Relación entre el estrés de fricción endotelial y la vasodilatación mediada por flujo en primigestantes saludables

Article information

La vasodilatación mediada por flujo (VMF) es una medida fisiológica que permite estimar de manera no invasiva la función endotelial. De igual forma, se la asocia con algunos factores de riesgo cardiovascular y con eventos cardiovasculares.

El objetivo de este estudio es presentar la primera exploración de la normalización de los datos de la VMF durante la gestación y examinar la relación del estrés de fricción endotelial (EFE) y la normalización de la vasodilatación mediada por flujo (nVMF) en esta población. Se encontró una relación entre la VMF y la nVMF (R2=0,782, p<0,05), pero no entre la VMF y el EFE (R2=0,782, p>0,05), ni entre el EFE y la nVMF (R2=0,013, p>0,05). Futuras investigaciones, cuidadosamente diseñadas, podrían estudiar esta propuesta en diferentes poblaciones. Los autores sugieren que la VMF y la nVMF, alguna vez podrán ser consideradas como herramientas con aplicabilidad clínica para estimar el riesgo cardiovascular.

Palabras clave:

embarazo

función endotelial

estrés de fricción

Flow-mediated vasodilation (FMV) is a physiological measure to non-invasively estimate endothelial function. Similarly, it is associated with some cardiovascular risk factors and cardiovascular events.

The aim of this study is to present the first exploration of the standardization of FMV data during pregnancy and examine the relationship of endothelial friction stress (EFE) and the normalization of flow-mediated vasodilation (nMFV) in this population. A relationship between VMF and nVMF (R2 = 0.782, p <0.05) was found, but not between the VMF and the EFE (R2 = 0.782, p> 0.05) or between the EFE and nVMF (R2 = 0.013, p> 0.05). Future research, carefully designed, could examine this proposal in different populations. We suggest that MFV and nMFV, may ever be seen as tools with clinical applications to estimate cardiovascular risk.

Keywords:

pregnancy

endothelial function

shear stress

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