Editorial
Transcatheter treatment of severe mitral regurgitation in Brazil: a new kid on the block
Tratamento transcateter da insuficiência mitral grave no Brasil: uma novidade na área
Guilherme F. Attizzania,b,
, Corrado Tamburinoa
Corresponding author
guilherme.attizzani@uhhospitals.org
Corresponding author. 11100 Euclid Avenue, Lakeside 3113, Cleveland, OH, USA, 44106.
Corresponding author. 11100 Euclid Avenue, Lakeside 3113, Cleveland, OH, USA, 44106.
Read
2262
Timeswas read the article
640
Total PDF
1622
Total HTML
Share statistics
array:25 [ "pii" => "S2214123515000290" "issn" => "22141235" "doi" => "10.1016/j.rbciev.2015.12.003" "estado" => "S300" "fechaPublicacion" => "2015-04-01" "aid" => "22" "copyright" => "Sociedade Brasileira de Hemodinâmica e Cardiologia Intervencionista" "copyrightAnyo" => "2015" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "edi" "cita" => "Rev Bras Cardiol Invasiva. 2015;23:82-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1772 "formatos" => array:3 [ "EPUB" => 314 "HTML" => 1093 "PDF" => 365 ] ] "Traduccion" => array:1 [ "pt" => array:20 [ "pii" => "S0104184315000351" "issn" => "01041843" "doi" => "10.1016/j.rbci.2015.12.003" "estado" => "S300" "fechaPublicacion" => "2015-04-01" "aid" => "22" "copyright" => "Sociedade Brasileira de Hemodinâmica e Cardiologia Intervencionista. Publicado por Elsevier Editora Ltda" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "edi" "cita" => "Rev Bras Cardiol Invasiva. 2015;23:82-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4745 "formatos" => array:3 [ "EPUB" => 224 "HTML" => 3088 "PDF" => 1433 ] ] "pt" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "Tratamento transcateter da insuficiência mitral grave no Brasil: uma novidade na área" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "82" "paginaFinal" => "83" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Transcatheter treatment of severe mitral regurgitation in Brazil: a new kid on the block" ] ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Guilherme F. Attizzani, Corrado Tamburino" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Guilherme F." "apellidos" => "Attizzani" ] 1 => array:2 [ "nombre" => "Corrado" "apellidos" => "Tamburino" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2214123515000290" "doi" => "10.1016/j.rbciev.2015.12.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2214123515000290?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0104184315000351?idApp=UINPBA00004N" "url" => "/01041843/0000002300000002/v2_201612240359/S0104184315000351/v2_201612240359/pt/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S2214123515000307" "issn" => "22141235" "doi" => "10.1016/j.rbciev.2015.12.004" "estado" => "S300" "fechaPublicacion" => "2015-04-01" "aid" => "23" "copyright" => "Sociedade Brasileira de Hemodinâmica e Cardiologia Intervencionista" "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Bras Cardiol Invasiva. 2015;23:84-90" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1853 "formatos" => array:3 [ "EPUB" => 292 "HTML" => 1200 "PDF" => 361 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Renal sympathetic denervation in patients with implantable cardioverter-defibrillator and electrical storm" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "84" "paginaFinal" => "90" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Denervação simpática renal em pacientes com cardiodesfibrilador implantável e tempestade elétrica" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2760 "Ancho" => 3500 "Tamanyo" => 1523918 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">(<span class="elsevierStyleBold">A</span>) Diagnostic confirmation of electrical storm, through implantable cardioverter-defibrillator interrogation and analysis of stored intracardiac electrograms, confirming that the antitachycardia therapies were appropriate and effective. (<span class="elsevierStyleBold">B</span>) The unsuccessful attempt at ventricular tachycardia reversion by antitachycardia pacing (ATP), triggering the onset of another ventricular tachycardia with different morphology, which was reversed by shock. VT: sustained ventricular tachycardia.