covid
Buscar en
Progresos de Obstetricia y Ginecología
Toda la web
Inicio Progresos de Obstetricia y Ginecología Estudio citogenético de un carcinoma escamoso de cérvix uterino
Journal Information
Vol. 45. Issue 8.
Pages 344-349 (January 2002)
Share
Share
Download PDF
More article options
Vol. 45. Issue 8.
Pages 344-349 (January 2002)
Full text access
Estudio citogenético de un carcinoma escamoso de cérvix uterino
Cytogenic analysis of a squamous carcinoma of the uterine cervix
Visits
4949
F. Alameda
Corresponding author
86780@imas.imim.es

Correspondencia: Departamento de Patología. Hospital del Mar. P.° Marítim, 25–28. 08003 Barcelona
, M.L. Mariñoso, F. Solé, S. Serrano
Departamento de Patología
P. Fustéa, C. Marinéa, R. Carrerasa
a Servicio de Obstetricia y Ginecología. Hospital del Mar. IMAS. Universitat Autónoma de Barcelona. Barcelona
This item has received
Article information
Resumen

Presentamos el caso de un carcinoma escamoso de cérvix uterino en una paciente de 50 años. En las células tumorales se halló la presencia del virus del papiloma humano (VPH) 16, sin otros virus acompañantes, y el estudio citogenético evidenció múltiples alteraciones cromosómicas especialmente en los cromosomas 5 y 8 así como múltiples alteraciones cromosómicas numéricas. Nuestro objetivo es enfatizar la importancia de practicar estudios citogenéticos en carcinomas escamosos de cérvix a la vez que efectuar una revisión de los datos existentes en la bibliografía

Palabras clave:
Cérvix
Carcinoma escamoso
VPH
Citogenética
Alteraciones cromosómicas
Abstract

We present a case of squamous cell carcinoma of the uterine cervix in a 50-year-old woman, with human papilloma virus-16 infection of the tumoral cells. Cytogenetic analysis of the tumoral cells showed chromosomal alterations, especially on chromosomes 5 and 8, as well as multiple chromosomal alterations. We review the data reported in the literature

