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Vol. 14. Issue 4.
Pages 240-244 (January 2010)
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Vol. 14. Issue 4.
Pages 240-244 (January 2010)
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Carcinoma papilar de tiroides, variante esclerosante difusa: un subtipo histológico de difícil diagnóstico
Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma: a Histological Type With Difficult Diagnosis
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Alfredo Romero1,
Corresponding author
aromero@cancer.gov.co

Correspondencia: Alfredo Ernesto Romero-Rojas. Instituto Nacional de Cancerología, Av. 1a No. 9-85, Bogotá, D.C., Colombia. Teléfono: 334 1997.
, Ivonne Meza2
1 Grupo de Patología, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia
2 Grupo de Patología, Universidad del Cauca, Popayán, Colombia
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Resumen

El carcinoma papilar de tiroides constituye el tumor maligno más frecuente de la glándula tiroides y en general tienden a tener un buen comportamiento biológico, sin embargo algunas variantes histológicas, como la esclerosante difusa tienden a mostrar una mayor agresividad con compromiso locorregional y metástasis a distancia. Esta variante es un reto diagnóstico para el patólogo por las especiales características arquitecturales y citológicas, ya que puede con llevar a diagnósticos incorrectos, en especial al ser confundido lesiones benignas con una tiroiditis linfocítica. Describimos un caso de un paciente atendido en Instituto Nacional de Cancerología de Colombia con carcinoma papilar de tiroides variedad esclerosante con enfermedad metastásica pulmonar. Por tratarse de una variante infrecuente de carcinoma papilar de tiroides reportamos este caso por las dificultades que genera tanto al clínico como al patólogo tanto en su detección inicial así como en su morfología, con las subsecuentes implicaciones debido a su comportamiento biológico más agresivo.

Palabras clave:
neoplasia de tiroides
carcinoma papilar
diagnóstico
Abstract

The papillary thyroid carcinoma is the most frequent thyroid neoplasm and usually it is a non aggressive tumor; nevertheless, some histological variants such as the diffuse sclerosing variant are more aggressive producing locoregional invasion and distant metastasis. This specific variant challenges the pathological diagnosis since the architectural and cytological characteristics might be confusing, particularly regarding benign lesions such as the lymphocytic thyroiditis. We present a case report of a patient at the National Cancer Institute of Colombia with a lung metastasis from a diffuse sclerosing papillary thyroid carcinoma. The difficulties for diagnosis, for both clinical and pathology experts, are illustrated as well as their relevance for determining the biological course of the disease.

Key words:
Thyroid neoplasms
carcinoma
papillary
diagnosis
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