41; Image from a control&#44; showing no hyperdensities at the base of the skull&#46;</p>"
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ISSN: 21735808
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