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Inicio Revista Colombiana de Psiquiatría (English Edition) Haematological adverse effects associated with olanzapine in adolescents with an...
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Vol. 53. Issue 1.
Pages 107-111 (January - March 2024)
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Vol. 53. Issue 1.
Pages 107-111 (January - March 2024)
Case Report
Haematological adverse effects associated with olanzapine in adolescents with anorexia nervosa: Three case reports
Efectos adversos hematológicos asociados con olanzapina en adolescentes con anorexia nerviosa: reporte de 3 casos
Elard Bottoni-Tito, Wendy Messa-Aguilar
Corresponding author
wenles.3@gmail.com

Corresponding author.
Departamento de Salud Mental, Unidad de Psiquiatría Infanto Juvenil, Hospital Nacional Edgardo Rebagliati Martins, Essalud, Lima, Peru
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Abstract
Objectives

To describe haematological adverse effects in adolescents with anorexia nervosa who are taking olanzapine.

Methods

Case series report.

Case report

The reported cases (two female patients and one male) were found to have blood test abnormalities after starting olanzapine and to rapidly recover their platelet and neutrophil values after the drug was discontinued. Low haemoglobin values persisted longer than observed in other series. These abnormalities became more noticeable when the dose of olanzapine was increased to 5 mg/day (initial dose 2.5 mg/day). It should be noted that two of the patients already had values indicative of mild neutropenia before they started the antipsychotic drug, and that these worsened as they continued taking the drug. In one of the patients there was only a decrease in neutrophil values, as well as mild anaemia.

Conclusions

This first case series of haematological abnormalities in adolescents with anorexia nervosa who are taking olanzapine found values corresponding to pancytopenia in two of the three cases reported. It would be worthwhile to consider heightening haematological surveillance in this population when starting treatment with olanzapine and rethinking our knowledge regarding the frequency of these side effects.

Keywords:
Olanzapine
Anorexia nervosa
Adolescent
Neutropenia
Anaemia
Resumen
Objetivos

Describir los efectos adversos hematológicos en adolescentes con anorexia nerviosa que toman olanzapina.

Métodos

Reporte de serie de casos.

Reporte de caso

En los casos reportados (2 mujeres y 1 varón) se evidenciaron alteraciones de las series sanguíneas tras el inicio de olanzapina y una recuperación rápida de los valores de plaquetas y neutrófilos tras la suspensión del fármaco. Los valores bajos de hemoglobina persistieron más que en las otras series. Dichas alteraciones se hicieron más ostensibles al incrementarse la dosis de olanzapina a 5 mg/día (dosis inicial, 2,5 mg/día). Cabe resaltar que antes del inicio del psicofármaco 2 de los pacientes ya tenían valores en la banda de la neutropenia leve, que fueron empeorando a medida que se instalaba el antipsicótico. En uno de los pacientes solo se redujeron los valores de neutrófilos junto con anemia leve.

Conclusiones

Este es el primer reporte de casos de alteraciones hematológicas en adolescentes con anorexia nerviosa que toman olanzapina, y se hallaron valores de pancitopenia en 2 de los 3 casos estudiados. Se debería considerar una mayor vigilancia hematológica en dicha población al iniciar el tratamiento con olanzapina y replantear nuestros conocimientos en cuanto a la frecuencia de dichos efectos secundarios.

Palabras clave:
Olanzapina
Anorexia nerviosa
Adolescente
Neutropenia
Anemia

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