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array:23 [ "pii" => "S003474501370026X" "issn" => "00347450" "doi" => "10.1016/S0034-7450(13)70026-X" "estado" => "S300" "fechaPublicacion" => "2013-12-01" "aid" => "70026" "copyright" => "Asociación Colombiana de Psiquiatría" "copyrightAnyo" => "2013" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Rev Colomb Psiquiatr. 2013;42:304-10" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 9477 "formatos" => array:3 [ "EPUB" => 64 "HTML" => 8987 "PDF" => 426 ] ] "itemSiguiente" => array:18 [ "pii" => "S0034745013700271" "issn" => "00347450" "doi" => "10.1016/S0034-7450(13)70027-1" "estado" => "S300" "fechaPublicacion" => "2013-12-01" "aid" => "70027" "copyright" => "Asociación Colombiana de Psiquiatría" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Rev Colomb Psiquiatr. 2013;42:311-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4155 "formatos" => array:3 [ "EPUB" => 49 "HTML" => 3360 "PDF" => 746 ] ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Signos de liberación cortical en pacientes con esquizofrenia, trastornos depresivos, trastorno afectivo bipolar, demencia y enfermedad cerebrovascular" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "311" "paginaFinal" => "319" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Cortical Release Signs in Patients with Schizophrenia, Depressive Disorders, and Bipolar Affective Disorder" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figura 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 759 "Ancho" => 1005 "Tamanyo" => 83831 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Reflejo palmomentoniano.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ricardo Andrés de la Espriella, José Fernando Hernández, Lina María Espejo" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Ricardo Andrés" "apellidos" => "de la Espriella" ] 1 => array:2 [ "nombre" => "José Fernando" "apellidos" => "Hernández" ] 2 => array:2 [ "nombre" => "Lina María" "apellidos" => "Espejo" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0034745013700271?idApp=UINPBA00004N" "url" => "/00347450/0000004200000004/v1_201401010022/S0034745013700271/v1_201401010022/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0034745013700258" "issn" => "00347450" "doi" => "10.1016/S0034-7450(13)70025-8" "estado" => "S300" "fechaPublicacion" => "2013-12-01" "aid" => "70025" "copyright" => "Asociación Colombiana de Psiquiatría" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Rev Colomb Psiquiatr. 2013;42:303" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2338 "formatos" => array:3 [ "EPUB" => 51 "HTML" => 1762 "PDF" => 525 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "La crisis del sistema de salud colombiano" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "303" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The Crisis in the Colombian Healthcare System" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carlos A. Palacio Acosta" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Carlos A." "apellidos" => "Palacio Acosta" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0034745013700258?idApp=UINPBA00004N" "url" => "/00347450/0000004200000004/v1_201401010022/S0034745013700258/v1_201401010022/es/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "titulo" => "“When I Want to Cry I Can’t”: Inability to Cry Following SSRI Treatment" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "304" "paginaFinal" => "310" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Jorge Carlos Holguín-Lew, Vaughan Bell" "autores" => array:2 [ 0 => array:4 [ "nombre" => "Jorge Carlos" "apellidos" => "Holguín-Lew" "email" => array:1 [ 0 => "jcholguin.conciencia@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Vaughan" "apellidos" => "Bell" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Departmento de Psiquiatría, Universidad de Antioquia, Colombia" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Visiting Senior Research Fellow, Institute of Psychiatry, King's College, London, United Kingdom" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "«Cuando quiero llorar, no lloro»: incapacidad para llorar tras el tratamiento con inhibidores selectivos de la recaptación de serotonina" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleDisplayedQuote" id="dsq0005"><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">“Cuando quiero llorar, no lloro, y a veces lloro sin querer…”</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">(Canción de Otoño en Primavera, <span class="elsevierStyleItalic">Rubén Darío</span>)</p></span></p><p id="par0010" class="elsevierStylePara elsevierViewall">Dysfunctions in emotional modulation, experience, and ex pres sion are frequent in patients with both primary and secon dary psychiatric disorders. Uncontrollable or involuntary crying has been widely reported after many types of neurological damage or disease, where it may be labelled as ‘pathological laughing or crying’, ‘pseudobulbar affect’, ‘emotionalism’ or ‘involuntary emotional expression disorder’ (IEED) to name but a few of the many terms in use.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Conversely, while crying is most typically associated with mood disorders, evidence that depression leads to more frequent crying, or, conversely, that severely depressed individuals lose their capacity to cry, is mixed, and little reliable empirical evidence for the connection between mood pathology and crying can be found in the literature.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> However, it is clear from the clinical literature that crying behaviour and emotional distress can dissociate, so people who experience involuntary crying may not necessarily experience the subjec tive emotional feeling that usually accompanies these episodes.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> This paper reports on 7 cases that demonstrate the reverse dissociation, an inability to cry after intervention with selective serotonin reuptake inhibitor (SSRI) medication, despite the subjective emotional feeling of sadness and the urge to cry, indicating a perhaps under-recognised adverse effect and providing further evidence for the neural basis of crying regulation.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Previous studies on the possible neurological basis of pathological crying have not come to any clear conclusions as to which neural circuits are implicated in the condition and, to complicate matters for those specifically interested in crying, it is often the case that excessive crying and excessive laughing are studied as the same phenomenon. The first and still influential theory of pathological laughing and crying suggests that it results from ‘disinhibition’ or ‘release phenomenon’ after damage to the voluntary inhibitory mechanisms in the upper brain stem.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> However, it has become increasingly clear that excessive crying is not obviously linked to damage to any one specific brain area.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Indeed, prior reports based on lesion data have implicated a wide range of specific cortical and subcortical areas, with recent theories focusing on two major pathways: the cerebro-ponto-cerebellar pathway<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> and the cortico-limbic-subcortico-thalamic-ponto-cerebellar network.