Article information
Resumen
El tratamiento neoadyuvante —también denominado “terapia primaria sistémica” o “terapia preoperatoria”— tiene cuatro finalidades en cáncer de mama: disminuir el volumen tumoral para hacer operable lo que antes era inoperable, mejorar las probabilidades para hacer una cirugía conservativa, analizar la quimiosensibilidad in vivo y evaluar el manejo de las micrometástasis. Esta revisión descriptiva toma en cuenta los principales estudios clínicos sobre terapia sistémica neoadyuvante publicados hasta mayo del 2009.
Palabras clave:
neoplasias de la mama
terapia neoadyuvante
protocolos antineoplásicos
trastuzumab
lapatinib
bevacizumab
tamoxifeno
tasas de supervivencia
supervivencia libre de enfermedad.
Abstract
Neoadjuvant treatment —also known as primary systemic therapy or preoperative therapy— has four objectives when applied to breast cancer: to reduce inoperable tumoral volume to operable size; to enhance the possiblility for conservative surgery; to analyze chemosensitivity in vivo; and, to evaluate the management of micrometastasis. This descriptive review takes into account the major clinical studies on systemic neoadjuvant therapy published as of May, 2009.
Key words:
Breast neoplasm
neoadjuvant therapy
antineoplastic protocols
trastuzumab
lapatinib
bevacizumab
tamoxifen
survival rate
disease free survival.
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