was read the article
array:24 [ "pii" => "S2530312022000510" "issn" => "25303120" "doi" => "10.1016/j.rcpeng.2022.08.008" "estado" => "S300" "fechaPublicacion" => "2022-07-01" "aid" => "398" "copyright" => "Asociación Colombiana de Psiquiatría" "copyrightAnyo" => "2020" "documento" => "article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Rev Colomb Psiquiatr. 2022;51:236-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0034745020301293" "issn" => "00347450" "doi" => "10.1016/j.rcp.2020.11.014" "estado" => "S300" "fechaPublicacion" => "2022-07-01" "aid" => "398" "copyright" => "Asociación Colombiana de Psiquiatría" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Rev Colomb Psiquiatr. 2022;51:236-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Reporte de caso</span>" "titulo" => "Psicosis por consumo de ayahuasca: un reporte de caso" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "236" "paginaFinal" => "239" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Ayahuasca-Induced Psychosis: A Case Report" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Harvey Ricardo Cerón Tapia, Mayra Alejandra González Guzmán, Sergio Andrés Córdoba Ortiz" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Harvey Ricardo" "apellidos" => "Cerón Tapia" ] 1 => array:2 [ "nombre" => "Mayra Alejandra" "apellidos" => "González Guzmán" ] 2 => array:2 [ "nombre" => "Sergio Andrés" "apellidos" => "Córdoba Ortiz" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2530312022000510" "doi" => "10.1016/j.rcpeng.2022.08.008" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2530312022000510?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0034745020301293?idApp=UINPBA00004N" "url" => "/00347450/0000005100000003/v1_202208240726/S0034745020301293/v1_202208240726/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2530312022000479" "issn" => "25303120" "doi" => "10.1016/j.rcpeng.2022.08.006" "estado" => "S300" "fechaPublicacion" => "2022-07-01" "aid" => "390" "copyright" => "Asociación Colombiana de Psiquiatría" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Colomb Psiquiatr. 2022;51:240-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Epistemology, Philosophy of Mind and Bioethics</span>" "titulo" => "Ego-dystonia: a review in search of definitions" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "240" "paginaFinal" => "244" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Egodistónico: Una Revisión en Busca de Definiciones" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ignacio Sandia, Trino Baptista" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Ignacio" "apellidos" => "Sandia" ] 1 => array:2 [ "nombre" => "Trino" "apellidos" => "Baptista" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0034745020301207" "doi" => "10.1016/j.rcp.2020.11.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0034745020301207?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2530312022000479?idApp=UINPBA00004N" "url" => "/25303120/0000005100000003/v1_202209230819/S2530312022000479/v1_202209230819/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2530312022000492" "issn" => "25303120" "doi" => "10.1016/j.rcpeng.2022.08.007" "estado" => "S300" "fechaPublicacion" => "2022-07-01" "aid" => "392" "copyright" => "Asociación Colombiana de Psiquiatría" "documento" => "article" "crossmark" => 1 "subdocumento" => "rev" "cita" => "Rev Colomb Psiquiatr. 2022;51:227-35" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review Article</span>" "titulo" => "Efficacy and safety of antipsychotics and antidepressants in the treatment of anorexia nervosa: a systematic review" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "227" "paginaFinal" => "235" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Eficacia y seguridad de antipsicóticos y antidepresivos en el tratamiento de la anorexia nerviosa: revisión sistemática" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 657 "Ancho" => 2004 "Tamanyo" => 110275 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Summary of assessment of risk of bias (RoB 2.0). CBT: cognitive-behavioural therapy.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Melisa Carrillo Márquez, Juliana Martínez Sánchez, Ana María Salazar, Carolina Vallejo Martínez, Felipe Valderrama, Diego Fernando Rojas-Gualdrón" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Melisa Carrillo" "apellidos" => "Márquez" ] 1 => array:2 [ "nombre" => "Juliana Martínez" "apellidos" => "Sánchez" ] 2 => array:2 [ "nombre" => "Ana María" "apellidos" => "Salazar" ] 3 => array:2 [ "nombre" => "Carolina Vallejo" "apellidos" => "Martínez" ] 4 => array:2 [ "nombre" => "Felipe" "apellidos" => "Valderrama" ] 5 => array:2 [ "nombre" => "Diego Fernando" "apellidos" => "Rojas-Gualdrón" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0034745020301219" "doi" => "10.1016/j.rcp.2020.11.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0034745020301219?