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Vol. 45. Issue 7.
Pages 280-286 (January 2002)
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Vol. 45. Issue 7.
Pages 280-286 (January 2002)
DOI: 10.1016/S0304-5013(02)75778-6
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Ganglio centinela en el carcinoma de mama. Estudio de 175 casos
Sentinel node in breast carcinoma. Study of 175 cases
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G. Zanón*, A. Torné, X. Iglesias
Instituto Clinico de Ginecología, Obstetricia y Neonatología (Icgon)
S. Vidal-Sicarta, M. Ortegaa, J. Pahisa, M. Velascob, P.L. Fernándezc, F. Ponsa
a Servicio de Medicina Nuclear. Hospital Clínic. Barcelona
b Radiodiagnóstico (CDI). Hospital Clínic. Barcelona
c Servicio de Anatomía Patológica. Unidad de Patología de la Mama. Hospital Clínic. Barcelona
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Resumen
Objetivo

Evaluar la eficacia del estudio selectivo del ganglio centinela en el carcinoma de mama

Sujetos

Se incluye en este trabajo a 175 pacientes repartidas en dos grupos. El primero de 105 formado por neoplasias en estadios T1 y T2 y que sirvió para realizar la necesaria curva de aprendizaje en el que realizamos estudio de ganglio centinela y linfadenectomía reglada. Una vez validada la técnica, el grupo de aplicación terapéutica fue formado por 70 pacientes en estadios T1 y T2 de tamaño inferior a 2,5 cm

Resultados

En el grupo de aplicación clínica hemos detectado el ganglio centinela correctamente en el 98,5% de los casos (eficacia), tanto por linfogammagrafía como intraoperatoriamente. Nuestra cifra de falsos negativos es del 0% con un seguimiento clínico de estas pacientes de 8 meses. La sensibilidad del procedimiento y el valor predictivo negativo son del 100%

Conclusiones

El estudio del ganglio centinela en el carcinoma de la mama nos ha permitido disminuir la morbilidad de la cirugía, reducir los ingresos hospitalarios y mejorar la recuperación de las pacientes

Palabras clave:
Ganglio centinela
Cáncer de mama
Estudio
Summary
Aim

To assess the efficacy of selective sentinel lymph node (SLN) identification in breast cancer

Subjects

One hundred seventy-five patients were included in this study. The patients were divided into two groups: the first group was composed of 105 patients with T1 and T2 tumors. This group represented the validation (with axillary lymphadenectomy) and learning curve group. After validation, the technique was applied to the remaining 70 patients (application group) with T1 and T2 tumors smaller than 2.5 cm

Results

In the application group, SLN was correctly identified by lymphoscintigraphy or surgery in 98.5%. The false negative rate in these patients was 0% with a clinical follow-up of 8 months. Sensitivity and negative predictive value were 100%

Conclusions

SLN assessment in patients with breast carcinoma reduces surgical morbidity and hospital admissions and improves patients' recovery

keywords:
Sentinel node
Breast cancer
Study
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Copyright © 2002. Sociedad Española de Ginecología y Obstetricia

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