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Vol. 46. Issue 6.
Pages 245-249 (January 2003)
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Vol. 46. Issue 6.
Pages 245-249 (January 2003)
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Estudio de la inestabilidad microsatélite en tumores borderline y carcinoma de ovario
Microsatellite instability in borderline tumors and ovarian carcinoma
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M. Vidaurretaa, I. Almansaa, M.T. Sanza, F. Tresserrab, L. Lópezb, M.L. Maestroa,
Corresponding author
mmaestro@hcsc.es

Correspondencia: Servicio Análisis Clínicos. Hospital Clínico San Carlos. Martín Lagos, s/n. 28040 Madrid. España
, S. Dexeusa
a Sección de Biología Tumoral. Servicio de Análisis Clínicos. Hospital Clínico San Carlos. Madrid. España
b Servicio de Ginecología y Obstetricia. Fundación Santiago Dexeus Font. Barcelona. España
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Resumen

El objetivo de nuestro estudio es determinar la inestabilidad de tres microsatélites (BAT25, BAT26 y NME1) y observar si está implicada en el desarrollo de los tumores esporádicos de ovario. El trabajo se ha llevado a cabo en 40 pacientes intervenidas quirúrgicamente por tumor de ovario esporádico. La comprobación de la inestabilidad se realizó por comparación del tejido sano y tumoral de cada una de las pacientes. Sólo se encontró inestabilidad en 3 casos: en BAT26 en tumor borderline; en BAT25 en cistoadenocarcinoma de células claras, y en NME1 en cistoadenocarcinoma papilar seroso en diferentes pacientes. La inestabilidad microsatélite no parece estar implicada en la aparición o el desarrollo de los tumores esporádicos de ovario

Palabras clave:
Inestabilidad
Microsatélite
Ovario
Borderline
Carcinoma
Summary

The aim of our study is instability's determination of three microsatellite (BAT25, BAT26 and NME1) and see if they are implicating in development of sporadic ovarian tumours. This study have been carrying out in 40 patients operated for sporadic ovarian tumour. The instability comprobation was realized for comparation between healthy tissue and tumour tissue of each patient. Was only found instability in 3 cases: in BAT26 in borderline tumour, in BAT25 in clear cells cystadenoma and instability in NME1 in papilar serous cystadenoma in diferents patients. The conclusion of this study is that microsatellite instability does not seem be implicated in apparition or development of sporadic ovarian tumours

Keywords:
Instability
Microsatellite
Ovarian
Borderline
Carcinoma
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Copyright © 2003. Sociedad Española de Ginecología y Obstetricia
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