was read the article
array:23 [ "pii" => "S2444866417301873" "issn" => "24448664" "doi" => "10.1016/j.pbj.2017.07.055" "estado" => "S300" "fechaPublicacion" => "2017-09-01" "aid" => "103.51" "copyrightAnyo" => "2017" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "abs" "cita" => "Porto Biomed J. 2017;2:198-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1106 "formatos" => array:3 [ "EPUB" => 94 "HTML" => 764 "PDF" => 248 ] ] "itemSiguiente" => array:18 [ "pii" => "S2444866417301885" "issn" => "24448664" "doi" => "10.1016/j.pbj.2017.07.056" "estado" => "S300" "fechaPublicacion" => "2017-09-01" "aid" => "103.52" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "abs" "cita" => "Porto Biomed J. 2017;2:199" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 801 "formatos" => array:3 [ "EPUB" => 85 "HTML" => 478 "PDF" => 238 ] ] "en" => array:9 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">PS020</span>" "titulo" => "Influence of energy drinks on hemodynamic parameters in young healthy adults – Randomized double-blind placebo controlled cross-over study" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "199" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Niemczyk, M. Stopa, M. Łobacz, K. Rutkowska, A. Radko" "autores" => array:5 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Niemczyk" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Stopa" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Łobacz" ] 3 => array:2 [ "nombre" => "K." "apellidos" => "Rutkowska" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Radko" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444866417301885?idApp=UINPBA00004N" "url" => "/24448664/0000000200000005/v2_201709090132/S2444866417301885/v2_201709090132/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2444866417301861" "issn" => "24448664" "doi" => "10.1016/j.pbj.2017.07.054" "estado" => "S300" "fechaPublicacion" => "2017-09-01" "aid" => "103.50" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "abs" "cita" => "Porto Biomed J. 2017;2:198" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 807 "formatos" => array:3 [ "EPUB" => 88 "HTML" => 484 "PDF" => 235 ] ] "en" => array:9 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">PS061</span>" "titulo" => "The relationship between Calcium-Scor and the risk of coronary artery disease in patients with heart failure" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "198" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Mahdi Safiabadi, Nasim Naderi, Sepideh Taghavi" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Mahdi" "apellidos" => "Safiabadi" ] 1 => array:2 [ "nombre" => "Nasim" "apellidos" => "Naderi" ] 2 => array:2 [ "nombre" => "Sepideh" "apellidos" => "Taghavi" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444866417301861?idApp=UINPBA00004N" "url" => "/24448664/0000000200000005/v2_201709090132/S2444866417301861/v2_201709090132/en/main.assets" ] "en" => array:9 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">PS083</span>" "titulo" => "Levels of 6-thioguanine nucleotides and clinical remission in inflammatory bowel disease – A systematic review and meta-analysis" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "198" "paginaFinal" => "199" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M.M. Estevinho, J. Afonso, I. Rosa, P. Lago, E. Trindade, L. Correia, C.C. Dias, F. Magro" "autores" => array:9 [ 0 => array:4 [ "nombre" => "M.M." "apellidos" => "Estevinho" "email" => array:1 [ 0 => "mmestevinho@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J." "apellidos" => "Afonso" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "I." "apellidos" => "Rosa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "P." "apellidos" => "Lago" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "E." "apellidos" => "Trindade" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] ] ] 5 => array:3 [ "nombre" => "L." "apellidos" => "Correia" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "aff0025" ] ] ] 6 => array:3 [ "nombre" => "C.C." "apellidos" => "Dias" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">6</span>" "identificador" => "aff0030" ] ] ] 7 => array:3 [ "nombre" => "F." "apellidos" => "Magro" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">7</span>" "identificador" => "aff0035" ] ] ] 8 => array:1 [ "colaborador" => "on behalf GEDII (Portuguese IBD Group)" ] ] "afiliaciones" => array:7 [ 0 => array:3 [ "entidad" => "Department of Pharmacology and Therapeutics, Faculty of Medicine of the University of Porto, Portugal" "etiqueta" => "1" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Gastroenterology Department, Instituto Português de Oncologia de Lisboa, Lisboa, Portugal" "etiqueta" => "2" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Gastroenterology Department, Centro Hospitalar do Porto, Porto, Portugal" "etiqueta" => "3" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Department of Pediatrics, Centro Hospitalar São João, Porto, Portugal" "etiqueta" => "4" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Department of Gastroenterology and Hepatology, Hospital de Santa Maria, University of Lisbon, Lisbon, Portugal" "etiqueta" => "5" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Department of Community Medicine, Information and Decision in Health, Faculty of Medicine of the University of Porto, Portugal; CINTESIS - Centre for Health Technology and Services Research, Porto, Portugal" "etiqueta" => "6" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Department of Gastroenterology, Faculty of Medicine, Centro Hospitalar São João, Porto, Portugal" "etiqueta" => "7" "identificador" => "aff0035" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Aim:</span> This systematic review and meta-analysis aimed i) to assess the clinical value of 6-thioguanine nucleotides (6-TGN) thresholds (200, 225, 230, 235, 250 and 260<span class="elsevierStyleHsp" style=""></span>pmol/8<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>108 RBC); and ii) to compare mean 6-TGN concentrations between patients with active disease and those achieving remission.