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Inicio Revista Colombiana de Psiquiatría Priapismo asociado con el uso de clozapina. Reporte de caso
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Vol. 40. Issue 2.
Pages 377-382 (June 2011)
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Vol. 40. Issue 2.
Pages 377-382 (June 2011)
Reporte de caso
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Priapismo asociado con el uso de clozapina. Reporte de caso
Priapism Associated With the Use of Clozapine. A Case Report
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Mauricio de la Espriella1,
Corresponding author
mauricio@delaespriella.org

Correspondencia: Mauricio de la Espriella, Hospital Mental Nuestra Señora del Perpetuo Socorro, Carrera 33 No. 5 Oeste 104, San Juan de Pasto, Colombia
1 Médico-psiquiatra. Gerente del Hospital Mental Nuestra Señora del Perpetuo Socorro. Profesor de Psiquiatría, Pontificia Universidad Javeriana
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Resumen
Introducción

El priapismo es un efecto secundario no previsible del uso de antipsicóticos atípicos, especialmente clozapina.

Método

Reporte de caso.

Resultados y conclusión

Se describe el caso de un paciente de 54 años. La afinidad de este fármaco por los receptores alfaadrenérgicos facilitaría la presencia de esta entidad; sin embargo, el uso de betabloqueadores o anticolinérgicos en el manejo inicial del priapismo apuntan a que otros sistemas estén afectados con el uso de clozapina. La continuidad de los antipsicóticos luego del priapismo dependerá de la afinidad a receptores alfaadrenérgicos, las características clínicas y tratamientos previos, así como la evaluación riesgo-beneficio del uso de estos medicamentos.

Palabras clave:
Clozapina
priapismo
agentes antipsicóticos
Abstract
Introduction

Priapism is a predictable side effect of the use of atypical antipsychotics, especially clozapine.

Method

Case report.

Results

We describe a 54 year-old patient with priapism. The affinity of this drug to alpha-adrenergic receptors facilitates the presence of priapism, however the use of beta-blockers or anticholinergic agents in the initial management of priapism suggest that other systems are affected by the use of clozapine. The continuation of antipsychotics after priapism depends on the affinity of alpha-adrenergic receptors, clinical features, and previous treatments and the risk-benefit assessment of the use of these drugs.

Key words:
Clozapine
priapism
antipsychotic agents
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Conflictos de interés: el autor manifiesta que no tiene conflictos de interés en este artículo.

Copyright © 2011. Asociación Colombiana de Psiquiatría
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