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One-month follow-up image (B) showing partial recanalisation of the left superior longitudinal, transverse, and sigmoid sinuses after treatment with dabigatran.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.L. Almarcha-Menargues, M.M. Martínez-Martínez, J. Fernández-Travieso" "autores" => array:3 [ 0 => array:2 [ "nombre" => "M.L." "apellidos" => "Almarcha-Menargues" ] 1 => array:2 [ "nombre" => "M.M." "apellidos" => "Martínez-Martínez" ] 2 => array:2 [ "nombre" => "J." 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"apellidos" => "Mora Pueyo" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0213485321000992" "doi" => "10.1016/j.nrl.2021.05.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485321000992?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580821001243?idApp=UINPBA00004N" "url" => "/21735808/0000003600000007/v1_202109160551/S2173580821001243/v1_202109160551/en/main.assets" ] "en" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Acute transverse myelitis following SARS-CoV-2 infection" "tieneTextoCompleto" => true "saludo" => "Dear Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "572" "paginaFinal" => "574" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "C. Jauregui-Larrañaga, A. Ostolaza-Ibáñez, M. Martín-Bujanda" "autores" => array:3 [ 0 => array:4 [ "nombre" => "C." "apellidos" => "Jauregui-Larrañaga" "email" => array:1 [ 0 => "carlota_l13@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Ostolaza-Ibáñez" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Martín-Bujanda" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Neurología, Complejo Hospitalario de Navarra (CHN), Navarra, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Mielitis transversa aguda asociada a infección por SARS-CoV-2" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2089 "Ancho" => 755 "Tamanyo" => 123536 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Sagittal T2-weighted MRI sequence of the spinal cord, showing slight hyperintensity of the T6-T11 segments, compatible with longitudinally extensive transverse myelitis.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">SARS-CoV-2, the virus that causes the disease COVID-19, was first described in Wuhan in December 2019. The typical symptoms of COVID-19 are fever, dry cough, dyspnoea, and general discomfort.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–9</span></a> The most severe cases involve massive release of proinflammatory cytokines that cause alveolar damage associated with respiratory insufficiency and multi-organ failure, leading to the death of the patient.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Neurological manifestations of SARS-CoV-2 infection include headache, dizziness, impaired level of consciousness, and anosmia.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> We present the case of a patient with acute transverse myelitis associated with SARS-CoV-2 infection.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient is a 53-year-old man with no relevant medical history who was diagnosed 2 days earlier with SARS-CoV-2 infection; he consulted due to dysaesthesia in the lower limbs and inability to walk independently. He presented no respiratory symptoms or lung involvement at any time.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Neurological examination revealed preserved motor strength, vibratory and tacto-algesic hypoaesthesia at the T9-T10 sensory level, exaggerated deep tendon reflexes in the lower limbs, bilateral Babinski sign, ataxic gait, and urinary retention.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Head and lumbar spine CT studies revealed no abnormal findings. A blood analysis detected mildly elevated levels of acute-phase reactants. Autoimmune test results were normal. Suspecting acute transverse myelitis, we performed a CSF analysis, which revealed pleocytosis with mononuclear cells and high protein levels, with no glucose uptake. A microbiological study of the CSF sample yielded negative results.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The neurological symptoms significantly worsened during hospitalisation, with progression to severe paraparesis, and a urinary catheter had to be placed.</p><p id="par0030" class="elsevierStylePara elsevierViewall">An MRI study (<a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1 and 2</a>) revealed a slight signal alteration in the T6-T11 segments, with hyperintensity on T2-weighted sequences; the lesion did not present gadolinium uptake or mass effect. These findings are compatible with longitudinally extensive transverse myelitis of the thoracic spinal cord.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">We administered a 5-day cycle of methylprednisolone dosed at 1000 mg per day, observing no improvement. Due to the ineffectiveness of the treatment, we administered intravenous immunoglobulins dosed at 0.4 g/kg/day for 5 days. Progression was satisfactory, and the patient was able to walk independently at discharge, although impaired proprioception persisted.</p><p id="par0040" class="elsevierStylePara elsevierViewall">The neurological manifestations of SARS-CoV-2 infection described to date are diverse, and present in up to one-third of patients.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The most frequent symptoms are headache, dizziness, altered level of consciousness, and anosmia. Isolated cases have been reported of seizures, acute encephalitis, stroke, Guillain-Barré syndrome, and transverse myelitis.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The diagnostic criteria for transverse myelitis include the presence of bilateral sensory, motor, and autonomic dysfunction at a defined sensory level, progression to the maximal level of disability between 4 hours and 21 days, evidence of spinal cord inflammation due to pleocytosis, elevated CSF IgG levels, and gadolinium uptake on MRI, with compressive, neoplastic, vascular, and post-radiation causes having been ruled out.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,6</span></a> SARS-CoV-2 infection is diagnosed with PCR testing of a nasopharyngeal swab, given the low sensitivity of PCR testing of CSF.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> The treatment of choice for transverse myelitis is high-dose methylprednisolone; if this is ineffective, intravenous immunoglobulins should be considered.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8,9</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">SARS-CoV-2 can affect the nervous system by direct invasion or through an exaggerated systemic inflammatory response to the virus. The latter mechanism causes increased permeability of the blood-brain barrier and massive release of proinflammatory cytokines, which in turn cause oedema and immune-mediated damage to the spinal cord.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> SARS-CoV-2 has been shown to invade human cells by binding to the angiotensin-converting enzyme 2 (ACE2) receptor.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8,10</span></a> Microarray studies have demonstrated ACE2 expression in the cerebral cortex, basal ganglia, hypothalamus, brainstem, and brain capillary endothelium.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> This marked ACE2 receptor expression in the human brain may explain the neuroinvasive capacity of the virus.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11,12</span></a> The virus may also spread through the central nervous system via the olfactory bulb; studies of intranasal inoculation with SARS-CoV-2 in mice have shown that the virus is able to penetrate the brain, brainstem, and spinal cord.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Currently, the mechanisms of SARS-CoV-2 virulence and the pathophysiology of COVID-19 are not fully understood. Despite this, it seems plausible that the abundant expression of ACE2 receptors in the brain parenchyma favours interaction with the virus, increasing the risk of neurological complications.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0060" class="elsevierStylePara elsevierViewall">This study received no funding of any kind.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflicts of interest" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Jauregui-Larrañaga C, Ostolaza-Ibáñez A, Martín-Bujanda M. Mielitis transversa aguda asociada a infección por SARS-CoV-2. Neurología. 2021;36:572–574.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2089 "Ancho" => 755 "Tamanyo" => 123536 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Sagittal T2-weighted MRI sequence of the spinal cord, showing slight hyperintensity of the T6-T11 segments, compatible with longitudinally extensive transverse myelitis.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 952 "Ancho" => 755 "Tamanyo" => 58254 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A close-up of the sagittal T2-weighted MRI sequence, showing hyperintensity of the T6-T11 segments.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. 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Year/Month | Html | Total | |
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2024 November | 13 | 0 | 13 |
2024 October | 56 | 9 | 65 |
2024 September | 92 | 20 | 112 |
2024 August | 88 | 14 | 102 |
2024 July | 104 | 12 | 116 |
2024 June | 58 | 5 | 63 |
2024 May | 60 | 6 | 66 |
2024 April | 57 | 14 | 71 |
2024 March | 69 | 14 | 83 |
2024 February | 70 | 14 | 84 |
2024 January | 79 | 10 | 89 |
2023 December | 110 | 10 | 120 |
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2023 October | 129 | 20 | 149 |
2023 September | 52 | 9 | 61 |
2023 August | 62 | 11 | 73 |
2023 July | 83 | 18 | 101 |
2023 June | 74 | 8 | 82 |
2023 May | 107 | 5 | 112 |
2023 April | 64 | 8 | 72 |
2023 March | 65 | 10 | 75 |
2023 February | 55 | 4 | 59 |
2023 January | 75 | 10 | 85 |
2022 December | 61 | 9 | 70 |
2022 November | 73 | 13 | 86 |
2022 October | 73 | 12 | 85 |
2022 September | 67 | 12 | 79 |
2022 August | 97 | 18 | 115 |
2022 July | 73 | 13 | 86 |
2022 June | 139 | 14 | 153 |
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2022 March | 94 | 16 | 110 |
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2021 December | 74 | 20 | 94 |
2021 November | 53 | 17 | 70 |
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2021 September | 40 | 25 | 65 |
2021 August | 8 | 20 | 28 |
2021 July | 0 | 1 | 1 |