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Original article
Neurological complications in critical patients with COVID-19
Complicaciones neurológicas en pacientes críticos por SARS-CoV-2
M.J. Abenza-Abildúaa,
Corresponding author
, M.T. Ramírez-Prietob, R. Moreno-Zabaletab, N. Arenas-Vallsb, M.A. Salvador-Mayab, C. Algarra-Lucasa, B. Rojo Moreno-Arronesb, B. Sánchez-Cordónc, J. Ojeda-Ruíz de Lunaa, C. Jimeno-Monteroa, F.J. Navacerrada-Barreroa, C. Borrue-Fernándeza, E. Malmierca-Corrald, P. Ruíz-Secod, P. González-Ruanod, I. Palmí-Cortésa, J. Fernández-Traviesoa, M. Mata-Álvarez de Santullanoa, M.L. Almarcha-Menarguesa, G. Gutierrez-Gutierreza..., J.A. Palacios Castañoe, R. Alonso Estebanf, N. Gonzalo-Garcíag, C. Pérez-LópezhVer más
a Sección de Neurología, Hospital Universitario Infanta Sofía, Madrid, Spain
b Sección de Neumología, Hospital Universitario Infanta Sofía, Madrid, Spain
c Sección de Neurorradiología, Hospital Universitario Infanta Sofía, Madrid, Spain
d Sección de Enfermedades Infecciosas, Hospital Universitario Infanta Sofía, Madrid, Spain
e Servicio de Psiquiatría, Hospital Universitario Infanta Sofía, Madrid, Spain
f Hospitalización a Domicilio, Hospital Universitario Infanta Sofía, Madrid, Spain
g Servicio de Rehabilitación, Hospital Universitario Infanta Sofía, Madrid, Spain
h Servicio de Neurocirugía, Complejo Universitario La Paz-Cantoblanco-Carlos III, Madrid, Spain
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Myopathy &#40;patient 17&#41;&#46; A&#41; Atrophy of the gastrocnemius and tibialis anterior muscles&#46; B&#41; Electroneuromyography study&#58; normal motor conduction velocity and motor potential amplitude in the right posterior tibial nerve&#46; C&#41; Needle electromyography of the right lateral head of the gastrocnemius muscle showing low amplitude and short duration of motor unit action potentials&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">SARS-CoV-2 infection in humans was first reported in China in December 2019&#46; In Spain&#44; the first cases were reported in March 2020&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Although this novel virus mainly causes respiratory signs and symptoms &#40;cough&#44; fever&#44; dyspnoea&#44; interstitial infiltrate in chest radiography or lung CT&#41; whose seriousness greatly determines disease severity and the risk of mortality&#44; cases have been reported since the beginning of the pandemic of such neurological symptoms &#40;or symptoms suggestive of neurological involvement&#41; as headache&#44; anosmia&#44; muscle pain&#44; insomnia&#44; confusion&#44; and bradyphrenia&#44; both in patients with mild COVID-19 and in critical patients requiring orotracheal intubation and admission to an intensive care unit &#40;ICU&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">SARS-CoV-2 is currently believed to present tropism for angiotensin-converting enzyme 2 &#40;ACE2&#41; receptors&#44; which the virus uses to enter the cell&#44; where it begins replicating&#46; ACE2 receptors are expressed in different organs and particularly the lungs&#44; heart&#44; kidneys&#44; intestines&#44; and brain&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In physiological conditions&#44; ACE2 receptors can be found in glial cells and neurons in the brain&#59; the hypothesis that the virus may cause neurological symptoms therefore seems plausible&#46; This could be confirmed with routine neurological tests &#40;brain MRI&#44; CT&#44; lumbar puncture&#44; electroneuromyography &#91;ENMG&#93;&#44; or electroencephalography &#91;EEG&#93;&#41;&#44; which may help us to understand the pathophysiology of the disease and the associated neurological complications&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Based on this assumption&#44; our centre has developed a protocol aiming to provide specific neurological care to patients with severe COVID-19 admitted to the ICU and requiring orotracheal intubation&#59; this protocol is intended to detect neurological complications as early as possible in order to reduce morbidity and mortality and minimise the risk of neurological sequelae&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The literature includes several series of patients with neurological involvement during acute SARS-CoV-2 infection&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#8211;13</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">We analysed the neurological complications of severe SARS-CoV-2 infection within 48&#8239;hours after the critical period of the disease&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Patients and methods</span><p id="par0040" class="elsevierStylePara elsevierViewall">We conducted a descriptive&#44; observational&#44; retrospective study of consecutive patients admitted to the ICU due to severe respiratory infection with SARS-CoV-2 between 1 April and 1 June 2020&#46; Our patients underwent a neurological evaluation within 48&#8239;hours of discharge from the ICU and transfer to a conventional inpatient ward&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">We analysed the following variables&#58; age&#44; sex&#44; general comorbidities&#44; neurological comorbidities&#44; previous pharmacological treatments&#44; source of infection&#44; time since the first general symptom and the first neurological symptom&#44; method used to establish diagnosis of SARS-CoV-2 infection&#44; description of neurological symptoms&#44; findings from the neurological examination&#44; neurological syndrome&#44; length of ICU stay &#40;days&#41;&#44; duration of hospitalisation &#40;days&#41;&#44; creatine kinase &#40;CK&#41; levels&#44; lumbar puncture findings&#44; CSF analysis results&#44; head CT&#44; brain or lumbar spine MRI&#44; EEG&#44; ENMG&#44; causal relationship between COVID-19 and neurological syndrome in the opinion of the neurologist&#44; treatment received for COVID-19 &#40;antiviral drugs&#44; antibiotics&#44; sedatives&#41;&#44; neurological treatment&#44; clinical progression&#44; and duration of neurological manifestations&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Data were anonymised and grouped&#46; Statistical analysis was performed using SPSS&#44; version 25 &#40;IBM&#41;&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The study was approved by our hospital&#8217;s research committee &#40;April 2020&#41;&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0060" class="elsevierStylePara elsevierViewall">A total of 54 patients were admitted to the ICU&#44; 30 of whom presented neurological symptoms&#58; 21 men &#40;72&#46;40&#37;&#41; and 9 women &#40;27&#46;60&#37;&#41;&#46; Mean age &#40;SD&#41; in our series was 57&#46;41 &#40;11&#46;61&#41; years &#40;range&#44; 25-74&#41;&#46; None of the patients were healthcare professionals&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Mean duration of hospitalisation was 34&#46;72 &#40;11&#46;44&#41; days &#40;range&#44; 16-59&#41;&#46; Mean stay at the ICU was 18&#46;83 &#40;14&#46;33&#41; days &#40;range&#44; 6-55&#41;&#46; The source of infection was unknown in most cases &#40;20 patients&#44; 66&#46;66&#37;&#41;&#59; the remaining patients were infected with SARS-CoV-2 in the family setting or by their partners &#40;8 patients&#44; 26&#46;66&#37;&#41; and during social gatherings or travel &#40;2 patients&#44; 6&#46;66&#37;&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">All patients presented bilateral pneumonia associated with severe respiratory insufficiency&#44; and therefore required admission to the ICU and orotracheal intubation&#46; All patients were sedated with remifentanil&#44; propofol&#44; midazolam&#44; or morphine hydrochloride&#44; which were suspended after discharge from the ICU&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Regarding medical history&#44; 8 patients &#40;26&#46;66&#37;&#41; had arterial hypertension&#44; 8 &#40;26&#46;66&#37;&#41; were obese&#44; and 6 &#40;20&#37;&#41; had type 2 diabetes mellitus&#46; None had history of neurological disease&#46; Only 8 patients &#40;26&#46;66&#37;&#41; were smokers&#44; and 2 &#40;6&#46;66&#37;&#41; had history of respiratory disease &#40;severe sleep apnoea-hypopnoea syndrome&#44; treated with continuous positive airway pressure&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Mean time between onset of the respiratory infection and onset of neurological symptoms was 9&#46;63 &#40;4&#46;1&#41; days &#40;range&#44; 3-36&#41;&#46; Twenty-one patients &#40;70&#37;&#41; required anticoagulation therapy with tinzaparin due to segmental pulmonary thromboembolism observed in follow-up lung CT scans performed during hospitalisation&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Twenty-eight patients &#40;93&#46;33&#37;&#41; presented acute confusional syndrome&#44; 15 &#40;50&#37;&#41; neuromuscular disorders&#44; 5 &#40;16&#46;66&#37;&#41; headache&#44; 4 &#40;13&#46;33&#37;&#41; cerebrovascular disease&#44; and 4 &#40;13&#46;33&#37;&#41; encephalopathy&#47;encephalitis&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Six patients underwent lumbar puncture&#59; CSF analysis revealed no alterations in cell counts&#44; glucose levels&#44; or protein levels&#46; In all cases&#44; PCR yielded negative results for SARS-CoV-2 in the CSF&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">CK levels were elevated in 28 patients &#40;93&#46;33&#37;&#41;&#59; mean CK level was 379&#46;69 &#40;309&#46;341&#41; &#956;g&#47;L &#40;range&#44; 61-1206&#41;&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">All patients underwent neuroimaging studies &#40;brain MRI or CT scan&#44; depending on the patient&#8217;s clinical status&#41;&#44; which revealed no alterations in 10 cases &#40;33&#46;33&#37;&#41;&#46; The remaining patients presented intraparenchymal haemorrhage &#40;2&#41;&#44; venous thrombosis &#40;2&#41;&#44; encephalopathy &#40;4&#41;&#44; cavernoma &#40;1&#41;&#44; and chronic lacunar lesions &#40;11&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">All patients underwent EEG&#44; with 8 &#40;26&#46;66&#37;&#41; presenting alterations &#40;mild diffuse slowing in all cases&#41;&#44; with no epileptiform activity&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Six patients &#40;20&#37;&#41; underwent ENMG studies&#44; which revealed normal motor and sensory nerve conduction velocities and a myopathic pattern in 5 cases &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Only one patient presented polyneuropathy&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">Patients were administered the following specific treatments for SARS-CoV-2 infection&#58; chloroquine&#47;hydroxychloroquine &#40;30 patients&#59; 100&#37;&#41;&#44; lopinavir&#47;ritonavir &#40;13&#59; 43&#46;33&#37;&#41;&#44; tocilizumab &#40;17&#59; 56&#46;66&#37;&#41;&#44; boluses of methylprednisolone &#40;15&#59; 50&#37;&#41;&#44; remdesivir &#40;2&#59; 6&#46;66&#37;&#41;&#44; and ceftriaxone &#40;28&#59; 93&#46;33&#37;&#41;&#46; All patients received active treatment with antiviral drugs or empirical antibiotic treatment during their stay at the ICU&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Twenty patients &#40;66&#46;66&#37;&#41; progressed favourably or remained stable&#44; 7 patients &#40;23&#46;33&#37;&#41; presented complications or progressive worsening&#44; and 3 patients &#40;10&#37;&#41; died&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">According to the informing neurologist&#8217;s judgement&#44; the relationship between COVID-19 and the neurological syndrome was probable causation in 66&#46;66&#37; of cases&#44; definite causation in 20&#37;&#44; and coincidental in 13&#46;34&#37;&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">No statistically significant association was observed between male sex and total hospitalisation time &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;358&#41;&#44; length of ICU stay &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;292&#41;&#44; or CK levels&#59; between presence of confusional symptoms and EEG alterations &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;486&#41;&#59; or between age and presence of myopathy &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;0&#46;06&#41;&#46; However&#44; we did find a statistically significant association between older age &#40;&#62; 50 years&#41; and longer ICU stay &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;002&#59; OR&#8239;&#61;&#8239;3&#46;594&#59; 95&#37; CI&#44; 1&#46;032&#8211;6&#46;022&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0135" class="elsevierStylePara elsevierViewall">When the pandemic started&#44; many neurologists had to become pulmonologists or internists to assist in the care of patients with SARS-CoV-2 infection&#59; in this context&#44; we observed the presentation of neurological symptoms in patients with COVID-19&#44; and especially in severe cases&#46; In the light of this&#44; our centre decided to design a protocol for systematic&#44; specific neurological evaluation of patients with COVID-19 who were admitted to the ICU and required orotracheal intubation&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">From an epidemiological viewpoint&#44; our series mainly included middle-aged men with no history of neurological disease&#44; with few individuals presenting the most frequent vascular risk factors &#40;hypertension&#44; diabetes&#41;&#59; this is consistent with the results from previous studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;11&#8211;14</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Within 48&#8722;72&#8239;h of discharge from the ICU&#44; most patients presented acute confusional syndrome presenting with disorientation to time and place&#44; difficulty retrieving words&#44; and fluctuating short-term memory problems&#46; Some patients also presented irritability and aggressiveness within the first few hours&#44; as has been described in other series&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> These patients presented similar symptoms&#44; regardless of their age or the length of their ICU stay&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Their symptoms were not correlated with EEG or brain MRI alterations&#44; and resolved completely&#46; The only EEG alteration observed was mild generalised background slowing&#44; which was not associated with epileptiform activity in any case&#46; None of the patients presented seizures during hospitalisation&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Imaging studies revealed the most common vascular alterations &#40;small intraparenchymal haemorrhages&#44; chronic lacunar lesions&#44; cerebral venous sinus thrombosis in patients with coagulation disorders in the context of COVID-19&#41;&#46; These findings have been reported by different authors since the beginning of the pandemic&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#8211;21</span></a> However&#44; cerebrovascular diseases were less frequent in our series than in other studies&#44; probably due to the lower mean age of our sample and the lower prevalence of vascular risk factors&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Furthermore&#44; some patients in our series presented radiological signs of encephalopathy&#44; which were found to be poorly correlated with their symptoms&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#8211;25</span></a> Likewise&#44; all CSF findings from patients undergoing lumbar puncture were normal &#40;the procedure was contraindicated in most patients&#44; since they were receiving anticoagulation therapy for pulmonary thrombosis&#41;&#46; These results&#44; together with negative PCR results in CSF&#44; are increasingly being reported in the literature&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">Despite an increasing number of reports of Guillain-Barr&#233; syndrome and seizures or status epilepticus among patients with COVID-19&#44;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">27&#8211;30</span></a> these manifestations were not observed in any of our patients&#46; However&#44; we did find clinical evidence of myopathy in half of the patients evaluated &#40;with several cases confirmed by ENMG&#41;&#59; these findings have not previously been described in other series&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#8211;14</span></a> Marked amyotrophy of the lower limbs initially suggested Guillain-Barr&#233;-like polyneuropathy or critical illness polyneuropathy&#44; but most patients showed normal motor and sensory nerve conduction velocities and a clearly myopathic pattern in the muscles studied &#40;usually the abductor pollicis brevis&#44; abductor digiti minimi&#44; tibialis anterior&#44; quadriceps&#44; and gastrocnemius muscles&#41;&#44; and normal tendon reflexes in the neurological examination&#46; Only the patient with the longest ICU stay &#40;55 days&#41; showed critical illness polyneuropathy in an ENMG study&#46; All patients showed slightly elevated CK levels&#46; Lumbar puncture yielded normal results in patients undergoing this procedure&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Hypothesis testing revealed a statistically significant association between older age &#40;&#62; 50 years&#41; and longer ICU stays&#44; as similar studies have also reported&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Our series is smaller than other published series&#44; such as that analysed by our colleagues from the ALBACOVID registry<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> or the sample included in the multicentre study conducted in Madrid at the beginning of the pandemic and analysing smell and taste disorders&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> This may be due to the characteristics of our hospital&#44; a small secondary healthcare centre with 270 beds serving a population of approximately 325 000 inhabitants &#40;larger series include patients from tertiary hospitals&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#44;31&#8211;34</span></a> However&#44; our series has the advantage that it is homogeneous&#58; our patients were young&#44; had no history of neurological disease or any other relevant medical history except for some cases of hypertension and diabetes mellitus&#44; and they all presented severe respiratory involvement requiring admission to the ICU&#46; All patients were attended by the same anaesthetists&#47;intensivists&#44; pulmonologists&#44; and neurologists&#46; As a result&#44; the neurological examination&#44; complementary tests&#44; and pharmacological treatment were similar in all cases&#44; minimising the risk of bias&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">Although our patients presented similar disorders to those reported in previous studies &#40;headache&#44; intracranial haemorrhage&#44; stroke&#44; encephalopathy&#44; etc&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;35&#8211;38</span></a> we found a significant number of patients with confusional syndrome and acute myopathy&#44; which was most probably inflammatory &#40;systemic reaction&#41; or associated with critical illness polyneuropathy&#44; rather than secondary to direct invasion by the virus&#46; We believe that both complications are associated with the severity of COVID-19 in these patients&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusions</span><p id="par0185" class="elsevierStylePara elsevierViewall">In our series&#44; severe COVID-19 was more frequent among men than women&#59; this is consistent with previous series&#46; Half of our patients presented acute myopathy&#44; and nearly all presented acute confusional syndrome