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2530312022000492?idApp=UINPBA00004N" "url" => "/25303120/0000005100000003/v1_202209230819/S2530312022000492/v1_202209230819/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Ayahuasca-induced psychosis: A case report" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "236" "paginaFinal" => "239" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Harvey Ricardo Cerón Tapia, Mayra Alejandra González Guzmán, Sergio Andrés Córdoba Ortiz" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Harvey Ricardo" "apellidos" => "Cerón Tapia" "email" => array:1 [ 0 => "Richarc56@hotmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Mayra Alejandra" "apellidos" => "González Guzmán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Sergio Andrés" "apellidos" => "Córdoba Ortiz" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Semillero de investigacion SEITOX, Facultad de Medicina, Universidad Surcolombiana, Neiva, Huila, Colombia" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Universidad Surcolombiana, Neiva, Huila, Colombia" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Unidad de Salud Mental, Hospital Universitario Hernando Moncaleano Perdomo, Neiva, Huila, Colombia" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Psicosis por consumo de ayahuasca: un reporte de caso" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Ayahuasca is a Quechua term composed of the prefix <span class="elsevierStyleItalic">aya</span>, meaning soul, spirit or dead person, and the root <span class="elsevierStyleItalic">waska</span>, which can be interpreted as vine, cord or rope. Thus it can mean “vine of the spirits”, “rope of the soul”, “cord of the dead” or “vine of death”.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–3</span></a> This substance has been widely used since ancient times by indigenous communities of the northwestern Amazon in countries including Colombia, Ecuador, Peru and Brazil.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2–4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">It is prepared with the Amazonian vine <span class="elsevierStyleItalic">Banisteriopsis caapi</span> and the leaves of the bush <span class="elsevierStyleItalic">Psychotria viridis</span>. This concoction contains biologically active chemical compounds such as <span class="elsevierStyleItalic">N,N</span>-dimethyltryptamine (DMT), which acts on 5-HT2A and other receptors.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> Administration thereof is associated with hallucinations, cognitive and perceptual changes, and a heavily altered sense of self and reality; this enables unconscious and subconscious thought content to be consciously exposed, accompanied by emotions and perceptions that may be overlooked in a conscious state. However, this substance is not considered addictive, as it neither stimulates compulsive consumption nor induces withdrawal symptoms.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Its use is associated with ritual purposes, in a magical/religious context, in pursuit of contact with the supernatural spiritual world and nearness to the sacred, and for medicinal purposes, with the aim of curing different types of diseases. It is credited with the ability to confer visions used by shamans to discover spells cast and diseases inflicted on affected persons. More than 70 South American indigenous communities use ayahuasca in the form of a hallucinogenic beverage made by preparing a decoction from the bark of this plant and mixing it with “chacrona” leaves, “chacrona” being a shrubby plant that Andean and Amazonian peoples have called <span class="elsevierStyleItalic">yage</span> since pre-Colombian times.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2,6–9</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Ayahuasca is a botanical hallucinogen used in a magical/religious context by indigenous groups of the Amazon in countries including Brazil, Peru and Colombia; an estimated 20,000 people worldwide are members of Brazilian ayahuasca religions, but epidemiological data on recreational use is limited.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In 2011, Lima and Tófoli published 1994–2007 reporting system results and identified 29 cases with characteristics of psychosis. They concluded that 19 were linked to ayahuasca use: four exhibited an immediate temporal relationship in individuals with no psychiatric history (first episode); five featured a relapse or recurrence and 10 involved ayahuasca use as a predisposing factor associated with others.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Based on the Beneficent Spiritist Center União do Vegetal’s (UDV’s) own censuses, the incidence of new psychotic episodes would be 10.8 per 100,000 person-years. The estimated overall risk of a psychotic break per use session would be less than two per 100,000 use episodes.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> A 2007 review by Gable estimated the risk of a psychotic episode per use session. According to the study, in around 25,000 ritual drinking sessions over a five-year period, only 13–24 cases were documented in which ayahuasca might have been a contributing factor in a psychotic incident, representing a rate of less than 0.1% and indicating that ayahuasca use is not a triggering event for sustained psychosis. Most of these episodes were transient in nature and resolved spontaneously.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Sensation of vivid visual images; altered auditory perception; heightened thought processing; brief but intense reactions of dysphoria, disorientation and symptoms of anxiety; and sensory and motor suppression interfering with a suitable relationship between the individual and their environment can be attributed to this preparation.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9,13,14</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Ayahuasca use for recreational purposes, in so-called “Ayahuasca tours”, offered on trips to countries such as Colombia, Peru and Brazil, is also being documented.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Considering that its use is becoming widespread outside the cultural context and the worldview in which it originated, we consider this case report to be very important.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0050" class="elsevierStylePara elsevierViewall">The patient was a 26-year-old man from a rural area and a member of an indigenous community in Colombia (Páez). He was single, had no children, lived with three siblings and their mother, and worked in agriculture and farming. He had been hospitalised on the mental health unit three years earlier due to behaviour consisting of paranoid delusions, visual and auditory hallucinations, insomnia, psychomotor restlessness, and heteroaggressive behaviour.</p><p id="par0055" class="elsevierStylePara elsevierViewall">He was admitted to the psychiatry department due to signs and symptoms for seven months consisting of behavioural changes and delusions, with subsequent exacerbation of his symptoms accompanied by aggressive behaviour towards his relatives and complex hallucinations. He stated that he was “tormented by a spirit”. He also reported that he decided to participate in an indigenous healing ceremony, presided over by a shaman, in which for the first time in his life he consumed a dark brown concoction with a bitter taste and earthy appearance called ayahuasca or <span class="elsevierStyleItalic">yage</span>. In the course of this ceremony, he experienced vivid visual delusions and hallucinations in which it was revealed to him that one of his neighbours had given him a potion, with subsequent infiltration of his body by an evil spirit. His delusional symptoms, focused on the devil, and aggressive behaviours then persisted over the following days (“I am tormented by unclean spirits. They tell me things. They are in my stomach. They do not let me read the Bible. My neighbour sent that spirit to me.”), whereupon he was taken to a hospital.</p><p id="par0060" class="elsevierStylePara elsevierViewall">In his mental examination, the patient appeared well dressed; participated actively in questioning; was disoriented to time and place but oriented to person; showed a cooperative attitude and hypoprosexia; and exhibited circumstantial, erratic language marked by bradylalia in a normal tone with bizarre associations, delusional ideas with paranoid and mystical content, and verbal and visual auditory hallucinations. This was consistent with his illogical/coherent thought content, with misguided judgement, illogical reasoning, moderate impulsiveness, anxiety and a lack of awareness of his disease and situation. Physical examination revealed no abnormalities and the patient's vital signs were within normal limits.</p><p id="par0065" class="elsevierStylePara elsevierViewall">The laboratory tests ordered (blood glucose, blood urea nitrogen, creatinine, complete blood count, liver panel, drug testing, serology, human immunodeficiency virus [HIV] and thyroid-stimulating hormone [TSH]) were in normal ranges. Neuroimaging (simple computed tomography of the head) did not reveal any structural abnormalities in the patient’s brain. Antipsychotic treatment was indicated with biperiden in 2-mg tablets every 8<span class="elsevierStyleHsp" style=""></span>h, clozapine 100<span class="elsevierStyleHsp" style=""></span>mg/12<span class="elsevierStyleHsp" style=""></span>h, risperidone 2<span class="elsevierStyleHsp" style=""></span>mg/8<span class="elsevierStyleHsp" style=""></span>h and sertraline 50<span class="elsevierStyleHsp" style=""></span>mg/24<span class="elsevierStyleHsp" style=""></span>h, and haloperidol and midazolam at doses of 5<span class="elsevierStyleHsp" style=""></span>mg/12<span class="elsevierStyleHsp" style=""></span>h in case of psychomotor agitation. After drug treatment was started, the patient’s symptoms were seen to improve, with him exhibiting a modulated affect, attenuated illogical/coherent thinking with paranoid delusions, absence of sensory/perceptual alterations, language with a normal tone and flow of speech, normal motor behaviour, still-weakened judgement and reasoning, and poor introspection and prospecting. Medical discharge and outpatient follow-up were considered in light of the patient’s favourable clinical course.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0070" class="elsevierStylePara elsevierViewall">We report the case of a patient with a history of episodes with paranoid delusions, visual and auditory hallucinations, insomnia, psychomotor restlessness, and heteroaggressive behaviour. In a context of ayahuasca use, this patient showed exacerbation of his symptoms with vivid illusions and visual hallucinations, inciting us to review the literature on these two factors.</p><p id="par0075" class="elsevierStylePara elsevierViewall">In the case reported, the clinical characteristics of ayahuasca-induced psychosis were seen to be similar to those in other published case reports: altered sensory perception, with visual hallucinations being most common, as in this case. It has also often been seen to be accompanied by psychomotor agitation, ataxia and tremors,<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> as well as somaesthetic alterations, other sensory alterations, altered thought content, dysphoria and emotional and affective lability.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,6</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Likewise, some case reports have featured plasma abnormalities such as increased prolactin, cortisol and growth hormone following ayahuasca use and moderate abnormalities in measurements of autonomic system functions such as temperature, respiration and pupil measurements.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> However, this case report featured only abnormalities related to exacerbation of psychosis, with no other associated clinical abnormalities.</p><p id="par0085" class="elsevierStylePara elsevierViewall">However, the incidence of psychosis after ayahuasca use has not been thoroughly elucidated. As seen, this type of presentation is rare, accounting for less than 1% of cases.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12,13</span></a> Several studies have been conducted that included ayahuasca use as part of treatment for psychiatric disorders and psychoactive substance use, yielding positive results with a significant reduction in intensity of psychiatric symptoms after one week of use and reduction of problematic use of substances such as cocaine, alcohol and tobacco,<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,6,9</span></a> unlike our patient, who after using the substance experienced heightening of his existing psychosis-related symptoms.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Systematic reviews on ayahuasca use and its relationship to psychotic episodes have indicated that this is a rare phenomenon, with these isolated cases usually marked by premorbid characteristics, especially a personal or family history of schizophrenia or schizophreniform disorders, psychotic depression or mania, or ongoing manic or psychotic symptoms; such people should avoid drinking this type of beverage. Thus this case report represents an instance of an isolated presentation of psychosis that also had important antecedents that heightened the condition following the use of this substance.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">In this vein, the differential diagnosis could include diagnosis of substance-induced mental disorders, based on DSM-V criteria when the characteristic symptoms of the disorder appear during use or up to one month later, as long as there is no evidence of a primary disorder<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>; however, as the patient had already suffered from psychiatric symptoms, a diagnosis of ayahuasca-induced schizophrenia was not seen to be founded.</p><p id="par0100" class="elsevierStylePara elsevierViewall">This study was not without limitations. First, a blood test to detect DMT was not performed; however, the patient had consumed the concoction seven months earlier, so DMT could not have been measured as it is rapidly eliminated in urine. The composition of the product and the amount ingested were not known for certain. Similarly, it was not very clear how much time had elapsed between the use of the substance and the onset of symptoms. The patient's history of psychosis also might have played an essential role in this episode. Finally, given that few case reports exist, the extent to which this beverage exacerbated his underlying medical condition was unknown.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of interest</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:3 [ "identificador" => "xres1773742" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1557990" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1773741" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1557989" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conflicts of interest" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-06-12" "fechaAceptado" => "2020-11-25" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1557990" "palabras" => array:4 [ 0 => "Ayahuasca" 1 => "Psychosis" 2 => "Intoxication" 3 => "Haloperidol" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1557989" "palabras" => array:4 [ 0 => "Ayahuasca" 1 => "Psicosis" 2 => "Intoxicación" 3 => "Haloperidol" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Psychosis induced by ayahuasca is a rare occurrence. However, due to an increase in the access and distribution of this substance, it is necessary to highlight the cases in which it occurs. We describe the case of a 26-year-old man who was admitted to the psychiatric service after seven months of changes in behaviour, delusions and the subsequent exacerbation of symptoms, after participating in a ritual ceremony during which he consumed an ayahuasca concoction for the first time. Initially, he required hospital treatment to control the acute psychotic episode, but after tolerating and responding well to the antipsychotic treatment, he was discharged with an outpatient follow-up.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La inducción de psicosis por ayahuasca es un evento poco frecuente. Sin embargo, debido a un aumento en el acceso y la distribución de esta sustancia, resulta menester destacar los casos en que se presenta. Se describe el caso de un paciente varón de 26 años que ingresó al servicio de psiquiatría por un cuadro clínico de 7 meses de evolución dado por cambios en el comportamiento, ideas delirantes y posterior exacerbación de los síntomas, tras participar en una ceremonia ritual en la que consumió por vez primera un brebaje de ayahuasca. Requirió inicialmente tratamiento hospitalario para controlar el episodio psicótico agudo, con buena respuesta y tolerancia al tratamiento farmacológico, lo que permitió continuar su seguimiento clínico ambulatorio.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:14 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Abate BECAL, Ena WLS, Comps AR. B c l, w s a (.). 2003;381–6." ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Neyra-ontaneda D. Psicosis inducida por ayahuasca?: reportede un. 2017;80:265–272." ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Overview focusing on developmental toxicology safety and side effects of ayahuasca in humans — an overview focusing. 2013;(April):37–41." ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The current state of research on ayahuasca: a systematic review of human studies assessing psychiatric symptoms, neuropsychological functioning, and neuroimaging" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.G. Santos" 1 => "F.M. Balthazar" 2 => "J.C. Bouso" 3 => "J.E.C. Hallak" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:1 [ "fecha" => "2016" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "LAS PROPIEDADES FARMACOCINÉTICAS DEL AYAHUASCA" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E. Cornejo" 1 => "G. Saúl" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:1 [ "fecha" => "2015" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "S CT. Neurociencias y aplicaciones psicoterapéuticas en el renacimiento de la investigación con psicodélicos Neurosciences and psycotherapeutic applications in the psychedelic research renaissaince. 2014;52(2):93–102." ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Halpern JH. Hallucinogens and dissociative agents naturally growing in the United States. 2004;102:131–138." ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Xarau SN, Pinillos MA, Hoffman RS. Emergent drugs (III): hallucinogenic plants and mushrooms. 2013;(III):505–18." ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Tortajada RE. Bloque de interés. 2015;2:75–91." ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Gambelunghe C, Aroni K, Rossi R, Moretti L, Bacci M. Identification of N,N-dimethyltryptamine and β-carbolines in psychotropic ayahuasca beverage. 2008;1059(May):1056–9." ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Santos RG, Bouso JC, Hallak JEC. Psychosis?: a systematic review of human studies. 2017;141–57." ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "G R, B JC, E J, H C. Ayahuasca: what mental health professionals need to know. 2017." ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Bilhimer MH, Schult RF, Higgs KV, Wiegand TJ, Gorodetsky RM, Acquisto NM. Case report acute intoxication following dimethyltryptamine ingestion. 2018;2018:3–6." ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Scroll P, For D. The effects of ayahuasca ritual participation on gay. 2014;(November):37–41." ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/25303120/0000005100000003/v1_202209230819/S2530312022000510/v1_202209230819/en/main.assets" "Apartado" => array:4 [ "identificador" => "66620" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case report" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/25303120/0000005100000003/v1_202209230819/S2530312022000510/v1_202209230819/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2530312022000510?idApp=UINPBA00004N" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 121 | 1 | 122 |
2024 October | 673 | 14 | 687 |
2024 September | 869 | 34 | 903 |
2024 August | 779 | 20 | 799 |
2024 July | 760 | 18 | 778 |
2024 June | 558 | 15 | 573 |
2024 May | 545 | 11 | 556 |
2024 April | 505 | 19 | 524 |
2024 March | 519 | 14 | 533 |
2024 February | 513 | 9 | 522 |
2024 January | 624 | 8 | 632 |
2023 December | 339 | 15 | 354 |
2023 November | 171 | 13 | 184 |
2023 October | 113 | 2 | 115 |
2023 September | 47 | 3 | 50 |
2023 August | 39 | 0 | 39 |
2023 July | 31 | 2 | 33 |
2023 March | 1 | 0 | 1 |