Comparison of effectiveness between different interventions in postconcussive symptoms in adolescents and young people: a literature review

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Fuente: Mayer AR, Quinn DK, Master CL. The spectrum of mild traumatic brain injury. A review. Neurology [Internet]. 2017;89(6):623–32. Available from: http://n.neurology.org/content/89/6/623.long." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Á.J. Reina Ruíz, A. Quintero Cabello" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Á.J." "apellidos" => "Reina Ruíz" ] 1 => array:2 [ "nombre" => "A." 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Vajagathali, V. Ramakrishnan" "autores" => array:2 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Vajagathali" ] 1 => array:2 [ "nombre" => "V." "apellidos" => "Ramakrishnan" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217358082400049X?idApp=UINPBA00004N" "url" => "/21735808/0000003900000004/v1_202404150507/S217358082400049X/v1_202404150507/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "Review article" "titulo" => "Comparison of effectiveness between different interventions in postconcussive symptoms in adolescents and young people: a literature review" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "372" "paginaFinal" => "382" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Á.J. Reina Ruíz, A. Quintero Cabello" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Á.J." "apellidos" => "Reina Ruíz" ] 1 => array:4 [ "nombre" => "A." "apellidos" => "Quintero Cabello" "email" => array:1 [ 0 => "anaqc@euosuna.org" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Área de Fisioterapia, Centro Universitario de Osuna, Sevilla, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Comparación de la efectividad entre distintas intervenciones en los síntomas posconmoción en adolescentes y jóvenes: una revisión bibliográfica" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 422 "Ancho" => 1603 "Tamanyo" => 53370 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Ideal diagnostic nosology of mild traumatic brain injury. cmTBI: complicated mild traumatic brain injury; Cnc: concussion; Cncsub: subconcussive blows; CT: computed tomography; MRI: magnetic resonance imaging; N: none; pCTE: probable chronic traumatic encephalopathy; PPCS: prolonged postconcussive symptoms; S: some; smTBI: single mild traumatic brain injury; Y: yes. Source: Mayer et al.<a class="elsevierStyleCrossRef" href="#bib0100">20</a>" ] ] ] "textoCompleto" => "IntroductionTraumatic brain injuryTraumatic brain injury (TBI) involves both primary lesions caused by an external mechanical force and secondary lesions resulting from the physiological and biomolecular changes caused by brain ischaemia and intracranial hypertension.<a class="elsevierStyleCrossRefs" href="#bib0005">1–3</a>Mild TBI is an acute brain lesion caused by an external force that prevents the individual from living a normal life in the social, psychological, and physical spheres.<a class="elsevierStyleCrossRefs" href="#bib0020">4,5</a>Concussion is a pathophysiological alteration of the brain caused by a mechanical force transmitted to the brain and resulting in transient neural dysfunction, with no evidence of structural damage in neuroimaging studies.<a class="elsevierStyleCrossRefs" href="#bib0030">6–8</a>According to the United States Centers for Disease Control and Prevention, the most common causes of TBI-related death are road traffic collisions in individuals younger than 15 years and falls in individuals older than 65.<a class="elsevierStyleCrossRef" href="#bib0045">9</a>Concussion may present with a wide range of symptoms, with the most important being headache and loss of consciousness after the lesion.<a class="elsevierStyleCrossRefs" href="#bib0040">8,10</a> Broglio et al.<a class="elsevierStyleCrossRef" href="#bib0055">11</a> describe dizziness as a predictor of prolonged recovery.Among men, the sports with the highest incidence of concussion are American football, ice hockey, and lacrosse; among women, these are ice hockey, soccer, and basketball.<a class="elsevierStyleCrossRefs" href="#bib0060">12,13</a>TBI is one of the best known health conditions and has a major impact worldwide, affecting millions of people of all ages every year. It is regarded as one of the most complex disabling injuries, resulting in a 15.7% loss of productivity, 14 times as much as that associated with spinal cord injury.<a class="elsevierStyleCrossRef" href="#bib0070">14</a>Around 80%–90% of concussions resolve within 7–10 days; however, in special populations (children and adolescents), recovery may take longer.<a class="elsevierStyleCrossRefs" href="#bib0035">7,15</a> Several awareness campaigns for TBI have been developed; in Spain, however, it is not widely known.<a class="elsevierStyleCrossRefs" href="#bib0040">8,16–18</a>Diagnosis and treatmentGreat advances have been made in diagnostic criteria over the past 10 years. TBI was traditionally defined as a “head injury,” comprising a broad diagnostic spectrum. Although the introduction of the term TBI has not improved the conceptualisation of the injury, it has been very helpful from an epidemiological, treatment, and research viewpoint. When different levels of severity were established, the concept of mild TBI began to be used. The universally used diagnosis of mild TBI is mainly based on the development of signs and symptoms resulting from an external impact against the head, causing alterations in brain function. However, mild TBI is underdiagnosed, and its diagnostic criteria have been modified and expanded over time.<a class="elsevierStyleCrossRefs" href="#bib0095">19,20</a> In their study, Mayer et al.<a class="elsevierStyleCrossRef" href="#bib0100">20</a> describe the current and the ideal diagnostic nosology of mild TBI and its different stages.According to their description of the current diagnostic nosology of this entity (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>), concussion (Cnc, in cyan) is the mildest form of injury and encompasses all other diagnoses. Single mild TBI (smTBI, in green) falls under the diagnosis of concussion, although no diagnostic criteria are currently available that differentiate single mild TBI from concussion. Complicated mild TBI (cmTBI, in red, orange, and purple) is a head injury associated with positive neuroimaging findings. Repetitive head injury (RHI, in yellow, orange, and blue) may occur in either of the previous diagnostic categories. Subconcussive blows (Cncsub, in white) are speculative and not officially recognised. Prolonged postconcussive symptoms (PPCS) may present in any acute diagnostic entity and are currently diagnosed as major or mild neurocognitive disorder due to TBI. Probable chronic traumatic encephalopathy (pCTE) occurs following smTBI. PPCS and pCTE present within 3 months of acute diagnosis.<elsevierMultimedia ident="fig0005"></elsevierMultimedia><a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a> presents the spectrum of mild TBI from the acute to the chronic phase. The colour code used is the same as that of <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>. Furthermore, it presents each entity as a distinct diagnosis rather than combining them, and defines each with a specific, objective biomarker (represented by vertical arrows), which currently only exists for cmTBI. The availability of evidence for in vivo biomarkers is indicated with Y for yes, S for some, or N for none.<elsevierMultimedia ident="fig0010"></elsevierMultimedia>In general terms, the management protocol for individuals presenting concussion always starts with physical and cognitive rest until symptoms disappear. The Post-Concussion Symptom Scale (PCSS) is applied from the first day after the injury (Table 1 in Supplementary Material). After 48 hours, or if symptoms do not resolve, the protocol establishes a process for patients to return to physical activity (Table 2 in Supplementary Material).<a class="elsevierStyleCrossRef" href="#bib0105">21</a> No standardised parameters have been established for therapeutic exercise.<a class="elsevierStyleCrossRef" href="#bib0110">22</a> Vestibular rehabilitation is a novel treatment for vestibular balance disorders, although evidence supporting its effectiveness remains limited.<a class="elsevierStyleCrossRefs" href="#bib0115">23–25</a> Furthermore, physical rest is considered the first-line treatment in these patients, despite the lack of evidence on its effects.<a class="elsevierStyleCrossRefs" href="#bib0130">26–28</a>Significance of the studyConcussion and mild TBI are frequently regarded as synonyms for the mildest form of TBI after a head impact.<a class="elsevierStyleCrossRef" href="#bib0145">29</a> In view of the controversies around these concepts, we will use both terms interchangeably.Few epidemiological data are available, although researchers from the United States have previously informed about the magnitude of this health problem for healthcare systems and the scientific community.<a class="elsevierStyleCrossRef" href="#bib0150">30</a>Adolescents and young adults are at greater risk of mild TBI (with the increase in sports practice playing an important role), and their recovery is more prolonged since they are still maturing from a physiological viewpoint.<a class="elsevierStyleCrossRef" href="#bib0155">31</a> Furthermore, emergency care of these patients presents limitations, with symptoms persisting in one-third of cases.<a class="elsevierStyleCrossRef" href="#bib0160">32</a>The purpose of this review is to analyse and compare the effects of different interventions (therapeutic exercise, vestibular rehabilitation, and physical rest) on the symptoms of concussion in adolescents and young adults.Material and methodsDesignThis study followed the PICO (patient, intervention, comparison, outcome) strategy (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>) to construct the research question and select the best available scientific evidence.<a class="elsevierStyleCrossRefs" href="#bib0165">33,34</a><elsevierMultimedia ident="tbl0005"></elsevierMultimedia>Research question: What are the benefits of therapeutic exercise on post-concussion symptoms in adolescents and young adults, as compared to physical rest and vestibular rehabilitation?Search strategyAn electronic search was performed on the following databases: Cochrane Library, PubMed, Web of Science, SPORTDiscus, CINAHL, LILACS, PEDro, Dialnet, Scopus, and ENFISPO.We used the following search strategy with keywords included in the Health Sciences Descriptors (DeCS) vocabulary and the Medical Subject Headings (MeSH) thesaurus:(brain concussion OR mild traumatic brain injury) AND (adolescent OR young adult) AND (exercise therapy OR rest OR vestibular rehabilitation). We only included clinical trials and reviews. We searched for articles published up to 12 December 2017.Our search yielded 6 articles. <a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a> presents the PRISMA flow diagram.