metricas
covid
Buscar en
Neurología (English Edition)
Toda la web
Inicio Neurología (English Edition) Opsoclonus-myoclonus syndrome and prostate cancer. An entity to be aware of
Journal Information

Statistics

Follow this link to access the full text of the article

Letter to the Editor
Opsoclonus-myoclonus syndrome and prostate cancer. An entity to be aware of
Síndrome de opsoclono-mioclono y cáncer de próstata. Una entidad a tener en cuenta
C. Guijarro-Castroa,
Corresponding author
cristina.guijarro@sen.es

Corresponding author.
, L. Estallo-Guijarrob
a Servicio de Neurología, Hospital Universitario HM Sanchinarro y Facultad de Medicina CEU-San Pablo de Madrid, Madrid, Spain
b Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain
Read
414
Times
was read the article
83
Total PDF
331
Total HTML
Share statistics
 array:23 [
  "pii" => "S2173580824000427"
  "issn" => "21735808"
  "doi" => "10.1016/j.nrleng.2024.02.004"
  "estado" => "S200"
  "fechaPublicacion" => "2024-02-29"
  "aid" => "1814"
  "copyright" => "Sociedad Española de Neurología"
  "copyrightAnyo" => "2024"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "es" => array:18 [
      "pii" => "S0213485324000574"
      "issn" => "02134853"
      "doi" => "10.1016/j.nrl.2023.02.003"
      "estado" => "S200"
      "fechaPublicacion" => "2024-02-05"
      "aid" => "1814"
      "copyright" => "Sociedad Española de Neurología"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:9 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>"
        "titulo" => "S&#237;ndrome de opsoclono-mioclono y c&#225;ncer de pr&#243;stata&#46; Una entidad a tener en cuenta"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Opsoclonus-myoclonus syndrome and prostate cancer&#46; An entity to be aware of"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "C&#46; Guijarro-Castro, L&#46; Estallo-Guijarro"
            "autores" => array:2 [
              0 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Guijarro-Castro"
              ]
              1 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "Estallo-Guijarro"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173580824000427"
          "doi" => "10.1016/j.nrleng.2024.02.004"
          "estado" => "S200"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580824000427?idApp=UINPBA00004N"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485324000574?idApp=UINPBA00004N"
      "url" => "/02134853/unassign/S0213485324000574/v1_202402050340/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2173580824000397"
    "issn" => "21735808"
    "doi" => "10.1016/j.nrleng.2024.02.001"
    "estado" => "S200"
    "fechaPublicacion" => "2024-03-10"
    "aid" => "1815"
    "copyright" => "Sociedad Espa&#241;ola de Neurolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Mutations in the type IV collagen gen &#40;<span class="elsevierStyleItalic">COL4A1</span>&#41; as an unusual etiology of cerebrovascular disease in young adults"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Mutaciones en el gen del col&#225;geno tipo IV &#40;<span class="elsevierStyleItalic">COL4A1</span>&#41; como etiolog&#237;a infrecuente de enfermedad cerebrovascular en el adulto joven"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2055
              "Ancho" => 2007
              "Tamanyo" => 342067
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0005"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">MRI scans&#46; a&#41; Coronal 3D time-of-flight sequence showing a saccular aneurysm &#40;yellow arrow&#41; on the terminal segment of the right intracranial internal carotid artery&#46; b&#41; Axial SWI sequence showing a focus of paramagnetic susceptibility &#40;green arrow&#41; in the right peritrigonal region&#44; corresponding to a chronic-subchronic haemorrhagic focus&#46; c&#41; Axial FLAIR sequence showing hyperintense lesions in both corona radiata&#44; in association with leukoencephalopathy&#46; d&#41; FLAIR sequence showing hyperintense lesions in periventricular areas&#44; as well as in the adjacent deep subcortical white matter&#44; compatible with leukoencephalopathy&#46; A porencephalic cyst &#40;orange arrow&#41; is also present&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Mart&#237;n Prieto, E&#46; Garc&#237;a-Serrano Fuertes, J&#46; Iglesias Bermejillo, A&#46; Luna Rodr&#237;guez"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Mart&#237;n Prieto"
            ]
            1 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Garc&#237;a-Serrano Fuertes"
            ]
            2 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Iglesias Bermejillo"
            ]
            3 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Luna Rodr&#237;guez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0213485324000550"
        "doi" => "10.1016/j.nrl.2023.02.004"
        "estado" => "S200"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485324000550?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580824000397?idApp=UINPBA00004N"
    "url" => "/21735808/unassign/S2173580824000397/v1_202403100744/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "S2173580822000797"
    "issn" => "21735808"
    "doi" => "10.1016/j.nrleng.2022.06.002"
    "estado" => "S200"
    "fechaPublicacion" => "2022-08-14"
    "aid" => "1758"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "The prevalence&#44; incidence&#44; and clinical assessment of neuromyelitis optica spectrum disorder in patients with demyelinating diseases"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Prevalencia&#44; incidencia y evaluaci&#243;n cl&#237;nica del trastorno del espectro de la neuromielitis &#243;ptica en paciente con enfermedades desmielinizantes"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46;A&#46; Mireles-Ram&#237;rez, I&#46;E&#46; Vel&#225;zquez-Brizuela, N&#46; S&#225;nchez-Rosales, Y&#46; M&#225;rquez-Pedroza, M&#46;R&#46; Hernandez-Preciado, G&#46; Gabriel Ortiz"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "M&#46;A&#46;"
              "apellidos" => "Mireles-Ram&#237;rez"
            ]
            1 => array:2 [
              "nombre" => "I&#46;E&#46;"
              "apellidos" => "Vel&#225;zquez-Brizuela"
            ]
            2 => array:2 [
              "nombre" => "N&#46;"
              "apellidos" => "S&#225;nchez-Rosales"
            ]
            3 => array:2 [
              "nombre" => "Y&#46;"
              "apellidos" => "M&#225;rquez-Pedroza"
            ]
            4 => array:2 [
              "nombre" => "M&#46;R&#46;"
              "apellidos" => "Hernandez-Preciado"
            ]
            5 => array:2 [
              "nombre" => "G&#46;"
              "apellidos" => "Gabriel Ortiz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580822000797?idApp=UINPBA00004N"
    "url" => "/21735808/unassign/S2173580822000797/v1_202208140508/en/main.assets"
  ]
  "en" => array:12 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Opsoclonus-myoclonus syndrome and prostate cancer&#46; An entity to be aware of"
    "tieneTextoCompleto" => true
    "saludo" => "Dear Editor&#44;"
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "C&#46; Guijarro-Castro, L&#46; Estallo-Guijarro"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "C&#46;"
            "apellidos" => "Guijarro-Castro"
            "email" => array:1 [
              0 => "cristina.guijarro@sen.es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "L&#46;"
            "apellidos" => "Estallo-Guijarro"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Neurolog&#237;a&#44; Hospital Universitario HM Sanchinarro y Facultad de Medicina CEU-San Pablo de Madrid&#44; Madrid&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Facultad de Medicina&#44; Universidad Aut&#243;noma de Madrid&#44; Madrid&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "S&#237;ndrome de opsoclono-mioclono y c&#225;ncer de pr&#243;stata&#46; Una entidad a tener en cuenta"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Paraneoplastic syndromes &#40;PNS&#41; are not usually observed in association with prostate cancer&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Very few descriptions have been found of opsoclonus-myoclonus syndrome &#40;OMS&#41; associated with prostate cancer&#44; with all cases presenting unfavourable outcomes&#46; We present the case of a patient with ocular flutter and ataxia appearing 2 years prior to diagnosis of prostate adenocarcinoma and urothelial carcinoma&#46; Strictly speaking&#44; our patient does not present opsoclonus but shows ocular flutter and ataxia&#44; which are included in the syndrome&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Clinical case&#58;</span> Our patient is a 68-year-old man with history of hypertension and diabetes&#44; a smoker &#40;12 cigarettes per day&#41;&#44; who had been under follow-up for 2 years by our department due to OMS&#44; after being referred by the ophthalmology department&#46; Despite screening for another tumour&#44; and treatment on several occasions of the previously identified urothelial carcinoma with no relapse&#44; he showed no improvement after several cycles of treatment with corticosteroids and intravenous immunoglobulins&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The neurological examination revealed rapid&#44; involuntary&#44; conjugate saccades in both eyes on the horizontal plane only&#44; predominantly in the left eye&#44; compatible with ocular flutter&#44; as well as mildly ataxic gait&#44; which progressed&#46; Results from a complete blood count&#44; biochemical testing&#44; serology study&#44; and immune profile were normal&#46; Tests for tumour markers&#44; onconeuronal antibodies&#44; and surface antigen antibodies &#40;against Hu&#44; Yo&#44; Ri&#44; Zic4&#44; CRMP5&#44; Tr&#44; NMDA&#44; GAD&#44; Ma1&#47;Ma2&#44; and amphiphysin&#41; yielded negative results&#46; A chest&#44; abdomen&#44; and pelvis CT scan revealed no abnormalities&#46; A PET-CT study ruled out underlying neoplasm&#46; Infectious and parainfectious causes were reasonably ruled out&#44; and the CSF analysis yielded normal results&#59; results for onconeuronal antibodies were negative&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">At 2 years of follow-up&#44; and due to an increase in prostate-specific antigen &#40;PSA&#41; to 6&#46;9 &#40;22&#37;&#41;&#44; a prostate MRI study was performed&#44; revealing a 15&#8239;mm lesion in the mid-apical region&#59; a biopsy confirmed acinar adenocarcinoma of the prostate&#44; Gleason score 6 &#40;3&#8239;&#43;&#8239;3&#41;&#44; with no lymphovascular or perineural invasion&#46; A robotic-assisted radical prostatectomy was performed without incident&#44; with the patient showing favourable progression and with a definitive diagnosis of acinar adenocarcinoma of the prostate&#44; Gleason score 7 &#40;3&#8239;&#43;&#8239;4&#41;&#46; The AJCC&#47;UICC staging system indicated pT2a&#44; Pnx&#44; and pMx&#59; we observed foci of high-grade prostatic intraepithelial neoplasia in the rest of the gland&#46; At 6 months&#44; the patient presented ataxia&#44; with some isolated saccades&#46; After one year&#44; he was asymptomatic&#46; The resolution of symptoms rules out a diagnosis of idiopathic OMS&#46; Previous measurements of PSA were &#60;&#8239;0&#46;03&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Since the last case published in <span class="elsevierStyleItalic">Neurolog&#237;a</span>&#44; we have not found any other description of OMS associated with prostate cancer&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In 2016&#44; Storstein et al&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> reported the largest series of cases of PNS associated with prostate cancer &#40;n&#8239;&#61;&#8239;37&#41;&#44; observing that the 3 most frequent syndromes were paraneoplastic cerebellar degeneration&#44; limbic encephalitis&#47;encephalomyelitis&#44; and subacute sensory neuronopathy&#46; In a literature search&#44; we identified only 5 cases of OMS associated with prostate cancer&#46; In four of these cases&#44; the alteration in ocular motility consisted of saccadic oscillations on the horizontal plane only&#44; as in our patient&#46; In 2 cases &#40;reported by Baloh et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#41;&#44; the patients developed alterations in ocular motility and gait&#44; as well as muscle spasms after diagnosis of prostate cancer&#46; The post mortem examination revealed chronic perivascular inflammation cells and microglial infiltration in the pons and medulla oblongata&#46; As in our case&#44; no antineuronal antibodies were detected&#46; The identification of such new antibodies as anti-glycine receptor antibodies&#44; which are membrane surface antigens&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> together with their association with OMS and the presence of this antibody in oat cells&#44; suggest an association of both processes&#46; The third patient described was a man with prostate cancer who presented a brainstem paraneoplastic syndrome and altered ocular motility on the horizontal plane&#59; an antibody targeting intraneuronal antigens was detected&#44; although the antigenic target could not be identified&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The fourth patient was a man with metastatic prostate cancer who&#44; 18 months later&#44; developed OMS with onconeuronal antibodies &#40;anti-Hu and anti-Yo&#41; and small-cell lung carcinoma&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> which improved with corticosteroids and chemotherapy&#46; In this case&#44; small-cell lung carcinoma was probably the cause of OMS&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The fifth case&#44; published in <span class="elsevierStyleItalic">Neurolog&#237;a</span>&#44; was a classical PNS associated with prostate cancer&#44; and showed favourable progression at one year&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Our patient was diagnosed with PNS due to the symptom improvement observed after one year of follow-up&#46; Unlike the other 5 patients&#44; in our patient the diagnosis of prostate cancer was established 2 years after onset of OMS and&#44; as in the case reported by Nasri&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> he presented 2 tumours&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">We would like to highlight that OMS is considered a classical PNS&#44; although it is rarely associated with prostate cancer&#59; however&#44; it should be considered in cancer screening studies&#44; even years later&#46; Furthermore&#44; even in the case of periodic treatment with immunoglobulins&#44; only treatment of the underlying tumour may help improve symptoms&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#8902;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Guijarro-Castro C&#44; Estallo-Guijarro L&#46; S&#237;ndrome de opsoclono-mioclono y c&#225;ncer de pr&#243;stata&#46; Una entidad a tener en cuenta&#46; Neurolog&#237;a&#46; 2024&#46; <span class="elsevierStyleInterRef" id="intr0005" href="https://doi.org/10.1016/j.nrl.2023.02.003">https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;nrl&#46;2023&#46;02&#46;003</span></p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A brainstem paraneoplastic syndrome associated with prostate cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;R&#46; Berger"
                            1 => "M&#46; Bensalem"
                            2 => "J&#46; Dalmau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/jnnp.2008.153015"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Neurosurg Psychiatry"
                        "fecha" => "2009"
                        "volumen" => "80"
                        "paginaInicial" => "934"
                        "paginaFinal" => "935"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19608787"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "S&#237;ndrome opsoclonus mioclonus de evoluci&#243;n benigna y c&#225;ncer de pr&#243;stata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46; Cuenca Hern&#225;ndez"
                            1 => "A&#46; Esquivel Lopez"
                            2 => "R&#46; Gordo Ma&#241;as"
                            3 => "D&#46; H&#237;pola Gonz&#225;lez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.nrl.2017.07.015"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurolog&#237;a"
                        "fecha" => "2020"
                        "volumen" => "35"
                        "paginaInicial" => "64"
                        "paginaFinal" => "65"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28958399"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prostate cancer&#46; Hu antibodies and paraneoplastic neurological syndromes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Storstein"
                            1 => "M&#46; Raspotnig"
                            2 => "R&#46; Vitaliani"
                            3 => "B&#46; Giometto"
                            4 => "F&#46; Graus"
                            5 => "W&#46; Grisold"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00415-016-8090-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol"
                        "fecha" => "2016"
                        "volumen" => "263"
                        "paginaInicial" => "1001"
                        "paginaFinal" => "1007"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27007485"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Novel brainstem syndrome associated with prostate carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;W&#46; Baloh"
                            1 => "S&#46;E&#46; DeRossett"
                            2 => "T&#46;F&#46; Cloughesy"
                            3 => "R&#46;W&#46; Kuncl"
                            4 => "N&#46;R&#46; Miller"
                            5 => "J&#46; Merrill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1212/wnl.43.12.2591"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurology"
                        "fecha" => "1993"
                        "volumen" => "43"
                        "paginaInicial" => "2591"
                        "paginaFinal" => "2596"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8255462"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1212/wnl.43.12.2591"
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;pubmed&#46;ncbi&#46;nlm&#46;nih&#46;gov&#47;8255462&#47;"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and immunological features of opsoclonus-myoclonus syndrome in the era of neuronal cell surface antibodies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Armangue"
                            1 => "L&#46; Sabater"
                            2 => "E&#46; Torres-Vega"
                            3 => "E&#46; Martinez-Hernandez"
                            4 => "H&#46; Arino"
                            5 => "M&#46; Petit-Pedrol"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jamaneurol.2015.4607"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA Neurol"
                        "fecha" => "2016"
                        "volumen" => "73"
                        "paginaInicial" => "417"
                        "paginaFinal" => "424"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26856612"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Paraneoplastic opsoclonus-myoclonus-ataxia syndrome revealing dual malignancy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Nasri"
                            1 => "I&#46; Kacem"
                            2 => "F&#46; Jerdak"
                            3 => "M&#46;B&#46; Djebara"
                            4 => "N&#46; Mejri"
                            5 => "Y&#46; Sidhom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10072-016-2632-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurol Sci"
                        "fecha" => "2016"
                        "volumen" => "37"
                        "paginaInicial" => "1723"
                        "paginaFinal" => "1725"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27329274"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735808/unassign/S2173580824000427/v1_202402290433/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/21735808/unassign/S2173580824000427/v1_202402290433/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580824000427?idApp=UINPBA00004N"
]
Article information
ISSN: 21735808
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 8 0 8
2024 October 35 4 39
2024 September 56 20 76
2024 August 55 10 65
2024 July 34 10 44
2024 June 37 5 42
2024 May 30 9 39
2024 April 38 3 41
2024 March 33 8 41
2024 February 5 14 19

Follow this link to access the full text of the article

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos