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Letter to the Editor
Intra-arterial gadolinium as an alternative to iodinated contrast agents in thrombectomy
Gadolinio intraarterial como alternativa al contraste yodado en la trombectomía
A. de Albóniga-Chindurza, J. Ortega-Quintanilla, J. Alcalde-López, E. Zapata-Arriaza, A. González
Corresponding author
ggjandro@gmail.com

Corresponding author.
Servicio de Radiología, Neurorradiología Intervencionista, Hospital Universitario Virgen del Rocío, Sevilla, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Thrombectomy has radically changed the management of ischaemic stroke due to large-vessel occlusion&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Angiography requires the use of iodinated contrast agents&#44; although gadolinium may be used in patients with a contraindication to these substances&#46; Gadolinium has been used widely in arterial interventions and peripheral angiography&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> It has also been used in carotid artery angiography&#44;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> in the treatment of dural arteriovenous fistulas&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and even in the assessment of patients with ischaemic stroke&#44; when results from non-invasive tests are inconclusive&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Gadolinium-enhanced cerebral angiography for thrombectomy may be an alternative in patients with history of severe adverse reactions to iodinated contrast agents&#46; Although this indication is known&#44; it is rarely mentioned in the literature&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> We recently treated 2 patients with aspiration thrombectomy using gadolinium as the contrast medium&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The first patient was a 69-year-old woman with hypertension and history of papillary carcinoma of the thyroid&#44; which was treated surgically 20 years previously&#46; She came to our hospital due to language impairment and right limb weakness of 6 hours&#8217; progression&#46; The neurological examination revealed severe dysphasia with right faciobrachiocrural hemiparesis&#44; scoring 17 points on the National Institutes of Health Stroke Scale &#40;NIHSS&#41;&#46; CT findings scored 8 on the Alberta Stroke Program Early CT Score &#40;ASPECTS&#41;&#44; with a hyperdense signal in the left middle cerebral artery&#59; CT angiography was not performed as the patient had presented anaphylaxis to contrast during a follow-up study of the thyroid cancer&#46; Laboratory analysis detected no remarkable alterations&#44; with creatinine clearance of 110&#8239;mL&#47;min&#46; Given strong suspicion of large-vessel occlusion&#44; we performed an angiography study with gadobutrol&#59; our patient&#8217;s relatives gave informed consent for the compassionate use of this contrast medium&#46; The study revealed left distal M1 segment occlusion &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Manual aspiration with a SOFIA 6&#8239;F catheter achieved successful recanalisation &#40;TICI grade 3&#41;&#46; The procedure required 26&#8239;mL Gadovist&#174; &#40;gadobutrol 604&#46;72&#8239;mg&#47;mL&#41; for 3 angiography runs&#44; and was performed with a monoplane angiography system&#59; the patient was not sedated during the procedure&#46; The patient scored 10 points on the NIHSS after the procedure&#44; and 4 at discharge&#46; No complications were recorded during hospitalisation&#59; unknown atrial fibrillation was detected&#44; and kidney function was normal&#46; An MRI study performed a week later revealed subacute punctiform ischaemic lesions in the caudate and lentiform nuclei and the left frontal subcortical region&#44; with no signs of haemorrhage&#46; No complications were observed after a year of follow-up&#44; with the patient scoring 0 on the modified Rankin Scale &#40;mRS&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Our second patient was a 68-year-old man&#44; a smoker&#44; with hypertension and history of oral epidermoid carcinoma&#44; which was treated with surgery and radiation therapy 7 years earlier&#46; He presented sudden-onset weakness of the left limbs&#44; difficulty speaking&#44; and anosognosia&#44; and scored 18 on the NIHSS&#46; CT findings scored 10 on the ASPECTS scale&#44; with images showing hyperdense signal in the right middle cerebral artery&#59; CT angiography was not performed as the patient had presented a severe reaction to contrast medium during an imaging study for cancer&#46; All laboratory parameters were within normal ranges&#44; with creatinine clearance of 90&#8239;mL&#47;min&#46; Femoral puncture was performed 2&#8239;hours and 15&#8239;minutes after symptom onset&#46; The patient&#8217;s family gave informed consent for the compassionate use of gadobutrol as a contrast medium&#46; The angiography study revealed internal carotid artery occlusion at the cervical level &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; We performed balloon angioplasty &#40;3&#8239;&#215;&#8239;20&#8239;mm&#41; of the occluded segment and subsequently inserted a SOFIA&#174; 6&#8239;F catheter until the internal carotid artery&#46; Manual aspiration thrombectomy achieved complete recanalisation &#40;TICI grade 3&#41; with a single pass&#46; Cervical angiography revealed underlying stenosis&#59; balloon angioplasty &#40;5&#8239;&#215;&#8239;20&#8239;mm&#41; was performed to place a Wallstent&#174; endoprosthesis stent measuring 9&#8239;&#215;&#8239;40&#8239;mm&#46; No signs of aggregation or any other complications were observed after 20&#8239;minutes&#46; We used a total of 110&#8239;mL undiluted gadobutrol for the angiography runs performed after thrombectomy and during endoprosthesis placement&#44; and gadobutrol at a 50&#58;50 dilution with saline solution for the rest&#46; We performed a total of 15 angiography runs&#44; including the study of the contralateral carotid artery&#46; The patient received 900&#8239;mg of intravenous lysine acetylsalicylate and did not require sedation&#46; His neurological symptoms improved&#44; with an NIHSS score of 10 at discharge&#46; No complications were observed during hospitalisation&#59; the permeability of the endoprosthesis was confirmed by Doppler ultrasound&#59; kidney function was preserved&#46; An MRI study conducted 8 days later revealed a subacute infarction in the