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Vol. 20. Issue 3.
Pages 149-153 (May - June 2013)
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Vol. 20. Issue 3.
Pages 149-153 (May - June 2013)
Open Access
Efectos cardiovasculares de fingolimod en el tratamiento de la esclerosis múltiple
Cardiovascular effects of fingolimod in the treatment of multiple sclerosis
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Miguel A. Urina1,2,
Corresponding author
miguelurina@fundacionbios.org

Correspondencia: carrera 50 No. 80-216, Barranquilla, Colombia.
, Catalina Rojas3, Daniela Urina1
1 Fundación del Caribe para la Investigación Biomédica. Barranquilla, Colombia
2 Universidad Simón Bolivar. Barranquilla, Colombia
3 Novartis. Bogotá, Colombia
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Fingolimod es un medicamento modificador de la enfermedad para pacientes con esclerosis múltiple de tipo recaída remisión; la molécula es un análogo de esfingosina fosfato que debido a su mecanismo de acción, produce en 0,5% de los pacientes, una disminución de la frecuencia cardíaca durante la administración de la primera dosis y un aumento leve de la presión arterial al segundo mes de tratamiento. En este articulo se revisan los mecanismos celulares por los cuales fingolimod causa estos eventos y se reportan recomendaciones de seguridad basados en la US Food and Drug Administration (FDA) para el inicio de pacientes en tratamiento con este medicamento.

Palabras clave:
frecuencia cardiaca ;farmacología

Fingolimod is a disease modifying drug for patients with relapse remitting multiple sclerosis (RRMS). The molecule is a sphingosine phosfate analog that because of its mechanism of action causes a decrease in heart rate during the administration of the first dosis and a slight increase in blood pressure in the second month of treatment in 0.5% of patients. We review in this article the cellular mechanisms by which fingolimod causes these events and report safety recommendations based on US Food and Drug Administration (FDA) for initiating treatment with this drug.

Keywords:
heart rate ;pharmacology
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Copyright © 2013. Sociedad Colombiana de Cardiología y Cirugía Cardiovascular
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