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A)<span class="elsevierStyleHsp" style=""></span>Atrofia muscular en gemelos y tibiales bilaterales. B)<span class="elsevierStyleHsp" style=""></span>Estudio ENMG: velocidad de conducción motora y amplitud del potencial del nervio tibial posterior derecho normales. C)<span class="elsevierStyleHsp" style=""></span>Estudio de aguja del músculo gemelo lateral derecho: potenciales de unidad motora de baja amplitud y duración.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.J. Abenza-Abildúa, M.T. Ramírez-Prieto, R. Moreno-Zabaleta, N. Arenas-Valls, M.A. Salvador-Maya, C. Algarra-Lucas, B. Rojo Moreno-Arrones, B. Sánchez-Cordón, J. Ojeda-Ruíz de Luna, C. Jimeno-Montero, F.J. Navacerrada-Barrero, C. Borrue-Fernández, E. Malmierca-Corral, P. Ruíz-Seco, P. González-Ruano, I. Palmí-Cortés, J. Fernández-Travieso, M. Mata-Álvarez de Santullano, M.L. Almarcha-Menargues, G. Gutierrez-Gutierrez, J.A. Palacios-Castaño, R. Alonso-Esteban, N. Gonzalo-García, C. Pérez-López" "autores" => array:24 [ 0 => array:2 [ "nombre" => "M.J." "apellidos" => "Abenza-Abildúa" ] 1 => array:2 [ "nombre" => "M.T." "apellidos" => "Ramírez-Prieto" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Moreno-Zabaleta" ] 3 => array:2 [ "nombre" => "N." "apellidos" => "Arenas-Valls" ] 4 => array:2 [ "nombre" => "M.A." "apellidos" => "Salvador-Maya" ] 5 => array:2 [ "nombre" => "C." "apellidos" => "Algarra-Lucas" ] 6 => array:2 [ "nombre" => "B." "apellidos" => "Rojo Moreno-Arrones" ] 7 => array:2 [ "nombre" => "B." "apellidos" => "Sánchez-Cordón" ] 8 => array:2 [ "nombre" => "J." "apellidos" => "Ojeda-Ruíz de Luna" ] 9 => array:2 [ "nombre" => "C." "apellidos" => "Jimeno-Montero" ] 10 => array:2 [ "nombre" => "F.J." "apellidos" => "Navacerrada-Barrero" ] 11 => array:2 [ "nombre" => "C." "apellidos" => "Borrue-Fernández" ] 12 => array:2 [ "nombre" => "E." "apellidos" => "Malmierca-Corral" ] 13 => array:2 [ "nombre" => "P." 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"apellidos" => "Pérez-López" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173580820302212" "doi" => "10.1016/j.nrleng.2020.07.012" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580820302212?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485320302462?idApp=UINPBA00004N" "url" => "/02134853/0000003500000009/v1_202011170721/S0213485320302462/v1_202011170721/es/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S2173580820302170" "issn" => "21735808" "doi" => "10.1016/j.nrleng.2020.07.008" "estado" => "S300" "fechaPublicacion" => "2020-11-01" "aid" => "1473" "copyright" => "Sociedad Española de Neurología" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Neurologia. 2020;35:628-32" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Standard headache and neuralgia treatments and SARS-CoV-2: opinion of the Spanish Society of Neurology’s Headache Study Group" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "628" "paginaFinal" => "632" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tratamientos habituales utilizados en cefaleas, neuralgias y SARS-CoV-2. 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"apellidos" => "Pérez-López" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">h</span>" "identificador" => "aff0040" ] ] ] ] "afiliaciones" => array:8 [ 0 => array:3 [ "entidad" => "Sección de Neurología, Hospital Universitario Infanta Sofía, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Sección de Neumología, Hospital Universitario Infanta Sofía, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Sección de Neurorradiología, Hospital Universitario Infanta Sofía, Madrid, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Sección de Enfermedades Infecciosas, Hospital Universitario Infanta Sofía, Madrid, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Servicio de Psiquiatría, Hospital Universitario Infanta Sofía, Madrid, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Hospitalización a Domicilio, Hospital Universitario Infanta Sofía, Madrid, Spain" "etiqueta" => "f" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Servicio de Rehabilitación, Hospital Universitario Infanta Sofía, Madrid, Spain" "etiqueta" => "g" "identificador" => "aff0035" ] 7 => array:3 [ "entidad" => "Servicio de Neurocirugía, Complejo Universitario La Paz-Cantoblanco-Carlos III, Madrid, Spain" "etiqueta" => "h" "identificador" => "aff0040" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Complicaciones neurológicas en pacientes críticos por SARS-CoV-2" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1355 "Ancho" => 2125 "Tamanyo" => 270655 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Myopathy (patient 17). A) Atrophy of the gastrocnemius and tibialis anterior muscles. B) Electroneuromyography study: normal motor conduction velocity and motor potential amplitude in the right posterior tibial nerve. C) Needle electromyography of the right lateral head of the gastrocnemius muscle showing low amplitude and short duration of motor unit action potentials.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">SARS-CoV-2 infection in humans was first reported in China in December 2019. In Spain, the first cases were reported in March 2020.