</p><p id="par0010" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Introduction:</span> Thiopurines are widely used as immunosuppressive drugs in the management of inflammatory bowel disease even though their minimum effective dose and dose–response relationship remain controversial. In addition, the monitoring of thiopurines’ pharmacological active metabolites is currently reserved for particular cases namely in refractory patients or when non-compliance or toxicity is suspected.</p><p id="par0015" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Methods:</span> Literature search was carried out following PRISMA and Cochrane Collaboration Guidelines and four databases were used (PubMed, Web of Science, ScienceDirect and the Cochrane Central Register of Controlled Trials). Statistical heterogeneity was assessed using the I2 statistic followed by subgroup and sensitivity analyses. Odds ratios (ORs) were computed under the random effects model.</p><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Results:</span> The systematic search identified 1384 records of which 25 matched the inclusion criteria and were retained for further analysis. From these, 22 were used in the cut-off comparisons while 12 were used in the 6-TGN mean differences analysis. The global OR for remission in patients with 6-TGN concentrations above the predefined thresholds was 3.95 (95%CI, 2.63–5.94; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001). When considering each of the six thresholds individually, the OR was significant for levels above 235<span class="elsevierStyleHsp" style=""></span>pmol/8<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>108 RBC (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2.25) and 250<span class="elsevierStyleHsp" style=""></span>pmol/8<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>108 (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>4.71). Mean 6-TGN levels were significantly superior among patients achieving clinical remission, with a pooled difference of 63.37<span class="elsevierStyleHsp" style=""></span>pmol/8<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>108 RBC (95%CI, 31.81-94.93; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001).</p><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Conclusion:</span> These results reinforce that 6-TGN levels are related to clinical remission and give an insight into the thresholds that may be used to guide clinical decisions.</p><p id="par0030" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Acknowledgements:</span> This work was supported by the Portuguese Group of Studies in Inflammatory Bowel Disease (GEDII).</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true ] "idiomaDefecto" => "en" "url" => "/24448664/0000000200000005/v2_201709090132/S2444866417301873/v2_201709090132/en/main.assets" "Apartado" => array:4 [ "identificador" => "68084" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Abstracts" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/24448664/0000000200000005/v2_201709090132/S2444866417301873/v2_201709090132/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444866417301873?idApp=UINPBA00004N" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 October | 2 | 2 | 4 |
2024 September | 14 | 4 | 18 |
2024 August | 19 | 7 | 26 |
2024 July | 12 | 3 | 15 |
2024 June | 11 | 4 | 15 |
2024 May | 8 | 4 | 12 |
2024 April | 10 | 3 | 13 |
2024 March | 13 | 5 | 18 |
2024 February | 3 | 4 | 7 |
2024 January | 7 | 6 | 13 |
2023 December | 2 | 7 | 9 |
2023 November | 7 | 9 | 16 |
2023 October | 8 | 6 | 14 |
2023 September | 8 | 3 | 11 |
2023 August | 4 | 4 | 8 |
2023 July | 5 | 5 | 10 |
2023 June | 16 | 1 | 17 |
2023 May | 38 | 4 | 42 |
2023 April | 26 | 0 | 26 |
2023 March | 8 | 2 | 10 |
2023 February | 11 | 9 | 20 |
2023 January | 13 | 14 | 27 |
2022 December | 9 | 8 | 17 |
2022 November | 7 | 12 | 19 |
2022 October | 11 | 13 | 24 |
2022 September | 11 | 8 | 19 |
2022 August | 12 | 7 | 19 |
2022 July | 11 | 13 | 24 |
2022 June | 15 | 8 | 23 |
2022 May | 19 | 3 | 22 |
2022 April | 21 | 9 | 30 |
2022 March | 33 | 13 | 46 |
2022 February | 34 | 4 | 38 |
2022 January | 23 | 6 | 29 |
2021 December | 14 | 8 | 22 |
2021 November | 18 | 11 | 29 |
2021 October | 15 | 12 | 27 |
2021 September | 7 | 10 | 17 |
2021 August | 8 | 8 | 16 |
2021 July | 9 | 6 | 15 |
2021 June | 8 | 5 | 13 |
2021 May | 13 | 6 | 19 |
2021 April | 51 | 12 | 63 |
2021 March | 32 | 4 | 36 |
2021 February | 11 | 7 | 18 |
2021 January | 12 | 9 | 21 |
2020 December | 10 | 9 | 19 |
2020 November | 9 | 7 | 16 |
2020 October | 10 | 8 | 18 |
2020 September | 9 | 11 | 20 |
2020 August | 16 | 13 | 29 |
2020 July | 26 | 12 | 38 |
2020 June | 11 | 2 | 13 |
2020 May | 16 | 5 | 21 |
2020 April | 14 | 4 | 18 |
2020 March | 11 | 4 | 15 |
2020 February | 5 | 2 | 7 |
2020 January | 5 | 1 | 6 |
2019 December | 11 | 7 | 18 |
2019 November | 6 | 7 | 13 |
2019 October | 11 | 9 | 20 |
2019 September | 23 | 6 | 29 |
2019 August | 18 | 3 | 21 |
2019 July | 11 | 7 | 18 |
2019 June | 42 | 12 | 54 |
2019 May | 55 | 15 | 70 |
2019 April | 28 | 4 | 32 |
2019 March | 37 | 3 | 40 |
2019 February | 46 | 0 | 46 |
2019 January | 41 | 3 | 44 |
2018 December | 41 | 1 | 42 |
2018 November | 36 | 6 | 42 |
2018 October | 38 | 2 | 40 |
2018 September | 16 | 3 | 19 |
2018 August | 14 | 10 | 24 |
2018 July | 25 | 10 | 35 |
2018 June | 37 | 12 | 49 |
2018 May | 37 | 13 | 50 |
2018 April | 45 | 9 | 54 |
2018 March | 32 | 9 | 41 |
2018 February | 33 | 15 | 48 |
2018 January | 8 | 15 | 23 |
2017 December | 23 | 19 | 42 |
2017 November | 11 | 18 | 29 |
2017 October | 19 | 17 | 36 |
2017 September | 12 | 10 | 22 |