after discharge from the ICU&#59; these symptoms resolved completely and were not correlated with EEG or neuroimaging findings&#46; Older age was found to be associated with longer ICU stays&#46; Studies with larger samples are needed to confirm our results&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Funding</span><p id="par0190" class="elsevierStylePara elsevierViewall">After this study was completed&#44; the lead author was awarded the COVID-19 research prize from the foundation for biomedical research and innovation of Hospital Universitario Infanta Sof&#237;a and Hospital Universitario del Henares&#44; in Madrid&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflicts of interest</span><p id="par0195" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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          "clase" => "keyword"
          "titulo" => "Keywords"
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          "palabras" => array:5 [
            0 => "COVID-19"
            1 => "Critical patient"
            2 => "Acute myopathy"
            3 => "Encephalopathy"
            4 => "SARS-CoV-2"
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          "palabras" => array:5 [
            0 => "COVID-19"
            1 => "Paciente cr&#237;tico"
            2 => "Miopat&#237;a aguda"
            3 => "Encefalopat&#237;as"
            4 => "SARS-CoV2"
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    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">We analysed the neurological complications of patients with severe SARS-CoV-2 infection who required intensive care unit &#40;ICU&#41; admission&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We conducted a retrospective&#44; observational&#44; descriptive study of consecutive patients admitted to the ICU due to severe respiratory symptoms secondary to SARS-CoV-2 infection between 1 April and 1 June 2020&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">We included 30 patients with neurological symptoms&#59; 21 were men &#40;72&#46;40&#37;&#41;&#44; and mean age &#40;standard deviation &#91;SD&#93;&#41; was 57&#46;41 years &#40;11&#46;61&#41;&#46; The mean duration of ICU stay was 18&#46;83 days &#40;14&#46;33&#41;&#46; The neurological conditions recorded were acute confusional syndrome in 28 patients &#40;93&#46;33&#37;&#41;&#44; neuromuscular disease in 15 &#40;50&#37;&#41;&#44; headache in 5 &#40;16&#46;66&#37;&#41;&#44; cerebrovascular disease in 4 &#40;13&#46;33&#37;&#41;&#44; and encephalopathies&#47;encephalitis in 4 &#40;13&#46;33&#37;&#41;&#46; CSF analysis results were normal in 6 patients &#40;20&#37;&#41;&#46; Brain MRI or head CT showed alterations in 20 patients &#40;66&#46;6&#37;&#41;&#46; EEG was performed in all patients &#40;100&#37;&#41;&#44; with 8 &#40;26&#46;66&#37;&#41; showing abnormal findings&#46; In 5 of the 15 patients with clinical myopathy&#44; diagnosis was confirmed with electroneuromyography&#46; We found a correlation between older age and duration of ICU stay &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;0&#46;002&#59; 95&#37; CI&#44; 4&#46;032&#8211;6&#46;022&#59; OR&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Severe COVID-19 mainly affects men&#44; as observed in other series&#46; Half of our patients presented acute myopathy&#44; and almost all patients left the ICU with acute confusional syndrome&#44; which fully resolved&#59; no correlation was found with EEG or neuroimaging findings&#46; Older age is associated with longer ICU stay&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
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          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Patients and methods"
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          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
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          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
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      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Nos proponemos analizar las complicaciones neurol&#243;gicas de los pacientes con infecci&#243;n grave por SARS-CoV2&#44; que han requerido ingreso en Unidad de Cuidados Intensivos &#40;UCI&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Pacientes y m&#233;todos</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Estudio descriptivo retrospectivo&#44; observacional&#44; de pacientes consecutivos ingresado en UCI por infecci&#243;n respiratoria grave por SARS-CoV-2&#44; desde el 1 de Abril hasta el 1 de Junio de 2020&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Registramos 30 pacientes con s&#237;ntomas neurol&#243;gicos&#44; 21 hombres &#40;72&#44;40&#37;&#41;&#44; edad media&#58; 57&#44;41 a&#241;os &#177; 11&#44;61 desviaci&#243;n est&#225;ndar &#40;DE&#41;&#46; Estancia media en UCI&#58; 18&#44;83&#8239;&#177;&#8239;14&#44;33 DE&#46; A