Original article
High Doses of Drugs Extensively Metabolized by CYP3A4 Were Needed to Reach Therapeutic Concentrations in Two Patients Taking Inducers
Dos pacientes que tomaban inductores necesitaron dosis altas de medicamentos metabolizados en gran medida por el CYP3A4 para alcanzar concentraciones terapéuticas
Nitin Chopraa, Can-Jun Ruanb, Betsy McCollumc, Judy Ognibened, Charles Sheltonc, Jose de Leone,f,g,
Corresponding author
a Addictions Division, Centre for Addiction and Mental Health, Toronto, Canada
b Laboratory of Clinical Psychopharmacology, Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China
c Eastern State Hospital, Lexington, Kentucky, USA
d Apalachee, Inc., Eastside Psychiatric Hospital, Tallahassee, Florida, USA
e University of Kentucky Mental Health Research Center, Eastern State Hospital, Lexington, Kentucky, USA
f Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain
g Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Álava, Spain
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