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Rodolfo Staico, Luciana Armaganijan, Dalmo A.R. Moreira, Paulo T.J. Medeiros, Jônatas Melo Neto, Dikran Armaganijan, Amanda G.M.R. Sousa, Alexandre Abizaid" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Rodolfo" "apellidos" => "Staico" ] 1 => array:2 [ "nombre" => "Luciana" "apellidos" => "Armaganijan" ] 2 => array:2 [ "nombre" => "Dalmo A.R." "apellidos" => "Moreira" ] 3 => array:2 [ "nombre" => "Paulo T.J." "apellidos" => "Medeiros" ] 4 => array:2 [ "nombre" => "Jônatas Melo" "apellidos" => "Neto" ] 5 => array:2 [ "nombre" => "Dikran" "apellidos" => "Armaganijan" ] 6 => array:2 [ "nombre" => "Amanda G.M.R." "apellidos" => "Sousa" ] 7 => array:2 [ "nombre" => "Alexandre" "apellidos" => "Abizaid" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S0104184315000363" "doi" => "10.1016/j.rbci.2015.12.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0104184315000363?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2214123515000307?idApp=UINPBA00004N" "url" => "/22141235/0000002300000002/v2_201612270115/S2214123515000307/v2_201612270115/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S2214123515000289" "issn" => "22141235" "doi" => "10.1016/j.rbciev.2015.12.002" "estado" => "S300" "fechaPublicacion" => "2015-04-01" "aid" => "21" "copyright" => "Sociedade Brasileira de Hemodinâmica e Cardiologia Intervencionista" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "edi" "cita" => "Rev Bras Cardiol Invasiva. 2015;23:78-81" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2557 "formatos" => array:3 [ "EPUB" => 336 "HTML" => 1762 "PDF" => 459 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "Post-TAVR coronary obstruction" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "78" "paginaFinal" => "81" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Obstrução coronária pós-TAVI" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1130 "Ancho" => 1519 "Tamanyo" => 162757 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Multidetector computed tomography analysis of the aortic valvar complex. (<span class="elsevierStyleBold">A</span>) Sinuses of Valsalva dimensions. (<span class="elsevierStyleBold">B</span>) Left main coronary artery height, measured perpendicular from aortic annulus. (<span class="elsevierStyleBold">C</span>) Left leaflet length. (<span class="elsevierStyleBold">D</span>) Aortic annulus measurements (area, perimeter, maximal, and minimal diameters).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Juan A. Terré, Ziad Sergie, George D. Dangas" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Juan A." "apellidos" => "Terré" ] 1 => array:2 [ "nombre" => "Ziad" "apellidos" => "Sergie" ] 2 => array:2 [ "nombre" => "George D." "apellidos" => "Dangas" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S010418431500034X" "doi" => "10.1016/j.rbci.2015.12.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S010418431500034X?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2214123515000289?idApp=UINPBA00004N" "url" => "/22141235/0000002300000002/v2_201612270115/S2214123515000289/v2_201612270115/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "Transcatheter treatment of severe mitral regurgitation in Brazil: a new kid on the block" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "82" "paginaFinal" => "83" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Guilherme F. Attizzani, Corrado Tamburino" "autores" => array:2 [ 0 => array:4 [ "nombre" => "Guilherme F." "apellidos" => "Attizzani" "email" => array:1 [ 0 => "guilherme.attizzani@uhhospitals.org" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Corrado" "apellidos" => "Tamburino" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Cardiology Department, Ferrarotto Hospital, University of Catania, Catania, Italy" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "The Valve and Structural Heart Intervention Center, Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Cleveland, Ohio, USA" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author. 11100 Euclid Avenue, Lakeside 3113, Cleveland, OH, USA, 44106." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Tratamento transcateter da insuficiência mitral grave no Brasil: uma novidade na área" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">While moderate-to-severe and severe mitral regurgitation (MR) lead to high rates of morbidity and mortality if no intervention is performed, a considerable number of patients are exclusively medically managed due to their high surgical risk;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> indeed, adverse event rates among high-risk patients whom undergo mitral valve surgery are relevant.