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> In a recent review of the literature, however, Nieuwenhuis-Mark et al<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> noted that the most commonly implicated areas from the lesion data include the limbic system, brain stem and frontal lobes, as well as evidence for excessive crying being linked to a greater level of overall damage and a lower ratio of serotonin transporter (SERT) binding ratios in the brain stem.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The link with serotonin transporter has emerged from two neuroimaging studies that have used radioligand binding to understand serotonin function in stroke patients with pathological crying. A single-photon emission computed tomography (SPECT) study by Murai<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> found lower SERT binding ratios in the midbrain and pons in pathological crying patients compared to non-affected controls, while a positron emission tomography (PET) study by Møller, Andersen et al<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> found a globally lower level of 5HT<span class="elsevierStyleInf">1A</span> receptor binding associated with pathological crying. This is in line with evidence that serotonergic medication is an effective treatment for excessive crying,<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> and that it typically resolves crying episodes at lower doses than are needed to treat depression. Furthermore, resolution of excessive crying typically occurs within days, in contrast to the several weeks typically needed for the mood elevating effects.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12–14</span></a> In line with this, excessive crying is recognized as a symptom of SSRI discontinuation syndrome.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">From this evidence, a clear prediction emerges that the over-modulation of serotonergic pathways would induce the inability to cry in some patients. However, this is a topic that has rarely been addressed in the clinical literature. In fact, to our knowledge, only two minor reports exist. In a letter to the editor, Oleshansky et al<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> discussed 3 patients who seemingly ‘lost’ their ability to cry after starting treatment with SSRI medication with examples of specific episodes that typically caused crying in the past but no longer triggered a tearful response. In addition, a short report by Opbroek et al.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> described 15 patients with sexual dysfunction after SSRI treatment, of which 60% (n=9), reported that they experienced<a name="p306"></a> the ability to cry ‘a lot less than usual’. However, no con textual details were given, so it is difficult to say to what extent this effect may have been due to changes in exposure to emotional stimuli, changes in appraisal of emotional events, or a loss of ability to control tears, all three of which are cited as possible processes having an effect on crying frequency.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In the present study we report a series of 7 psychiatric patients without neurological damage who presented with an inability to cry during treatment with SSRIs, even during extremely sad or moving situations that were cited as likely to have previously initiated a crying episode. We discuss implications for serotonergic models of emotional control and the understanding of how subjective emotional feeling and emotional expression may dissociate.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Case Reports</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Case 1</span><p id="par0035" class="elsevierStylePara elsevierViewall">A female patient aged 43, presented to psychiatric consultation due to a depressive episode, with profound sadness and anhedonia, sleep disturbance, low energy, negative cognitions, and difficulties in concentration. On the first consultation, she scored 27 on the Beck Depression Inventory version 1A (BDI). A neurological examination and recent CT scan reported no abnormalities and she had no history of neurological disease or acquired brain injury. A general physical examination found no abnormalities and blood, glucose, thyroid, hepatic function and creatinine tests were all in the normal range. The patient was started on escitalopram 10<span class="elsevierStyleHsp" style=""></span>mg/day. After five weeks of treatment she reported feeling quite well and her score on the BDI reduced to 8, within the ‘no depression’ range. After 2 months of treatment, she felt she was no longer depressed and considered that her day-to-day functioning, relationships and quality of life had returned to normal. However, she mentioned she had noticed something that seemed very curious to her — her pet dog had died one week ago and although she felt very sad and wanted to cry, she was unable. She reported the experience as puzzling: “I felt a bit strange, you know… I really wanted to cry, and I was feeling like if I was on the brink of doing it, but it is like if my face and my eyes could not do it”. She was emphatic in saying that she was not apathetic, that her capacity for enjoying life was preserved, that it was something only affecting her capacity for crying. She did not want to stop the medication, fearing a relapse. The patient has continued taking the medication, and the inability to cry has persisted. She considered this as a curious but tolerable side-effect, although she wondered if being unable to cry would have later consequences because of “repressed sad feelings”, considering crying as cathartic and that being unable to cry might “not be good for your mental health”.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Case 2</span><p id="par0040" class="elsevierStylePara elsevierViewall">A 23 year-old male patient presented to psychiatric consultation with a history of obsessive compulsive disorder commencing around the age of 15. His obsessions included intrusive thoughts concerning obscenities and contamination. His compulsions were restricted to washing rituals. He did not tolerate sertraline, because of nausea and sleepiness, and he was subsequently started on fluvoxamine which was increased to 300<span class="elsevierStyleHsp" style=""></span>mg/day and was tolerated well. After 8 weeks of taking fluvoxamine, severity, frequency and interference of both obsessions and compulsions were greatly diminished. He reported no comorbid depression, but fulfilled criteria for generalised anxiety disorder, although he reported that he felt his tendency for excessive worry had improved with treatment. After four months of treatment he noticed that he was unable to cry. Two weeks before the consultation he ended his romantic relationship and felt sad, wanting to cry, but could not, as if his “capacity for crying was frozen”. He was neither apathetic, nor depressed (BDI score 7). After discussing the matter with him, he preferred not to change fluvoxamine treatment, because, apart from the inability to cry, he was very satisfied with the results of the treatment and considered this side effect a minor inconvenience.