nivel sindr&#243;mico&#58; 28 pacientes &#40;93&#44;33&#37;&#41; con s&#237;ndrome confusional agudo&#44; 15 pacientes &#40;50&#37;&#41; con patolog&#237;a neuromuscular&#44; 5 &#40;16&#44;66&#37;&#41; cefalea&#44; 4 &#40;13&#44;33&#37;&#41; con patolog&#237;a cerebrovascular&#44; y 4 &#40;13&#44;33&#37;&#41; con encefalopat&#237;as&#47;encefalitis&#46; Punci&#243;n lumbar normal en 6 pacientes &#40;20&#37;&#41;&#46; La RMN craneal o TAC craneal mostr&#243; alteraciones en 20 casos &#40;66&#44;6&#37;&#41;&#46; Se realiz&#243; EEG en todos los pacientes &#40;100&#37;&#41;&#44; alterado en 8 pacientes &#40;26&#44;66&#37;&#41;&#46; En 5 de los 15 pacientes con miopat&#237;a cl&#237;nica se ha podido confirmar con ENMG&#46; Hemos encontrado relaci&#243;n entre la mayor edad y los d&#237;as de ingreso en UCI &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;0&#44;002&#44; IC 95&#37; 4&#44;032-6&#44;022&#59; OR&#58;&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">La infecci&#243;n grave por COVID-19 afecta mayoritariamente a hombres&#44; similar a lo descrito en otras series&#46; La mitad de nuestros pacientes presentan una miopat&#237;a aguda&#44; y casi la totalidad de los pacientes salen de la UCI con sindromes confusionales agudos&#44; que evolucionan a la resoluci&#243;n completa&#44; sin correlacionarse con los resultados del EEG o de pruebas de neuroimagen&#46; La mayor edad s&#237; se asocia con un mayor n&#250;mero de d&#237;as de estancia en UCI&#46;</p></span>"
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            "identificador" => "abst0025"
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            "identificador" => "abst0030"
            "titulo" => "Pacientes y m&#233;todos"
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          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
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    "NotaPie" => array:1 [
      0 => array:1 [
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Abenza-Abild&#250;a MJ&#44; Ram&#237;rez-Prieto MT&#44; Moreno-Zabaleta R&#44; Arenas-Valls N&#44; Salvador-Maya MA&#46; Algarra-Lucas C&#44; et al&#46; Complicaciones neurol&#243;gicas en pacientes cr&#237;ticos por SARS-CoV-2&#46; Neurolog&#237;a&#46; 2020&#59;35&#58;621&#8211;627&#46;</p>"
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            "imagen" => "gr1.jpeg"
            "Alto" => 645
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Some vascular lesions detected in our series&#46; A&#41; Patient 8&#58; 2 small left parietal cortico-subcortical haematomas in the convexity&#46; B&#41; Patient 1&#58; acute haematoma in the right caudate nucleus&#44; with opening to the ventricular system&#46; C&#41; Patient 26&#58; hyperintense subacute ischaemic lesions in both parietal lobes&#44; in the border zone of the middle cerebral and anterior cerebral artery territories&#46;</p>"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Myopathy &#40;patient 17&#41;&#46; A&#41; Atrophy of the gastrocnemius and tibialis anterior muscles&#46; B&#41; Electroneuromyography study&#58; normal motor conduction velocity and motor potential amplitude in the right posterior tibial nerve&#46; C&#41; Needle electromyography of the right lateral head of the gastrocnemius muscle showing low amplitude and short duration of motor unit action potentials&#46;</p>"
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          "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">CI&#58; confidence interval&#59; CK&#58; creatine kinase&#59; EEG&#58; electroencephalography&#59; ICU&#58; intensive care unit&#59; OR&#58; odds ratio&#59; SD&#58; standard deviation&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">N&#8239;&#61;&#8239;30&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col"><span class="elsevierStyleItalic">P</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col">OR&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95&#37; CI</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Lower limit&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Upper limit&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Sex &#40;men&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Length of ICU stay &#40;patients &#62; 50 years&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;032&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">6&#46;022&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">CK level&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#46;226&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#8211;1&#46;240&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">115&#46;529&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Duration of hospitalisation&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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Article information
ISSN: 21735808
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos