Scientific letter
Endobronchial Valves in the Management of Recurrent Hemoptysis: A Case Report
Válvulas endobronquiales en el manejo de la hemoptisis recurrente, a propósito de un caso
Alan Jhunior Solis Solis
, Carmen Angela Centeno Clemente, Antoni Rosell Gratacos
Corresponding author
Interventional Pulmonology Department, Hospital University Germans Trias I Pujol, Badalona, Barcelona, Spain
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Members of the ASTURPAR group" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2659663624000444?idApp=UINPBA00004N" "url" => "/26596636/0000000600000003/v1_202409130640/S2659663624000444/v1_202409130640/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>" "titulo" => "Endobronchial Valves in the Management of Recurrent Hemoptysis: A Case Report" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">Dear Editor</span>," "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Alan Jhunior Solis Solis, Carmen Angela Centeno Clemente, Antoni Rosell Gratacos" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Alan Jhunior" "apellidos" => "Solis Solis" "email" => array:1 [ 0 => "alanjhuniorsolis@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Carmen Angela" "apellidos" => "Centeno Clemente" ] 2 => array:2 [ "nombre" => "Antoni" "apellidos" => "Rosell Gratacos" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Interventional Pulmonology Department, Hospital University Germans Trias I Pujol, Badalona, Barcelona, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Válvulas endobronquiales en el manejo de la hemoptisis recurrente, a propósito de un caso" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1897 "Ancho" => 3333 "Tamanyo" => 582611 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A and B) CT scan of the coronal and transverse slices, caverns in LUL with loss of volume and structural damage of the left lung. (C) Revision bronchoscopy, clots in left main bronchus from LUL. (D) Spiration EBV number 9 in lingula. (E) Spiration EBV number 6 at the top. (F) Chest X-ray, zoom of the LUL apical region showing the 2 EBVs.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Recurrent hemoptysis in patients with structural lung disease is a common complication that can be life-threatening and difficult to manage.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1–3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Endobronchial valves (EBVs) were initially designed for lung volume reduction in severe emphysema, and other indications include the treatment of bronchopleural fistulas and persistent postoperative air leaks.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1,3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">We report the use of EBVs in the management of a patient with recurrent threatening hemoptysis despite arterial embolization.</p><p id="par0020" class="elsevierStylePara elsevierViewall">A 29-year-old man with a history of pulmonary tuberculosis in childhood presented with apical cavities in the left upper lobe (LUL) and sequelae including structural damage and loss of volume of the left lung (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). In the last 6 months, he was frequently hospitalized for life-threatening hemoptysis, requiring admission to the respiratory semi-critical care unit and bronchial artery embolization (BAE) on up to six occasions. After the last embolization, he had persistent hemoptysis, complicated by acute pulmonary embolism (PE) in the right lower lobe that required placement of an inferior vena cava filter. PE was probably secondary to embolization with Glubran 2® (GEM SRL, Viareggio, Italy). The indication for urgent surgery (left pneumonectomy) was rejected due to the high surgical risk, and after assessment with interventional pulmonology unit, EBVs were placed.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Under sedation and relaxation by anesthesiology, the therapeutic flexible bronchoscope (BF-1TH190, Olympus-Europe, Hamburg, Germany) was introduced via a number 8.5<span class="elsevierStyleHsp" style=""></span>mm orotracheal tube. The presence of fresh clots and remaining bleeding were observed in the left main bronchus coming from both bronchi of the culmen and the lingula. EBVs (Spiration IBV Valve System®, Olympus, Tokyo, Japan) of 6<span class="elsevierStyleHsp" style=""></span>mm and 9<span class="elsevierStyleHsp" style=""></span>mm respectively were placed, with good bronchial occlusion (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The patient's clinical progress was optimal, with no recurrence of hemoptysis, and he was discharged from hospital. For 6 months, he had no episodes of hemoptysis and finally underwent left pneumonectomy after a new episode of hemoptysis, when he was in better condition.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Hospital management of life-threatening hemoptysis includes general measures and protection of the main airway. In the latter case, embolization of the bronchial arteries and/or bronchoscopy procedures may facilitate the therapeutic option.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1,6</span></a> This, currently, in cases of persistent hemoptysis with a specific bleeding site, is surgical resection, that may be indicated after considering the greater risk of postoperative complications and mortality.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1,3,6</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The objective of endoscopic treatment in the management of hemoptysis is to achieve local tamponade and hemostasis in endoluminal lesions, especially lung cancer, and various treatments such as balloon occlusion, electrocautery, argon plasma coagulation, among others, have been described<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1,6</span></a>; however, these methods are of little use in the treatment of hemoptysis caused by tuberculosis or distal structural pulmonary disease.