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Case 3</span><p id="par0045" class="elsevierStylePara elsevierViewall">A 30 year-old male patient presented to consultation because of a depressive episode that started at least 5 months previously, with a score of 25 on the BDI. This was his third major depressive episode. A CT scan, neurological examination, thyroid levels, and other general laboratory exams were normal. The patient had a history of good response and remission with sertraline 100<span class="elsevierStyleHsp" style=""></span>mg/day in all previous episodes and was subsequently restarted on this treatment regime. After 8 weeks of treatment, his depression was in remission, scoring 5 (‘no depression’) on the BDI. However, he noticed that he was unable to cry, even when feeling sad. He described the situation where his mother was diagnosed with a severe coronary disease, and, although he felt very sad and wanted to cry, he couldn’t because “it was as if I had no tears, as if my face didn’t remember how to cry”. He remembered having the same experience during previous treatments, but he did not feel the need to mention it. Subsequent to this point, the patient has been on the treatment for 12 months, and the inabi lity to cry has diminished, although he says that it is still present to a certain degree. He considers that crying could be healthy on some occasions, but that usually he was not a “very tearful person” and that he only tended to cry and being excessively moved by events when depressed or with severe stressors.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Case 4</span><p id="par0050" class="elsevierStylePara elsevierViewall">A 45 year-old female patient presented to consultation with her fourth depressive episode. She had previously been prescribed buproprion and venlafaxine but these treatments were abandoned because of side-effects (mainly headache, constipation, irritability and dizziness). She also had previous treatment with f luoxetine 20<span class="elsevierStyleHsp" style=""></span>mg/day that she tolerated<a name="p307"></a> better, although with diminished libido. After discussing alternatives, the patient was prescribed citalopram 20<span class="elsevierStyleHsp" style=""></span>mg/day. A CT scan, neurological examination, thyrioid test and other medical examinations were normal. The initial BDI score was 23. After 4 weeks, she reported feeling much better and quite comfortable with the citalopram (BDI score 13). However, after week 12 she complained of diminished sexual desire and a delay in reaching orgasm. Although in her opinion, the side-effect was less than with fluoxetine, she was motivated to request a consultation to discuss alternatives. During the meeting she remarked “a quite surprising inability to cry”. She noticed that when watching very moving films (an event that almost always led her to cry) she “simply couldn’t cry”. She reported no apathy, depression, anhedonia or other mood manifestations (BDI score 9). She found that the experience of not being able to cry was surprising, but not really distressing. Buspirone, up to 40<span class="elsevierStyleHsp" style=""></span>mg/day for 6 weeks, was added to her treatment regime in an attempt to address the sexual side-effects. Sexual function improved although not to levels previous to treatment. She also noticed that her ability to cry had improved (e.g., she would shed tears in a very moving movie, she cried during a memorial service and found that in both occasions “it felt right and relieving to cry”). She remains on both treatments and feels satisfied with them.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Case 5</span><p id="par0055" class="elsevierStylePara elsevierViewall">A 60 year-old woman presented to consultation with a seventh major depressive episode and a history of previous treatments with sertraline and escitalopram. CT scan was reported as normal for her age, with no evidence of vascular disease or atrophy or other findings that would make think about a neurological disease. Although she had a history of hypothyroidism, she was on treatment and a recent thyroid work-up was within normal range. She was subsequently prescribed escitalopram 10<span class="elsevierStyleHsp" style=""></span>mg/day and, after 7 weeks of treatment, she reported significant improvement. However, she noted that she was unable to cry when going to the cemetery to visit her husband's grave or when one of her grand children had an accident. She felt that “I was very sad but I was like dry inside. I wanted to cry, but couldn’t shed a single tear”. After 10 weeks, her depression was markedly improved although her inability to cry continued. She is still on the same treatment and the inability to cry continues without change although the patient does not feel this side-effect warrants a change of treatment. She was not concerned by the inability to cry in itself, but she considered that the fact she was not able to shed tears when visiting her late husband's tomb “was not right”.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Case 6</span><p id="par0060" class="elsevierStylePara elsevierViewall">A 35 year-old male patient reported to consultation with a third depressive episode. A neurological examination found no abnormalities, and other medical tests (blood, thyroid, HIV, blood sugar, etc.) were normal. The patient had no prior history of previous pharmacological treatment. He was started on escitalopram 10<span class="elsevierStyleHsp" style=""></span>mg/day and reported that his depression had significantly improved after 4 weeks. However, he complained about a significant decrease in sexual desire and delayed ejaculation. He also noticed that, paradoxically, when feeling sad, he was unable to cry. For example, he remembered that he saw reports of hostages being released he felt very moved, saying “emotionally I was crying, but in my face no change happened”. Similarly during a very difficult argument with his boyfriend he remembered that “I wanted to cry, I feel like crying, but my body doesn’t respond, like if my crying apparatus is broken”. He wanted to wait longer before thinking about changing his medication hoping that the sexual side effects would subside. He experienced the inability to cry as something curious, but not especially distressing. However, he wanted to be able to cry in appropriate situations, for example, during a memorial service, because it seemed to him that not being able to cry in some circumstances might not be polite or healthy. Several weeks later, he went on a three day trip, and forgot to take his medication. Besides the usual discomfort due to sudden SSRI discontinuation, he had several “crying spells”. He described these spells as “crying without reason, like veritable storm of tears”. He was emphatic in denying any sad mood accompanying the crying spells. After a further consultation, the patients started mirtazapine, that was not well tolerated due to excessive sleepiness. Subsequently, he was prescribed brupropion, and had a noticeable increase in anxiety and irritability. Finally, he was started on reboxetine, that effectively treated his depression without sexual dysfunction. He has reported no further episodes of an inability to cry.