La dureza de la ciencia dura: ¿mito o realidad? Elementos para una discusión

Article information

Resumen

Objetivo

Discutir aspectos metodológicos relacionados con la calidad de las investigaciones preclínicas y la aplicabilidad de principios de investigación clínica y medicina basada en la evidencia para evaluar la validez y calidad de los estudios preclínicos.

Método

Análisis crítico de publicaciones selectas.

Resultados

El ejercicio de la investigación (preclínica y clínica) exige indicadores rigurosos que permitan determinar la validez y generalización de sus hallazgos. Es deseable el desarrollo de metodologías para determinar su peso y hacer posible su revisión sistemática.

Conclusiones

Se exige un replanteamiento del quehacer científico, a la luz del reconocimiento de sus limitaciones, la urgencia de sus aportes y la responsabilidad que esta tiene frente al bienestar de la humanidad.

Palabras clave:

metodología

medicina basada en evidencia

investigación

Abstract

Objective

To discuss methodological issues concerning the quality and applicability of clinical research and evidence-based medicine principles to pre-clinical research.

Methods

Critical analysis of selected writings.

Results

Rigorous standards to determine the quality and generalization of pre-clinical findings are needed; methods to systematically review the evidence and its weight have not been developed for pre-clinical research.

Conclusions

Never before has a debate about the limitations of pre-clinical research been more relevant, given the momentousness of its contributions and its obligation towards the well-being of humankind.

Key words:

Methodology

evidence-based medicine

research

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El pensamiento no es letra muerta. Ningún argumento ni verdad poseen valor si no convencen al sujeto que obra; si la voluntad de ese último, esclarecida por la razón, no lo conduce a vivir iluminado por la verdad; por ello la voluntad de saber que moviliza todo el proceso del pensar termina por la aceptación voluntaria de la verdad. (1)

Conflicto de interés: el autor manifiesta que no tienen ningún conflicto de interés en este artículo.

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