<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4,5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In our case, the patient presented recurrent threatening hemoptysis after several embolizations, and the use of EBV was agreed upon prior to the elective surgical option.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Case reports have been reported on the use of EBV in the management of recurrent life-threatening hemoptysis in both benign and malignant pathology.</p><p id="par0050" class="elsevierStylePara elsevierViewall">In the case of benign pathology, Frey et al. placed 2 Spiration EBVs in the LUL of a patient with septic pulmonary embolisms due to <span class="elsevierStyleItalic">Staphylococcus</span> bacteremia and recurrent hemoptysis, in whom BAE could not be performed.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Koegelenberg et al. placed 2 Spiration EBVs in the right upper lobe (RUL) and LUL in a patient with hemoptysis and tuberculosis sequelae with aspergilloma.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Lalla et al. reported another case of a Zephyr type EBV placed in the LUL of a man with HIV and active tuberculosis and recurrent hemoptysis, in whom the valve was removed after 6 months with no recurrence of hemoptysis.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> All cases were successful.</p><p id="par0055" class="elsevierStylePara elsevierViewall">In malignant pathology, Patel et al. report two cases of Spiration EBV placement, the first in squamous cell carcinoma of RUL, and the second in an esophageal neoplasia with mediastinal invasion that caused hemoptysis from the RUL. Both cases were successful, and there was no recurrence of hemoptysis.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">It has been suggested that the effectiveness of EBV in the management of hemoptysis is due to atelectasis, which in turn promotes local tamponade, favoring clot formation and reducing blood flow to the bleeding area through hypoxic vasoconstriction.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1,2</span></a> If the etiology of hemoptysis is benign and/or reversible, the EBV can be removed after treatment.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2,4</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">There are two types of EBV: Zephyr valves that are used in the management of hemoptysis of infectious etiology<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1,4</span></a>; and Spiration valves that are used in the management of hemoptysis of both infectious and malignant etiology.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1–3</span></a> In our case, we opted for Spiration valves due to the greater experience of our team.</p><p id="par0070" class="elsevierStylePara elsevierViewall">This procedure could be an alternative in the management of recurrent hemoptysis in patients who are not candidates for surgery or as a preliminary step toward elective surgery.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Informed consent</span><p id="par0075" class="elsevierStylePara elsevierViewall">Informed consent was obtained from the patient for the publication of his clinical data and the use of diagnostic images.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Funding</span><p id="par0080" class="elsevierStylePara elsevierViewall">The authors declare that no funding was received for this article.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Authors’ contributions</span><p id="par0085" class="elsevierStylePara elsevierViewall">All the listed authors have made substantial contributions to all areas as outlined therein.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflicts of interest</span><p id="par0090" class="elsevierStylePara elsevierViewall">None of the authors has any conflict of interest of any type.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Informed consent" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Funding" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Authors’ contributions" ] 3 => array:2 [ "identificador" => "sec0020" "titulo" => "Conflicts of interest" ] 4 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1897 "Ancho" => 3333 "Tamanyo" => 582611 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A and B) CT scan of the coronal and transverse slices, caverns in LUL with loss of volume and structural damage of the left lung. (C) Revision bronchoscopy, clots in left main bronchus from LUL. (D) Spiration EBV number 9 in lingula. (E) Spiration EBV number 6 at the top. (F) Chest X-ray, zoom of the LUL apical region showing the 2 EBVs.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0035" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endobronchial valve placement as salvage therapy in the management of hemoptysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.W. Frey" 1 => "M. Postigo" 2 => "L.R. Pitts" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/LBR.0000000000000898" "Revista" => array:6 [ "tituloSerie" => "J Bronchology Interv Pulmonol" "fecha" => "2023" "volumen" => "30" "paginaInicial" => "301" "paginaFinal" => "303" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/36083199" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0040" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endobronchial valves for treatment of hemoptysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B. Patel" 1 => "D. Abi-Fadel" 2 => "J. Rosenheck" 3 => "T. Bartter" 4 => "Z. Boujaoude" 5 => "W. 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