<a class="elsevierStyleCrossRef" href="#bib0175">35</a><elsevierMultimedia ident="fig0015"></elsevierMultimedia>Study selectionWe included randomised clinical trials published in English or Spanish between 1 January 2010 and 1 October 2018 and including adolescents and young adults (ages 13–25 years) with concussion or mild TBI. The methodological quality of the studies was evaluated with the PEDro scale; only studies achieving a minimum score of 6 points were included in our review.We excluded all articles analysing interventions other than therapeutic exercise, vestibular rehabilitation, and physical rest, as well as those only including patients aged over 25 years.Synthesis of resultsTherapeutic exerciseIn the study by Kurowski et al.,<a class="elsevierStyleCrossRef" href="#bib0180">36</a> the intervention group completed a home aerobic cycling programme, cycling for 80% of the duration that exacerbated symptoms, whereas the control group completed a full-body stretching programme that rotated on a 2-week basis. Caregivers were asked to gather data on post-concussion symptoms using the Post-Concussion Symptom Inventory (PCSI).Self-reported post-concussion symptoms (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>) decreased significantly (F = 4.11; P = .044) in the cycling group as compared to the stretching group; however, differences in caregiver-reported PCSI ratings between groups were not significant (F = 0.17; P = .68).<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>In the study by Micay et al.,<a class="elsevierStyleCrossRef" href="#bib0185">37</a> the control group followed an intervention focusing on progressive increases in intensity and duration on a cycle ergometer, according to the Berlin consensus statement (stage 1: no exercise; stage 2: light aerobic exercise; stage 3: sport-specific exercise; stage 4: non-contact training drills; stage 5: full contact practice; and stage 6: return to sport). The intervention group completed 8 sessions of aerobic exercise on a cycle ergometer over the course of 11 days (2 days of exercise followed by one day of rest). The first session lasted 10 minutes, at an intensity of 50% of the participant’s age-predicted maximal heart rate, whereas the following 7 sessions lasted 20 minutes, with intensity increasing by 5% of the individual’s age-predicted maximal heart rate per session. Post-concussion symptoms improved significantly in the intervention group (t[7] = 7.8; P < .01) as compared to controls (t[6] = 2.5; P < .05) (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).In the study by Chan et al.,<a class="elsevierStyleCrossRef" href="#bib0190">38</a> all participants received a session of occupational therapy and attended a consultation with a physician and a physiatrist before randomisation. The intervention group completed an aerobic training programme with a stationary bicycle at 60% of maximal aerobic capacity for 15 minutes, 10 minutes of sport-specific coordination exercises, and visualisation and imagery techniques, as well as a home exercise programme.Post-concussion symptoms improved significantly in the intervention group as compared to the control group.The variables depression, fatigue, and balance were evaluated with the Beck Youth Inventories Second Edition, the Pediatric Quality of Life Multidimensional Fatigue Scale, and the Balance Error Scoring System, respectively; results were gathered for exploratory and descriptive purposes, showing a minimal change in the intervention group (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).Vestibular rehabilitationIn the study by Schneider et al.,<a class="elsevierStyleCrossRef" href="#bib0195">39</a> the control and intervention groups performed non-provocative range of motion exercises, stretching, and postural education, and were instructed to rest until symptom freedom, followed by a protocol of graded exertion. The intervention group also underwent cervical spine physiotherapy based on manual therapy for the cervical and thoracic spine (joint mobilisation techniques), cervical neuromotor retraining exercises (craniovertebral flexor and extensor retraining), and sensorimotor retraining exercises, as well as vestibular rehabilitation based on an individualised programme of habituation, gaze stabilisation, adaptation exercises, standing and dynamic balance exercises, and canalith repositioning manoeuvres.The intervention group showed improvements in all variables (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>) as compared to the control group (χ2 = 13.08; P < .001).<elsevierMultimedia ident="tbl0015"></elsevierMultimedia>In the study by Reneker et al.,<a class="elsevierStyleCrossRef" href="#bib0200">40</a> the control group completed interventions ranging from sham, subtherapeutic, and non-progressive therapeutic techniques to minimally progressive therapeutic techniques, as well as cervical isometric exercises, gentle cervical spine range of motion exercises, and vestibulo-ocular reflex cancellation exercises, whereas the intervention group completed a vestibular rehabilitation programme (including habituation and adaptation techniques), oculomotor and neuromotor control (including proprioceptive and kinaesthetic awareness), and balance exercises to be performed at home, as well as exercise education. Individuals with cervical dysfunction were treated with soft tissue release, mobilisations, and/or thrust manipulations.The intervention group showed a significantly shorter symptomatic recovery time than the control group (log-rank = 0.13) (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>).In these studies, post-concussion symptoms were analysed with the Sport Concussion Assessment Tool 2 (which includes a list of symptoms that is identical to that of the PCSS)<a class="elsevierStyleCrossRef" href="#bib0195">39</a> and the PCSS,<a class="elsevierStyleCrossRef" href="#bib0200">40</a> which detected improvements in these symptoms. Schneider et al.<a class="elsevierStyleCrossRef" href="#bib0195">39</a> assess pain, dizziness, and balance with the Numeric Pain Rating Scale, the Dizziness Handicap Inventory, and the Activities-specific Balance Confidence Scale, reporting improvements in all 3 variables in the intervention group.Physical restIn the study by Thomas et al.,<a class="elsevierStyleCrossRef" href="#bib0205">41</a> participants were randomly allocated to strict rest for 5 days (intervention group) or 2 days (control group). Patients in both groups were instructed to follow the ACE-Emergency Department care plan, according to which they had to rest for a set period before stepwise return to school and physical exercise. Return to exercise started with 10–15 minutes of aerobic training on a cycle ergometer or running to increase heart rate, followed by sport-specific non-contact activities, non-contact progression exercises, contact exercises, and finally return to sport. The authors found no significant differences in post-concussion symptoms or balance between groups (<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>).<elsevierMultimedia ident="tbl0020"></elsevierMultimedia>DiscussionAccording to some studies, early intervention with rest, therapeutic exercise, and vestibular rehabilitation improves post-concussion symptoms in adolescents and young adults.<a class="elsevierStyleCrossRefs" href="#bib0180">36–40</a>Regarding therapeutic exercise, the studies by Kurowski et al.,<a class="elsevierStyleCrossRef" href="#bib0180">36</a> Micay et al.,<a class="elsevierStyleCrossRef" href="#bib0185">37</a> and Chan et al.<a class="elsevierStyleCrossRef" href="#bib0190">38</a> report significant improvements in post-concussion symptoms in patients completing an aerobic exercise protocol, despite differences in intensity (50%–80% of maximal aerobic capacity). However, the intergroup differences observed in the study by Micay et al.<a class="elsevierStyleCrossRef" href="#bib0185">37</a> may have been due to the small size of the sample and the small number of female patients included.In line with these results, other studies<a class="elsevierStyleCrossRefs" href="#bib0180">36–38</a> have shown that aerobic training at 80% of maximal aerobic capacity significantly reduces post-concussion symptoms as compared to the control intervention.Leddy et al.<a class="elsevierStyleCrossRef" href="#bib0210">42</a> found a correlation between a low heart rate threshold and poorer prognosis (ie, longer recovery time). In another study,<a class="elsevierStyleCrossRef" href="#bib0215">43</a> 20 minutes of sub-threshold aerobic exercise was found to decrease post-concussion symptoms and prevent long recovery times (> 30 days) as compared to stretching (control intervention).However, Maerlander et al.<a class="elsevierStyleCrossRef" href="#bib0220">44</a> found that high levels of exertion are associated with longer recovery times. In contrast, moderate physical exertion may be beneficial, although more specific guidance is needed on several parameters. In any case, that study included a small sample, as well as a small number of men.Yuan et al.<a class="elsevierStyleCrossRef" href="#bib0225">45</a> reported the benefits of aerobic training as compared to stretching, which they attribute to the increase in global efficiency and the decrease in normalised characteristic path length. Kurowski et al.<a class="elsevierStyleCrossRef" href="#bib0180">36</a> propose vestibular rehabilitation as a complementary treatment for individuals with vestibular and oculomotor symptoms, as these patients are less likely to benefit from the aerobic exercise intervention studied.Schneider et al.<a class="elsevierStyleCrossRef" href="#bib0195">39</a> and Reneker et al.<a class="elsevierStyleCrossRef" href="#bib0200">40</a> provide solid evidence that vestibular rehabilitation considerably decreases post-concussion symptoms associated with vestibular system alterations as compared to controls, after 8 weeks of treatment. Likewise, Kleffelgaard et al.<a class="elsevierStyleCrossRef" href="#bib0230">46</a> reported the short-term benefits (2–3 months) of vestibular rehabilitation on post-concussion symptoms. However, it should be noted that the study included patients aged 16–60 years with mild-to-moderate TBI.The studies by Schneider et al.<a class="elsevierStyleCrossRef" href="#bib0195">39</a> and Reneker et al.<a class="elsevierStyleCrossRef" href="#bib0200">40</a> included complementary interventions in addition to vestibular rehabilitation. Schneider et al.<a class="elsevierStyleCrossRef" href="#bib0195">39</a> underscore the positive effects of combining vestibular rehabilitation with exercise.Thomas et al.<a class="elsevierStyleCrossRef" href="#bib0235">47</a> did not observe differences in post-concussion symptoms as a function of the duration of physical rest prescribed. Other studies report similar results. Sufrinko et al.<a class="elsevierStyleCrossRef" href="#bib0240">48</a> observed no improvement in post-concussion symptoms within 10 days of the lesion, and Varner et al.<a class="elsevierStyleCrossRef" href="#bib0245">49</a> found no improvements at weeks 2 and 4. These findings may be due to short follow-up times (7–30 days).<a class="elsevierStyleCrossRefs" href="#bib0240">48,49</a> These studies show that long rest periods are associated with increased symptom reporting and lower mental activity.