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Case 7</span><p id="par0065" class="elsevierStylePara elsevierViewall">A 34 year-old female patient reported to consultation owing to an onset of a major depressive episode. The patient had a prior diagnosis of dysthymia and double depression (a concept used more widely in the Americas, that describes an acute episode of major depressive disorder superimposed on dysthymia<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a>), and had a history of good symptomatic response to paroxetine. She was therefore restarted on paroxetine 20<span class="elsevierStyleHsp" style=""></span>mg, but after 5 weeks the response was still partial and therefore the dosage was increased. Three weeks later she reported having continued improvement and after 12 weeks she was reported feeling significantly improved and did no longer qualified for a diagnosis of major depression. However she complained of low sexual desire and delay in orgasm. She also noticed that “When I want to cry, I can’t. It's like my body had forgotten how to cry. I try, but I can’t.” For example, one of her neighbours died, an event that usually would have led her to cry, but he was not able to do so. She noticed a similar inability after arguments with her partner or mother. She was concerned whether being unable to cry was normal or whether it would have negative consequences. However, she preferred to continue paroxetine treatment, because of the improvement of her mood symptoms. In order to improve sexual response, burproprion 150<span class="elsevierStyleHsp" style=""></span>mg/day was added. After several weeks, sexual desire and response improved. However, her inability to cry has continued.<a name="p308"></a></p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discussion</span><p id="par0070" class="elsevierStylePara elsevierViewall">We have reported 7 cases in which patients treated with a diverse range of SSRIs presented with an inability to cry after several weeks of treatment, even when distressed and in situation which would normally lead to crying. This was recounted by patients as if the bodily systems involved in crying were “frozen”, had “broken” or that the “body had forgotten how to cry”, in which the patients demonstrated a dissociation between the presence of subjective feelings of distress and an urge to cry; and the expressive, motor components of affect. It is important to emphasise that the patients were neither apathetic nor blunted in their feelings — i.e. their subjective experience of emotion was preserved.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Significantly, several of the patients reports that this inability manifested itself in situations where they would normally have cried on previous, pre-treatment, occasions; that they appraised the situation as emotionally distressing; and that they experienced an urge to cry. Nieuwenhuis-Mark et al<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> have criticised some earlier studies of crying, noting that they often do not specifically address differences in exposure to emotional stimuli, changes in appraisal of emotional events, or the control of the urge and expression of tears, and it is notable that, unlike the present study, neither of the previous two reports of reduced crying after SSRI treatment<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> allow these factors to be fully accounted for.</p><p id="par0080" class="elsevierStylePara elsevierViewall">These case studies provide further evidence of the importance of serotonergic systems in the control of crying. While all SSRI medication is thought to derive its clinical effect from the high affinity for the serotonin transporter and the in creases in the eff iciency of post-synaptic 5HT transmission,<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> the secondary effects of individual compounds are remarkably variable. Indeed, compounds associated with inability to cry in the present study have a range of secondary effects: fluvoxamine on sigma-1 receptors, paroxetine on muscarinic receptors, sertraline on dopamine receptors, and citalopram and escitalopram on histamine receptors (review in Carrasco et al<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a>). The fact that in the present study an inability to cry was associated with a range of SSRIs with differing secondary effects suggests that it is the primary action on increasing synaptic availability of serotonin which mediates the effect. This is in line with clinical evidence that SSRIs can treat pathological crying,<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> that SSRI discontinuation can lead to crying spells<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>, and the radioligand neuroimaging evidence of lower serotonin turnover in subcortical areas associated with pathological crying after stroke.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">It is notable that all patients reported here described a dissociation between crying and subjective feelings of sadness. Indeed, this dissociation has been reported previously, although typically in its opposite form, where pathological crying is present without the subjective emotional component. This has been reported in cases of acquired brain injury, stroke, multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease and Alzheimer's disease (see review in Wortzel et al<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a>), as well as a side-effect of deep brain stimulation to the caudal internal capsule<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a>, and the subthalamic nucleus.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> While this dissociation is most commonly reported after neurological disorder, as the phenomena of experienced emotion without the normal behavioural expression is known in schizophrenia, where diminished facial expression of emotion can be accompanied by a full subjective emotional experience.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">From a psychopathological point of view, an understanding of how expression and subjective emotion may dissociate is still in a very preliminary state with a more refined conceptualisation still lacking. With this in mind, we offer a tentative classification of how syndromes could be categorised by the distinction of emotional expression and emotional experience (<a class="elsevierStyleCrossRef" href="#tbl0005">table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">At present, the justification for our classification is largely based on clinical observation: patients complain of excesses or deficits in the experience of some emotions and/or their expression. On the basis of the value of dissociation in cognitive neuropsychiatry research<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a>, this plausible although tentative descriptive classification suggests that there may be distinct mechanisms underlying subjective experience and emotional expression (importantly, beyond the simple control of the musculature), although exactly how distinct and how separable in terms of cognitive and neural subsystems remains to be seen. For example, we would expect at the least a significant two-way feedback between the experience and expression components considering evidence that voluntarily forming expressions can have a reciprocal effect on mood (e.g. Kleinke et al<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a>).