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Edema muscular de los vientres musculares del infraespinoso y redondo mayor derecho. c) Infiltración grasa del vientre muscular del infraespinoso derecho.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Alvarado, Y. Lin-Miao, M. Carrillo-Arolas" "autores" => array:3 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Alvarado" ] 1 => array:2 [ "nombre" => "Y." "apellidos" => "Lin-Miao" ] 2 => array:2 [ "nombre" => "M." 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"apellidos" => "Mora Pueyo" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0213485321000992" "doi" => "10.1016/j.nrl.2021.05.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485321000992?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580821001243?idApp=UINPBA00004N" "url" => "/21735808/0000003600000007/v1_202109160551/S2173580821001243/v1_202109160551/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S217358082100122X" "issn" => "21735808" "doi" => "10.1016/j.nrleng.2021.04.002" "estado" => "S300" "fechaPublicacion" => "2021-09-01" "aid" => "1609" "copyright" => "Sociedad Española de Neurología" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Neurologia. 2021;36:567-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Bell’s palsy following COVID-19 vaccination: a case report" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "567" "paginaFinal" => "568" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Parálisis de Bell tras vacunación COVID-19: a propósito de un caso" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 534 "Ancho" => 905 "Tamanyo" => 48822 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Bell’s palsy in our patient.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "G. 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"apellidos" => "Martínez Gimeno" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0213485321000657" "doi" => "10.1016/j.nrl.2021.04.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485321000657?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217358082100122X?idApp=UINPBA00004N" "url" => "/21735808/0000003600000007/v1_202109160551/S217358082100122X/v1_202109160551/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Parsonage-Turner syndrome post-infection by SARS-CoV-2: a case report" "tieneTextoCompleto" => true "saludo" => "Dear Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "568" "paginaFinal" => "571" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Alvarado, Y. Lin-Miao, M. Carrillo-Arolas" "autores" => array:3 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Alvarado" "email" => array:1 [ 0 => "malvarado@mutuaterrassa.cat" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Y." "apellidos" => "Lin-Miao" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Carrillo-Arolas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Medicina Física y Rehabilitación, Hospital Universitario Mútua de Terrassa, Terrassa, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Neurología, Hospital Universitario Mútua de Terrassa, Terrassa, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Síndrome de Parsonage-Turner postinfección por SARS-CoV-2: a propósito de un caso" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 445 "Ancho" => 1505 "Tamanyo" => 101528 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">a) Patient with right scapular winging and limited range of shoulder movement. b) T1-weighted MRI sequence of the shoulder. Oedema of the bellies of the right infraspinatus and teres major muscles. c) Fatty infiltration in the belly of the right infraspinatus muscle.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Parsonage-Turner syndrome (PTS) or acute brachial neuritis is a rare cause of neuromuscular involvement in the shoulder, characterised by sudden onset of intense pain followed by muscle weakness and atrophy.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–3</span></a> Aetiology is heterogeneous; the immune-mediated response against the brachial plexus is considered an essential part of its aetiopathogenesis.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Although cases have been reported of viral infection before onset of brachial neuritis, there are currently no published cases of PTS associated with previous SARS-CoV-2 infection, as far as we are aware.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We describe the case of a 38-year-old man who developed PTS after severe bilateral pneumonia due to SARS-CoV-2 infection, who was admitted to the intensive care unit and treated with hydroxychloroquine, lopinavir/ritonavir, interferon beta, corticosteroids, and invasive mechanical ventilation. He was kept under deep sedation for several days, and received prone position ventilation on 2 occasions. As a relevant complication, we should mention septic shock secondary to ischaemic pancolitis due to SARS-CoV-2 infection, which was confirmed by anatomical pathology; the patient underwent ileostomy surgery.</p><p id="par0015" class="elsevierStylePara elsevierViewall">During a visit to the rehabilitation department for functional recovery, the patient reported a 5-day history of continuous, progressive pain in both shoulders accompanied by a burning and tingling sensation, which disrupted sleep and partially remitted with conventional analgesics. He subsequently presented progressive muscle weakness in both shoulders, which limited his ability to perform activities of daily living.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The physical examination revealed bilateral atrophy of the deltoid, supraspinatus, and infraspinatus muscles, right scapular winging, and hypoaesthesia in the deltoid area (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>a). An electrophysiological study revealed left brachial plexopathy with predominant involvement of the segment proximal to the upper trunk and distal to the C5 nerve root, and absence of sensory response in the lateral antebrachial cutaneous nerve, with signs of acute motor axon loss in the trapezius, deltoid, and serratus anterior muscles (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). An MRI study revealed oedema of the bellies of both infraspinatus muscles and tendinosis of both supraspinatus muscles (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>b and c).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">In view of these findings, he was diagnosed with PTS. The patient was treated with non-steroidal anti-inflammatory drugs combined with long-acting opioids and prednisone. He also started rehabilitation therapy to improve balance and pain control.</p><p id="par0030" class="elsevierStylePara elsevierViewall">PTS presents uncertain aetiology,<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> predominantly affects men,<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–3</span></a> and may be associated with viral infections, autoimmune mechanisms, immunisation, microtrauma, or surgical procedures.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Twenty-five percent of patients may present systemic viral infection prior to symptom onset<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,6</span></a> and almost one-third of patients present these symptoms bilaterally and symmetrically.</p><p id="par0035" class="elsevierStylePara elsevierViewall">In terms of pathophysiology, sensitised lymphocytes have a special affinity for brachial plexus nerves, causing perineural oedema similar to that associated with urticaria.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Our main hypothesis is that SARS-CoV-2 infection triggered an immune-mediated reaction involving the brachial plexus. Trauma may reasonably be ruled out as the cause of the symptoms, as the patient was only placed in the prone position on 2 occasions, presenting no pain or limitation of shoulder movement during hospitalisation. Numerous reports in the literature describe neurological symptoms and diseases in patients with SARS-CoV-2 infection during the COVID-19 pandemic, including ischaemic cerebrovascular disease,<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,8</span></a> polyneuropathies, and even necrotising encephalomyelitis attributed to a neuroinvasive effect in a patient with COVID-19.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,8</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Diagnostic suspicion of PTS is established according to the symptoms reported by the patient and supported by the electrophysiological study, which in addition to enabling a better identification of the condition, also helps to rule out other possible causes and assess severity.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9–11</span></a> MRI has been demonstrated to be useful in diagnosing PTS; the characteristic pattern includes neurogenic muscle oedema followed by atrophy of the supraspinatus, infraspinatus, and deltoid muscles, as well as fatty infiltration.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,12</span></a> All these findings were identified in our patient.</p><p id="par0045" class="elsevierStylePara elsevierViewall">There is currently no specific treatment for this syndrome, as non-steroidal anti-inflammatory drugs are insufficient in the acute phase, and the use of opioids is necessary. Some studies use gabapentin for neuromodulation.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Rehabilitation therapy is essential to improve joint mobility and strength and to control pain. Outcomes are heterogeneous and depend on pain intensity, the extent of plexus involvement, and whether presentation is bilateral or unilateral; all of these factors are predictors of recovery.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors have received no funding for this study.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflicts of interest" ] 2 => array:2 [ "identificador" => "xack555140" "titulo" => "Acknowledgements" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Alvarado M, Lin-Miao Y, Carrillo-Arolas M. Síndrome de Parsonage-Turner postinfección por SARS-CoV-2: a propósito de un caso. Neurología. 2021;36:568–571.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 445 "Ancho" => 1505 "Tamanyo" => 101528 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">a) Patient with right scapular winging and limited range of shoulder movement. b) T1-weighted MRI sequence of the shoulder. Oedema of the bellies of the right infraspinatus and teres major muscles. c) Fatty infiltration in the belly of the right infraspinatus muscle.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 3657 "Ancho" => 2083 "Tamanyo" => 485566 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">a) Lack of response in the left lateral antebrachial cutaneous nerve, but preserved response in the right side. b) Spontaneous activity in the left serratus anterior muscle. c) Spontaneous activity in the left trapezius muscle. d) Spontaneous activity in the left deltoid muscle.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:14 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute brachial neuritis (Parsonage-Turner syndrome): MR imaging appearance—report of three cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.A. 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