<a class="elsevierStyleCrossRef" href="#bib0235">47</a>Therapeutic exercise and vestibular rehabilitation have been shown to be the most effective approaches, with the studies included in this review reporting significant improvements.ConclusionTherapeutic exercise in general, and aerobic training in particular, improves post-concussion symptoms and quality of life in adolescents and young adults. Improvements are more marked when therapeutic exercise is combined with vestibular rehabilitation. Prolonged rest may result in longer symptom duration.Physiotherapists play an essential role in supervising patients during therapeutic exercise and vestibular rehabilitation, ensuring that the intervention is performed correctly and establishing the most appropriate parameters according to the patient’s age and severity, in coordination with a multidisciplinary team.In the light of the above, there is a need to standardise interventions in terms of intensity, number of sessions, and quantity of contents, adapting them to the needs of children and adolescents to increase treatment adherence.FundingThis study has received no specific funding from any public, commercial, or non-profit organisation.Conflicts of interestThe authors have no conflicts of interest to declare." "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres2129548" "titulo" => "Abstract" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Development" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Conclusión" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1808586" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres2129549" "titulo" => "Resumen" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0020" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0025" "titulo" => "Desarrollo" ] 2 => array:2 [ "identificador" => "abst0030" "titulo" => "Conclusión" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1808587" "titulo" => "Palabras clave" ] 4 => array:3 [ "identificador" => "sec0005" "titulo" => "Introduction" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0010" "titulo" => "Traumatic brain injury" ] 1 => array:2 [ "identificador" => "sec0015" "titulo" => "Diagnosis and treatment" ] 2 => array:2 [ "identificador" => "sec0020" "titulo" => "Significance of the study" ] ] ] 5 => array:3 [ "identificador" => "sec0025" "titulo" => "Material and methods" "secciones" => array:6 [ 0 => array:2 [ "identificador" => "sec0030" "titulo" => "Design" ] 1 => array:2 [ "identificador" => "sec0035" "titulo" => "Search strategy" ] 2 => array:2 [ "identificador" => "sec0040" "titulo" => "Study selection" ] 3 => array:3 [ "identificador" => "sec0045" "titulo" => "Synthesis of results" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0050" "titulo" => "Therapeutic exercise" ] ] ] 4 => array:2 [ "identificador" => "sec0055" "titulo" => "Vestibular rehabilitation" ] 5 => array:2 [ "identificador" => "sec0060" "titulo" => "Physical rest" ] ] ] 6 => array:2 [ "identificador" => "sec0065" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0070" "titulo" => "Conclusion" ] 8 => array:2 [ "identificador" => "sec0075" "titulo" => "Funding" ] 9 => array:2 [ "identificador" => "sec0080" "titulo" => "Conflicts of interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-12-14" "fechaAceptado" => "2021-08-06" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1808586" "palabras" => array:5 [ 0 => "Traumatic Brain Injury" 1 => "Concussion" 2 => "Exercise therapy" 3 => "Vestibular rehabilitation" 4 => "Rest" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1808587" "palabras" => array:5 [ 0 => "Traumatismo craneoencefálico" 1 => "Conmoción cerebral" 2 => "Ejercicio físico terapéutico" 3 => "Terapia vestibular" 4 => "Descanso" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "IntroductionCurrently, concussion considers a problem of great magnitude, adolescents and young people being the population at risk, since it is in the process of maturation. Our goal has been to compare the effectiveness of different interventions (exercise therapy, vestibular rehabilitation and rest) in adolescents and young people with concussion. DevelopmentA bibliographic search was carried out in the main databases. Once the inclusion/exclusion criteria and the PEDro methodological scale were applied, 6 articles were reviewed. The results support the use of exercise and vestibular rehabilitation in the initial stages to reduce post-concussion symptoms. According to most authors, therapeutic physical exercise and vestibular rehabilitation report greater benefits, although a protocol that unifies assessment scales, study variables and analysis parameters would be needed to be able to make the inference in the target population. ConclusiónFrom the moment of hospital discharge, the combined application of exercise and vestibular rehabilitation could be the best option to reduce post-concussion symptoms." "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Development" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Conclusión" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "IntroducciónActualmente la conmoción cerebral se considera un problema de gran magnitud, siendo los adolescentes y jóvenes la población de riesgo, ya que se encuentran en proceso de maduración. Nuestro objetivo ha sido comparar la eficacia de diferentes intervenciones (ejercicio físico terapéutico, terapia vestibular y descanso) en adolescentes y jóvenes con conmoción cerebral. DesarrolloSe realizó una búsqueda bibliográfica en las principales bases de datos. Una vez aplicados los criterios de inclusión/exclusión y la escala metodológica Physiotherapy Evidence Database PEDro, fueron revisados seis artículos. Los resultados apoyan la utilización del ejercicio y la terapia vestibular en las etapas iniciales para disminuir los síntomas posconmoción. Según la mayoría de los autores, el ejercicio físico terapéutico y la terapia vestibular reportan mayores beneficios, aunque se necesitaría un protocolo que unificara escalas de valoración, variables de estudio y parámetros de análisis para poder realizar la inferencia en la población diana. ConclusiónDesde el momento del alta hospitalaria del paciente, la aplicación combinada de ejercicio físico y terapia vestibular, podría considerarse como la mejor opción para disminuir los síntomas posconmoción." "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0020" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0025" "titulo" => "Desarrollo" ] 2 => array:2 [ "identificador" => "abst0030" "titulo" => "Conclusión" ] ] ] ] "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "The following is Supplementary data to this article:<elsevierMultimedia ident="upi0005"></elsevierMultimedia>" "etiqueta" => "Appendix A" "titulo" => "Supplementary data" "identificador" => "sec0090" ] ] ] ] "multimedia" => array:8 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1307 "Ancho" => 2500 "Tamanyo" => 294722 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Current diagnostic nosology of mild traumatic brain injury. cmTBI: complicated mild traumatic brain injury; Cnc: concussion; Cncsub: subconcussive blows; pCTE: probable chronic traumatic encephalopathy; PPCS: prolonged postconcussive symptoms; RHI: repetitive head injury; smTBI: single mild traumatic brain injury. Source: Mayer et al.<a class="elsevierStyleCrossRef" href="#bib0100">20</a>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 422 "Ancho" => 1603 "Tamanyo" => 53370 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Ideal diagnostic nosology of mild traumatic brain injury. cmTBI: complicated mild traumatic brain injury; Cnc: concussion; Cncsub: subconcussive blows; CT: computed tomography; MRI: magnetic resonance imaging; N: none; pCTE: probable chronic traumatic encephalopathy; PPCS: prolonged postconcussive symptoms; S: some; smTBI: single mild traumatic brain injury; Y: yes. Source: Mayer et al.<a class="elsevierStyleCrossRef" href="#bib0100">20</a>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 2166 "Ancho" => 2500 "Tamanyo" => 349980 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Flow chart of the article selection process." ] ] 3 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Patient \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Adolescents and young adults with concussion/mild traumatic brain injury \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Intervention \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Therapeutic exercise \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Comparison \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vestibular rehabilitation and rest \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Outcome \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Improvement in post-concussion symptoms \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3510645.png" ] ] ] ] "descripcion" => array:1 [ "en" => "PICO strategy." ] ] 4 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0025" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "BESS: Balance Error Scoring System; BYI-2: Beck Youth Inventories, Second Edition; CG: control group; IG: intervention group; PCSI: Post-Concussion Symptom Inventory; PCSS: Post-Concussion Symptom Scale; PedsQL-MFS: Pediatric Quality of Life Multidimensional Fatigue Scale." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Study \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Population \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Intervention \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variables \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Results</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">PCSI (post-concussion symptoms)</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Kurowski et al.<a class="elsevierStyleCrossRef" href="#bib0180">36</a> (PEDro: 6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">N = 30Age (years):12–17Sex:13 males17 females \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">CG: 5–6 sessions/week of aerobic trainingt = 6 weeksN = 155 males10 femalesIG: 5–6 sessions/week of full-body stretchingt = 6 weeksN = 158 males7 females \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Post-concussion symptoms (PCSI) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">CG (patient/carer)Week 0: 38(13–63)/39 (24–54)Week 1: 24(9–39)/26(7–46)Week 2: 16(2–31)/22(3–39)Week 3: 13(–2 to 28)/19 (0–38)Week 4: 12(–3 to 27)/18 (–1 to 36)Week 5: 8(–4 to 21)/12(–4 to 28)Week 6: 7(–6 to 21)/13(–8 to 33)Week 7: 6(–5 to 19)/8(–7 to 20) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">IG (patient/caregiver)Week 0: 40 (13–68)/48 (22–72)Week 1: 28 (9–46)/25 (8–42)Week 2: 22 (3–40)/19 (–2 to 38)Week 3: 27 (4–49)/26 (–1 to 52)Week 4: 25 (–1 to 50)/21 (–4 to 45)Week 5: 27 (–3 to 55)/19 (–4 to 42)Week 6: 21 (–6 to 46)/16 (–5 to 36)Week 7: 17 (–7 to 38)/9 (–1 to 18) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Micay et al.<a class="elsevierStyleCrossRef" href="#bib0185">37</a> (PEDro: 6)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">N = 16Age (years): 14–18Sex:15 males1 female</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">CG: usual care (Berlin 2016 guidelines)N = 87 males1 femaleIG: 8 sessions of aerobic exercise (cycle ergometer)t = 11 daysN = 88 males</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Post-concussion symptoms (PCSS)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">PCSS (post-concussion symptoms)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">CG:Week 1: 19 (17–20.5)Week 2: 13 (10–15)Week 3: 12 (9.5–14)Week 4: 9 (5.5–9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">IG:Week 1: 23.5 (19.5–27)Week 2: 14 (10.5–18.5)Week 3: 7.5 (3.5–12)Week 4: 4.5 (1–10.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="8" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Chan et al.<a class="elsevierStyleCrossRef" href="#bib0190">38</a> (PEDro: 7)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="8" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">N = 19Age (years):12–18Sex:5 males14 females</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="8" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CG: treatment as usualt = 6 weeksN = 91 male8 femalesIG: treatment as usual, active rehabilitation, light coordination and sport-specific exercises, visualisation and imagery techniques, and home exercise programmet = 6 weeksN = 104 males6 females</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="8" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Post-concussion symptoms (PCSS)Depression (BYI-2)Fatigue (PedsQL-MFS)Balance (BESS)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">PCSS (post-concussion symptoms)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">CG:Baseline:56.9 (31.0)End of intervention:40.3 (29.