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Although this novel virus mainly causes respiratory signs and symptoms (cough, fever, dyspnoea, interstitial infiltrate in chest radiography or lung CT) whose seriousness greatly determines disease severity and the risk of mortality, cases have been reported since the beginning of the pandemic of such neurological symptoms (or symptoms suggestive of neurological involvement) as headache, anosmia, muscle pain, insomnia, confusion, and bradyphrenia, both in patients with mild COVID-19 and in critical patients requiring orotracheal intubation and admission to an intensive care unit (ICU).</p><p id="par0015" class="elsevierStylePara elsevierViewall">SARS-CoV-2 is currently believed to present tropism for angiotensin-converting enzyme 2 (ACE2) receptors, which the virus uses to enter the cell, where it begins replicating. ACE2 receptors are expressed in different organs and particularly the lungs, heart, kidneys, intestines, and brain.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In physiological conditions, ACE2 receptors can be found in glial cells and neurons in the brain; the hypothesis that the virus may cause neurological symptoms therefore seems plausible. This could be confirmed with routine neurological tests (brain MRI, CT, lumbar puncture, electroneuromyography [ENMG], or electroencephalography [EEG]), which may help us to understand the pathophysiology of the disease and the associated neurological complications.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Based on this assumption, our centre has developed a protocol aiming to provide specific neurological care to patients with severe COVID-19 admitted to the ICU and requiring orotracheal intubation; this protocol is intended to detect neurological complications as early as possible in order to reduce morbidity and mortality and minimise the risk of neurological sequelae.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The literature includes several series of patients with neurological involvement during acute SARS-CoV-2 infection.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5–13</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">We analysed the neurological complications of severe SARS-CoV-2 infection within 48 hours after the critical period of the disease.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Patients and methods</span><p id="par0040" class="elsevierStylePara elsevierViewall">We conducted a descriptive, observational, retrospective study of consecutive patients admitted to the ICU due to severe respiratory infection with SARS-CoV-2 between 1 April and 1 June 2020. Our patients underwent a neurological evaluation within 48 hours of discharge from the ICU and transfer to a conventional inpatient ward.</p><p id="par0045" class="elsevierStylePara elsevierViewall">We analysed the following variables: age, sex, general comorbidities, neurological comorbidities, previous pharmacological treatments, source of infection, time since the first general symptom and the first neurological symptom, method used to establish diagnosis of SARS-CoV-2 infection, description of neurological symptoms, findings from the neurological examination, neurological syndrome, length of ICU stay (days), duration of hospitalisation (days), creatine kinase (CK) levels, lumbar puncture findings, CSF analysis results, head CT, brain or lumbar spine MRI, EEG, ENMG, causal relationship between COVID-19 and neurological syndrome in the opinion of the neurologist, treatment received for COVID-19 (antiviral drugs, antibiotics, sedatives), neurological treatment, clinical progression, and duration of neurological manifestations.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Data were anonymised and grouped. Statistical analysis was performed using SPSS, version 25 (IBM).</p><p id="par0055" class="elsevierStylePara elsevierViewall">The study was approved by our hospital’s research committee (April 2020).</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0060" class="elsevierStylePara elsevierViewall">A total of 54 patients were admitted to the ICU, 30 of whom presented neurological symptoms: 21 men (72.40%) and 9 women (27.60%). Mean age (SD) in our series was 57.41 (11.61) years (range, 25-74). None of the patients were healthcare professionals.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Mean duration of hospitalisation was 34.72 (11.44) days (range, 16-59). Mean stay at the ICU was 18.83 (14.33) days (range, 6-55). The source of infection was unknown in most cases (20 patients, 66.66%); the remaining patients were infected with SARS-CoV-2 in the family setting or by their partners (8 patients, 26.66%) and during social gatherings or travel (2 patients, 6.66%).</p><p id="par0070" class="elsevierStylePara elsevierViewall">All patients presented bilateral pneumonia associated with severe respiratory insufficiency, and therefore required admission to the ICU and orotracheal intubation. All patients were sedated with remifentanil, propofol, midazolam, or morphine hydrochloride, which were suspended after discharge from the ICU.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Regarding medical history, 8 patients (26.66%) had arterial hypertension, 8 (26.66%) were obese, and 6 (20%) had type 2 diabetes mellitus. None had history of neurological disease. Only 8 patients (26.66%) were smokers, and 2 (6.66%) had history of respiratory disease (severe sleep apnoea-hypopnoea syndrome, treated with continuous positive airway pressure).</p><p id="par0080" class="elsevierStylePara elsevierViewall">Mean time between onset of the respiratory infection and onset of neurological symptoms was 9.63 (4.1) days (range, 3-36). Twenty-one patients (70%) required anticoagulation therapy with tinzaparin due to segmental pulmonary thromboembolism observed in follow-up lung CT scans performed during hospitalisation.</p><p id="par0085" class="elsevierStylePara elsevierViewall">Twenty-eight patients (93.33%) presented acute confusional syndrome, 15 (50%) neuromuscular disorders, 5 (16.66%) headache, 4 (13.33%) cerebrovascular disease, and 4 (13.33%) encephalopathy/encephalitis.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Six patients underwent lumbar puncture; CSF analysis revealed no alterations in cell counts, glucose levels, or protein levels. In all cases, PCR yielded negative results for SARS-CoV-2 in the CSF.</p><p id="par0095" class="elsevierStylePara elsevierViewall">CK levels were elevated in 28 patients (93.33%); mean CK level was 379.69 (309.341) μg/L (range, 61-1206).</p><p id="par0100" class="elsevierStylePara elsevierViewall">All patients underwent neuroimaging studies (brain MRI or CT scan, depending on the patient’s clinical status), which revealed no alterations in 10 cases (33.33%). The remaining patients presented intraparenchymal haemorrhage (2), venous thrombosis (2), encephalopathy (4), cavernoma (1), and chronic lacunar lesions (11) (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">All patients underwent EEG, with 8 (26.66%) presenting alterations (mild diffuse slowing in all cases), with no epileptiform activity.</p><p id="par0110" class="elsevierStylePara elsevierViewall">Six patients (20%) underwent ENMG studies, which revealed normal motor and sensory nerve conduction velocities and a myopathic pattern in 5 cases (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Only one patient presented polyneuropathy.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">Patients were administered the following specific treatments for SARS-CoV-2 infection: chloroquine/hydroxychloroquine (30 patients; 100%), lopinavir/ritonavir (13; 43.33%), tocilizumab (17; 56.66%), boluses of methylprednisolone (15; 50%), remdesivir (2; 6.66%), and ceftriaxone (28; 93.33%). All patients received active treatment with antiviral drugs or empirical antibiotic treatment during their stay at the ICU.</p><p id="par0120" class="elsevierStylePara elsevierViewall">Twenty patients (66.66%) progressed favourably or remained stable, 7 patients (23.33%) presented complications or progressive worsening, and 3 patients (10%) died.</p><p id="par0125" class="elsevierStylePara elsevierViewall">According to the informing neurologist’s judgement, the relationship between COVID-19 and the neurological syndrome was probable causation in 66.66% of cases, definite causation in 20%, and coincidental in 13.34%.</p><p id="par0130" class="elsevierStylePara elsevierViewall">No statistically significant association was observed between male sex and total hospitalisation time (<span class="elsevierStyleItalic">P</span> = .358), length of ICU stay (<span class="elsevierStyleItalic">P</span> = .292), or CK levels; between presence of confusional symptoms and EEG alterations (<span class="elsevierStyleItalic">P</span> = .486); or between age and presence of myopathy (<span class="elsevierStyleItalic">P</span> = 0.06). However, we did find a statistically significant association between older age (> 50 years) and longer ICU stay (<span class="elsevierStyleItalic">P</span> = .002; OR = 3.594; 95% CI, 1.032–6.022) (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0135" class="elsevierStylePara elsevierViewall">When the pandemic started, many neurologists had to become pulmonologists or internists to assist in the care of patients with SARS-CoV-2 infection; in this context, we observed the presentation of neurological symptoms in patients with COVID-19, and especially in severe cases. In the light of this, our centre decided to design a protocol for systematic, specific neurological evaluation of patients with COVID-19 who were admitted to the ICU and required orotracheal intubation.</p><p id="par0140" class="elsevierStylePara elsevierViewall">From an epidemiological viewpoint, our series mainly included middle-aged men with no history of neurological disease, with few individuals presenting the most frequent vascular risk factors (hypertension, diabetes); this is consistent with the results from previous studies.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,11–14</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Within 48−72 h of discharge from the ICU, most patients presented acute confusional syndrome presenting with disorientation to time and place, difficulty retrieving words, and fluctuating short-term memory problems. Some patients also presented irritability and aggressiveness within the first few hours, as has been described in other series.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> These patients presented similar symptoms, regardless of their age or the length of their ICU stay.</p><p id="par0150" class="elsevierStylePara elsevierViewall">Their symptoms were not correlated with EEG or brain MRI alterations, and resolved completely. The only EEG alteration observed was mild generalised background slowing, which was not associated with epileptiform activity in any case. None of the patients presented seizures during hospitalisation.</p><p id="par0155" class="elsevierStylePara elsevierViewall">Imaging studies revealed the most common vascular alterations (small intraparenchymal haemorrhages, chronic lacunar lesions, cerebral venous sinus thrombosis in patients with coagulation disorders in the context of COVID-19). These findings have been reported by different authors since the beginning of the pandemic.<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16–21</span></a> However, cerebrovascular diseases were less frequent in our series than in other studies, probably due to the lower mean age of our sample and the lower prevalence of vascular risk factors.</p><p id="par0160" class="elsevierStylePara elsevierViewall">Furthermore, some patients in our series presented radiological signs of encephalopathy, which were found to be poorly correlated with their symptoms.<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22–25</span></a> Likewise, all CSF findings from patients undergoing lumbar puncture were normal (the procedure was contraindicated in most patients, since they were receiving anticoagulation therapy for pulmonary thrombosis). These results, together with negative PCR results in CSF, are increasingly being reported in the literature.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">Despite an increasing number of reports of Guillain-Barré syndrome and seizures or status epilepticus among patients with COVID-19,<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">27–30</span></a> these manifestations were not observed in any of our patients. However, we did find clinical evidence of myopathy in half of the patients evaluated (with several cases confirmed by ENMG); these findings have not previously been described in other series.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11–14</span></a> Marked amyotrophy of the lower limbs initially suggested Guillain-Barré-like polyneuropathy or critical illness polyneuropathy, but most patients showed normal motor and sensory nerve conduction velocities and a clearly myopathic pattern in the muscles studied (usually the abductor pollicis brevis, abductor digiti minimi, tibialis anterior, quadriceps, and gastrocnemius muscles), and normal tendon reflexes in the neurological examination. Only the patient with the longest ICU stay (55 days) showed critical illness polyneuropathy in an ENMG study. All patients showed slightly elevated CK levels. Lumbar puncture yielded normal results in patients undergoing this procedure.</p><p id="par0170" class="elsevierStylePara elsevierViewall">Hypothesis testing revealed a statistically significant association between older age (> 50 years) and longer ICU stays, as similar studies have also reported.</p><p id="par0175" class="elsevierStylePara elsevierViewall">Our series is smaller than other published series, such as that analysed by our colleagues from the ALBACOVID registry<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> or the sample included in the multicentre study conducted in Madrid at the beginning of the pandemic and analysing smell and taste disorders.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> This may be due to the characteristics of our hospital, a small secondary healthcare centre with 270 beds serving a population of approximately 325 000 inhabitants (larger series include patients from tertiary hospitals).<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14,31–34</span></a> However, our series has the advantage that it is homogeneous: our patients were young, had no history of neurological disease or any other relevant medical history except for some cases of hypertension and diabetes mellitus, and they all presented severe respiratory involvement requiring admission to the ICU. All patients were attended by the same anaesthetists/intensivists, pulmonologists, and neurologists. As a result, the neurological examination, complementary tests, and pharmacological treatment were similar in all cases, minimising the risk of bias.</p><p id="par0180" class="elsevierStylePara elsevierViewall">Although our patients presented similar disorders to those reported in previous studies (headache, intracranial haemorrhage, stroke, encephalopathy, etc),<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,35–38</span></a> we found a significant number of patients with confusional syndrome and acute myopathy, which was most probably inflammatory (systemic reaction) or associated with critical illness polyneuropathy, rather than secondary to direct invasion by the virus. We believe that both complications are associated with the severity of COVID-19 in these patients.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusions</span><p id="par0185" class="elsevierStylePara elsevierViewall">In our series, severe COVID-19 was more frequent among men than women; this is consistent with previous series. Half of our patients presented acute myopathy, and nearly all presented acute confusional syndrome after discharge from the ICU; these symptoms resolved completely and were not correlated with EEG or neuroimaging findings. Older age was found to be associated with longer ICU stays. Studies with larger samples are needed to confirm our results.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Funding</span><p id="par0190" class="elsevierStylePara elsevierViewall">After this study was completed, the lead author was awarded the COVID-19 research prize from the foundation for biomedical research and innovation of Hospital Universitario Infanta Sofía and Hospital Universitario del Henares, in Madrid.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflicts of interest</span><p id="par0195" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres1710593" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Patients and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1513004" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1710592" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Pacientes y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1513003" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Patients and methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Conclusions" ] 9 => array:2 [ "identificador" => "sec0030" "titulo" => "Funding" ] 10 => array:2 [ "identificador" => "sec0035" "titulo" => "Conflicts of interest" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-07-08" "fechaAceptado" => "2020-07-29" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1513004" "palabras" => array:5 [ 0 => "COVID-19" 1 => "Critical patient" 2 => "Acute myopathy" 3 => "Encephalopathy" 4 => "SARS-CoV-2" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1513003" "palabras" => array:5 [ 0 => "COVID-19" 1 => "Paciente crítico" 2 => "Miopatía aguda" 3 => "Encefalopatías" 4 => "SARS-CoV2" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">We analysed the neurological complications of patients with severe SARS-CoV-2 infection who required intensive care unit (ICU) admission.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We conducted a retrospective, observational, descriptive study of consecutive patients admitted to the ICU due to severe respiratory symptoms secondary to SARS-CoV-2 infection between 1 April and 1 June 2020.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">We included 30 patients with neurological symptoms; 21 were men (72.40%), and mean age (standard deviation [SD]) was 57.41 years (11.61). The mean duration of ICU stay was 18.83 days (14.33). The neurological conditions recorded were acute confusional syndrome in 28 patients (93.33%), neuromuscular disease in 15 (50%), headache in 5 (16.66%), cerebrovascular disease in 4 (13.33%), and encephalopathies/encephalitis in 4 (13.33%). CSF analysis results were normal in 6 patients (20%). Brain MRI or head CT showed alterations in 20 patients (66.6%). EEG was performed in all patients (100%), with 8 (26.66%) showing abnormal findings. In 5 of the 15 patients with clinical myopathy, diagnosis was confirmed with electroneuromyography. We found a correlation between older age and duration of ICU stay (<span class="elsevierStyleItalic">P</span> = 0.002; 95% CI, 4.032–6.022; OR).</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Severe COVID-19 mainly affects men, as observed in other series. Half of our patients presented acute myopathy, and almost all patients left the ICU with acute confusional syndrome, which fully resolved; no correlation was found with EEG or neuroimaging findings. Older age is associated with longer ICU stay.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Patients and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducción</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Nos proponemos analizar las complicaciones neurológicas de los pacientes con infección grave por SARS-CoV2, que han requerido ingreso en Unidad de Cuidados Intensivos (UCI).</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Pacientes y métodos</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Estudio descriptivo retrospectivo, observacional, de pacientes consecutivos ingresado en UCI por infección respiratoria grave por SARS-CoV-2, desde el 1 de Abril hasta el 1 de Junio de 2020.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Registramos 30 pacientes con síntomas neurológicos, 21 hombres (72,40%), edad media: 57,41 años ± 11,61 desviación estándar (DE). Estancia media en UCI: 18,83 ± 14,33 DE. A nivel sindrómico: 28 pacientes (93,33%) con síndrome confusional agudo, 15 pacientes (50%) con patología neuromuscular, 5 (16,66%) cefalea, 4 (13,33%) con patología cerebrovascular, y 4 (13,33%) con encefalopatías/encefalitis. Punción lumbar normal en 6 pacientes (20%). La RMN craneal o TAC craneal mostró alteraciones en 20 casos (66,6%). Se realizó EEG en todos los pacientes (100%), alterado en 8 pacientes (26,66%). En 5 de los 15 pacientes con miopatía clínica se ha podido confirmar con ENMG. Hemos encontrado relación entre la mayor edad y los días de ingreso en UCI (<span class="elsevierStyleItalic">P</span> = 0,002, IC 95% 4,032-6,022; OR:).</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">La infección grave por COVID-19 afecta mayoritariamente a hombres, similar a lo descrito en otras series. La mitad de nuestros pacientes presentan una miopatía aguda, y casi la totalidad de los pacientes salen de la UCI con sindromes confusionales agudos, que evolucionan a la resolución completa, sin correlacionarse con los resultados del EEG o de pruebas de neuroimagen. La mayor edad sí se asocia con un mayor número de días de estancia en UCI.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Pacientes y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Abenza-Abildúa MJ, Ramírez-Prieto MT, Moreno-Zabaleta R, Arenas-Valls N, Salvador-Maya MA. Algarra-Lucas C, et al. Complicaciones neurológicas en pacientes críticos por SARS-CoV-2. Neurología. 2020;35:621–627.</p>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 645 "Ancho" => 1600 "Tamanyo" => 101109 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Some vascular lesions detected in our series. A) Patient 8: 2 small left parietal cortico-subcortical haematomas in the convexity. B) Patient 1: acute haematoma in the right caudate nucleus, with opening to the ventricular system. C) Patient 26: hyperintense subacute ischaemic lesions in both parietal lobes, in the border zone of the middle cerebral and anterior cerebral artery territories.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1355 "Ancho" => 2125 "Tamanyo" => 270655 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Myopathy (patient 17). A) Atrophy of the gastrocnemius and tibialis anterior muscles. B) Electroneuromyography study: normal motor conduction velocity and motor potential amplitude in the right posterior tibial nerve. C) Needle electromyography of the right lateral head of the gastrocnemius muscle showing low amplitude and short duration of motor unit action potentials.</p>" ] ] 2 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">CI: confidence interval; CK: creatine kinase; EEG: electroencephalography; ICU: intensive care unit; OR: odds ratio; SD: standard deviation.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">N = 30 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"><span class="elsevierStyleItalic">P</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">OR \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95% CI</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Lower limit \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Upper limit \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mean age (SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">57.41 years (11.61) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sex (men) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 (72.40%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Length of ICU stay (patients > 50 years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.002 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.594 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.032 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.022 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CK level \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.226 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">–1.240 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">↓380.301 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">115.529 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Duration of hospitalisation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.0358 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.453 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.579 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.399 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">EEG alterations \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.293 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.073 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">–4.275 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.367 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2905171.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Descriptive and analytic study of our sample.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:38 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 3 | 0 | 3 |
2024 October | 24 | 1 | 25 |
2024 September | 34 | 2 | 36 |
2024 August | 31 | 3 | 34 |
2024 July | 23 | 2 | 25 |
2024 June | 25 | 2 | 27 |
2024 May | 25 | 3 | 28 |
2024 April | 42 | 5 | 47 |
2024 March | 50 | 3 | 53 |
2024 February | 33 | 15 | 48 |
2024 January | 37 | 5 | 42 |
2023 December | 29 | 6 | 35 |
2023 November | 30 | 6 | 36 |
2023 October | 32 | 15 | 47 |
2023 September | 19 | 3 | 22 |
2023 August | 18 | 6 | 24 |
2023 July | 24 | 9 | 33 |
2023 June | 25 | 8 | 33 |
2023 May | 19 | 5 | 24 |
2023 April | 28 | 1 | 29 |
2023 March | 13 | 0 | 13 |
2023 February | 14 | 3 | 17 |
2023 January | 24 | 2 | 26 |
2022 December | 25 | 7 | 32 |
2022 November | 41 | 7 | 48 |
2022 October | 32 | 7 | 39 |
2022 September | 23 | 17 | 40 |
2022 August | 23 | 11 | 34 |
2022 July | 26 | 12 | 38 |
2022 June | 22 | 14 | 36 |
2022 May | 26 | 10 | 36 |
2022 April | 23 | 8 | 31 |
2022 March | 28 | 11 | 39 |
2022 February | 46 | 15 | 61 |
2022 January | 47 | 23 | 70 |
2021 December | 34 | 11 | 45 |
2021 November | 31 | 26 | 57 |
2021 October | 34 | 17 | 51 |
2021 September | 41 | 28 | 69 |
2021 August | 47 | 17 | 64 |
2021 July | 48 | 23 | 71 |
2021 June | 56 | 13 | 69 |
2021 May | 49 | 27 | 76 |
2021 April | 65 | 29 | 94 |
2021 March | 110 | 30 | 140 |
2021 February | 50 | 31 | 81 |
2021 January | 33 | 31 | 64 |
2020 December | 23 | 24 | 47 |
2020 November | 9 | 7 | 16 |
2020 October | 2 | 4 | 6 |