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Therefore, there is a large unmet need for transcatheter therapies in this setting.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In this edition of <span class="elsevierStyleItalic">Revista Brasileira de Cardiologia Invasiva</span>, Brito Jr. et al.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> describe the first two percutaneous edge-to-edge mitral valve repairs utilizing the MitraClip™ (Abbott Vascular, Abbott Park, USA) device performed in Brazil. We would like to congratulate the authors for their pioneering work in this important field.</p><p id="par0010" class="elsevierStylePara elsevierViewall">While the only randomized trial published to date comparing MitraClip™ implantation with mitral valve surgery included mostly (∼ 70%) patients with primary (<span class="elsevierStyleItalic">i.e.</span>, degenerative) MR, the scenario in which mitral valve surgery delivers excellent results,<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> large real world registries, such as ACCESS-EU,<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> GRASP,<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and TRAMI,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> included mostly patients with secondary (<span class="elsevierStyleItalic">i.e.</span>, functional) MR, reflecting the potential of also utilizing MitraClip™ in the setting in which mitral valve surgery delivers worse results, such as lack of survival benefit and high rates of recurrence coupled with high morbidity and mortality.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Randomized trials comparing MitraClip™ implantation with mitral valve surgery for patients with severe functional MR, such as the ongoing COAPT (Clinical Outcomes Assessment of the MitraClip<span class="elsevierStyleSup">TM</span> Percutaneous Therapy for High Surgical Risk Patients; NCT01626079) study, will certainly shed more light on the ideal approach for this particular subset of patients. We believe, however, that the approval of MitraClip™ for both primary and secondary MR in Brazil was extremely mature and important as it relied not only on randomized data, which could restrict its indications for primary MR, but also on large real-world experiences that included thousands of patients with functional MR (<span class="elsevierStyleItalic">i.e.</span>, those with the higher likelihood of receiving no surgical intervention)<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> whom were successfully treated, mostly demonstrating sustained long-term results.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Increasing experience has enabled the expansion of MitraClip™ indications, which were initially limited by the strict echocardiographic criteria proposed in the EVEREST II study.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In fact, while our group was a pioneer in the implantation of this novel device in Italy back in 2008, we also recently demonstrated the potential for expanding the indications to more complex anatomical scenarios, while maintaining favorable outcomes.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,8</span></a> While predictors of acutely unsuccessful MitraClip™ procedure have been demonstrated by Lubos et al.,<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> we identified long-term predictors of unfavorable clinical outcomes after MitraClip™ implantation,<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> which ultimately enabled a more refined understanding of this intervention. Importantly, however, the learning curve associated with MitraClip™ may be relatively steep; therefore, following the echocardiographic criteria initially proposed by the EVEREST II study<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> may be the best way to start a new program while progressively transitioning to more complex scenarios.</p><p id="par0020" class="elsevierStylePara elsevierViewall">MitraClip™ implantation is associated with hemodynamic improvement, left ventricle reverse remodeling, and improvement in quality of life. When reduction of MR to ≤ 2+ is achieved, the procedure can be considered successful, just as demonstrated in the two cases described by Brito Jr. et al.