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Letter to the Editor
Reduction of photoparoxysmal response from patients with drug-resistant photosensitive epilepsy by using Z1 filters
Reducción de la respuesta fotoparoxística en pacientes con epilepsia fotosensible farmacorresistente mediante el uso de filtros Z1
O.A. Martineza,
Corresponding author
omartinez@hbritanico.com.ar

Corresponding author.
, L. Lagosb, G. Ernstc, R. Ebnerb
a Neurology Department. Hospital Británico de Buenos Aires, Argentina
b Ophthalmology Department, Hospital Británico de Buenos Aires, Argentina
c Scientific Advisory Committee, Hospital Británico de Buenos Aires, Argentina
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Reflex epilepsy is characterized by seizures triggered by a specific stimulus&#46; Photosensitive epilepsy &#40;PSE&#41; has seizures provoked by photic stimuli&#46; PSE is the most common form of reflex epilepsy and affects 2&#8211;5&#37; of patients with epilepsy&#46; The main feature is photosensitivity&#44; which is an abnormal paroxysmal electrical reaction in the brain induced by strobe lights&#46; The photoparoxysmal response &#40;PPR&#41; is the appearance of epileptiform activity induced by intermittent photic stimulation &#40;IPS&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Capovilla G et al&#44; have demonstrated that Z1-filter&#44; was more effective than four other colored types of lenses in reducing the response to IPS in PSE patients&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">3</span></a> These results were confirmed in a multicenter study&#44; the use of Z1 filters abolished PPR in 75&#46;9&#37; and a 17&#46;9&#37; of PPR attenuation&#44; evaluated by increased latency between the stimulus and the appearance of PPR&#44; reduced duration of PPR&#44; disappearance of clinical manifestations&#44; or change to a less severe type according to Waltz&#39;s classification in17&#46;9&#37; from patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">It has been previously described that 30&#37; of patients with epilepsy have no control of their seizures&#44; despite the use of 2 or more correctly used AEDs&#44; considering this condition as Drug Resistant Epilepsy &#40;DRE&#41;&#46; Valproic acid can control photosensitivity in about 40&#37; of cases&#46; There are no studies focusing on patients with PSE who are refractory to Valproic Acid&#46; We selected from our database&#44; those patients who had PSE&#44; and continued with seizures despite the use of Valproic Acid in doses of at least 1500<span class="elsevierStyleHsp" style=""></span>mg&#47;day or higher and a new AED&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">6&#8211;9</span></a> Most of patients &#40;<span class="elsevierStyleItalic">n</span>&#58;9&#41;&#44; have shown plasma levels of Valproic Acid were within the therapeutic range&#46; Nevertheless&#44; in the rest of patients &#40;<span class="elsevierStyleItalic">n</span>&#58;6&#41; these levels could not be obtained&#46; In all of studied population&#44; Valproic Acid dosis was tolerated without toxic effects&#46; The correlation between plasma levels of Valproic Acid and PPR wasn&#8217;t studied&#46; None of the patients received AEDs or other drugs that were hepatic inducers&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The aim of this study was to assess whether the use of Z1 filters can reduce PPR in patients with drug-resistant PSE&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Prospective study to analyze the role of Z1 filters in the PPR from patients with drug-resistant PSE was performed&#46; It was approved by the Ethics Committee of the Hospital Britanico&#46; All patients signed an informed consent form&#46; Patients with PSE&#44; who had seizures despite being medicated with valproic acid at a minimum dose of 1500<span class="elsevierStyleHsp" style=""></span>mg and at least one of the following AEDs &#40;levetiracetam&#58; 1000&#8211;3000<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#44; lacosamide 200&#8211;400<span class="elsevierStyleHsp" style=""></span>mg&#47;day and topiramate 200&#8211;400<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#41;&#46; For each patient&#44; the maximum tolerated dose without adverse effects was used&#46;were included&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Before performing the EEG&#44; a complete ophthalmological examination was performed on all patients&#46; An EEG was performed in a twilight room with 32-channel equipment &#40;Neurovirtual&#174;&#41;&#46; Longitudinal&#44; transversal and reference assemblies were used&#44; according to the International 10&#47;20 System&#46; After 20<span class="elsevierStyleHsp" style=""></span>min of recording&#44; the IPS was performed with a photo-stimulator placed 30<span class="elsevierStyleHsp" style=""></span>cm from the patient&#39;s face&#46; Each stimulation lasted 1<span class="elsevierStyleHsp" style=""></span>ms for 5<span class="elsevierStyleHsp" style=""></span>s at 30-s intervals&#46; Frequencies between 3 and 50<span class="elsevierStyleHsp" style=""></span>Hz were used&#46;3 EEG recording with Intermittent Photic Stimulation&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Identical IPS protocol was implemented after the application of the Z&#46;1 filter &#40;Zeiss&#8482;&#41; in front of the patient&#39;s eyes&#46; PPR was evaluated using the Scale described by Waltz patients&#44;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a> which gives a score from 1 to 4 according to the severity of the response to IPS&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">We included 15 patients with PSE&#46; Mean age was 30&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;8 years&#46; 53&#46;4&#37; were female&#46; PPR without the use of Z&#46;1 filter showed that the population in this study presented PPR in the following distribution&#58; Type 4&#58; 20&#37; &#40;<span class="elsevierStyleItalic">n</span>&#58; 3&#41;&#59; Type 3&#58; 46&#46;6&#37; &#40;<span class="elsevierStyleItalic">n</span>&#58; 7&#41;&#59; Type 2&#58; 20&#37; &#40;<span class="elsevierStyleItalic">n</span>&#58; 3&#41;&#59; Type 1&#58; 13&#46;4&#37; &#40;<span class="elsevierStyleItalic">n</span>&#58; 2&#41;&#59; Type 1 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; Our findings showed a significant decrease in PPR severity after the use of Filters Zeiss F&#46;1 filters &#40;0&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;2 vs&#46; 2&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;9&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; With the use of Zeiss F&#46;1 filters&#44; in more than half of the patients &#40;60&#37;&#41; PPR was abolished &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46; Type 1 were 6 patients and with PPR Abolition&#44; 9 patients&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">In our study the Z1 Filters were effective in reducing photosensitivity in PSE patients treated with valproic acid and second or third generation AED&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">To our knowledge&#44; there are no studies on the reduction of PPR with the use of Z1 filters only in patients with valproic acid associated with a third generation AED&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">To avoid photosensitivity&#44; different strategies can be adopted&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a> For example&#44; avoiding places where this type of light stimuli are more frequent&#44; treatment with AEDs or the use of special filters&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">5</span></a> We agree that the Z1 filters are effective&#44; even in patients receiving pharmacological treatment with 2 AEDs&#46;</p></span>"
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es en pt

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