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">IG:Baseline:51.5 (27.8)End of intervention:25.0 (19.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">BYI-2 (depression)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">CG:Baseline:14.7 (13.4)End of intervention:10.2 (9.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">IG:Baseline:12.7 (8.8)End of intervention:12.2 (8.3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">PedsQL-MFS (fatigue)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">CG:Baseline:36.3 (18.5)End of intervention:32.2 (16.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">IG:Baseline:40.8 (14.6)End of intervention:17.0 (11.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">BESS (balance)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CG:Baseline:16.3 (15.7)End of intervention:11.4 (7.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">IG:Baseline:16.0 (8.1)End of intervention:10.3 (3.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3510644.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Summary of the results of studies into therapeutic exercise." ] ] 5 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0030" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "ABC: Activities-specific Balance Confidence scale; CG: control group; DHI: Dizziness Handicap Inventory; IG: intervention group; N1: discharged; N2: not discharged; NPRS: Numeric Pain Rating Scale; SCAT2: Sport Concussion Assessment Tool 2." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Study \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Population \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Intervention \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variable \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Results</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="8" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Schneider et al.<a class="elsevierStyleCrossRef" href="#bib0195">39</a>(PEDro: 8)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="8" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">N = 31Age (years):12–30Sex:18 males13 females</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="8" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">CG: non-provocative range of motion exercises, stretching, postural education, and rest until symptom freedom, followed by graded exertiont = 8 weeksN = 167 males9 femalesIG: non-provocative range of motion exercises, stretching, postural education, and rest until symptom freedom, followed by graded exertion, cervical spinal physiotherapy, and vestibular rehabilitationt = 8 weeksN = 1511 males4 females</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="8" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Pain intensity (NPRS)Balance (ABC)Dizziness (DHI)Concussion (SCAT2)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">NPRS (pain intensity), median change (range)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">CG:Baseline:Neck pain: 3(0–9)Headache: 4(0–9)Dizziness: 5(0–8)End ofintervention(N1 = 1,N2 = 12):Neck pain: –4/–1.5 (–8 to 3)Headache: –7/–2.5 (–7 to 1)Dizziness: –5/–1.5 (–6 to 0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">IG:Baseline:Neck pain: 3(0–7)Headache: 4(0–8)Dizziness: 3(0–8)End ofintervention(N1 = 11,N2 = 4):Neck pain: −3 (−5 to 0)/−1 (−5 to 0)Headache: −3 (−8 to 0)/−2.5 (−4 to 0)Dizziness: −2(−7 to 0)/−1 (−4 to 1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">ABC (balance), median change (range)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">CG:Baseline:85% (45%–100%)End ofintervention(N1 = 1,N2 = 12):30/12.75(0–55) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">IG:Baseline:80% (40%–95%)End ofintervention(N1 = 11,N2 = 4): 8(0–52)/19.5(−6 to 43.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">DHI (dizziness), median change (range)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">CG:Baseline: 42(0–66)End ofintervention(N1 = 1,N2 = 12): −48/−21 (−58 to 2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">IG:Baseline: 46(6–84)End ofintervention(N1 = 11,N2 = 4): −24 (−50 to−6)/−13 (−16 to −8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">SCAT2 (concussion)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">CG:Baseline:70(47–92)End ofintervention(N1 = 1,N2 = 12):26/12 (−5to 42) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">IG:Baseline:71(52–96)End ofintervention(N1 = 11,N2 = 4): 18(10–30)/8.5 (−9 to11) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Reneker et al.<a class="elsevierStyleCrossRef" href="#bib0200">40</a>(PEDro: 7)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">N = 41Mean age (years):10–23Sex:25 males16 females</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CG: sham or minimally progressive therapeutic techniques, cervical spine range of motion exercises, and vestibulo-ocular reflex cancellation exercisest = 14 monthsN = 1911 males8 femalesIG: vestibular rehabilitation, oculomotor and neuromotor control, home programme of balance exercises, exercise educationt = 14 monthsN = 2214 males8 females</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Post-concussion symptoms (PCSS)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">PCSS (post-concussion symptoms)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Day 0CG: veryhigh (21–43:39.2)IG: veryhigh (21–43:39.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Symptomrecovery(≤9)CG: day 17IG: day 13.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3510642.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Summary of results reported by studies on vestibular rehabilitation." ] ] 6 => array:8 [ "identificador" => "tbl0020" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0035" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "BESS: Balance Error Scoring System; CG: control group; IG: intervention group; PCSS: Post-Concussion Symptom Scale." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Study \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Population \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Intervention \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variable \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Results</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " rowspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Thomas et al.<a class="elsevierStyleCrossRef" href="#bib0205">41</a>(PEDro: 7)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">N = 99Age(years): 11–22Sex:65 males34 females</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CG (usual care): 1–2 days of rest, followed by return to school and stepwise return to physical activityt = 10 daysN = 5032 males18 femalesIG (strict rest): 5 days of rest, followed by return to school and stepwise return to physical activityt = 10 daysN = 4933 males16 females</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Post-concussion symptoms (PCSS)Balance (BESS)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">PCSS (post-concussion symptoms)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">CG:Day 3:17 (11–24)Day 10:8 (4–12) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">IG:Day 3:24 (17–30)Day 10:12.5 (8–17) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">BESS (balance)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CG:Day 0<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a>:8.4(6.6–10.2)Day 3:22.4 (18.8–25.9)Day 10:19(15.9–22.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">IG:Day 0<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a>:10.8(8.2–13.4)Day 3:23.6(21.0–26.1)Day 10:21(18.4–23.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3510643.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "Performed on floor/ground." ] ] ] "descripcion" => array:1 [ "en" => "Summary of results reported by studies into physical rest for patients with post-concussion symptoms." ] ] 7 => array:5 [ "identificador" => "upi0005" "tipo" => "MULTIMEDIAECOMPONENTE" "mostrarFloat" => false "mostrarDisplay" => true "Ecomponente" => array:2 [ "fichero" => "mmc1.doc" "ficheroTamanyo" => 19845 ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:49 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathophysiology of traumatic brain injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. 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Comparación de la efectividad entre distintas intervenciones en los síntomas posconmoción en adolescentes y jóvenes: una revisión bibliográfica

Á.J. Reina Ruíz, A. Quintero Cabello

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anaqc@euosuna.org

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Área de Fisioterapia, Centro Universitario de Osuna, Sevilla, Spain

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with no evidence of structural damage in neuroimaging studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#8211;8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">According to the United States Centers for Disease Control and Prevention&#44; the most common causes of TBI-related death are road traffic collisions in individuals younger than 15 years and falls in individuals older than 65&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Concussion may present with a wide range of symptoms&#44; with the most important being headache and loss of consciousness after the lesion&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;10</span></a> Broglio et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> describe dizziness as a predictor of prolonged recovery&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Among men&#44; the sports with the highest incidence of concussion are American football&#44; ice hockey&#44; and lacrosse&#59; among women&#44; these are ice hockey&#44; soccer&#44; and basketball&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;13</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">TBI is one of the best known health conditions and has a major impact worldwide&#44; affecting millions of people of all ages every year&#46; It is regarded as one of the most complex disabling injuries&#44; resulting in a 15&#46;7&#37; loss of productivity&#44; 14 times as much as that associated with spinal cord injury&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Around 80&#37;&#8211;90&#37; of concussions resolve within 7&#8211;10 days&#59; however&#44; in special populations &#40;children and adolescents&#41;&#44; recovery may take longer&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;15</span></a> Several awareness campaigns for TBI have been developed&#59; in Spain&#44; however&#44; it is not widely known&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;16&#8211;18</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Diagnosis and treatment</span><p id="par0045" class="elsevierStylePara elsevierViewall">Great advances have been made in diagnostic criteria over the past 10 years&#46; TBI was traditionally defined as a &#8220;head injury&#44;&#8221; comprising a broad diagnostic spectrum&#46; Although the introduction of the term TBI has not improved the conceptualisation of the injury&#44; it has been very helpful from an