Demostrar la relación entre los valores preoperatorios de Ca-125 y Ca 19.9 con el grado de enfermedad en las pacientes intervenidas por endometriosis.
Sujetos y métodosEstudio retrospectivo. Muestra aleatoria de 85 casos de pacientes sometidas a cirugía por endometriosis, confirmada durante la intervención, en el Hospital General Universitario de Alicante, entre febrero de 1996 y enero de 2003.
ResultadosSe encontraron diferencias estadísticamente significativas en los valores medios de Ca-125 (p = 0,006) y Ca 19.9 (p = 0,003), en función del grado de enfermedad (III o IV). Se construyó una curva ROC (receiver operating characteristics) para ambos parámetros.
ConclusionesLos marcadores Ca-125 y Ca 19.9 son útiles para descartar endometriosis de grado IV en el preoperatorio, y así una intervención dificultosa. Los umbrales óptimos para su valoración son Ca-125 < 38,5 U/ml y Ca 19.9 < 13 U/ml. La presencia de ambas condiciones descartará endometriosis de grado IV, con una probabilidad del 97,7%<.
To demonstrate the relationship between presurgical levels of Ca-125 and Ca 19.9 and grade of endometriosis.
Subjects and methodsWe performed a retrospective study of a random sample of 85 patients who underwent surgery for endometriosis in the Hospital General Universitario de Alicante (Spain) between February, 1996 and January, 2003. In all patients, the diagnosis was confirmed during the intervention.
ResultsSignificant differences were found in the mean levels of Ca-125 (p=0.006) and Ca 19.9 (p=0.003) depending on disease severity (grade III or IV). Receiver Operating Characteristic (ROC) curves were designed for both grades.
ConclusionsConclusions: Ca-125 and Ca 19.9 are useful in ruling out grade IV endometriosis before surgery and can thus be used to predict the difficulty of the intervention. The optimal thresholds were Ca- 125 < 38.5 UI/mL and Ca 19.9 < 13 UI/mL. The presence of both conditions rules out grade IV endometriosis with 97.7% confidence.