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Importantly, one should not expect that MR will be completely abolished with MitraClip™; in fact, improvement in quality of life was comparable in patients with 1+ and 2+ MR post-procedure in a recent analysis of the EVEREST II study.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Similarly to transcatheter aortic valve implantation, structural heart intervention centers that include MitraClip™ in their armamentarium will certainly observe an increase in the overall rates of referrals for mitral valve dysfunction evaluation; therefore, not only transcatheter but also surgical mitral valve interventions will likely increase (<span class="elsevierStyleItalic">i.e.</span>, “halo effect”). This may become even more important when reimbursement for the MitraClip™ procedure is an issue. For example, while expected for the second semester of 2015, to date in the United States there is no full coverage for MitraClip™ implantation. Nonetheless, this fact has not stopped centers of excellence from adopting this novel technique, thereby offering a broader spectrum of structural heart disease interventions to their patients.</p><p id="par0030" class="elsevierStylePara elsevierViewall">While MitraClip™ is the only Food and Drug Administration-approved transcatheter procedure to treat severe MR, transcatheter balloon expandable aortic valves have been implanted in the mitral position to treat dysfunctional surgical bioprosthesis and annuloplasty rings<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> with promising results; in addition, native mitral valves with important annular calcification have also been treated in a similar fashion.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> While these interventions probably represent the only therapeutic option for prohibitive surgical risk patients, the ultimate goal in this field is the possibility of implanting dedicated transcatheter heart valves in the mitral position. Several different devices are currently being tested, but the initial human experience is still in its infancy.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence and outcomes of unoperated patients with severe symptomatic mitral regurgitation and heart failure: comprehensive analysis to determine the potential role of MitraClip for this unmet need" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.S. Goel" 1 => "N. Bajaj" 2 => "B. Aggarwal" 3 => "S. Gupta" 4 => "K.L. Poddar" 5 => "M. Ige" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2013.08.723" "Revista" => array:7 [ "tituloSerie" => "J Am Coll Cardiol." "fecha" => "2014" "volumen" => "63" "numero" => "2" "paginaInicial" => "185" "paginaFinal" => "186" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24036029" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of mitral valve annuloplasty combined with revascularization in patients with functional ischemic mitral regurgitation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Mihaljevic" 1 => "B.K. Lam" 2 => "J. Rajeswaran" 3 => "M. Takagaki" 4 => "M.S. Lauer" 5 => "A.M. Gillinov" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2007.02.043" "Revista" => array:7 [ "tituloSerie" => "J Am Coll Cardiol." "fecha" => "2007" "volumen" => "49" "numero" => "22" "paginaInicial" => "2191" "paginaFinal" => "2201" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17543639" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tratamento percutâneo da insuficiência mitral por MitraClip<span class="elsevierStyleSup">®</span>: relato dos dois primeiros procedimentos no Brasil" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F.S. Brito Jr." 1 => "A. Siciliano" 2 => "C.H. Fischer" 3 => "M.L. Vieira" 4 => "A. Rabischoffski" 5 => "F. Papa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Bras Cardiol Inv." "fecha" => "2015" "volumen" => "23" "numero" => "2" "paginaInicial" => "156" "paginaFinal" => "160" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "comentario" => "Erratum in: N Engl J Med. 2011;365(2):189. Glower, Donald G [corrected to Glower, Donald D]." "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Percutaneous repair or surgery for mitral regurgitation" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "EVEREST II Investigators" "etal" => true "autores" => array:6 [ 0 => "T. Feldman" 1 => "E. Foster" 2 => "D.D. Glower" 3 => "S. Kar" 4 => "M.J. Rinaldi" 5 => "P.S. Fail" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa1009355" "Revista" => array:7 [ "tituloSerie" => "N Engl J Med." "fecha" => "2011" "volumen" => "364" "numero" => "15" "paginaInicial" => "1395" "paginaFinal" => "1406" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21463154" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Percutaneous mitral valve interventions in the real world: early and 1-year results from the ACCESS- EU, a prospective, multicenter, nonrandomized post-approval study of the MitraClip therapy in Europe" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Maisano" 1 => "O. Franzen" 2 => "S. Baldus" 3 => "U. Schäfer" 4 => "J. Hausleiter" 5 => "C. Butter" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2013.02.094" "Revista" => array:7 [ "tituloSerie" => "J Am Coll Cardiol." "fecha" => "2013" "volumen" => "62" "numero" => "12" "paginaInicial" => "1052" "paginaFinal" => "1061" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23747789" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extended use of percutaneous edge-to-edge mitral valve repair beyond EVEREST (Endovascular Valve Edge-to-Edge Repair) criteria - 30-day and 12-month clinical and echocardiographic outcomes from the GRASP (Getting Reduction of Mitral Insufficiency by Percutaneous Clip Implantation) registry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.F. Attizzani" 1 => "Y. Ohno" 2 => "Capodanno" 3 => "S. Cannata" 4 => "F. Dipasqua" 5 => "S. Immé" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol Intv." "fecha" => "2015" "volumen" => "8" "numero" => "1 Pt A" "paginaInicial" => "74" "paginaFinal" => "82" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute outcomes after MitraClip therapy in highly aged patients: results from the German Transcatheter Mitral Valve Interventions (TRAMI) Registry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W. Schillinger" 1 => "M. Hünlich" 2 => "S. Baldus" 3 => "T. Ouarrak" 4 => "P. Boekstegers" 5 => "U. Hink" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4244/EIJV9I1A13" "Revista" => array:7 [ "tituloSerie" => "EuroIntervention." "fecha" => "2013" "volumen" => "9" "numero" => "1" "paginaInicial" => "84" "paginaFinal" => "90" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23579108" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Percutaneous mitral valve repair with the MitraClip system for severe mitral regurgitation in patients with surgical mitral valve repair failure" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Grasso" 1 => "Y. Ohno" 2 => "G.F. Attizzani" 3 => "S. Cannata" 4 => "S. Immè" 5 => "M. Barbanti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2013.09.045" "Revista" => array:7 [ "tituloSerie" => "J Am Coll Cardiol." "fecha" => "2014" "volumen" => "63" "numero" => "8" "paginaInicial" => "836" "paginaFinal" => "838" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24161329" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "MitraClip therapy in surgical high-risk patients: identification of echocardiographic variables affecting acute procedural outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Lubos" 1 => "M. Schluter" 2 => "E. Vettorazzi" 3 => "B. Goldmann" 4 => "D. Lubs" 5 => "J. Schirmer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol Intv." "fecha" => "2014" "volumen" => "7" "numero" => "4" "paginaInicial" => "394" "paginaFinal" => "402" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictors of clinical outcomes after edge-to-edge percutaneous mitral valve repair" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "GRASP-IT Investigators" "etal" => true "autores" => array:6 [ 0 => "D. Capodanno" 1 => "M. Adamo" 2 => "M. Barbanti" 3 => "C. Giannini" 4 => "M.L. Laudisa" 5 => "S. Cannata" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ahj.2015.04.010" "Revista" => array:7 [ "tituloSerie" => "Am Heart J" "fecha" => "2015" "volumen" => "170" "numero" => "1" "paginaInicial" => "187" "paginaFinal" => "195" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26093881" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Improved functional status and quality of life in prohibitive surgical risk patients with degenerative mitral regurgitation after transcatheter mitral valve repair" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.S. Lim" 1 => "M.R. Reynolds" 2 => "T. Feldman" 3 => "S. Kar" 4 => "H.C. Herrmann" 5 => "A. Wang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2013.10.021" "Revista" => array:7 [ "tituloSerie" => "J Am Coll Cardiol." "fecha" => "2014" "volumen" => "64" "numero" => "2" "paginaInicial" => "182" "paginaFinal" => "192" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24184254" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transcatheter mitral valve-in-ring implantation in prohibitive surgical risk patients: single center initial experience in the United States" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G.F. Attizzani" 1 => "C.C. Tam" 2 => "A. Markowitz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Catheter Cardiovasc Interv." "fecha" => "2015" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transapical mitral valve implantation for the treatment of severe native mitral valve stenosis in a prohibitive surgical risk patient - importance of comprehensive cardiac computed tomography procedural planning" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.F. Attizzani" 1 => "A. Fares" 2 => "C.C. Tam" 3 => "B. Padaliya" 4 => "S. Mazzurco" 5 => "K. Popovich" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "J Am Coll Cardiol Intv." "fecha" => "2015" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/22141235/0000002300000002/v2_201612270115/S2214123515000290/v2_201612270115/en/main.assets" "Apartado" => array:4 [ "identificador" => "43276" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Editorials" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/22141235/0000002300000002/v2_201612270115/S2214123515000290/v2_201612270115/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2214123515000290?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 October | 16 | 0 | 16 |
| 2024 September | 4 | 1 | 5 |
| 2024 August | 13 | 2 | 15 |
| 2024 July | 11 | 0 | 11 |
| 2024 June | 9 | 6 | 15 |
| 2024 May | 19 | 1 | 20 |
| 2024 April | 9 | 4 | 13 |
| 2024 March | 17 | 7 | 24 |
| 2024 February | 16 | 5 | 21 |
| 2024 January | 7 | 1 | 8 |
| 2023 December | 8 | 5 | 13 |
| 2023 November | 8 | 3 | 11 |
| 2023 October | 8 | 2 | 10 |
| 2023 September | 9 | 1 | 10 |
| 2023 August | 6 | 5 | 11 |
| 2023 July | 12 | 4 | 16 |
| 2023 June | 5 | 1 | 6 |
| 2023 May | 6 | 5 | 11 |
| 2023 April | 11 | 1 | 12 |
| 2023 March | 5 | 1 | 6 |
| 2023 February | 8 | 3 | 11 |
| 2023 January | 6 | 5 | 11 |
| 2022 December | 10 | 2 | 12 |
| 2022 November | 9 | 5 | 14 |
| 2022 October | 14 | 8 | 22 |
| 2022 September | 9 | 7 | 16 |
| 2022 August | 9 | 6 | 15 |
| 2022 July | 7 | 4 | 11 |
| 2022 June | 8 | 8 | 16 |
| 2022 May | 9 | 6 | 15 |
| 2022 April | 6 | 10 | 16 |
| 2022 March | 9 | 9 | 18 |
| 2022 February | 5 | 5 | 10 |
| 2022 January | 8 | 5 | 13 |
| 2021 December | 9 | 8 | 17 |
| 2021 November | 11 | 7 | 18 |
| 2021 October | 17 | 6 | 23 |
| 2021 September | 6 | 9 | 15 |
| 2021 August | 4 | 6 | 10 |
| 2021 July | 7 | 3 | 10 |
| 2021 June | 6 | 8 | 14 |
| 2021 May | 15 | 12 | 27 |
| 2021 April | 31 | 9 | 40 |
| 2021 March | 31 | 7 | 38 |
| 2021 February | 10 | 4 | 14 |
| 2021 January | 17 | 8 | 25 |
| 2020 December | 4 | 10 | 14 |
| 2020 November | 5 | 6 | 11 |
| 2020 October | 5 | 4 | 9 |
| 2020 September | 10 | 13 | 23 |
| 2020 August | 8 | 5 | 13 |
| 2020 July | 3 | 3 | 6 |
| 2020 June | 5 | 0 | 5 |
| 2020 May | 5 | 4 | 9 |
| 2020 April | 1 | 2 | 3 |
| 2020 March | 3 | 2 | 5 |
| 2020 February | 7 | 6 | 13 |
| 2020 January | 5 | 5 | 10 |
| 2019 December | 6 | 10 | 16 |
| 2019 November | 4 | 2 | 6 |
| 2019 October | 4 | 2 | 6 |
| 2019 September | 4 | 1 | 5 |
| 2019 August | 2 | 0 | 2 |
| 2019 July | 3 | 13 | 16 |
| 2019 June | 1 | 0 | 1 |
| 2019 May | 7 | 15 | 22 |
| 2018 November | 1 | 0 | 1 |
| 2018 October | 1 | 0 | 1 |
| 2018 September | 6 | 3 | 9 |
| 2018 August | 44 | 15 | 59 |
| 2018 July | 31 | 10 | 41 |
| 2018 June | 61 | 9 | 70 |
| 2018 May | 47 | 9 | 56 |
| 2018 April | 69 | 9 | 78 |
| 2018 March | 114 | 7 | 121 |
| 2018 February | 86 | 14 | 100 |
| 2018 January | 34 | 8 | 42 |
| 2017 December | 70 | 9 | 79 |
| 2017 November | 34 | 10 | 44 |
| 2017 October | 18 | 10 | 28 |
| 2017 September | 24 | 10 | 34 |
| 2017 August | 27 | 11 | 38 |
| 2017 July | 25 | 11 | 36 |
| 2017 June | 48 | 12 | 60 |
| 2017 May | 52 | 16 | 68 |
| 2017 April | 43 | 14 | 57 |
| 2017 March | 25 | 32 | 57 |
| 2017 February | 25 | 9 | 34 |
| 2017 January | 26 | 14 | 40 |
| 2016 December | 33 | 18 | 51 |
| 2016 November | 17 | 8 | 25 |
| 2016 October | 14 | 8 | 22 |
| 2016 September | 20 | 8 | 28 |
| 2016 August | 28 | 10 | 38 |
| 2016 July | 27 | 18 | 45 |
Show all