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(A) Baseline evaluation at admission (29.3<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>12.7<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>15.3<span class="elsevierStyleHsp" style=""></span>mm). (B) Follow-up evaluation 6 weeks later (7.45<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>8.35<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>4.7<span class="elsevierStyleHsp" style=""></span>mm).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "I. Saldaña-Inda, E. Garcés-Antón, J.M. Navasa-Melado, C. Bernal-Lafuente, H. Tejada-Meza" "autores" => array:5 [ 0 => array:2 [ "nombre" => "I." 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"apellidos" => "Santos- Lasaosa" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S021348532200202X" "doi" => "10.1016/j.nrl.2022.09.008" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021348532200202X?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580822001596?idApp=UINPBA00004N" "url" => "/21735808/0000003800000008/v1_202310050953/S2173580822001596/v1_202310050953/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Direct carotid puncture for the endovascular treatment of acute ischaemic stroke associated to aortic arch atheroma" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "606" "paginaFinal" => "607" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "I. Saldaña-Inda, E. Garcés-Antón, J.M. Navasa-Melado, C. Bernal-Lafuente, H. Tejada-Meza" "autores" => array:5 [ 0 => array:4 [ "nombre" => "I." "apellidos" => "Saldaña-Inda" "email" => array:1 [ 0 => "isaldanna@salud.aragon.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "E." "apellidos" => "Garcés-Antón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "J.M." "apellidos" => "Navasa-Melado" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "C." 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"apellidos" => "Tejada-Meza" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Stroke Unit – Department of Neurology, Hospital Universitario Miguel Servet, Zaragoza, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Stroke Unit – Department of Neurology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Interventional Neuroradiology Unit – Department of Radiology, Hospital Universitario Miguel Servet, Zaragoza, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Department of Radiology, Hospital Universitario Miguel Servet, Zaragoza, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Instituto de Investigación Sanitaria (IIS) de Aragón. Universidad de Zaragoza, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Punción carotidea directa en el tratamiento endovascular del ictus isquémico asociado a ateromatosis del arco aórtico" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1084 "Ancho" => 2508 "Tamanyo" => 211393 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Axial CT angiography images showing a hypodense fibrolipid plaque at the level of the aortic arch (red arrow). (A) Baseline evaluation at admission (29.3<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>12.7<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>15.3<span class="elsevierStyleHsp" style=""></span>mm). (B) Follow-up evaluation 6 weeks later (7.45<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>8.35<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>4.7<span class="elsevierStyleHsp" style=""></span>mm).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We report the case of a 61-year-old woman with a history of tobacco use, hypertension, and hyperlipidaemia. She was brought to our emergency department five hours after sudden onset of language impairment and right-side weakness. At admission the National Institutes of Health Stroke Scale (NIHSS) score was 23. Non-contrast computed tomography (CT) of the brain showed hypoattenuations in the left insular, lenticular and M2 regions (ASPECTS 7). Ensuing CT angiography (CTA) revealed an occlusion of the left middle cerebral artery (MCA) at the M1 segment and a voluminous (29.3<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>12.7<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>15.3<span class="elsevierStyleHsp" style=""></span>mm) hypodense atherosclerotic plaque in the aortic arch, proximal to the subclavian and common carotid arteries (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>-A). Urgent mechanical thrombectomy (MT) with stent retriever was performed by direct percutaneous carotid access under ultrasound guidance. MCA perfusion was re-established in<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>50% of the territory (mTICI 2b) and haemostasis was achieved using an AngioSeal 6F closure device. No procedure-related complications occurred. Neurological examination at the following day revealed a significant improvement of the motor function and comprehension, the NIHSS score was 9. Dual antiplatelet therapy with aspirin and clopidogrel and a high intensity statin was started. The patient refused to undergo a transoesophageal echocardiography (TEE). A contrast enhanced transthoracic echocardiogram was performed showing an anechoic plaque proximal to the subclavian artery of identical dimensions to the one described in the CTA. No mobile thrombus was identified. One week later she was asymptomatic and was discharged home. Follow-up CTA was performed six weeks later, revealing a significant reduction of the atherosclerotic plaque, now measuring 7.45<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>8.35<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>4.7<span class="elsevierStyleHsp" style=""></span>mm (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>-B). She remained asymptomatic and reported no complications at the follow-up visit.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Aortic arch atheroma (AAA) is a manifestation of systemic atherosclerosis and a potential source of artery-to-artery thromboembolism. Severe arch atheroma increases the risk of stroke up to four times and double the risk of recurrence.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">1,2</span></a> Ulceration, thickness<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>4<span class="elsevierStyleHsp" style=""></span>mm and the presence of a mobile thrombus confer the biggest overall risk of embolism.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">3–5</span></a> TEE is the procedure of choice for measurement and detection in the elective setting. Performed as part of the evaluation after an acute stroke, it allows for precise detection and characterization of the plaque, as well as being able to determine the presence of a mobile thrombus.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">6</span></a> CTA is a non-invasive technique routinely performed in the acute phase of ischaemic stroke to detect large vessels occlusions. It also detects the presence of plaques in the aortic arch and provide information about its location, size, and density. Additionally, it can assess the anatomical configuration of the patient</p><p id="par0015" class="elsevierStylePara elsevierViewall">Data for mechanical thrombectomy in presence of complex plaques in the aortic arch is scarce, but iatrogenic embolization from the plaque is a known and feared complication. It can happen while navigating the aortic arch, particularly among patients with difficult vascular anatomy.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">7</span></a> Trans-femoral catheterization is the standard access route for MT, but direct carotid puncture (DCP) has been reconsidered as an alternative access route in the last years. Several case series and multicentric registries are available.<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">8–10</span></a> DCP has the advantage to bypass the aortic arch, reducing the periprocedural risk of stroke in such patients and shortening revascularization times.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">11</span></a> CTA performed in the acute phase of ischaemic stroke is of special importance here. It can assess the aortic arch and supra-aortic vessels and identify the subset of patients that might benefit from DCP as the initial access strategy.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">11</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Medical treatment for AAA focus on blood pressure control, high intensity statin therapy, lifestyle changes and strict glycaemic control. The optimal antithrombotic management remains uncertain. The ARCH trial (Aortic Arch Related Cerebral Hazard)<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">12</span></a> is the only randomized trial conducted specifically on this topic. It compared double antiplatelet therapy with aspirin plus clopidogrel (DAPT) against anticoagulation with warfarin. The DAPT arm showed a non-significant reduction in the rate of recurrent stroke and a significant reduction in vascular death compared to warfarin, while major haemorrhage rates were similar. Unfortunately, lower than expected event rates and slow recruitment ended the trial prematurely, so these results must be interpreted with caution.</p><p id="par0025" class="elsevierStylePara elsevierViewall">In conclusion, AAA is a manifestation of systemic atherosclerosis and a significant source of embolism and stroke recurrence. The antithrombotic regime is uncertain, but high intensity statin therapy and DAPT seem reasonable. CT angiography performed in the acute phase of ischaemic stroke can assess the patient vascular anatomy and the characteristics of the aortic arch. If a complex plaque is present, DCP should be considered as the initial access strategy for MT. This approach has comparable reperfusion rates and can reduce the periprocedural risk of stroke and shorten procedure times.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1084 "Ancho" => 2508 "Tamanyo" => 211393 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Axial CT angiography images showing a hypodense fibrolipid plaque at the level of the aortic arch (red arrow). (A) Baseline evaluation at admission (29.3<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>12.7<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>15.3<span class="elsevierStyleHsp" style=""></span>mm). (B) Follow-up evaluation 6 weeks later (7.45<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>8.35<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>4.7<span class="elsevierStyleHsp" style=""></span>mm).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:12 [ 0 => array:3 [ "identificador" => "bib0065" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aortic sources of embolism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Viedma-Guiard" 1 => "C. Guidoux" 2 => "P. Amarenco" 3 => "E. 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 3 | 0 | 3 |
2024 October | 12 | 1 | 13 |
2024 September | 40 | 9 | 49 |
2024 August | 33 | 2 | 35 |
2024 July | 13 | 4 | 17 |
2024 June | 22 | 4 | 26 |
2024 May | 9 | 3 | 12 |
2024 April | 15 | 3 | 18 |
2024 March | 29 | 4 | 33 |
2024 February | 36 | 5 | 41 |
2024 January | 21 | 13 | 34 |
2023 December | 27 | 5 | 32 |
2023 November | 74 | 26 | 100 |
2023 October | 83 | 44 | 127 |