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Vol. 45. Issue 7.
Pages 273-279 (January 2002)
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Vol. 45. Issue 7.
Pages 273-279 (January 2002)
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Efecto del tabaco sobre los resultados de un programa de fecundación in vitro
Effect of tobacco on the results of an in vitro fertilization program
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N. Mendoza
Corresponding author
nmendozal@sego.es

Correspondencia: Unidad de Reproducción Humana. Servicio de Ginecología y Obstetricia. Hospital Virgen de las Nieves. Avenida de las Fuerzas Armadas, 2. 18014 Granada
, V. Maldonado, R. Villegas, S. Sedeño, M.D. López, L. Martínez, J. Fontes, A.I. Núñez
Unidad de Reproducción Humana. Servicio de Ginecología y Obstetricia. Hospital Universitario Virgen de las Nieves. Granada.
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Resumen
Objetivo

Comprobar si existen diferencias dependientes del hábito de fumar en los resultados de nuestro programa de fecundación in vitro.

Pacientes y método

Realizamos un análisis retrospectivo de 1.041 pacientes incluidas en un programa de fecundación in vitro desde el año 1998 hasta el 2001, las cuales se dividieron en tres grupos de 614 mujeres no fumadoras, 308 fumadoras de menos de 15 cigarrillos por día y 119 fumadoras de más de esta cantidad

Resultados

La tasa de implantación y de embarazos fue similar en los tres grupos de pacientes. Las muy fumadoras necesitaron más dosis de hormona foliculoestimulante para llegar a un desarrollo folicular adecuado y alcanzaron niveles menores de estradiol al final del ciclo (p<0,05). Las no fumadoras obtuvieron un mayor número de folículos maduros y de ovocitos que las fumadoras (p<0,05)

Conclusión

Aunque la consecución del embarazo no se afecta por el hecho de fumar, otros parámetros, como el desarrollo folicular, el nivel de estradiol o el número de ovocitos recuperados, disminuyen con el consumo de tabaco

Palabras clave:
Embarazo
Fecundación in vitro
Tabaquismo
Aim

Determine whether smoking affects the results of our in vitro fertilization program

Patients and method

We performed a retrospective study of 1,041 patients included in an in vitro fertilization program from 1998 to 2001. The patients were divided into three groups: 614 non-smoking women, 308 women who smoked less than 15 cigarettes per day and 119 who smoked more than 15 cigarettes per day

Results

The rate of implantation and pregnancy was similar in the three groups. Heavy smokers required higher doses of follicle-stimulating hormone to achieve sufficient follicular development and had lower estradiol levels at the end of the cycle (p<0.05). Non-smokers had a higher number of mature follicles and ovocytes than did smokers (p<0.05)

Conclusion

Although pregnancy rates are unaffected by smoking, other parameters such as follicular development, estradiol levels or the number of ovocytes recovered are reduced by smoking

keywords:
Pregnancy
In vitro fertilization
Smoking
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Copyright © 2002. Sociedad Española de Ginecología y Obstetricia
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