epidemiological&#44; treatment&#44; and research viewpoint&#46; When different levels of severity were established&#44; the concept of mild TBI began to be used&#46; The universally used diagnosis of mild TBI is mainly based on the development of signs and symptoms resulting from an external impact against the head&#44; causing alterations in brain function&#46; However&#44; mild TBI is underdiagnosed&#44; and its diagnostic criteria have been modified and expanded over time&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19&#44;20</span></a> In their study&#44; Mayer et al&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> describe the current and the ideal diagnostic nosology of mild TBI and its different stages&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">According to their description of the current diagnostic nosology of this entity &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; concussion &#40;Cnc&#44; in cyan&#41; is the mildest form of injury and encompasses all other diagnoses&#46; Single mild TBI &#40;smTBI&#44; in green&#41; falls under the diagnosis of concussion&#44; although no diagnostic criteria are currently available that differentiate single mild TBI from concussion&#46; Complicated mild TBI &#40;cmTBI&#44; in red&#44; orange&#44; and purple&#41; is a head injury associated with positive neuroimaging findings&#46; Repetitive head injury &#40;RHI&#44; in yellow&#44; orange&#44; and blue&#41; may occur in either of the previous diagnostic categories&#46; Subconcussive blows &#40;Cnc<span class="elsevierStyleInf">sub</span>&#44; in white&#41; are speculative and not officially recognised&#46; Prolonged postconcussive symptoms &#40;PPCS&#41; may present in any acute diagnostic entity and are currently diagnosed as major or mild neurocognitive disorder due to TBI&#46; Probable chronic traumatic encephalopathy &#40;pCTE&#41; occurs following smTBI&#46; PPCS and pCTE present within 3 months of acute diagnosis&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a> presents the spectrum of mild TBI from the acute to the chronic phase&#46; The colour code used is the same as that of <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46; Furthermore&#44; it presents each entity as a distinct diagnosis rather than combining them&#44; and defines each with a specific&#44; objective biomarker &#40;represented by vertical arrows&#41;&#44; which currently only exists for cmTBI&#46; The availability of evidence for in vivo biomarkers is indicated with Y for yes&#44; S for some&#44; or N for none&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">In general terms&#44; the management protocol for individuals presenting concussion always starts with physical and cognitive rest until symptoms disappear&#46; The Post-Concussion Symptom Scale &#40;PCSS&#41; is applied from the first day after the injury &#40;Table 1 in Supplementary Material&#41;&#46; After 48&#8239;hours&#44; or if symptoms do not resolve&#44; the protocol establishes a process for patients to return to physical activity &#40;Table 2 in Supplementary Material&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> No standardised parameters have been established for therapeutic exercise&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> Vestibular rehabilitation is a novel treatment for vestibular balance disorders&#44; although evidence supporting its effectiveness remains limited&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23&#8211;25</span></a> Furthermore&#44; physical rest is considered the first-line treatment in these patients&#44; despite the lack of evidence on its effects&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">26&#8211;28</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Significance of the study</span><p id="par0065" class="elsevierStylePara elsevierViewall">Concussion and mild TBI are frequently regarded as synonyms for the mildest form of TBI after a head impact&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> In view of the controversies around these concepts&#44; we will use both terms interchangeably&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Few epidemiological data are available&#44; although researchers from the United States have previously informed about the magnitude of this health problem for healthcare systems and the scientific community&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Adolescents and young adults are at greater risk of mild TBI &#40;with the increase in sports practice playing an important role&#41;&#44; and their recovery is more prolonged since they are still maturing from a physiological viewpoint&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> Furthermore&#44; emergency care of these patients presents limitations&#44; with symptoms persisting in one-third of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">The purpose of this review is to analyse and compare the effects of different interventions &#40;therapeutic exercise&#44; vestibular rehabilitation&#44; and physical rest&#41; on the symptoms of concussion in adolescents and young adults&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Material and methods</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Design</span><p id="par0085" class="elsevierStylePara elsevierViewall">This study followed the PICO &#40;patient&#44; intervention&#44; comparison&#44; outcome&#41; strategy &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41; to construct the research question and select the best available scientific evidence&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">33&#44;34</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Research question&#58;</span> What are the benefits of therapeutic exercise on post-concussion symptoms in adolescents and young adults&#44; as compared to physical rest and vestibular rehabilitation&#63;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Search strategy</span><p id="par0095" class="elsevierStylePara elsevierViewall">An electronic search was performed on the following databases&#58; Cochrane Library&#44; PubMed&#44; Web of Science&#44; SPORTDiscus&#44; CINAHL&#44; LILACS&#44; PEDro&#44; Dialnet&#44; Scopus&#44; and ENFISPO&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">We used the following search strategy with keywords included in the Health Sciences Descriptors &#40;DeCS&#41; vocabulary and the Medical Subject Headings &#40;MeSH&#41; thesaurus&#58;</p><p id="par0105" class="elsevierStylePara elsevierViewall">&#40;brain concussion OR mild traumatic brain injury&#41; AND &#40;adolescent OR young adult&#41; AND &#40;exercise therapy OR rest OR vestibular rehabilitation&#41;&#46; We only included clinical trials and reviews&#46; We searched for articles published up to 12 December 2017&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Our search yielded 6 articles&#46; <a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a> presents the PRISMA flow diagram&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a></p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Study selection</span><p id="par0115" class="elsevierStylePara elsevierViewall">We included randomised clinical trials published in English or Spanish between 1 January 2010 and 1 October 2018 and including adolescents and young adults &#40;ages 13&#8211;25 years&#41; with concussion or mild TBI&#46; The methodological quality of the studies was evaluated with the PEDro scale&#59; only studies achieving a minimum score of 6 points were included in our review&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">We excluded all articles analysing interventions other than therapeutic exercise&#44; vestibular rehabilitation&#44; and physical rest&#44; as well as those only including patients aged over 25 years&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Synthesis of results</span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Therapeutic exercise</span><p id="par0125" class="elsevierStylePara elsevierViewall">In the study by Kurowski et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> the intervention group completed a home aerobic cycling programme&#44; cycling for 80&#37; of the duration that exacerbated symptoms&#44; whereas the control group completed a full-body stretching programme that rotated on a 2-week basis&#46; Caregivers were asked to gather data on post-concussion symptoms using the Post-Concussion Symptom Inventory &#40;PCSI&#41;&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Self-reported post-concussion symptoms &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41; decreased significantly &#40;<span class="elsevierStyleItalic">F</span>&#8239;&#61;&#8239;4&#46;11&#59; <span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;044&#41; in the cycling group as compared to the stretching group&#59; however&#44; differences in caregiver-reported PCSI ratings between groups were not significant &#40;<span class="elsevierStyleItalic">F</span>&#8239;&#61;&#8239;0&#46;17&#59; <span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;68&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0135" class="elsevierStylePara elsevierViewall">In the study by Micay et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> the control group followed an intervention focusing on progressive increases in intensity and duration on a cycle ergometer&#44; according to the Berlin consensus statement &#40;stage 1&#58; no exercise&#59; stage 2&#58; light aerobic exercise&#59; stage 3&#58; sport-specific exercise&#59; stage 4&#58; non-contact training drills&#59; stage 5&#58; full contact practice&#59; and stage 6&#58; return to sport&#41;&#46; The intervention group completed 8 sessions of aerobic exercise on a cycle ergometer over the course of 11 days &#40;2 days of exercise followed by one day of rest&#41;&#46; The first session lasted 10&#8239;minutes&#44; at an intensity of 50&#37; of the participant&#8217;s age-predicted maximal heart rate&#44; whereas the following 7 sessions lasted 20&#8239;minutes&#44; with intensity increasing by 5&#37; of the individual&#8217;s age-predicted maximal heart rate per session&#46; Post-concussion symptoms improved significantly in the intervention group &#40;t&#91;7&#93;&#8239;&#61;&#8239;7&#46;8&#59; <span class="elsevierStyleItalic">P</span>&#8239;&#60;&#8239;&#46;01&#41; as compared to controls &#40;t&#91;6&#93;&#8239;&#61;&#8239;2&#46;5&#59; <span class="elsevierStyleItalic">P</span>&#8239;&#60;&#8239;&#46;05&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">In the study by Chan et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a> all participants received a session of occupational therapy and attended a consultation with a physician and a physiatrist before randomisation&#46; The intervention group completed an aerobic training programme with a stationary bicycle at 60&#37; of maximal aerobic capacity for 15&#8239;minutes&#44; 10&#8239;minutes of sport-specific coordination exercises&#44; and visualisation and imagery techniques&#44; as well as a home exercise programme&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Post-concussion symptoms improved significantly in the intervention group as compared to the control group&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">The variables depression&#44; fatigue&#44; and balance were evaluated with the Beck Youth Inventories Second Edition&#44; the Pediatric Quality of Life Multidimensional Fatigue Scale&#44; and the Balance Error Scoring System&#44; respectively&#59; results were gathered for exploratory and descriptive purposes&#44; showing a minimal change in the intervention group &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Vestibular rehabilitation</span><p id="par0155" class="elsevierStylePara elsevierViewall">In the study by Schneider et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> the control and intervention groups performed non-provocative range of motion exercises&#44; stretching&#44; and postural education&#44; and were instructed to rest until symptom freedom&#44; followed by a protocol of graded exertion&#46; The intervention group also underwent cervical spine physiotherapy based on manual therapy for the cervical and thoracic spine &#40;joint mobilisation techniques&#41;&#44; cervical neuromotor retraining exercises &#40;craniovertebral flexor and extensor retraining&#41;&#44; and sensorimotor retraining exercises&#44; as well as vestibular rehabilitation based on an individualised programme of habituation&#44; gaze stabilisation&#44; adaptation exercises&#44; standing and dynamic balance exercises&#44; and canalith repositioning manoeuvres&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">The intervention group showed improvements in all variables &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41; as compared to the control group &#40;&#967;<span class="elsevierStyleSup">2</span>&#8239;&#61;&#8239;13&#46;08&#59; <span class="elsevierStyleItalic">P</span>&#8239;&#60;&#8239;&#46;001&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0165" class="elsevierStylePara elsevierViewall">In the study by Reneker et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> the control group completed interventions ranging from sham&#44; subtherapeutic&#44; and non-progressive therapeutic techniques to minimally progressive therapeutic techniques&#44; as well as cervical isometric exercises&#44; gentle cervical spine range of motion exercises&#44; and vestibulo-ocular reflex cancellation exercises&#44; whereas the intervention group completed a vestibular rehabilitation programme &#40;including habituation and adaptation techniques&#41;&#44; oculomotor and neuromotor control &#40;including proprioceptive and kinaesthetic awareness&#41;&#44; and balance exercises to be performed at home&#44; as well as exercise education&#46; Individuals with cervical dysfunction were treated with soft tissue release&#44; mobilisations&#44; and&#47;or thrust manipulations&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">The intervention group showed a significantly shorter symptomatic recovery time than the control group &#40;log-rank&#8239;&#61;&#8239;0&#46;13&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">In these studies&#44; post-concussion symptoms were analysed with the Sport Concussion Assessment Tool 2 &#40;which includes a list of symptoms that is identical to that of the PCSS&#41;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> and the PCSS&#44;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> which detected improvements in these symptoms&#46; Schneider et al&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> assess pain&#44; dizziness&#44; and balance with the Numeric Pain Rating Scale&#44; the Dizziness Handicap Inventory&#44; and the Activities-specific Balance Confidence Scale&#44; reporting improvements in all 3 variables in the intervention group&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Physical rest</span><p id="par0180" class="elsevierStylePara elsevierViewall">In the study by Thomas et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a> participants were randomly allocated to strict rest for 5 days &#40;intervention group&#41; or 2 days &#40;control group&#41;&#46; Patients in both groups were instructed to follow the ACE-Emergency Department care plan&#44; according to which they had to rest for a set period before stepwise return to school and physical exercise&#46; Return to exercise started with 10&#8211;15&#8239;minutes of aerobic training on a cycle ergometer or running to increase heart rate&#44; followed by sport-specific non-contact activities&#44; non-contact progression exercises&#44; contact exercises&#44; and finally return to sport&#46; The authors found no significant differences in post-concussion symptoms or balance between groups &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Discussion</span><p id="par0185" class="elsevierStylePara elsevierViewall">According to some studies&#44; early intervention with rest&#44; therapeutic exercise&#44; and vestibular rehabilitation improves post-concussion symptoms in adolescents and young adults&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">36&#8211;40</span></a></p><p id="par0190" class="elsevierStylePara elsevierViewall">Regarding therapeutic exercise&#44; the studies by Kurowski et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> Micay et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> and Chan et al&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a> report significant improvements in post-concussion symptoms in patients completing an aerobic exercise protocol&#44; despite differences in intensity &#40;50&#37;&#8211;80&#37; of maximal aerobic capacity&#41;&#46; However&#44; the intergroup differences observed in the study by Micay et al&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> may have been due to the small size of the sample and the small number of female patients included&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">In line with these results&#44; other studies<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">36&#8211;38</span></a> have shown that aerobic training at 80&#37; of maximal aerobic capacity significantly reduces post-concussion symptoms as compared to the control intervention&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">Leddy et al&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a> found a correlation between a low heart rate threshold and poorer prognosis &#40;ie&#44; longer recovery time&#41;&#46; In another study&#44;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">43</span></a> 20&#8239;minutes of sub-threshold aerobic exercise was found to decrease post-concussion symptoms and prevent long recovery times &#40;&#62;&#8239;30 days&#41; as compared to stretching &#40;control intervention&#41;&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">However&#44; Maerlander et al&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a> found that high levels of exertion are associated with longer recovery times&#46; In contrast&#44; moderate physical exertion may be beneficial&#44; although more specific guidance is needed on several parameters&#46; In any case&#44; that study included a small sample&#44; as well as a small number of men&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">Yuan et al&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a> reported the benefits of aerobic training as compared to stretching&#44; which they attribute to the increase in global efficiency and the decrease in normalised characteristic path length&#46; Kurowski et al&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> propose vestibular rehabilitation as a complementary treatment for individuals with vestibular and oculomotor symptoms&#44; as these patients are less likely to benefit from the aerobic exercise intervention studied&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">Schneider et al&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> and Reneker et al&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> provide solid evidence that vestibular rehabilitation considerably decreases post-concussion symptoms associated with vestibular system alterations as compared to controls&#44; after 8 weeks of treatment&#46; Likewise&#44; Kleffelgaard et al&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">46</span></a> reported the short-term benefits &#40;2&#8211;3 months&#41; of vestibular rehabilitation on post-concussion symptoms&#46; However&#44; it should be noted that the study included patients aged 16&#8211;60 years with mild-to-moderate TBI&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">The studies by Schneider et al&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> and Reneker et al&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> included complementary interventions in addition to vestibular rehabilitation&#46; Schneider et al&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> underscore the positive effects of combining vestibular rehabilitation with exercise&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">Thomas et al&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">47</span></a> did not observe differences in post-concussion symptoms as a function of the duration of physical rest prescribed&#46; Other studies report similar results&#46; Sufrinko et al&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">48</span></a> observed no improvement in post-concussion symptoms within 10 days of the lesion&#44; and Varner et al&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a> found no improvements at weeks 2 and 4&#46; These findings may be due to short follow-up times &#40;7&#8211;30 days&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">48&#44;49</span></a> These studies show that long rest periods are associated with increased symptom reporting and lower mental activity&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">47</span></a></p><p id="par0230" class="elsevierStylePara elsevierViewall">Therapeutic exercise and vestibular rehabilitation have been shown to be the most effective approaches&#44; with the studies included in this review reporting significant improvements&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conclusion</span><p id="par0235" class="elsevierStylePara elsevierViewall">Therapeutic exercise in general&#44; and aerobic training in particular&#44; improves post-concussion symptoms and quality of life in adolescents and young adults&#46; Improvements are more marked when therapeutic exercise is combined with vestibular rehabilitation&#46; Prolonged rest may result in longer symptom duration&#46;</p><p id="par0240" class="elsevierStylePara elsevierViewall">Physiotherapists play an essential role in supervising patients during therapeutic exercise and vestibular rehabilitation&#44; ensuring that the intervention is performed correctly and establishing the most appropriate parameters according to the patient&#8217;s age and severity&#44; in coordination with a multidisciplinary team&#46;</p><p id="par0245" class="elsevierStylePara elsevierViewall">In the light of the above&#44; there is a need to standardise interventions in terms of intensity&#44; number of sessions&#44; and quantity of contents&#44; adapting them to the needs of children and adolescents to increase treatment adherence&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Funding</span><p id="par0250" class="elsevierStylePara elsevierViewall">This study has received no specific funding from any public&#44; commercial&#44; or non-profit organisation&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conflicts of interest</span><p id="par0255" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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              "titulo" => "Conclusi&#243;n"
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          "titulo" => "Introduction"
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            0 => array:2 [
              "identificador" => "sec0010"
              "titulo" => "Traumatic brain injury"
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              "titulo" => "Diagnosis and treatment"
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              "identificador" => "sec0020"
              "titulo" => "Significance of the study"
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          "titulo" => "Material and methods"
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              "titulo" => "Design"
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              "titulo" => "Study selection"
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              "titulo" => "Synthesis of results"
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                0 => array:2 [
                  "identificador" => "sec0050"
                  "titulo" => "Therapeutic exercise"
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              "identificador" => "sec0055"
              "titulo" => "Vestibular rehabilitation"
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              "identificador" => "sec0060"
              "titulo" => "Physical rest"
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          "titulo" => "Discussion"
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          "titulo" => "Conclusion"
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          "titulo" => "Funding"
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          "identificador" => "sec0080"
          "titulo" => "Conflicts of interest"
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          "titulo" => "References"
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    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2019-12-14"
    "fechaAceptado" => "2021-08-06"
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          "clase" => "keyword"
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          "palabras" => array:5 [
            0 => "Traumatic Brain Injury"
            1 => "Concussion"
            2 => "Exercise therapy"
            3 => "Vestibular rehabilitation"
            4 => "Rest"
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          "palabras" => array:5 [
            0 => "Traumatismo craneoencef&#225;lico"
            1 => "Conmoci&#243;n cerebral"
            2 => "Ejercicio f&#237;sico terap&#233;utico"
            3 => "Terapia vestibular"
            4 => "Descanso"
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    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Currently&#44; concussion considers a problem of great magnitude&#44; adolescents and young people being the population at risk&#44; since it is in the process of maturation&#46; Our goal has been to compare the effectiveness of different interventions &#40;exercise therapy&#44; vestibular rehabilitation and rest&#41; in adolescents and young people with concussion&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Development</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">A bibliographic search was carried out in the main databases&#46; Once the inclusion&#47;exclusion criteria and the PEDro methodological scale were applied&#44; 6 articles were reviewed&#46; The results support the use of exercise and vestibular rehabilitation in the initial stages to reduce post-concussion symptoms&#46; According to most authors&#44; therapeutic physical exercise and vestibular rehabilitation report greater benefits&#44; although a protocol that unifies assessment scales&#44; study variables and analysis parameters would be needed to be able to make the inference in the target population&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conclusi&#243;n</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">From the moment of hospital discharge&#44; the combined application of exercise and vestibular rehabilitation could be the best option to reduce post-concussion symptoms&#46;</p></span>"
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Introducci&#243;n</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Actualmente la conmoci&#243;n cerebral se considera un problema de gran magnitud&#44; siendo los adolescentes y j&#243;venes la poblaci&#243;n de riesgo&#44; ya que se encuentran en proceso de maduraci&#243;n&#46; Nuestro objetivo ha sido comparar la eficacia de diferentes intervenciones &#40;ejercicio f&#237;sico terap&#233;utico&#44; terapia vestibular y descanso&#41; en adolescentes y j&#243;venes con conmoci&#243;n cerebral&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Desarrollo</span><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; una b&#250;squeda bibliogr&#225;fica en las principales bases de datos&#46; Una vez aplicados los criterios de inclusi&#243;n&#47;exclusi&#243;n y la escala metodol&#243;gica <span class="elsevierStyleItalic">Physiotherapy Evidence Database</span> PEDro&#44; fueron revisados seis art&#237;culos&#46; Los resultados apoyan la utilizaci&#243;n del ejercicio y la terapia vestibular en las etapas iniciales para disminuir los s&#237;ntomas posconmoci&#243;n&#46; Seg&#250;n la mayor&#237;a de los autores&#44; el ejercicio f&#237;sico terap&#233;utico y la terapia vestibular reportan mayores beneficios&#44; aunque se necesitar&#237;a un protocolo que unificara escalas de valoraci&#243;n&#44; variables de estudio y par&#225;metros de an&#225;lisis para poder realizar la inferencia en la poblaci&#243;n diana&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusi&#243;n</span><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Desde el momento del alta hospitalaria del paciente&#44; la aplicaci&#243;n combinada de ejercicio f&#237;sico y terapia vestibular&#44; podr&#237;a considerarse como la mejor opci&#243;n para disminuir los s&#237;ntomas posconmoci&#243;n&#46;</p></span>"
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            "apendice" => "<p id="par0265" class="elsevierStylePara elsevierViewall">The following is Supplementary data to this article&#58;<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Supplementary data"
            "identificador" => "sec0090"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Current diagnostic nosology of mild traumatic brain injury&#46; cmTBI&#58; complicated mild traumatic brain injury&#59; Cnc&#58; concussion&#59; Cnc<span class="elsevierStyleInf">sub</span>&#58; subconcussive blows&#59; pCTE&#58; probable chronic traumatic encephalopathy&#59; PPCS&#58; prolonged postconcussive symptoms&#59; RHI&#58; repetitive head injury&#59; smTBI&#58; single mild traumatic brain injury&#46;</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Source&#58; Mayer et al&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Ideal diagnostic nosology of mild traumatic brain injury&#46; cmTBI&#58; complicated mild traumatic brain injury&#59; Cnc&#58; concussion&#59; Cnc<span class="elsevierStyleInf">sub</span>&#58; subconcussive blows&#59; CT&#58; computed tomography&#59; MRI&#58; magnetic resonance imaging&#59; N&#58; none&#59; pCTE&#58; probable chronic traumatic encephalopathy&#59; PPCS&#58; prolonged postconcussive symptoms&#59; S&#58; some&#59; smTBI&#58; single mild traumatic brain injury&#59; Y&#58; yes&#46;</p> <p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Source&#58; Mayer et al&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p>"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Flow chart of the article selection process&#46;</p>"
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        "etiqueta" => "Table 1"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Patient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Adolescents and young adults with concussion&#47;mild traumatic brain injury&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intervention&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Therapeutic exercise&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comparison&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vestibular rehabilitation and rest&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Outcome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Improvement in post-concussion symptoms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">PICO strategy&#46;</p>"
        ]
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">BESS&#58; Balance Error Scoring System&#59; BYI-2&#58; Beck Youth Inventories&#44; Second Edition&#59; CG&#58; control group&#59; IG&#58; intervention group&#59; PCSI&#58; Post-Concussion Symptom Inventory&#59; PCSS&#58; Post-Concussion Symptom Scale&#59; PedsQL-MFS&#58; Pediatric Quality of Life Multidimensional Fatigue Scale&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Population&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variables&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Results</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">PCSI &#40;post-concussion symptoms&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Kurowski et al&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> &#40;PEDro&#58; 6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N&#8239;&#61;&#8239;30Age &#40;years&#41;&#58;12&#8211;17Sex&#58;13 males17 females&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">CG&#58; 5&#8211;6 sessions&#47;week of aerobic trainingt&#8239;&#61;&#8239;6 weeksN&#8239;&#61;&#8239;155 males10 femalesIG&#58; 5&#8211;6 sessions&#47;week of full-body stretchingt&#8239;&#61;&#8239;6 weeksN&#8239;&#61;&#8239;158 males7 females&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Post-concussion symptoms &#40;PCSI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">CG &#40;patient&#47;carer&#41;Week 0&#58; 38&#40;13&#8211;63&#41;&#47;39 &#40;24&#8211;54&#41;Week 1&#58; 24&#40;9&#8211;39&#41;&#47;26&#40;7&#8211;46&#41;Week 2&#58; 16&#40;2&#8211;31&#41;&#47;22&#40;3&#8211;39&#41;Week 3&#58; 13&#40;&#8211;2 to 28&#41;&#47;19 &#40;0&#8211;38&#41;Week 4&#58; 12&#40;&#8211;3 to 27&#41;&#47;18 &#40;&#8211;1 to 36&#41;Week 5&#58; 8&#40;&#8211;4 to 21&#41;&#47;12&#40;&#8211;4 to 28&#41;Week 6&#58; 7&#40;&#8211;6 to 21&#41;&#47;13&#40;&#8211;8 to 33&#41;Week 7&#58; 6&#40;&#8211;5 to 19&#41;&#47;8&#40;&#8211;7 to 20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">IG &#40;patient&#47;caregiver&#41;<span class="elsevierStyleBold">Week 0&#58;</span> 40 &#40;13&#8211;68&#41;&#47;48 &#40;22&#8211;72&#41;<span class="elsevierStyleBold">Week 1&#58;</span> 28 &#40;9&#8211;46&#41;&#47;25 &#40;8&#8211;42&#41;<span class="elsevierStyleBold">Week 2&#58;</span> 22 &#40;3&#8211;40&#41;&#47;19 &#40;&#8211;2 to 38&#41;<span class="elsevierStyleBold">Week 3&#58;</span> 27 &#40;4&#8211;49&#41;&#47;26 &#40;&#8211;1 to 52&#41;<span class="elsevierStyleBold">Week 4&#58;</span> 25 &#40;&#8211;1 to 50&#41;&#47;21 &#40;&#8211;4 to 45&#41;<span class="elsevierStyleBold">Week 5&#58;</span> 27 &#40;&#8211;3 to 55&#41;&#47;19 &#40;&#8211;4 to 42&#41;<span class="elsevierStyleBold">Week 6&#58;</span> 21 &#40;&#8211;6 to 46&#41;&#47;16 &#40;&#8211;5 to 36&#41;<span class="elsevierStyleBold">Week 7&#58;</span> 17 &#40;&#8211;7 to 38&#41;&#47;9 &#40;&#8211;1 to 18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Micay et al&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> &#40;PEDro&#58; 6&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N&#8239;&#61;&#8239;16Age &#40;years&#41;&#58; 14&#8211;18Sex&#58;15 males1 female</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">CG&#58; usual care &#40;Berlin 2016 guidelines&#41;N&#8239;&#61;&#8239;87 males1 femaleIG&#58; 8 sessions of aerobic exercise &#40;cycle ergometer&#41;t&#8239;&#61;&#8239;11 daysN&#8239;&#61;&#8239;88 males</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Post-concussion symptoms &#40;PCSS&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">PCSS &#40;post-concussion symptoms&#41;</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">CG&#58;Week 1&#58; 19 &#40;17&#8211;20&#46;5&#41;Week 2&#58; 13 &#40;10&#8211;15&#41;Week 3&#58; 12 &#40;9&#46;5&#8211;14&#41;Week 4&#58; 9 &#40;5&#46;5&#8211;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">IG&#58;<span class="elsevierStyleBold">Week 1&#58;</span> 23&#46;5 &#40;19&#46;5&#8211;27&#41;<span class="elsevierStyleBold">Week 2&#58;</span> 14 &#40;10&#46;5&#8211;18&#46;5&#41;<span class="elsevierStyleBold">Week 3&#58;</span> 7&#46;5 &#40;3&#46;5&#8211;12&#41;<span class="elsevierStyleBold">Week 4&#58;</span> 4&#46;5 &#40;1&#8211;10&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " rowspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chan et al&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a> &#40;PEDro&#58; 7&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#8239;&#61;&#8239;19Age &#40;years&#41;&#58;12&#8211;18Sex&#58;5 males14 females</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CG&#58; treatment as usualt&#8239;&#61;&#8239;6 weeksN&#8239;&#61;&#8239;91 male8 femalesIG&#58; treatment as usual&#44; active rehabilitation&#44; light coordination and sport-specific exercises&#44; visualisation and imagery techniques&#44; and home exercise programmet&#8239;&#61;&#8239;6 weeksN&#8239;&#61;&#8239;104 males6 females</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Post-concussion symptoms &#40;PCSS&#41;Depression &#40;BYI-2&#41;Fatigue &#40;PedsQL-MFS&#41;Balance &#40;BESS&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">PCSS &#40;post-concussion symptoms&#41;</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">CG&#58;Baseline&#58;56&#46;9 &#40;31&#46;0&#41;End of intervention&#58;40&#46;3 &#40;29&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">IG&#58;<span class="elsevierStyleBold">Baseline&#58;</span>51&#46;5 &#40;27&#46;8&#41;<span class="elsevierStyleBold">End of intervention&#58;</span>25&#46;0 &#40;19&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">BYI-2 &#40;depression&#41;</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">CG&#58;Baseline&#58;14&#46;7 &#40;13&#46;4&#41;End of intervention&#58;10&#46;2 &#40;9&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">IG&#58;<span class="elsevierStyleBold">Baseline&#58;</span>12&#46;7 &#40;8&#46;8&#41;<span class="elsevierStyleBold">End of intervention&#58;</span>12&#46;2 &#40;8&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">PedsQL-MFS &#40;fatigue&#41;</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">CG&#58;Baseline&#58;36&#46;3 &#40;18&#46;5&#41;End of intervention&#58;32&#46;2 &#40;16&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">IG&#58;<span class="elsevierStyleBold">Baseline&#58;</span>40&#46;8 &#40;14&#46;6&#41;<span class="elsevierStyleBold">End of intervention&#58;</span>17&#46;0 &#40;11&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">BESS &#40;balance&#41;</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CG&#58;Baseline&#58;16&#46;3 &#40;15&#46;7&#41;End of intervention&#58;11&#46;4 &#40;7&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IG&#58;<span class="elsevierStyleBold">Baseline&#58;</span>16&#46;0 &#40;8&#46;1&#41;<span class="elsevierStyleBold">End of intervention&#58;</span>10&#46;3 &#40;3&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Summary of the results of studies into therapeutic exercise&#46;</p>"
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        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">ABC&#58; Activities-specific Balance Confidence scale&#59; CG&#58; control group&#59; DHI&#58; Dizziness Handicap Inventory&#59; IG&#58; intervention group&#59; N<span class="elsevierStyleInf">1</span>&#58; discharged&#59; N<span class="elsevierStyleInf">2</span>&#58; not discharged&#59; NPRS&#58; Numeric Pain Rating Scale&#59; SCAT2&#58; Sport Concussion Assessment Tool 2&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Population&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Intervention&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Results</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " rowspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Schneider et al&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a>&#40;PEDro&#58; 8&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N&#8239;&#61;&#8239;31Age &#40;years&#41;&#58;12&#8211;30Sex&#58;18 males13 females</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">CG&#58; non-provocative range of motion exercises&#44; stretching&#44; postural education&#44; and rest until symptom freedom&#44; followed by graded exertiont&#8239;&#61;&#8239;8 weeksN&#8239;&#61;&#8239;167 males9 femalesIG&#58; non-provocative range of motion exercises&#44; stretching&#44; postural education&#44; and rest until symptom freedom&#44; followed by graded exertion&#44; cervical spinal physiotherapy&#44; and vestibular rehabilitationt&#8239;&#61;&#8239;8 weeksN&#8239;&#61;&#8239;1511 males4 females</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Pain intensity &#40;NPRS&#41;Balance &#40;ABC&#41;Dizziness &#40;DHI&#41;Concussion &#40;SCAT2&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">NPRS &#40;pain intensity&#41;&#44; median change &#40;range&#41;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">CG&#58;Baseline&#58;Neck pain&#58; 3&#40;0&#8211;9&#41;Headache&#58; 4&#40;0&#8211;9&#41;Dizziness&#58; 5&#40;0&#8211;8&#41;End ofintervention&#40;N<span class="elsevierStyleInf">1</span>&#8239;&#61;&#8239;1&#44;N<span class="elsevierStyleInf">2</span>&#8239;&#61;&#8239;12&#41;&#58;Neck pain&#58; &#8211;4&#47;&#8211;1&#46;5 &#40;&#8211;8 to 3&#41;Headache&#58; &#8211;7&#47;&#8211;2&#46;5 &#40;&#8211;7 to 1&#41;Dizziness&#58; &#8211;5&#47;&#8211;1&#46;5 &#40;&#8211;6 to 0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">IG&#58;Baseline&#58;Neck pain&#58; 3&#40;0&#8211;7&#41;Headache&#58; 4&#40;0&#8211;8&#41;Dizziness&#58; 3&#40;0&#8211;8&#41;End ofintervention&#40;N<span class="elsevierStyleInf">1</span>&#8239;&#61;&#8239;11&#44;N<span class="elsevierStyleInf">2</span>&#8239;&#61;&#8239;4&#41;&#58;Neck pain&#58; &#8722;3 &#40;&#8722;5 to 0&#41;&#47;&#8722;1 &#40;&#8722;5 to 0&#41;Headache&#58; &#8722;3 &#40;&#8722;8 to 0&#41;&#47;&#8722;2&#46;5 &#40;&#8722;4 to 0&#41;Dizziness&#58; &#8722;2&#40;&#8722;7 to 0&#41;&#47;&#8722;1 &#40;&#8722;4 to 1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">ABC &#40;balance&#41;&#44; median change &#40;range&#41;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">CG&#58;Baseline&#58;85&#37; &#40;45&#37;&#8211;100&#37;&#41;End ofintervention&#40;N<span class="elsevierStyleInf">1</span>&#8239;&#61;&#8239;1&#44;N<span class="elsevierStyleInf">2</span>&#8239;&#61;&#8239;12&#41;&#58;30&#47;12&#46;75&#40;0&#8211;55&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">IG&#58;Baseline&#58;80&#37; &#40;40&#37;&#8211;95&#37;&#41;End ofintervention&#40;N<span class="elsevierStyleInf">1</span>&#8239;&#61;&#8239;11&#44;N<span class="elsevierStyleInf">2</span>&#8239;&#61;&#8239;4&#41;&#58; 8&#40;0&#8211;52&#41;&#47;19&#46;5&#40;&#8722;6 to 43&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">DHI &#40;dizziness&#41;&#44; median change &#40;range&#41;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">CG&#58;Baseline&#58; 42&#40;0&#8211;66&#41;End ofintervention&#40;N<span class="elsevierStyleInf">1</span>&#8239;&#61;&#8239;1&#44;N<span class="elsevierStyleInf">2</span>&#8239;&#61;&#8239;12&#41;&#58; &#8722;48&#47;&#8722;21 &#40;&#8722;58 to 2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">IG&#58;Baseline&#58; 46&#40;6&#8211;84&#41;End ofintervention&#40;N<span class="elsevierStyleInf">1</span>&#8239;&#61;&#8239;11&#44;N<span class="elsevierStyleInf">2</span>&#8239;&#61;&#8239;4&#41;&#58; &#8722;24 &#40;&#8722;50 to&#8722;6&#41;&#47;&#8722;13 &#40;&#8722;16 to &#8722;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">SCAT2 &#40;concussion&#41;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">CG&#58;Baseline&#58;70&#40;47&#8211;92&#41;End ofintervention&#40;N<span class="elsevierStyleInf">1</span>&#8239;&#61;&#8239;1&#44;N<span class="elsevierStyleInf">2</span>&#8239;&#61;&#8239;12&#41;&#58;26&#47;12 &#40;&#8722;5to 42&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">IG&#58;Baseline&#58;71&#40;52&#8211;96&#41;End ofintervention&#40;N<span class="elsevierStyleInf">1</span>&#8239;&#61;&#8239;11&#44;N<span class="elsevierStyleInf">2</span>&#8239;&#61;&#8239;4&#41;&#58; 18&#40;10&#8211;30&#41;&#47;8&#46;5 &#40;&#8722;9 to11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " rowspan="2" align="left" valign="\n
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                  \t\t\t\t">Reneker et al&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a>&#40;PEDro&#58; 7&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
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                  \t\t\t\t">N&#8239;&#61;&#8239;41Mean age &#40;years&#41;&#58;10&#8211;23Sex&#58;25 males16 females</td><td class="td" title="\n
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                  \t\t\t\t  " rowspan="2" align="left" valign="\n
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                  \t\t\t\t">CG&#58; sham or minimally progressive therapeutic techniques&#44; cervical spine range of motion exercises&#44; and vestibulo-ocular reflex cancellation exercisest&#8239;&#61;&#8239;14 monthsN&#8239;&#61;&#8239;1911 males8 femalesIG&#58; vestibular rehabilitation&#44; oculomotor and neuromotor control&#44; home programme of balance exercises&#44; exercise educationt&#8239;&#61;&#8239;14 monthsN&#8239;&#61;&#8239;2214 males8 females</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
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                  \t\t\t\t">Post-concussion symptoms &#40;PCSS&#41;</td><td class="td" title="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">PCSS &#40;post-concussion symptoms&#41;</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Day 0CG&#58; veryhigh &#40;21&#8211;43&#58;39&#46;2&#41;IG&#58; veryhigh &#40;21&#8211;43&#58;39&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Symptomrecovery&#40;&#8804;9&#41;CG&#58; day 17IG&#58; day 13&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t">Thomas et al&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a>&#40;PEDro&#58; 7&#41;</td><td class="td" title="\n
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                  \t\t\t\t">CG &#40;usual care&#41;&#58; 1&#8211;2 days of rest&#44; followed by return to school and stepwise return to physical activityt&#8239;&#61;&#8239;10 daysN&#8239;&#61;&#8239;5032 males18 femalesIG &#40;strict rest&#41;&#58; 5 days of rest&#44; followed by return to school and stepwise return to physical activityt&#8239;&#61;&#8239;10 daysN&#8239;&#61;&#8239;4933 males16 females</td><td class="td" title="\n
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                  \t\t\t\t">CG&#58;Day 0<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&#58;8&#46;4&#40;6&#46;6&#8211;10&#46;2&#41;Day 3&#58;22&#46;4 &#40;18&#46;8&#8211;25&#46;9&#41;Day 10&#58;19&#40;15&#46;9&#8211;22&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
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                            0 => "C&#46; Werner"
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Article information

ISSN: 21735808
Original language: English

DOI:10.1016/j.nrleng.2023.04.006

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