right temporolateral area&#44; insula&#44; and lentiform nucleus&#59; the latter area displayed haemosiderin deposition&#46; One year later&#44; the patient scored 3 on the mRS and had presented no other remarkable events&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The families of both patients gave informed consent for the compassionate use of gadolinium&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The need for immediate treatment of ischaemic stroke precludes the administration of premedication for iodinated contrast agents in patients with history of severe allergic reactions&#46; Male et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> published a similar case&#58; they successfully performed mechanical thrombectomy for right M1 occlusion using intra-arterial gadolinium in a patient with history of anaphylaxis to iodinated contrast agents&#46; Although gadolinium is a known alternative&#44; few cases have been published&#44; which is why we decided to share our experience with this contrast medium&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Gadolinium is widely used in MRI studies to characterise central nervous system lesions&#44; and is particularly useful in patients with inflammatory and tumoural diseases&#46; Significant efforts are currently being made to describe gadolinium deposits in the central nervous system&#46; Although its clinical significance is uncertain&#44; the possibility of gadolinium accumulation in the brain makes molecularly stable types of gadolinium a reasonable option&#46; Non-ionic and macrocyclic gadolinium-based contrast agents &#40;eg&#44; gadobutrol&#41; are preferred&#59; linear contrasts are being discontinued in many countries&#46; Gadolinium deposition in the dentate nucleus and globus pallidus may be associated with repeated exposure to high doses of this contrast agent&#44; and may even play a role in blood-brain barrier permeability&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a> No other specific complications of intra-arterial administration have been described&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The summary of product characteristics of gadobutrol indicates the possibility of administering doses of up to 0&#46;3&#8239;mL&#47;kg&#46; We administered 0&#46;37&#8239;mL&#47;kg to the first patient &#40;71&#8239;kg&#41; and 0&#46;77&#8239;mL&#47;kg to the second &#40;85&#8239;kg&#41;&#46; This difference is explained by the difficulty of treating tandem occlusions&#59; in these patients&#44; angioplasty requires cervical angiography runs&#44; in addition to a study of the contralateral carotid artery to confirm the position of the circle of Willis&#46; We administered a 50&#58;50 dilution to our second patient with a view to reducing the total dose of gadobutrol&#46; In this patient&#44; image quality was significantly lower than in conventional studies&#46; However&#44; images obtained with undiluted gadobutrol were practically indistinguishable from those obtained with iodinated contrast agents&#46; Undiluted gadobutrol was used in post-thrombectomy studies and during endoprosthesis placement&#46; Biplane imaging is not available at our centre&#44; so we had to perform more angiography runs and therefore required more gadobutrol&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Kidney function was monitored for a week and showed no significant alterations&#46; One year after the procedure&#44; neither patient developed contrast-related complications&#44; such as nephrogenic systemic fibrosis&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> MRI studies performed during hospitalisation showed no unexpected findings&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">We report 2 cases of successful thrombectomy with gadobutrol-enhanced imaging and no complications associated with this contrast medium&#46; Compassionate use of gadobutrol may be considered in patients with clear contraindications to iodinated contrast agents&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; de Alb&#243;niga-Chindurza A&#44; Ortega-Quintanilla J&#44; Alcalde-L&#243;pez J&#44; Zapata-Arriaza E&#44; Gonz&#225;lez A&#46; Gadolinio intraarterial como alternativa al contraste yodado en la trombectom&#237;a&#46; Neurolog&#237;a&#46; 2020&#59;35&#58;681&#8211;683&#46;</p>"
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                      "titulo" => "Spontaneous closure of a dural arteriovenous fistula immediately after cerebral angiography using a gadolinium contrast agent"
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                          "autores" => array:4 [
                            0 => "K&#46; Tsuji"
                            1 => "N&#46; Nakagawa"
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                      "doi" => "10.1016/j.jstrokecerebrovasdis.2014.06.019"
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                          "etal" => false
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                      "titulo" => "Gadolinium to the rescue for mechanical thrombectomy in acute ischemic stroke"
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Male"
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;J&#46; McDonald"
                            1 => "R&#46;J&#46; McDonald"
                            2 => "D&#46;F&#46; Kallmes"
                            3 => "M&#46;E&#46; Jentoft"
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                          "etal" => true
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                            2 => "M&#46; &#321;asecki"
                            3 => "R&#46; Chaber"
                            4 => "A&#46; Olchowy"
                            5 => "K&#46; Ka&#322;wak"
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                      "titulo" => "ESUR Contrast Medium Safety Committee&#46; Nephrogenic systemic fibrosis and gadolinium-based contrast media&#58; updated ESUR Contrast Medium Safety Committee guidelines"
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                            2 => "T&#46; Alm&#233;n"
                            3 => "M&#46;F&#46; Bellin"
                            4 => "M&#46; Bertolotto"
                            5 => "G&#46; Bongartz"
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                        "tituloSerie" => "Eur Radiol"
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos