Case Report
“Chasing the Dragon”: A Fatal Case Report of Toxic Leucoencéphalopathie Due to Inhaled Heroin
“Chasing the Dragon”: A Fatal Case Report of Toxic Leukoencephalopathy Due to Inhaled Heroin
Sergio Andrés Ochoa-Orozcoa,b,
, Julio César Gutiérrez-Seguraa,b, Ana María Coral-Leitonc, Efraín Alberto Trejos-Orozcob, Óscar Iván Gutiérrez-Sanjuánd, Julián David Carvajal-Guevaraa,b
Corresponding author
a Departamento de Psiquiatría, Universidad Tecnológica de Pereira, Colombia
b Grupo de Investigación Psiquiatría, Neurociencia y Comunidad, Universidad Tecnológica de Pereira, Colombia
c Servicio de Psiquiatría, Hospital San Rafael, Pasto, Colombia
d Servicio de Medicina Interna, Universidad Tecnológica de Pereira, Colombia
Read
2082
Timeswas read the article
272
Total PDF
1810
Total HTML
Share statistics
array:24 [ "pii" => "S0034745019300320" "issn" => "00347450" "doi" => "10.1016/j.rcp.2019.06.003" "estado" => "S300" "fechaPublicacion" => "2020-10-01" "aid" => "319" "copyright" => "Asociación Colombiana de Psiquiatría" "copyrightAnyo" => "2019" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Rev Colomb Psiquiatr. 2020;49:289-92" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "en" => array:19 [ "pii" => "S2530312020300710" "issn" => "25303120" "doi" => "10.1016/j.rcpeng.2019.06.001" "estado" => "S300" "fechaPublicacion" => "2020-10-01" "aid" => "319" "copyright" => "Asociación Colombiana de Psiquiatría" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Rev Colomb Psiquiatr. 2020;49:289-92" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "“<span class="elsevierStyleItalic">Chasing the Dragon</span>”: A Fatal Case Report of Toxic Leucoencéphalopathie Due to Inhaled Heroin" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "289" "paginaFinal" => "292" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "“<span class="elsevierStyleItalic">Chasing the Dragon</span>”: A Fatal Case Report of Toxic Leukoencephalopathy Due to Inhaled Heroin" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 986 "Ancho" => 1272 "Tamanyo" => 165342 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Cranial computed tomography scan (up) showing spread white matter (WM) hypodense images located at the semi-oval centers, the internal capsules, corticospinal aces, occipital regions, and cerebellum. Brain magnetic resonance (down) revealed hypointense lesions in T1 sequences, hyperintense and symmetric T2 sequence lesions in WM at the semi-oval centers, basal nuclei, corticospinal tracts, cerebellum, the corpus callosum and the mesencephalic and bulbar regions.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Sergio Andrés Ochoa-Orozco, Julio César Gutiérrez-Segura, Ana María Coral-Leiton, Efraín Alberto Trejos-Orozco, Óscar Iván Gutiérrez-Sanjuán, Julián David Carvajal-Guevara" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Sergio Andrés" "apellidos" => "Ochoa-Orozco" ] 1 => array:2 [ "nombre" => "Julio César" "apellidos" => "Gutiérrez-Segura" ] 2 => array:2 [ "nombre" => "Ana María" "apellidos" => "Coral-Leiton" ] 3 => array:2 [ "nombre" => "Efraín Alberto" "apellidos" => "Trejos-Orozco" ] 4 => array:2 [ "nombre" => "Óscar Iván" "apellidos" => "Gutiérrez-Sanjuán" ] 5 => array:2 [ "nombre" => "Julián David" "apellidos" => "Carvajal-Guevara" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0034745019300320" "doi" => "10.1016/j.rcp.2019.06.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0034745019300320?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2530312020300710?idApp=UINPBA00004N" "url" => "/25303120/0000004900000004/v1_202012152101/S2530312020300710/v1_202012152101/en/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S0034745019300265" "issn" => "00347450" "doi" => "10.1016/j.rcp.2019.03.004" "estado" => "S300" "fechaPublicacion" => "2020-10-01" "aid" => "313" "copyright" => "Asociación Colombiana de Psiquiatría" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Rev Colomb Psiquiatr. 2020;49:293-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Reporte de caso</span>" "titulo" => "¿Trastorno de conducta o trastorno de personalidad límite? La importancia de la intervención precoz" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "293" "paginaFinal" => "296" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Behavioural disorder or borderline personality disorder? The importance of early intervention" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Fernando Rodríguez Otero, Tamara del Pino Medina Dorta, Casimiro Cabrera-Abreu" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Fernando" "apellidos" => "Rodríguez Otero" ] 1 => array:2 [ "nombre" => "Tamara del Pino" "apellidos" => "Medina Dorta" ] 2 => array:2 [ "nombre" => "Casimiro" "apellidos" => "Cabrera-Abreu" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2530312020300801" "doi" => "10.1016/j.rcpeng.2019.03.008" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2530312020300801?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0034745019300265?idApp=UINPBA00004N" "url" => "/00347450/0000004900000004/v1_202012152108/S0034745019300265/v1_202012152108/es/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0034745020300743" "issn" => "00347450" "doi" => "10.1016/j.rcp.2020.05.006" "estado" => "S300" "fechaPublicacion" => "2020-10-01" "aid" => "359" "copyright" => "Asociación Colombiana de Psiquiatría" "documento" => "article" "crossmark" => 1 "subdocumento" => "rev" "cita" => "Rev Colomb Psiquiatr. 2020;49:279-88" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artículo de revisión</span>" "titulo" => "Trastornos psiquiátricos en los niños y adolescentes en tiempo de la pandemia por COVID-19" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "279" "paginaFinal" => "288" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Psychiatric disorders in children and adolescents during the COVID-19 pandemic" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1433 "Ancho" => 2500 "Tamanyo" => 285413 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Consejos prácticos para la atención de telepsiquiatría a niños niñas y adolescentes. Tomado y adaptado de Roth et al.<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">45</span></a>.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Juan David Palacio-Ortiz, Juan Pablo Londoño-Herrera, Alejandro Nanclares-Márquez, Paula Robledo-Rengifo, Claudia Patricia Quintero-Cadavid" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Juan David" "apellidos" => "Palacio-Ortiz" ] 1 => array:2 [ "nombre" => "Juan Pablo" "apellidos" => "Londoño-Herrera" ] 2 => array:2 [ "nombre" => "Alejandro" "apellidos" => "Nanclares-Márquez" ] 3 => array:2 [ "nombre" => "Paula" "apellidos" => "Robledo-Rengifo" ] 4 => array:2 [ "nombre" => "Claudia Patricia" "apellidos" => "Quintero-Cadavid" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2530312020300928" "doi" => "10.1016/j.rcpeng.2020.11.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2530312020300928?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0034745020300743?idApp=UINPBA00004N" "url" => "/00347450/0000004900000004/v1_202012152108/S0034745020300743/v1_202012152108/es/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "“<span class="elsevierStyleItalic">Chasing the Dragon</span>”: A Fatal Case Report of Toxic Leucoencéphalopathie Due to Inhaled Heroin" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "289" "paginaFinal" => "292" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Sergio Andrés Ochoa-Orozco, Julio César Gutiérrez-Segura, Ana María Coral-Leiton, Efraín Alberto Trejos-Orozco, Óscar Iván Gutiérrez-Sanjuán, Julián David Carvajal-Guevara" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Sergio Andrés" "apellidos" => "Ochoa-Orozco" "email" => array:1 [ 0 => "saochoa@utp.edu.co" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Julio César" "apellidos" => "Gutiérrez-Segura" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Ana María" "apellidos" => "Coral-Leiton" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "Efraín Alberto" "apellidos" => "Trejos-Orozco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Óscar Iván" "apellidos" => "Gutiérrez-Sanjuán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 5 => array:3 [ "nombre" => "Julián David" "apellidos" => "Carvajal-Guevara" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Departamento de Psiquiatría, Universidad Tecnológica de Pereira, Colombia" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Grupo de Investigación Psiquiatría, Neurociencia y Comunidad, Universidad Tecnológica de Pereira, Colombia" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Psiquiatría, Hospital San Rafael, Pasto, Colombia" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Medicina Interna, Universidad Tecnológica de Pereira, Colombia" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>. Teléfono de contacto: 3185471811." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "“<span class="elsevierStyleItalic">Chasing the Dragon</span>”: A Fatal Case Report of Toxic Leukoencephalopathy Due to Inhaled Heroin" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 981 "Ancho" => 1255 "Tamanyo" => 197426 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Cranial computed tomography scan (up) showing spread white matter (WM) hypodense images located at the semi-oval centers, the internal capsules, corticospinal aces, occipital regions, and cerebellum. Brain magnetic resonance (down) revealed hypointense lesions in T1 sequences, hyperintense and symmetric T2 sequence lesions in WM at the semi-oval centers, basal nuclei, corticospinal tracts, cerebellum, the corpus callosum and the mesencephalic and bulbar regions.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Leukoencephalopathy is the structural damage of cerebral white matter due to the destruction of myelin. Multiple conditions may lead to leukoencephalopathy, such as genetic disorders, primary demyelinating diseases, infections, metabolic disorders, brain trauma (diffuse axonal damage), and vascular diseases, among others;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">1</span></a> although toxins remain as a prevalent and disabling cause.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Toxic leukoencephalopathy (TL) is caused by the exposure of a wide variety of agents including environmental toxins, toluene, cranial irradiation, substance abuse or medications such as chemotherapy.<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">3,4</span></a> TL may be due to idiosyncratic reaction as well as dose or time exposure related. TL prevalence remains unknown, and it is considered a rare entity.</p><p id="par0015" class="elsevierStylePara elsevierViewall">However, an over increasing frequency has been reported due to industrial chemicals use, chemotherapy, or psychoactive substances abuse.<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">2,4</span></a> Inhaled heroin use has been associated with the incidence of TL since the 1980s.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">5</span></a> Brain damage mechanism remains unknown, but some suspected hypothesis include toxins derived from heroin molecular modification induced by heating, or and hypoxic-ischemic pathology.<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">6,7</span></a> In the present report, we present a fatal case of TL in a young man with inhaled heroin consumption.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Case Presentation</span><p id="par0020" class="elsevierStylePara elsevierViewall">A 28 years-old man from the urban area of Pereira (Colombia) was admitted to the emergency department presenting a rapid and progressive onset of asthenia, adynamia, dizziness, disorientation, muscle weakness and ataxic gait, installed over the past two weeks. He had no medical or surgical record, except for substance abuse such as marijuana and cocaine since he was 15 years old. He reported inhaled heroin use over the last two years, with an increasing pattern in the last six months.</p><p id="par0025" class="elsevierStylePara elsevierViewall">He was admitted in regular physical conditions, emaciated, distractible, with hypomimia, bradylalia, bradypsychia, fluctuating akinetic mutism, abulia, with apathy, impaired immediate memory, slowness of movement, hypotonia, slightly decreased generalized muscle strength and ataxic gait. Osteotendinous reflexes were normal and no Babinski sign was found. Hemodynamics parameters were stable, and no signs of respiratory difficulty were reported.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Total blood count showed mild leukocytosis. The other laboratory tests (urinary function, blood gases, serum sodium, infectious diseases test such as HIV, syphilis, hepatitis B virus, and hepatitis C virus) were unremarkable. Cranial computed tomography scan (CT) showed spread white matter (WM) hypodense images located at the semi-oval centers, posterior limb of the internal capsules, corticospinal aces, occipital regions, and cerebellum.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Brain magnetic resonance (MR) revealed hypointense lesions in T1 sequences, hyperintense and symmetric T2 sequence lesions in WM at the semi-oval centers, basal nuclei, corticospinal tracts, cerebellum, the posterior area of the corpus callosum as well as in mesencephalic and bulbar regions (<a class="elsevierStyleCrossRef" href="#fig0005">fig. 1</a>). The patient worsens three days after admission, with neurological impairment, stupor, hemodynamic instability, respiratory failure, and death.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">After the patient died, the family signed the informed consent to use the clinical and radiological records to present and publish the case for scientific and academic purposes, conserving the privacy and identity of the patient out of the record.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Literature Review</span><p id="par0045" class="elsevierStylePara elsevierViewall">WM covers approximately half of the brain and it is composed of multiple intra and interhemispheric tracts. WM dysfunction due to myelin damage may produce neuropsychiatric symptoms such as distractibility, memory impairment, personality changes, psychosis, mood changes, and dementia.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">4</span></a> TL must be considered in patients with neurobehavioral deficit who were exposed to toxins or substances.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">2</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Heroin (diacetylmorphine) is a semisynthetic drug, derived from morphine and originated from the poppy <span class="elsevierStyleItalic">(Papaver somniferous),</span> first synthesized in the late 19<span class="elsevierStyleSup">th</span> century and initially emerged as antitussive medicine. Heroin quickly showed great addictive potential, so it was labeled as an illicit substance.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">8</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">“Chasing the Dragon” is the popular name given to inhaled heroin consumption.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">9</span></a> When heated on aluminum folds, heroin becomes a reddish-brown gelatinous substance that releases a thick, white smoke that resembles a dragon tail. This smoke is “pursued” or inhaled through a straw or a tubular structure. This technique is also called “Chinese blow”. This practice was recognized for the first time in Hong Kong in the 1950s, but nowadays it has been extended to users all over the world.<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">9,10</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Despite inhaled heroin consumption is frequent, and the association with TL is known, it has rarely been reported.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">11</span></a> The first and largest outbreak of TL associated with the use of inhaled heroin was reported in 1982 in the Netherlands, including 47 cases, of which 11 died.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">5</span></a> Since 1982, sporadic cases have been reported in Taiwan, Hong Kong, the United States, and China, among others<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">5,10-12</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Autopsies from TL patients associated with the use of inhaled heroin reveal spongiform degeneration, the formation of vacuoles in the oligodendroglia and myelin sheaths, with demyelination of the brain, cerebral stem, cerebellum, and spinal cord; these findings are called spongiform leukoencephalopathy<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">12,13</span></a> Pyrolysate, a compound resulting from the combustion of heroin, seems to be responsible for cerebral damage<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">6,10</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">In a German study carried out in 2014, eight death patients due to heroin TL showed increased serum lactate, suggestive of cerebral hypoxia; increased choline, suggestive of axonal compromise; and decreased n-acetyl-aspartate, suggestive of mitochondrial dysfunction.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">7</span></a> Image findings in the TL include a compromise of symmetrical dentate nuclei, cerebellum, cerebral WM with bilateral symmetric hypersignal in the posterior limb of the internal capsule.<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">13,14</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Heroin TL progress through three stages. Initial symptoms include motor restlessness, apathy, bradyphrenia, and cerebellar ataxia. In the second stage, there is worsening of cerebellar symptoms, hyperactive deep tendon reflexes, myoclonic jerks, and hypertonia. In the final stage, manifestations include stretching spasms, diaphoresis, fever, hypotonia, areflexia, and akinetic mutism, and in some cases death.<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">10-12</span></a> Heroin TL mortality ranges between 23 and 25%, and death occurs mainly due to respiratory failure. There is no effective treatment for TL<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">10-12</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">United Nations Office on Drugs and Crime reported that, worldwide, approximately 5% of the global adult population has used drugs at least once, in the lifetime, another 0.6% suffered from drug use disorders (SUD). About 28 million years of “healthy life” were lost worldwide in 2015 because of premature death and disability caused by SUD. Opioids, including heroin, remain the most harmful drugs and are responsible for 70% of the SUD global burden.<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">15</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">In Colombia, there were about 32 thousand people consuming heroin in 2013, with an expected increase to date. Medellin, Cali, Pereira, and Armenia are the more affected cities by the heroin-related disorders.<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">16,17</span></a> In this epidemiological context, patients with TL due to heroin consumption, just like this clinical case, will be more frequently seen at emergency departments and psychiatric institutions.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conclusions</span><p id="par0090" class="elsevierStylePara elsevierViewall">Inhaled heroin consumption is a risk factor for TL, with severe neurological compromise and high disability and death risk. Since heroin consumption is becoming more frequent, and there have been identified methadone treatment barriers,<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">17</span></a> this may be considered a public health issue.</p><p id="par0095" class="elsevierStylePara elsevierViewall">It's necessary to improve programs focused on heroin consumption prevention, consequences treatment, and elimination of the barriers to getting adequate treatment alternatives.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conflicts of Interests</span><p id="par0100" class="elsevierStylePara elsevierViewall">None.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres1435030" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Case" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Discussion" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1309988" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1435029" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Caso clínico" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Discusión" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1309989" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case Presentation" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Literature Review" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conclusions" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflicts of Interests" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-03-13" "fechaAceptado" => "2019-06-04" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1309988" "palabras" => array:3 [ 0 => "Heroin" 1 => "Leukoencephalopathies" 2 => "Colombia" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1309989" "palabras" => array:3 [ 0 => "Heroína" 1 => "Leucoencefalopatía" 2 => "Colombia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Leukoencephalopathy is a myelin disorder caused by multiple agents, including substance abuse.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Case</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A 28-year-old man arrived at the emergency department having suffered from asthenia, dizziness, disorientation and ataxia for two months. He had a two-year history of heroin inhalation. He arrived in a normal physical condition. Brain magnetic resonance showed bilateral diffuse hypointense lesions in the white matter. At day 3 after admission, he presented neurological deterioration, stupor, haemodynamic instability, respiratory failure, and died.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Discussion</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Toxic leukoencephalopathy symptoms start with inattention, memory and personality changes, and may eventually cause dementia and death. Heroin inhalation is a common practice and can lead to leukoencephalopathy.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Leukoencephalopathy associated with heroin inhalation is a rare entity that mainly affects young adults and has a high social impact. Its aetiology is unclear, it has no effective treatment and there is a high mortality rate. Heroin consumption is on the rise in Colombia, so TL should be considered by medical staff.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Case" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Discussion" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducción</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La leucoencefalopatía es una patología de la mielina producida por múltiples agentes, incluidas las sustancias de abuso.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Caso clínico</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Un varón de 28 años llegó urgencias por 2 meses de astenia, mareo, desorientación y ataxia. Tenía antecedentes de consumo inhalado de heroína por 2 años. Presentaba condiciones físicas regulares. La resonancia magnética cerebral mostró lesiones hipointensas difusas bilaterales en la sustancia blanca. Al tercer día presentó empeoramiento de su estado neurológico, estupor, inestabilidad hemodinámica, insuficiencia respiratoria y muerte.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Discusión</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Los síntomas de leucoencefalopatía tóxica (LT) comienzan con falta de atención, cambios en la memoria y la personalidad, y finalmente demencia y muerte. El consumo de heroína inhalada es una práctica frecuente con riesgo de que produzca LT.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La leucoencefalopatía asociada con el uso de heroína inhalada es una entidad rara que afecta principalmente a adultos jóvenes y tiene un alto impacto social. Su etiología no está clara, no tiene un tratamiento efectivo y tiene altas tasas de mortalidad. El consumo de heroína está aumentando en Colombia, por lo que el personal médico debe tener en cuenta la LT.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Caso clínico" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Discusión" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Este caso fue presentado en la modalidad de <span class="elsevierStyleItalic">short oral presentation</span> en el <span class="elsevierStyleItalic">18</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">th</span></span><span class="elsevierStyleItalic">WPA World Congress of Psychiatry,</span> en Ciudad de México, entre el 27 y el 30 de septiembre de 2018.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 981 "Ancho" => 1255 "Tamanyo" => 197426 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Cranial computed tomography scan (up) showing spread white matter (WM) hypodense images located at the semi-oval centers, the internal capsules, corticospinal aces, occipital regions, and cerebellum. Brain magnetic resonance (down) revealed hypointense lesions in T1 sequences, hyperintense and symmetric T2 sequence lesions in WM at the semi-oval centers, basal nuclei, corticospinal tracts, cerebellum, the corpus callosum and the mesencephalic and bulbar regions.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib0090" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Classification and diagnostic criteria for demyelinating diseases of the central nervous system: Where do we stand today?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Mathey" 1 => "M. Michaud" 2 => "S. Pittion-Vouyovitch" 3 => "M. Debouverie" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Revue neurologique." "fecha" => "2018" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0095" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The expanding prominence of toxic leukoencephalopathy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.M. Filley" 1 => "B.V. McConnell" 2 => "C.A. Anderson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Neuropsych Clin Neurosci." "fecha" => "2017" "volumen" => "29" "paginaInicial" => "308" "paginaFinal" => "318" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0100" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Toxic leukoencephalopathy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.M. Filley" 1 => "B. Kleinschmidt-DeMasters" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM200108093450606" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med." "fecha" => "2001" "volumen" => "345" "paginaInicial" => "425" "paginaFinal" => "432" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11496854" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0105" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:1 [ "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "editores" => "C.de Medeiros Rimkus, C.S.Andrade, C.da Costa Leite, A.M.McKinney, L.T.Lucato" "titulo" => "Toxic leukoencephalopathies, including drug, medication, environmental, and radiation-induced encephalopathic syndromes, Seminars in Ultrasound, CT and MRI" "serieFecha" => "2014" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0110" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leucoencephalopathy after inhaling “heroin” pyrolysate" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "E.C. Wolters" 1 => "F. Stam" 2 => "R. Lousberg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet." "fecha" => "1982" "volumen" => "320" "paginaInicial" => "1233" "paginaFinal" => "1237" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0115" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathology of toxic leucoencephalopathy in drug abuse supports hypoxic-ischemic pathophysiology/etiology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Alturkustani" 1 => "L.C. Ang" 2 => "D. Ramsay" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/neup.12377" "Revista" => array:6 [ "tituloSerie" => "Neuropathology." "fecha" => "2017" "volumen" => "37" "paginaInicial" => "321" "paginaFinal" => "328" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28276094" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0120" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased densities of nitric oxide synthase expressing neurons in the temporal cortex and the hypothalamic paraventricular nucleus of polytoxicomanic heroin overdose victims: possible implications for heroin neurotoxicity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "H.-G. Bernstein" 1 => "K. Trübner" 2 => "P. Krebs" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.acthis.2013.07.006" "Revista" => array:6 [ "tituloSerie" => "Acta Histochem." "fecha" => "2014" "volumen" => "116" "paginaInicial" => "182" "paginaFinal" => "190" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23953641" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0125" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Heroin prescription and history" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V. Berridge" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMe0904243" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med." "fecha" => "2009" "volumen" => "361" "paginaInicial" => "820" "paginaFinal" => "821" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19692694" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0130" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Heroin smoking by ‘chasing the dragon’: origins and history" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Strang" 1 => "P. Griffiths" 2 => "M. Gossop" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1360-0443.1997.9266734.x" "Revista" => array:6 [ "tituloSerie" => "Addiction." "fecha" => "1997" "volumen" => "92" "paginaInicial" => "673" "paginaFinal" => "683" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9246796" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0135" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "‘Chasing the dragon’: new knowledge for an old practice" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.P. Cordova" 1 => "S. Balan" 2 => "J. Romero" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MJT.0b013e31820b8856" "Revista" => array:6 [ "tituloSerie" => "Am J Ther." "fecha" => "2014" "volumen" => "21" "paginaInicial" => "52" "paginaFinal" => "55" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21519216" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0140" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leucoencephalopathy following abuse of sniffed heroin" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "R. Lefaucheur" 1 => "A. Lebas" 2 => "E. Gérardin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jocn.2016.09.023" "Revista" => array:6 [ "tituloSerie" => "J Clin Neurosci." "fecha" => "2017" "volumen" => "35" "paginaInicial" => "70" "paginaFinal" => "72" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27742371" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0145" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Toxic leucoencephalopathy after ‘chasing the dragon’" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Singh" 1 => "M. Saini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.11622/smedj.2015094" "Revista" => array:6 [ "tituloSerie" => "Singapore Med J." "fecha" => "2015" "volumen" => "56" "paginaInicial" => "e102" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26106246" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0169500206001619" "estado" => "S300" "issn" => "01695002" ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0150" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute radiologic manifestations of America's opioid epidemic" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D.D. Bates" 1 => "K. Gallagher" 2 => "H. Yu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1148/rg.2018170114" "Revista" => array:6 [ "tituloSerie" => "RadioGraphics." "fecha" => "2018" "volumen" => "38" "paginaInicial" => "109" "paginaFinal" => "123" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29320313" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0155" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The addicted brain: Imaging neurological complications of recreational drug abuse" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Montoya-Filardi" 1 => "M. Mazón" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Radiología (English Edition)." "fecha" => "2017" "volumen" => "59" "paginaInicial" => "17" "paginaFinal" => "30" "itemHostRev" => array:3 [ "pii" => "S0923753419376148" "estado" => "S300" "issn" => "09237534" ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0160" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "United Nations. Global overview of drug demand and supply: Latest trends, cross-cutting issues. World Drug Report 2018. 2. Austria: 2018." ] ] ] 15 => array:3 [ "identificador" => "bib0165" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Estudio Nacional de consumo de sustancias psicoactivas en Colombia 2013. Bogotá: Observatorio de Drogas de Colombia; 2013." ] ] ] 16 => array:3 [ "identificador" => "bib0170" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "La heroína en Colombia: producción, usos e impacto en la salud pública. Bogotá: Observatorio de Drogas de Colombia; 2016." ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/00347450/0000004900000004/v1_202012152108/S0034745019300320/v1_202012152108/en/main.assets" "Apartado" => array:4 [ "identificador" => "70608" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Reportes de caso" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00347450/0000004900000004/v1_202012152108/S0034745019300320/v1_202012152108/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0034745019300320?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 21 | 0 | 21 |
| 2024 October | 81 | 17 | 98 |
| 2024 September | 90 | 8 | 98 |
| 2024 August | 61 | 5 | 66 |
| 2024 July | 54 | 3 | 57 |
| 2024 June | 40 | 1 | 41 |
| 2024 May | 51 | 9 | 60 |
| 2024 April | 50 | 9 | 59 |
| 2024 March | 63 | 2 | 65 |
| 2024 February | 75 | 5 | 80 |
| 2024 January | 80 | 1 | 81 |
| 2023 December | 65 | 4 | 69 |
| 2023 November | 46 | 10 | 56 |
| 2023 October | 75 | 9 | 84 |
| 2023 September | 38 | 1 | 39 |
| 2023 August | 62 | 2 | 64 |
| 2023 July | 50 | 6 | 56 |
| 2023 June | 18 | 4 | 22 |
| 2023 May | 41 | 1 | 42 |
| 2023 April | 49 | 0 | 49 |
| 2023 March | 40 | 7 | 47 |
| 2023 February | 21 | 2 | 23 |
| 2023 January | 29 | 3 | 32 |
| 2022 December | 41 | 9 | 50 |
| 2022 November | 33 | 9 | 42 |
| 2022 October | 29 | 7 | 36 |
| 2022 September | 37 | 8 | 45 |
| 2022 August | 41 | 12 | 53 |
| 2022 July | 36 | 7 | 43 |
| 2022 June | 39 | 12 | 51 |
| 2022 May | 25 | 12 | 37 |
| 2022 April | 47 | 16 | 63 |
| 2022 March | 43 | 16 | 59 |
| 2022 February | 54 | 4 | 58 |
| 2022 January | 65 | 8 | 73 |
| 2021 December | 37 | 8 | 45 |
| 2021 November | 48 | 15 | 63 |
| 2021 October | 35 | 20 | 55 |
Show all