</p><p id="par0100" class="elsevierStylePara elsevierViewall">It is also notable that the patients reported here did not report apathy or emotional blunting, suggesting that inability to cry was dissociated from both. This is important as each can evidently present as symptoms of major depression, and moreover, each has been reported as a result of SSRI treatment.<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> In this case series, however, an inability to cry was associated with other ‘inhibitory’ side-effects: in cases 4, 6 and 7, sexual dysfunction was apparent and, interestingly, intervention to counteract or compensate for this well-known serotoninergic side-effect also reversed the inability to cry. In patient 6, the reversal of inability to cry can be considered extreme, because of the subsequent presentation of crying spells on unplanned withdrawal of citalopram. Although there is no research that addresses this directly, we wonder whether these ‘inhibitory’ effects may be on a continuum,<a name="p309"></a> where greater serotonergic modulation has an increasingly inhibitory effect on some function or patients to the point of apathy at the most extreme end of the spectrum.</p><p id="par0105" class="elsevierStylePara elsevierViewall">With regards to the possible clinical effects of an inability to cry, it is notable that the experience was reported as noteworthy enough to mention to a doctor but not particularly distressing in itself. The reporting of this experience in a clinical context remind us of the social and cultural components of emotional expression that form part of the attribution that something seems out of the ordinary or emotionally ‘wrong’ and it is notable that several of the patients mentioned that they were concerned about the consequences for their mental health, reflecting the widespread view that crying is cathartic.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> However, empirical support for the catharsis hypothesis is mixed and the cathartic effect of crying has been found to be modulated by the response of others, as much as any intrinsic value to crying itself.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> Perhaps most relevantly, a recent study, albeit solely on women,<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> found that while the majority (89%) reported relief from crying, those with symptoms of depression, anxiety, anhedonia and/or alexithymia reported that crying left them feeling worse or just the same. However, in this case series, the majority of patients had recovered from their index diagnosis while being unable to cry, and it is not clear from this evidence whether this inability prevents them from accessing a useful form of emotional release, protects them from unhelpful crying spells (particularly considering the psychological and neurobiological vulnerability factors still present in recovered depressed patients<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a>), or has no effect either way.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conclusions</span><p id="par0110" class="elsevierStylePara elsevierViewall">We report a dissociation between intact subjective emotional distress and impaired ability to cry related to the use of SSRI medication. Although the study has limitations inherent to case series (mainly selection bias and retrospective analysis) we hope that it stimulates further research in this area particularly in light of its theoretical support from the previous literature on the serotonin system and crying. From a clinical perspective an inability to cry may diminish the tolerability and acceptability of treatment for the patient, particularly in light of the popularly accepted ‘cathartis model’ of crying despite the fact that the current literature does support the popular idea that being unable to cry is emotionally harmful. From a scientific perspective, the clinical dissociation of emotional experience and expression suggests a distinction between underlying cognitive and neurobiological mechanisms and provides a basis for further prospective studies in this area.</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conflicto de intereses</span><p id="par0115" class="elsevierStylePara elsevierViewall">Jorge Holguin Lew ha sido conferencista remunerado en actividades académicas financiadas por Astra Zeneca, Lundbeck, Jannssen, Novartis, Eli-Lilly y Servier. Ha asistido a congresos y actividades académicas en donde su desplazamiento, inscripción y estadía ha sido financiada por estas casas farmacéuticas. No posee acciones de ninguna de estas compañías ni recibe honorarios por afiliación laboral directa.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:2 [ "identificador" => "xres301968" "titulo" => array:5 [ 0 => "Abstract" 1 => "Introduction" 2 => "Method" 3 => "Results" 4 => "Discussion" ] ] 1 => array:2 [ "identificador" => "xpalclavsec285017" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres301969" "titulo" => array:5 [ 0 => "Resumen" 1 => "Introducción" 2 => "Método" 3 => "Resultados" 4 => "Discusión" ] ] 3 => array:2 [ "identificador" => "xpalclavsec285016" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Case Reports" "secciones" => array:7 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Case 1" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Case 2" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Case 3" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Case 4" ] 4 => array:2 [ "identificador" => "sec0035" "titulo" => "Case 5" ] 5 => array:2 [ "identificador" => "sec0040" "titulo" => "Case 6" ] 6 => array:2 [ "identificador" => "sec0045" "titulo" => "Case 7" ] ] ] 6 => array:2 [ "identificador" => "sec0050" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0055" "titulo" => "Conclusions" ] 8 => array:2 [ "identificador" => "sec0060" "titulo" => "Conflicto de intereses" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2012-09-19" "fechaAceptado" => "2013-01-01" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec285017" "palabras" => array:5 [ 0 => "Antidepressant" 1 => "SSRI" 2 => "Adverse effects" 3 => "Crying" 4 => "Emotionalism" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec285016" "palabras" => array:5 [ 0 => "Antidepresivos" 1 => "SSRI" 2 => "Efectos adversos" 3 => "Llanto" 4 => "Emocionalismo" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">We describe seven cases of patients with an inability to cry after treatment with selective serotonin re-uptake inhibitor (SSRI) medication, even during sad or distressing situations that would have normally initiated a crying episode, in the light of the role of the serotonergic system in emotional expression.</p> <span class="elsevierStyleSectionTitle" id="sect0015">Method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Case series drawn from patients attended in a secondary care psychiatry service.</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">While excessive crying without emotional distress has been previously reported in the literature, and is associated with reduced serotonin function, these reports suggest cases of the reverse dissociation, where emotional distress and an urge to cry was present, but crying was impaired.</p> <span class="elsevierStyleSectionTitle" id="sect0025">Discussion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Although the case series presented here is new, these cases are consistent with the neuroscience of crying and their relationship with serotonergic function, and provide preliminary evidence for a double dissociation between subjective emotional experience and the behavioural expression of crying. This helps to further illuminate the neuroscience of emotional expression and suggests the possibility that the phenomenon is an under-recognised adverse effect of SSRI treatment.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Introducción</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Se describen los casos de 7 pacientes con incapacidad para llorar tras tratamiento con un inhibidor de la recaptación de serotonina (ISRS), situación que se presenta aun en situaciones estresantes o tristes, que normalmente les habrían iniciado una respuesta de llanto. Los casos se examinan a la luz de lo que se conoce acerca del papel del sistema serotoninérgico en la expresión emocional.</p> <span class="elsevierStyleSectionTitle" id="sect0040">Método</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Serie de casos de pacientes que acuden a un servicio de atención secundaria en psiquiatría.<a name="p305"></a></p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Mientras el llanto excesivo sin estrés emocional ya se había descrito en la literatura asociado con una función serotoninérgica reducida, los presentes reportes apuntan casos de la disociación inversa, en los que el estrés emocional y la urgencia de llorar se encontraban presentes, pero con incapacidad para el llanto.</p> <span class="elsevierStyleSectionTitle" id="sect0050">Discusión</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Aunque la serie de casos aquí presentada es nueva, concuerdan con la neurociencia del llanto y su relación con la función serotoninérgica, y proveen evidencia preliminar para una disociación doble entre la experiencia emocional subjetiva y la expresión conductual del llanto. Esto ayuda a elucidar la neurociencia de la expresión emocional y apunta la posibilidad de que el fenómeno sea un efecto adverso poco detectado del tratamiento con ISRS.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Experience</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Expression</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Absent or diminished \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Present or excessive \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Absent or diminshed</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Apathy, negativism \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pathological crying and/or laughing \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Gelastic seizures \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Crying spells (e.g. SSRI withdrawal) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Present or excessive</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Aprosodia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mood lability \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Affective blunting or flat affect \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Explosiveness \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Facial akinesia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Excessive tendency to cry \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Inability to cry \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab445585.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Examples of affective symptoms classified as disorders of emotional experience and expression</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:32 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Understanding excessive crying in neurologic disorders: nature, pathophysiology, assessment, consequences, and treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.E. Nieuwenhuis-Mark" 1 => "A. van Hoek" 2 => "A. Vingerhoets" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/WNN.0b013e31816be8f8" "Revista" => array:6 [ "tituloSerie" => "Cogn Behav Neurol" "fecha" => "2008" "volumen" => "21" "paginaInicial" => "111" "paginaFinal" => "123" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18541989" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is there a relationship between depression and crying?. A review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.J. Vingerhoets" 1 => "J. Rottenberg" 2 => "A. Cevaal" 3 => "J.K. Nelson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1600-0447.2006.00948.x" "Revista" => array:6 [ "tituloSerie" => "Acta Psychiatr Scand" "fecha" => "2007" "volumen" => "115" "paginaInicial" => "340" "paginaFinal" => "351" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17430411" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pseudobulbar crying induced by stimulation in the region of the subthalamic nucleus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.S. Okun" 1 => "D.V. Raju" 2 => "B.L. Walter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neurol Neurosurg Psychiatry" "fecha" => "2004" "volumen" => "75" "paginaInicial" => "921" "paginaFinal" => "923" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15146017" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of pathological affect: variability of response for laughter and crying" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. McCullagh" 1 => "A. Feinstein" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1176/jnp.12.1.100" "Revista" => array:6 [ "tituloSerie" => "J Neuropsychiatry Clin Neurosci" "fecha" => "2000" "volumen" => "12" "paginaInicial" => "100" "paginaFinal" => "102" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10678522" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Some problems in neurology. II: Pathological laughing and crying" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S.A.K. Wilson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Neurol Psychopathol" "fecha" => "1924" "volumen" => "IV" "paginaInicial" => "299" "paginaFinal" => "333" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Emotions, behaviours and mood changes in stroke" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Carota" 1 => "F. Staub" 2 => "J. Bogousslavsky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Opin Neurol" "fecha" => "2002" "volumen" => "15" "paginaInicial" => "57" "paginaFinal" => "69" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11796952" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathological laughter and crying: a link to the cerebellum" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Parvizi" 1 => "S.W. Anderson" 2 => "C.O. Martin" 3 => "H. Damasio" 4 => "A.R. Damasio" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Brain" "fecha" => "2001" "volumen" => "124" "paginaInicial" => "1708" "paginaFinal" => "1719" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11522574" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathophysiology of involuntary emotional expression disorder" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.V. Rabins" 1 => "D.B. Arciniegas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "CNS Spectr" "fecha" => "2007" "volumen" => "12" "paginaInicial" => "17" "paginaFinal" => "22" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17426671" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuroimaging of serotonin transporters in post-stroke pathological crying" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T. Murai" 1 => "H. Barthel" 2 => "J. Berrouschot" 3 => "D. Sorger" 4 => "D.Y. von Cramon" 5 => "U. Müller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Psychiatry Res" "fecha" => "2003" "volumen" => "123" "paginaInicial" => "207" "paginaFinal" => "211" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12928109" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serotonin 5HT<span class="elsevierStyleInf">1A</span> receptor availability and pathological crying after stroke" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Møller" 1 => "G. Andersen" 2 => "A. Gjedde" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1600-0404.2007.00869.x" "Revista" => array:6 [ "tituloSerie" => "Acta Neurol Scand" "fecha" => "2007" "volumen" => "116" "paginaInicial" => "83" "paginaFinal" => "90" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17661792" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pharmaceutical interventions for emotionalism after stroke" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.O. House" 1 => "M.L. Hackett" 2 => "C.S. Anderson" 3 => "J.A. Horrocks" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Cochrane Database Syst Rev" "fecha" => "2004" "numero" => "2" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of pathologic laughing and weeping with amitriptyline" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.B. Schiffer" 1 => "R.M. Herndon" 2 => "R.A. Rudick" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM198506063122303" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1985" "volumen" => "312" "paginaInicial" => "1480" "paginaFinal" => "1482" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3887172" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathological laughing and crying following stroke: validation of a measurement scale and a double-blind treatment study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.G. Robinson" 1 => "R.M. Parikh" 2 => "J.R. Lipsey" 3 => "S.E. Starkstein" 4 => "T.R. Price" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1176/ajp.150.2.286" "Revista" => array:6 [ "tituloSerie" => "Am J Psychiatry" "fecha" => "1993" "volumen" => "150" "paginaInicial" => "286" "paginaFinal" => "293" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8422080" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathological laughter and crying in patients with multiple system atrophy-cerebellar type" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Parvizi" 1 => "J. Joseph" 2 => "D.Z. Press" 3 => "J.D. Schmahmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/mds.21348" "Revista" => array:6 [ "tituloSerie" => "Mov Disord" "fecha" => "2007" "volumen" => "22" "paginaInicial" => "798" "paginaFinal" => "803" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17290465" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The nature of the discontinuation syndrome associated with antidepressant drugs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.C. Shelton" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Clin Psychiatry" "fecha" => "2006" "volumen" => "67" "numero" => "Suppl 4" "paginaInicial" => "3" "paginaFinal" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17092189" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inability to cry during SRI treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.A. Oleshansky" 1 => "L.A. Labbate" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Clin Psychiatry" "fecha" => "1996" "volumen" => "57" "paginaInicial" => "593" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9010125" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Emotional blunting associated with SSRI-induced sexual dysfunction. Do SSRIs inhibit emotional responses?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A. Opbroek" 1 => "P.L. Delgado" 2 => "C. Laukes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "doi:10.1017/S1461145702002870" "Revista" => array:6 [ "tituloSerie" => "Int J Neuropsychopharmacol" "fecha" => "2002" "volumen" => "5" "paginaInicial" => "147" "paginaFinal" => "151" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12135539" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "“Double depression”: superimposition of acute depressive episodes on chronic depressive disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.B. Keller" 1 => "R.W. Shapiro" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1176/ajp.139.4.438" "Revista" => array:6 [ "tituloSerie" => "Am J Psychiatry" "fecha" => "1982" "volumen" => "139" "paginaInicial" => "438" "paginaFinal" => "442" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7065289" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Selectivity of antidepressants: from the monoamine hypothesis of depression to the SSRI revolution and beyond" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.J. Owens" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Clin Psychiatry" "fecha" => "2004" "volumen" => "65" "numero" => "Suppl 4" "paginaInicial" => "5" "paginaFinal" => "10" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15600376" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical effects of pharmacological variations in selective serotonin reuptake inhibitors: an overview" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.L. Carrasco" 1 => "C. Sandner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1368-5031.2005.00681.x" "Revista" => array:6 [ "tituloSerie" => "Int J Clin Pract" "fecha" => "2005" "volumen" => "59" "paginaInicial" => "1428" "paginaFinal" => "1434" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16351675" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathological laughing and crying: epidemiology, pathophysiology and treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H.S. Wortzel" 1 => "T.J. Oster" 2 => "C.A. Anderson" 3 => "D.B. Arciniegas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "CNS Drugs" "fecha" => "2008" "volumen" => "22" "paginaInicial" => "531" "paginaFinal" => "545" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18547124" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathological crying caused by high-frequency stimulation in the region of the caudal internal capsule" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H.L. Low" 1 => "F.T. Sayer" 2 => "C.R. Honey" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archneurol.2007.53" "Revista" => array:6 [ "tituloSerie" => "Arch Neurol" "fecha" => "2008" "volumen" => "65" "paginaInicial" => "264" "paginaFinal" => "266" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18268198" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathological crying induced by deep brain stimulation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L. Wojtecki" 1 => "J. Nickel" 2 => "L. Timmermann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/mds.21266" "Revista" => array:6 [ "tituloSerie" => "Mov Disord" "fecha" => "2007" "volumen" => "22" "paginaInicial" => "1314" "paginaFinal" => "1316" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17534982" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Facial expressions of emotions and schizophrenia: a review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.K. Mandal" 1 => "R. Pandey" 2 => "A.B. Prasad" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Schiz Bull" "fecha" => "1998" "volumen" => "24" "paginaInicial" => "399" "paginaFinal" => "412" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cognitive neuropsychiatry: towards a scientific psychopathology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.W. Halligan" 1 => "A.S. David" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/35058586" "Revista" => array:6 [ "tituloSerie" => "Nat Rev Neurosci" "fecha" => "2001" "volumen" => "2" "paginaInicial" => "209" "paginaFinal" => "215" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11256082" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of self-generated facial expressions on mood" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.L. Kleinke" 1 => "T.R. Peterson" 2 => "T.R. Rutledge" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Pers Soc Psychol" "fecha" => "1998" "volumen" => "74" "paginaInicial" => "272" "paginaFinal" => "279" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "SSRI-induced apathy syndrome: a clinical review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W.J. Barnhart" 1 => "E.H. Makela" 2 => "M.J. Latocha" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Psychiatr Pract" "fecha" => "2004" "volumen" => "10" "paginaInicial" => "196" "paginaFinal" => "199" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15330228" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is crying beneficial?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Rottenberg" 1 => "L.M. Bylsma" 2 => "A.J. Vingerhoets" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Curr Dir Psychol Sci" "fecha" => "2008" "volumen" => "17" "paginaInicial" => "400" "paginaFinal" => "404" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "When is crying cathartic? An international study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.M. Bylsma" 1 => "A.J. Vingerhoets" 2 => "J. Rottenberg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Soc Clin Psychol" "fecha" => "2008" "volumen" => "27" "paginaInicial" => "1165" "paginaFinal" => "1187" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tears of sorrow, tears of joy: An individual differences approach to crying in Dutch females" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Rottenberg" 1 => "L.M. Bylsma" 2 => "V. Wolvin" 3 => "A.J. Vingerhoets" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pers Individ Dif" "fecha" => "2008" "volumen" => "45" "paginaInicial" => "367" "paginaFinal" => "372" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Remitted depression studies as tests of the cognitive vulnerability hypotheses of depression onset: a critique and conceptual analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "N. Just" 1 => "L.Y. Abramson" 2 => "L.B. Alloy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Psychol Rev" "fecha" => "2001" "volumen" => "21" "paginaInicial" => "63" "paginaFinal" => "83" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11148896" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "‘It's not over when it's over’: persistent neurobiological abnormalities in recovered depressed patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Z. Bhagwagar" 1 => "P.J. Cowen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Psychol Med" "fecha" => "2008" "volumen" => "38" "paginaInicial" => "307" "paginaFinal" => "313" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18444278" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/00347450/0000004200000004/v1_201401010022/S003474501370026X/v1_201401010022/en/main.assets" "Apartado" => array:4 [ "identificador" => "21945" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Artículos originales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00347450/0000004200000004/v1_201401010022/S003474501370026X/v1_201401010022/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S003474501370026X?idApp=UINPBA00004N" ]
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2024 September | 1163 | 13 | 1176 |
2024 August | 1122 | 23 | 1145 |
2024 July | 1025 | 15 | 1040 |
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2024 May | 753 | 19 | 772 |
2024 April | 841 | 18 | 859 |
2024 March | 1076 | 29 | 1105 |
2024 February | 932 | 17 | 949 |
2024 January | 1073 | 9 | 1082 |
2023 December | 885 | 9 | 894 |
2023 November | 821 | 10 | 831 |
2023 October | 756 | 14 | 770 |
2023 September | 539 | 17 | 556 |
2023 August | 391 | 10 | 401 |
2023 July | 319 | 13 | 332 |
2023 June | 269 | 18 | 287 |
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2023 April | 223 | 31 | 254 |
2023 March | 236 | 17 | 253 |
2023 February | 179 | 19 | 198 |
2023 January | 220 | 12 | 232 |
2022 December | 191 | 15 | 206 |
2022 November | 153 | 31 | 184 |
2022 October | 167 | 27 | 194 |
2022 September | 172 | 37 | 209 |
2022 August | 181 | 29 | 210 |
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2022 May | 233 | 40 | 273 |
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2021 August | 812 | 36 | 848 |
2021 July | 1008 | 44 | 1052 |
2021 June | 1515 | 10 | 1525 |
2021 May | 3385 | 17 | 3402 |
2021 April | 4270 | 12 | 4282 |
2021 March | 2577 | 27 | 2604 |
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2021 January | 2093 | 17 | 2110 |
2020 December | 1840 | 6 | 1846 |
2020 November | 1064 | 16 | 1080 |
2020 October | 464 | 7 | 471 |
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2020 March | 974 | 17 | 991 |
2020 February | 901 | 7 | 908 |
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2019 December | 777 | 6 | 783 |
2019 November | 741 | 11 | 752 |
2019 October | 938 | 9 | 947 |
2019 September | 654 | 13 | 667 |
2019 August | 405 | 8 | 413 |
2019 July | 373 | 8 | 381 |
2019 June | 491 | 34 | 525 |
2019 May | 533 | 35 | 568 |
2019 April | 514 | 18 | 532 |
2019 March | 618 | 2 | 620 |
2019 February | 438 | 8 | 446 |
2019 January | 138 | 0 | 138 |
2018 December | 33 | 7 | 40 |
2018 November | 18 | 6 | 24 |
2018 October | 6 | 13 | 19 |
2018 September | 20 | 3 | 23 |
2018 August | 14 | 0 | 14 |
2018 July | 8 | 2 | 10 |
2018 June | 8 | 0 | 8 |
2018 May | 60 | 2 | 62 |
2018 April | 24 | 0 | 24 |
2018 March | 4 | 0 | 4 |
2018 February | 7 | 0 | 7 |
2018 January | 10 | 0 | 10 |
2017 December | 14 | 2 | 16 |
2017 November | 11 | 1 | 12 |
2017 October | 23 | 5 | 28 |
2017 September | 14 | 1 | 15 |
2017 August | 17 | 2 | 19 |
2017 July | 11 | 1 | 12 |
2017 June | 3 | 2 | 5 |
2017 May | 13 | 1 | 14 |
2017 April | 13 | 1 | 14 |
2017 March | 18 | 60 | 78 |
2017 February | 9 | 2 | 11 |
2017 January | 2 | 0 | 2 |
2016 December | 4 | 1 | 5 |
2016 November | 7 | 0 | 7 |
2016 October | 8 | 2 | 10 |
2016 September | 15 | 1 | 16 |
2016 August | 7 | 2 | 9 |
2016 July | 15 | 3 | 18 |
2016 June | 43 | 8 | 51 |
2016 May | 40 | 11 | 51 |
2016 April | 36 | 4 | 40 |
2016 March | 50 | 9 | 59 |
2016 February | 37 | 7 | 44 |
2016 January | 43 | 9 | 52 |
2015 December | 37 | 6 | 43 |
2015 November | 46 | 4 | 50 |
2015 October | 28 | 8 | 36 |
2015 September | 34 | 3 | 37 |
2015 August | 29 | 2 | 31 |
2015 July | 34 | 7 | 41 |
2015 June | 10 | 1 | 11 |
2015 May | 40 | 7 | 47 |
2015 April | 11 | 10 | 21 |
2015 March | 13 | 9 | 22 |
2015 February | 8 | 4 | 12 |
2015 January | 7 | 4 | 11 |
2014 December | 22 | 7 | 29 |
2014 November | 13 | 2 | 15 |
2014 October | 20 | 4 | 24 |
2014 September | 15 | 2 | 17 |
2014 August | 14 | 3 | 17 |
2014 July | 18 | 1 | 19 |
2014 June | 25 | 6 | 31 |
2014 February | 0 | 1 | 1 |