Keywords:
Uterine cervix
Squamous cell carcinoma
Human papilloma virus
Cytogenetics
Chromosomal alterations
Full text is only aviable in PDF
Bibliografía
[1.]
G.T. Chung, D.P. Huang, K.W. Lo, M.K. Chan, F.W. Wong.
Genetic lesion in the carcinogenesis of cervical cancer.
Anticancer Res, 12 (1992), pp. 1485-1490
[2.]
C.M. Wilke, B.K. Hall, A. Hoge, W. Paradee, D.I. Smith, T.W. Glover.
FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites.
Hum Mol Genet, 5 (1996), pp. 187-195
[3.]
Y.F. Wong, T.K. Chung, T.H. Cheung, P.O. Tam, A.M. Chang.
Frequent loss of heterozygosity of chromosome 3 short arm detected by PCR-based microsatellite polymorphisms in cervical squamous cell carcinoma.
Cancer Lett, 115 (1997), pp. 161-164
[4.]
I.I. Witsuba, F.D. Montellano, S. Milchgrub, A.K. Virmani, C. Behrens, H. Chen, et al.
Deletions of chromosome 3p are frequent and early events in the pathogenesis of uterine cervical carcinoma.
Cancer Res, 57) (1997), pp. 3154-3158
[5.]
D.L. Greenspan, D.C. Connolly, R. Wu, R.Y. Lei, J.T. Vogelstein, Y.T. Kim, et al.
Loss of FHIT expression in cervical carcinoma cell lines and primary tumors.
Cancer Res, 57 (1997), pp. 4692-4698
[6.]
T. Segawa, T. Sasagawa, H. Yamazaki, J. Sakaike, H. Ishikawa, M. Inoue.
Fragile Histidine triad transcription abnormalities and human papillomavirus E6 E7 mRNA expression in the development of cervical carcinoma.
Cancer, 85 (1999), pp. 2001-2010
[7.]
J.S. Rader, D.S. Gerhard, M.J. O'Sullivan, Y. Li, L. Li, H. Liapis, et al.
Cervival Intraepithelial neoplasia III shows frequent allelic loss in 3p and 6p.
Gen Chrom Cancer, 22 (1998), pp. 57-65
[8.]
H.F. Mark, K. Santoro, W. Campbell, E. Hann, J. Lathrop.
Integration of human papillomavirus sequences in cervical tumor cell lines.
Ann Clin Lab Sci, 26 (1996), pp. 147-153
[9.]
N. Nagai.
Gene diagnosis of uterina cancer.
Rinsho Byori, 42 (1994), pp. 372-379
[10.]
S.V. Petrov, N.N. Mazurenko, N.M. Sukhova, I.P. Moroz, V.M. Katsenel'- son, N.T. Raikhlin, et al.
Cell oncogene expression in normal, metaplastic, dysplastic epithelium and squamous cell carcinoma of the uterine cervix.
Ark Patol, 56 (1994), pp. 22-31
[11.]
C. Aoyama, J. Peters, S. Senadheera, P. Liu, H. Shimada.
Uterine cervical dysplasia and cancer: identification of c-myc status by quantitative polymerase chain reaction.
Diagn Mol Pathol, 7 (1998), pp. 324-330
[12.]
A. Dellas, E. Schultheiss, M.R. Leivas, H. Moch, J. Torhorst.
Association of p27Kip1, Cyclin-E and C-MYC expression with progression and prognosis in HPV positive cervical neoplasms.
Anticancer Res, 18 (1998), pp. 3991-3998
[13.]
C. Mugica-Van Herckenrode, J.A. Rodríguez, V. Iriarte-Campo, A. Carracedo, F. Barros.
Definition of a region of loss of heterozygosity at chromo-some 11q in cervical carcinoma.
Diagn Mol Pathol, 8 (1999), pp. 92-96
[14.]
A.B. Mitra, V.V. Murty, R.G. LI, M. Pratap, U.K. Luthra, R.S. Chaganti.
Allelotype analysis of cervical carcinoma.
Cancer Res, 54 (1994), pp. 4481-4487
[15.]
R.M. Busby-earle, C.M. Steel, A.R. Williams, B. Cohen, C.C. Bird.
P53 mutations in cervical carcinogenesis- low frequency and lack of correlation with human papillomavirus status.
Br J Cancer, 69 (1994), pp. 732-737
[16.]
M.I. Gallego, D.B. Zimonjic, N.C. Popescu, J.A. DiPaolo, P.A. Lazo.
Integration site of human papillomavirus type 18 DNA in chromosome band 8q22.1 of C4-I Cervical Carcinoma: Dnase I hypersensitivity and methylation of cellular flanking sequences.
Gen Chrom Cancer, 9 (1994), pp. 28-32
[17.]
P.A. Lazo.
The molecular genetics of cervical carcinoma.
Br J Cancer, 80 (1999), pp. 2008-2018
[18.]
K. Milde-Langosch, S. Riethdorf, T. Löning.
Association of HPV infection with carcinoma of the cervix uteri and its precursor lesions: Theoretical and practical implications.
Wirchows Arch, 437 (2000), pp. 227-233
[19.]
A.M. Kersmaekers, A. Van der Vijver, G.G. Kenter, G.J. Fleuren.
Genetic alterations during the progression of squamous cell carcinomas of the uterine cervix.
Gen Chrom Cancer, 26 (1999), pp. 346-354
[20.]
PVHfast, PharmaGen, S.A. Madrid. Spain. Disponible en: http://www.pharmagen.es
[21.]
R.M. Resnick, M.T. Cornelissen, D.K. Wright, G.H. Eichinger, H.S. Fox, J. Ter Schegget, et al.
Detection and typing of human papillomavirus in archival cervical cancer specimens by DNA amplification with consensus primers.
J Natl Cancer Inst, 82 (1990), pp. 1477-1484
Copyright © 2002. Sociedad Española de Ginecología y Obstetricia
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos