COVID-19
Regístrese
metricas
covid
Revista Colombiana de Psiquiatría (English Edition)
Buscar en
Revista Colombiana de Psiquiatría (English Edition)
Toda la web
Inicio Revista Colombiana de Psiquiatría (English Edition) Subjective Cognitive and Communicative Complaints and Health-Related Quality of ...
Journal Information
Back to article

Statistics

Follow this link to access the full text of the article

Artículo original
Subjective Cognitive and Communicative Complaints and Health-Related Quality of Life in Parkinson's Disease with and without Mild Cognitive Impairment
Quejas subjetivas cognitivas y comunicativas y Calidad de Vida Relacionada con la Salud en la Enfermedad de Parkinson con y Sin Deterioro Cognitivo Leve
Alberto Jaramillo-Jimeneza,b,c,d,e,1,
Corresponding author
alberto.jaramilloj@udea.edu.co

Corresponding author.
, Yamile Bocanegrab,c,1, Omar Buriticáb, David Antonio Pineda Salazarb,c, Leonardo Moreno Gómezf, Carlos Andrés Tobón Quinteroc,g, Daniel Camilo Aguirre-Acevedob,c, Melissa Sierra Castrillonb,c, Daniel Vasquezb, Juan Esteban Velez-Hernandezb, Miguel Germán Bordaa,e,h, Elkin García-Cifuentesb,h, David Fernando Aguillónb,c, Lucía Madrigal-Zapatab, Dag Aarslanda,i, Francisco Loperab
a Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway
b Grupo de Neurociencias de Antioquia, Universidad de Antioquia, School of Medicine, Medellín, Colombia
c Grupo Neuropsicología y Conducta, Universidad de Antioquia, School of Medicine, Medellín, Colombia
d Semillero de Investigación SINAPSIS, Universidad de Antioquia, School of Medicine, Medellín, Colombia
e Faculty of Health Sciences, University of Stavanger, Stavanger, Norway
f Unidad de Neurología, Hospital Pablo Tobón Uribe, Medellín, Colombia
g Área de investigación e Innovación, Institución Prestadora de Servicios de Salud (IPS Universitaria), Medellín, Colombia
h Semillero de Neurociencias y Envejecimiento, Ageing Institute, Medical School, Pontificia Universidad Javeriana, Bogotá, Colombia
i Department of Old Age Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom
Ver más
Read
14
Times
was read the article
6
Total PDF
8
Total HTML
Share statistics
 array:23 [
  "pii" => "S2530312023000814"
  "issn" => "25303120"
  "doi" => "10.1016/j.rcpeng.2023.11.004"
  "estado" => "S300"
  "fechaPublicacion" => "2023-10-01"
  "aid" => "480"
  "copyright" => "Asociación Colombiana de Psiquiatría"
  "copyrightAnyo" => "2021"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "fla"
  "cita" => "Rev Colomb Psiquiatr. 2023;52:305-13"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2530312023000759"
    "issn" => "25303120"
    "doi" => "10.1016/j.rcpeng.2021.07.008"
    "estado" => "S300"
    "fechaPublicacion" => "2023-10-01"
    "aid" => "482"
    "copyright" => "Asociación Colombiana de Psiquiatría"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Rev Colomb Psiquiatr. 2023;52:314-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "&#8220;Learning to learn&#8221; in the Extended Inverted Classroom&#58; An evaluation of the effects of interactive teaching on knowledge and cognitive regulation in medical students"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "314"
          "paginaFinal" => "319"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "&#171;Aprendiendo a aprender&#187; en el Aula Invertida Extendida&#58; una evaluaci&#243;n sobre los efectos de la ense&#241;anza interactiva en el conocimiento y la regulaci&#243;n cognitiva de estudiantes de Medicina"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Luis Carlos Dom&#237;nguez, Claudia Marcela Mora, Jorge Alberto Restrepo"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Luis Carlos"
              "apellidos" => "Dom&#237;nguez"
            ]
            1 => array:2 [
              "nombre" => "Claudia Marcela"
              "apellidos" => "Mora"
            ]
            2 => array:2 [
              "nombre" => "Jorge Alberto"
              "apellidos" => "Restrepo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0034745021001360"
        "doi" => "10.1016/j.rcp.2021.07.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0034745021001360?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2530312023000759?idApp=UINPBA00004N"
    "url" => "/25303120/0000005200000004/v1_202312071909/S2530312023000759/v1_202312071909/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2530312023000747"
    "issn" => "25303120"
    "doi" => "10.1016/j.rcpeng.2021.07.007"
    "estado" => "S300"
    "fechaPublicacion" => "2023-10-01"
    "aid" => "479"
    "copyright" => "Asociaci&#243;n Colombiana de Psiquiatr&#237;a"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Rev Colomb Psiquiatr. 2023;52:297-304"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Does the COVID-19 pandemic condition the delusional content of patients with psychosis&#63; An observational study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "297"
          "paginaFinal" => "304"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "&#191;La pandemia de COVID-19 condiciona el contenido delirante de los pacientes con psicosis&#63; Un estudio observacional"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1707
              "Ancho" => 2501
              "Tamanyo" => 186039
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0365"
              "detalle" => "Fig&#46; "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Main reasons for consultation of patients seen in psychiatric emergency departments between 11 March and 11 June 2020&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ana P&#233;rez-Balaguer, Bel&#233;n Sanz-Aranguez-&#193;vila, Elena Gil-Benito, Luz Mar&#237;a Solari-Heresmann, Pablo del Sol-Calder&#243;n, Lydia Gayubo-Moreo, Rosario de Arce-Cord&#243;n"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Ana"
              "apellidos" => "P&#233;rez-Balaguer"
            ]
            1 => array:2 [
              "nombre" => "Bel&#233;n"
              "apellidos" => "Sanz-Aranguez-&#193;vila"
            ]
            2 => array:2 [
              "nombre" => "Elena"
              "apellidos" => "Gil-Benito"
            ]
            3 => array:2 [
              "nombre" => "Luz Mar&#237;a"
              "apellidos" => "Solari-Heresmann"
            ]
            4 => array:2 [
              "nombre" => "Pablo"
              "apellidos" => "del Sol-Calder&#243;n"
            ]
            5 => array:2 [
              "nombre" => "Lydia"
              "apellidos" => "Gayubo-Moreo"
            ]
            6 => array:2 [
              "nombre" => "Rosario"
              "apellidos" => "de Arce-Cord&#243;n"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0034745021001335"
        "doi" => "10.1016/j.rcp.2021.07.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0034745021001335?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2530312023000747?idApp=UINPBA00004N"
    "url" => "/25303120/0000005200000004/v1_202312071909/S2530312023000747/v1_202312071909/en/main.assets"
  ]
  "en" => array:22 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Art&#237;culo original</span>"
    "titulo" => "Subjective Cognitive and Communicative Complaints and Health-Related Quality of Life in Parkinson&#39;s Disease with and without Mild Cognitive Impairment"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "305"
        "paginaFinal" => "313"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Alberto Jaramillo-Jimenez, Yamile Bocanegra, Omar Buritic&#225;, David Antonio Pineda Salazar, Leonardo Moreno G&#243;mez, Carlos Andr&#233;s Tob&#243;n Quintero, Daniel Camilo Aguirre-Acevedo, Melissa Sierra Castrillon, Daniel Vasquez, Juan Esteban Velez-Hernandez, Miguel Germ&#225;n Borda, Elkin Garc&#237;a-Cifuentes, David Fernando Aguill&#243;n, Luc&#237;a Madrigal-Zapata, Dag Aarsland, Francisco Lopera"
        "autores" => array:16 [
          0 => array:4 [
            "nombre" => "Alberto"
            "apellidos" => "Jaramillo-Jimenez"
            "email" => array:1 [
              0 => "alberto.jaramilloj@udea.edu.co"
            ]
            "referencia" => array:7 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              3 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
              4 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff0025"
              ]
              5 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "fn0005"
              ]
              6 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Yamile"
            "apellidos" => "Bocanegra"
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "fn0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Omar"
            "apellidos" => "Buritic&#225;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "David Antonio"
            "apellidos" => "Pineda Salazar"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Leonardo"
            "apellidos" => "Moreno G&#243;mez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">f</span>"
                "identificador" => "aff0030"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Carlos Andr&#233;s"
            "apellidos" => "Tob&#243;n Quintero"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">g</span>"
                "identificador" => "aff7"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Daniel Camilo"
            "apellidos" => "Aguirre-Acevedo"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Melissa"
            "apellidos" => "Sierra Castrillon"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          8 => array:3 [
            "nombre" => "Daniel"
            "apellidos" => "Vasquez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          9 => array:3 [
            "nombre" => "Juan Esteban"
            "apellidos" => "Velez-Hernandez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          10 => array:3 [
            "nombre" => "Miguel Germ&#225;n"
            "apellidos" => "Borda"
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff0025"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">h</span>"
                "identificador" => "aff0035"
              ]
            ]
          ]
          11 => array:3 [
            "nombre" => "Elkin"
            "apellidos" => "Garc&#237;a-Cifuentes"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">h</span>"
                "identificador" => "aff0035"
              ]
            ]
          ]
          12 => array:3 [
            "nombre" => "David Fernando"
            "apellidos" => "Aguill&#243;n"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          13 => array:3 [
            "nombre" => "Luc&#237;a"
            "apellidos" => "Madrigal-Zapata"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          14 => array:3 [
            "nombre" => "Dag"
            "apellidos" => "Aarsland"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">i</span>"
                "identificador" => "aff0040"
              ]
            ]
          ]
          15 => array:3 [
            "nombre" => "Francisco"
            "apellidos" => "Lopera"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:9 [
          0 => array:3 [
            "entidad" => "Centre for Age-Related Medicine &#40;SESAM&#41;&#44; Stavanger University Hospital&#44; Stavanger&#44; Norway"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Grupo de Neurociencias de Antioquia&#44; Universidad de Antioquia&#44; School of Medicine&#44; Medell&#237;n&#44; Colombia"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Grupo Neuropsicolog&#237;a y Conducta&#44; Universidad de Antioquia&#44; School of Medicine&#44; Medell&#237;n&#44; Colombia"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Semillero de Investigaci&#243;n SINAPSIS&#44; Universidad de Antioquia&#44; School of Medicine&#44; Medell&#237;n&#44; Colombia"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
          4 => array:3 [
            "entidad" => "Faculty of Health Sciences&#44; University of Stavanger&#44; Stavanger&#44; Norway"
            "etiqueta" => "e"
            "identificador" => "aff0025"
          ]
          5 => array:3 [
            "entidad" => "Unidad de Neurolog&#237;a&#44; Hospital Pablo Tob&#243;n Uribe&#44; Medell&#237;n&#44; Colombia"
            "etiqueta" => "f"
            "identificador" => "aff0030"
          ]
          6 => array:3 [
            "entidad" => "&#193;rea de investigaci&#243;n e Innovaci&#243;n&#44; Instituci&#243;n Prestadora de Servicios de Salud &#40;IPS Universitaria&#41;&#44; Medell&#237;n&#44; Colombia"
            "etiqueta" => "g"
            "identificador" => "aff7"
          ]
          7 => array:3 [
            "entidad" => "Semillero de Neurociencias y Envejecimiento&#44; Ageing Institute&#44; Medical School&#44; Pontificia Universidad Javeriana&#44; Bogot&#225;&#44; Colombia"
            "etiqueta" => "h"
            "identificador" => "aff0035"
          ]
          8 => array:3 [
            "entidad" => "Department of Old Age Psychiatry&#44; Institute of Psychiatry&#44; Psychology&#44; and Neuroscience&#44; King&#39;s College London&#44; London&#44; United Kingdom"
            "etiqueta" => "i"
            "identificador" => "aff0040"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Quejas subjetivas cognitivas y comunicativas y Calidad de Vida Relacionada con la Salud en la Enfermedad de Parkinson con y Sin Deterioro Cognitivo Leve"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 980
            "Ancho" => 2923
            "Tamanyo" => 176433
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Correlation between the global HRQoL and the Cognition and Communication dimensions&#46; 95&#37;CI&#58; 95&#37; confidence interval&#59; FDR&#58; false discovery ratio&#59; PD- nMCI&#58; Parkinson&#39;s disease without mild cognitive impairment&#59; PD-MCI&#58; Parkinson&#39;s disease with mild cognitive impairment&#59; PDQ-39&#58; Parkinson&#39;s Disease Questionnaire-39&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Parkinson&#39;s disease &#40;PD&#41; is one of the most prevalent neurodegenerative diseases and is primarily related to motor symptoms&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">1</span></a> However&#44; cognitive decline in PD patients has been highlighted among other non-motor symptoms due to its high prevalence&#44; and its negative effects on wellbeing and prognosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">2&#44;3</span></a> Mild cognitive impairment &#40;MCI&#41; due to PD &#40;PD-MCI&#41; is present in approximately 36&#37; of the PD cases&#44; even at the early stages of the disease&#44; and it has been identified as a risk factor for progression to PD dementia &#40;PDD&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">1&#44;3</span></a> In PD patients with normal cognition&#44; the presence of subjective cognitive complaints seems to be an indicator of the subsequent onset of MCI and functional decline&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">4</span></a> On the other hand&#44; up to 89&#37; of PD patients present speech difficulties such as dysarthria&#44; hypophonia&#44; and loss of articulation&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">11</span></a> Also&#44; language disorders at the pragmatic level have been reported in PD&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">12</span></a> Therefore&#44; speech and language disorders could generate subjective communication complaints related to language impairment at the phonemic and pragmatic level&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">As evidence-based medicine perspectives have emphasized the importance of patient-reported outcome measures in chronic diseases&#44; the health-related quality of life &#40;HRQoL&#41; has become a crucial target in neurodegenerative diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">5</span></a> The HRQoL is a multidimensional construct including physical and mental health&#44; social&#44; emotional&#44; and other domains&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">6</span></a> Thus&#44; this patient-centered approach considers the patient&#39;s beliefs&#44; ideas&#44; and subjective perception of health&#44; as well as the implications of the disease symptoms over satisfaction and individual well-being&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">7</span></a> However&#44; the perception of mental health &#40;especially of subjective cognitive complaints&#41; could be affected by several factors in PD patients&#44; such as mood symptoms&#44;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">8</span></a> lack of knowledge about the cognitive symptoms related to PD&#44;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">9</span></a> and lack of self-awareness for cognitive deficits &#40;i&#46;e&#46; anosognosia&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">10</span></a> Given the possible confounder effect of anosognosia in advanced stages of PD &#40;i&#46;e&#46; PDD&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">10</span></a> evaluating the impact of subjective cognitive and communicative complaints on HRQoL in earlier stages of PD &#40;i&#46;e&#46; MCI&#41; is valuable for a better understanding of the determinants of HRQoL&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Few preliminary studies have compared the HRQoL in PD patients with and without MCI&#44;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">11</span></a> thus&#44; our first objective is to compare the HRQoL in PD patients with and without MCI&#46; In addition&#44; we are not aware of studies exploring the relationship between self-perceived cognition-communication difficulties and HRQoL&#46; Therefore&#44; our second objective is to explore the potential relationships between the subjective cognitive and communicative complaints&#44; and HRQoL in PD patients with and without MCI&#46; We hypothesize that PD patients with MCI will have a worse HRQoL&#44; and they will report more subjective cognitive and communicative complaints that will be correlated with a worse HRQoL&#46; Our exploratory results may contribute to the patient-centered approach enhancing the comprehension of the effects of MCI over self-perceived mental health and HRQoL in PD patients&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Materials and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Sample selection</span><p id="par0020" class="elsevierStylePara elsevierViewall">This is a secondary analysis of the project &#8220;Procesamiento del lenguaje de acci&#243;n en pacientes con enfermedad ganglio-basal desde una perspectiva neuropsicol&#243;gica y neurofisiol&#243;gica&#8221; &#40;&#8220;Action language processing in patients with basal-ganglia disease from a neuropsychological and neurophysiological perspective&#8221;&#41; carried out at the Universidad de Antioquia &#40;University of Antioquia&#41; in 2015&#44; recruiting a convenience sample of PD patients from the outpatient service of the Grupo de Neurociencias de Antioquia &#40;Neurosciences group of Antioquia&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">12</span></a> The study had the approval of the Ethical Research Committee of the Universidad de Antioquia &#40;Certificate No&#46; 15-10-569&#41;&#44; and all participants signed an informed consent form before enrolment in the study&#46; The data was handled and kept following national health and data privacy protocols&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">We included 29 PD patients without MCI &#40;PD-nMCI&#41; and 11 PD patients with MCI &#40;PD-MCI&#41;&#46; Participants with parkinsonian syndromes other than PD&#44; other major neurological or psychiatric disorders&#44; and dementia &#40;based on impairment in cognition and function&#41;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">13</span></a> were excluded&#46; Detailed criteria regarding PD and MCI diagnosis are stated below&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Clinical assessment</span><p id="par0030" class="elsevierStylePara elsevierViewall">A team of two neurologists and one trained physician &#40;general practitioner&#41; determined the PD diagnosis following the Movement Disorder Society clinical diagnostic criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">14</span></a> The Hoehn &#38; Yahr scale<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">15</span></a> and the Unified Parkinson&#39;s Disease Rating Scale part III &#40;UPDRS-III&#41;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">16</span></a> were used for evaluating the severity of the disease and motor symptoms&#44; respectively&#46; Levodopa Equivalent Daily Dose &#40;LEDD&#41; was determined from the individual medication of patients&#44; all patients had received stable antiparkinsonian treatment during at least 4 weeks before evaluations&#46; All assessments were completed in phase &#8216;On&#8217; of levodopa treatment&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The PD-nMCI patients had a Montreal Cognitive Assessment score &#40;MoCA&#41; of 23 or above &#40;according to validation in the Colombian population<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">17&#44;18</span></a>&#41;&#46; The PD-MCI patients were diagnosed following the level one task force criteria of the Movement Disorders Society<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">19</span></a> &#40;i&#46;e&#46; observed or self-reported gradual cognitive decline in the clinical or neuropsychological examination&#44; MoCA<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>23&#44; and no significant cognition-related functional decline&#41;&#46; In those who reported subjective cognitive complaints&#44; the evaluator examined carefully if the difficulties are related to functional decline &#40;i&#46;e&#46; impairs the ability of the patient to perform instrumental or basic activities of daily living&#41;&#46; The latter was assessed using the Barthel Index<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">20</span></a> and Lawton &#38; Brody scale&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">21</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">All the neuropsychological tests &#40;i&#46;e&#46; Neuropsychiatric Inventory&#44; MoCA&#44; Lawton &#38; Brody&#44; Barthel&#44; and HRQoL scale&#41; were performed by a team of 3 trained psychologists who also confirmed PD-MCI diagnosis and absence of exclusion criteria &#40;i&#46;e&#46; dementia&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Since anosognosia could influence subjective cognitive or communicative complaints&#44; due to the lack of awareness deficits&#44;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">10</span></a> we evaluated anosognosia especially in the PD-MCI group through the clinical examination but none of the patients presented this symptom&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Health-related quality of life</span><p id="par0050" class="elsevierStylePara elsevierViewall">HRQoL was assessed with a specific scale for PD&#44; the Parkinson&#39;s Disease Questionnaire-39 &#40;PDQ-39&#41;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">22</span></a> due to its reliability&#44; psychometric properties&#44; validation across different countries&#44; and translations in many languages&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">8</span></a>&#46; The questionnaire consists of 39 items grouped in eight dimensions &#40;i&#46;e&#46; mobility&#44; activities of daily living&#44; emotional wellbeing&#44; stigma&#44; social support&#44; cognition&#44; communication&#44; and bodily discomfort&#41; and an averaged summary index of the 8 dimensions of PDQ-39 &#40;PDQ-39 SI&#41; that provides a measure of the global HRQoL&#46; Each of the 39 items was scored using a 5-point Likert scale&#44; ranging from &#8220;never&#8221; to &#8220;always&#47;cannot do at all&#8221;&#46; Therefore&#44; a higher score in PDQ-39 indicates a poor HRQoL&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">22</span></a> To avoid mistakes while filling up the PDQ-39&#44; the evaluator marked the patients&#8217; answers in the form&#44; and clarified any item if necessary&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Based on previously reported methods&#44;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">23</span></a> we analyzed the Cognition dimension as a measure of subjective cognitive complaints&#44; and the Communication dimension was used as a measure of subjective communicative complaints&#46; High scores in the Cognition or Communication dimension indicates high subjective cognitive or communication difficulties reported by the patient&#46; The Cognition dimension includes 4 items &#40;items 30-33&#41; of the PDQ-39&#44; such as impaired concentration&#44; memory complaints&#44; and cognitive fluctuations &#40;e&#46;g&#46;&#44; Had problems with your concentration when reading&#44; watching TV&#44; etc&#46;&#63;&#59; Felt your memory was bad&#63;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">22</span></a> The Communication dimension includes 3 items &#40;items 34-36&#41; of the PDQ-39 that point out speech and communication problems &#40;e&#46;g&#46;&#44; Had difficulty with your speech&#63;&#59; Felt unable to communicate with people properly&#63;&#59; Felt ignored by people&#63;&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Finally&#44; the PDQ-39 SI was taken as our outcome variable&#44; indicating the global HRQoL&#46; To face the circularity problems when analyzing the influence of a dimension over the summary index of the PDQ-39&#44; we adjusted the PDQ-39 SI excluding the items of the Cognition or Communication dimension as appropriate &#40;see &#8220;Statistical analysis&#8221;&#41;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Statistical analysis</span><p id="par0065" class="elsevierStylePara elsevierViewall">Demographic and clinical group differences were assessed using Mann-Whitney&#39;s U for continuous variables&#44; and the Chi-square test for categorical variables&#46; Group differences in clinical and demographic variables &#40;i&#46;e&#46; age&#44; years of education&#44; gender&#44; and motor symptoms&#41; were explored to evaluate the homogeneity between groups&#44; and the effect size was calculated using the Wilcoxon r statistic &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>Z&#47;&#8730;N&#41; for continuous variables<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">24</span></a>&#44; and the phi coefficient &#8212;&#966;&#61;&#8730;&#40;X<span class="elsevierStyleSup">2</span>&#47;N&#41;&#8212; for categorical variables&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">25</span></a> Given the possible confounder effect of motor symptoms due to heterogeneity between PD-nMCI and PD-MCI groups&#44; we controlled the subsequent analyses for the score of the UPDRS-III&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">For our first objective&#44; group differences of the non-adjusted PDQ-39 SI were evaluated and its effect size was calculated using the Wilcoxon r statistic&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">24</span></a> An additional analysis of the group differences in each of the eight dimensions of PDQ-39 was also performed&#44; and these resulting p-values were corrected for multiple testing using the false discovery rate &#40;FDR&#41; method setting a significance threshold of &#46;05&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">26</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">For our second objective&#44; non-parametric bivariate correlations between the Cognition dimension score and an adjusted PDQ-39 SI &#40;excluding the items of the Cognition dimension&#41; were performed following previous methods&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">27</span></a> Similarly&#44; to explore the correlations between the score of the Communication dimension and PDQ-39 SI&#44; we computed an adjusted summary index &#40;PDQ-39 SI&#41; excluding the items of the Communication dimension to avoid circularity issues&#46; Each correlation model was performed separately in both groups&#44; and the resulting <span class="elsevierStyleItalic">P</span>-values of these correlations were corrected for multiple testing using the FDR method&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">In addition&#44; given the differences in motor symptoms &#40;UPDRS-III&#41;&#44; the results of the latter correlation models were checked in each group using non-parametric partial correlations controlling for the effect of UPDRS-III&#46; These resulting <span class="elsevierStyleItalic">P</span>-values were also corrected for multiple testing &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Previous reports suggested a possible confounder effect of depression or anxiety in the self-perception of cognition difficulties&#46;<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">8&#44;28</span></a> Thus&#44; we used the Neuropsychiatric Inventory &#40;NPI&#41;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">29</span></a> to measure depression and anxiety symptoms based on synoptic scores &#40;i&#46;e&#46; frequency &#215; severity&#41; of the corresponding items&#46; In each group&#44; we conducted non-parametric bivariate correlations between the PDQ-39 variables &#40;i&#46;e&#46; Cognition and Communication dimensions&#44; as well as each of the adjusted summary indexes of the PDQ-39&#41;&#44; and the NPI scores of depression and anxiety&#44; in order to examine these potential confounders &#40;<a class="elsevierStyleCrossRef" href="#sec0090">Table 1 of the supplementary material</a>&#41;&#46; Additional non-parametric partial correlations controlling for the effect of depression&#44; anxiety&#44; as well as the combined effect of depression&#44; anxiety&#44; and motor symptoms&#44; were explored &#40;<a class="elsevierStyleCrossRef" href="#sec0090">Table 2 of the supplementary material</a>&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Non-parametric bivariate correlations between the Cognition and Communication dimensions&#44; and the non-adjusted PDQ-39 SI&#44; were also conducted to explore the dimension-total correlations as part of the psychometric characteristics of the instrument &#40;<a class="elsevierStyleCrossRef" href="#sec0090">Table 3 of the supplementary material</a>&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Given the possible effect of our sample size in the <span class="elsevierStyleItalic">P</span>-values&#44; and to provide a better scale for measuring the amount of information the test supplies against the hypothesis&#44; we rescaled all the <span class="elsevierStyleItalic">P</span>-values into Shannon information values &#40;S-values&#41; following previously described methods&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">30</span></a> Statistical analyses were performed using SPSS &#40;version 25&#41;<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">31</span></a> and JASP &#40;version 0&#46;13&#46;1&#46;0&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">32</span></a></p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Results</span><p id="par0100" class="elsevierStylePara elsevierViewall">40 patients were included&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> summarizes the characteristics of PD-MCI and PD-nMCI patients&#44; showing homogeneity between groups except for the MoCA test &#40;used for classification of the cognitive status of the groups&#41;&#44; and motor symptoms&#46; The latter can be seen in the higher UPDRS-III score of the PD-MCI group&#46; We did not find significant differences for age&#44; neuropsychiatric symptoms &#40;NPI Total&#41;&#44; nor depression &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;939&#59; r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8211;&#46;012&#41; or anxiety scores &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;397&#59; r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8211;&#46;134&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Differences in global HRQoL</span><p id="par0105" class="elsevierStylePara elsevierViewall">The median score of the PDQ-39 SI in the PD-nMCI group was 13&#46;6&#44; and in the PD-MCI group was 29&#46;3&#46; The PDQ-39 SI scores were higher in PD-MCI patients &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;030&#41;&#44; exhibiting a moderate effect size of the difference &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8211;&#46;342&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">figure 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">Patients diagnosed with PD-MCI reported higher scores in all the dimensions of PDQ-39 &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Differences were found in three dimensions after correction for multiple testing &#40;i&#46;e&#46; Cognition&#44; Communication&#44; and Bodily discomfort&#41;&#46; Estimations of the effect size showed large differences in the Cognition dimension&#46; A moderate effect size of the difference was found in the Communication&#44; and Bodily discomfort dimensions&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Self-perceived cognition and its relation to HRQoL</span><p id="par0115" class="elsevierStylePara elsevierViewall">The median &#91;interquartile range&#93; cognition-adjusted PDQ-39 SI in the PD-nMCI group was 15&#46;6 &#91;6&#46;43-28&#46;99&#93;&#44; and in the PD-MCI group was 30&#46;48 &#91;10&#44;12-43&#44;63&#93;&#44; as reported in <a class="elsevierStyleCrossRef" href="#sec0090">figure 2J of the supplementary material</a>&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0010">Figure 2A</a> depicts the bivariate non-parametric correlation between the Cognition dimension and the Cognition-adjusted PDQ-39 SI &#40;i&#46;e&#46; excluding the items of the Cognition dimension&#41;&#46; After correction for multiple testing&#44; significant strong correlations were seen in the PD-MCI group but not in the PD-nMCI group&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">Similar findings were observed when controlling the correlations for the group differences in motor symptoms &#40;UPDRS-III&#41;&#46; The Cognition dimension and the global HRQoL &#40;i&#46;e&#46; cognition-adjusted PDQ-39 SI&#41; were significantly correlated only in the PD-MCI group&#44; as reported in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Self-perceived communication and its relation to HRQoL</span><p id="par0130" class="elsevierStylePara elsevierViewall">The median &#91;interquartile range&#93; Communication-adjusted PDQ-39 SI in the PD-nMCI group was 12&#46;86 &#91;6&#46;43-27&#46;80&#93;&#44; and in the PD-MCI group was 29&#46;88 &#91;12&#46;80-43&#46;33&#93;&#44; as showed in <a class="elsevierStyleCrossRef" href="#sec0090">figure 2K of the supplementary material</a>&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0010">Figure 2B</a> shows the bivariate correlation between the Communication dimension and the Communication-adjusted PDQ-39 SI &#40;i&#46;e&#46; excluding the items of the Communication dimension&#41;&#46; Significant correlations were seen in both groups after correcting for multiple testing&#46; However&#44; the PD-MCI group exhibited strong correlations while the PD-nMCI had moderate correlations&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> shows the results of these correlations when controlling for motor symptoms &#40;UPDRS-III&#41;&#46; The Communication dimension and the global HRQoL &#40;i&#46;e&#46; communication-adjusted PDQ-39 SI&#41; were significantly correlated only in the PD-MCI group&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Effect of depression and anxiety symptoms over self-perceived cognition or communication difficulties and global HRQoL</span><p id="par0145" class="elsevierStylePara elsevierViewall">As we did not find group differences in depression or anxiety scores&#44; we did not adjust the main correlation models for these confounders&#46; In spite of it&#44; we explored in each group the correlation of these symptoms&#44; and the PDQ-39 dimensions&#44; adjusted and unadjusted PDQ-39 summary indexes&#46; Given the exploratory nature of these correlations&#44; we did not perform correction for multiple testing&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">As showed in <a class="elsevierStyleCrossRef" href="#sec0090">Table 1 of the supplementary material</a>&#44; none of the groups exhibited significant correlations between the depression or anxiety scores and the analyzed PDQ-39 scores &#40;i&#46;e&#46; Cognition&#44; Communication&#44; PDQ-39 SI&#44; cognition-adjusted PDQ-39 SI&#44; and communication-adjusted PDQ-39 SI&#41;&#46; Depression only showed significant strong correlations in the PD-MCI group with the Emotional well-being dimension &#40;&#961;&#61;&#46;62&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;002&#41;&#46; In the PD-nMCI group&#44; depression was significantly correlated with the stigma &#40;&#961;&#61;&#46;479&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;009&#41; and the social support dimensions &#40;&#961;&#61;&#46;545&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;002&#41;&#46; Anxiety scores were not correlated with any of the PDQ-39 variables in none of the groups &#40;<a class="elsevierStyleCrossRef" href="#sec0090">Table 1 of the supplementary material</a>&#41;&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Finally&#44; we explored non-parametric partial correlations between the Cognition and Communication dimensions&#44; and the adjusted PDQ-39 SI&#44; these correlations were controlled for depression&#44; anxiety and the combination of motor and mood symptoms &#40;<a class="elsevierStyleCrossRef" href="#sec0090">Table 2 of the supplementary material</a>&#41;&#46; In the PD-MCI group&#44; our findings regarding the relationship between the Cognition and Communication dimension and the adjusted PDQ-39 SI remain consistent after controlling the correlation models for all the possible confounders&#46; Also&#44; the PD-nMCI group exhibited significant correlations between the Communication-adjusted PDQ-39 SI and the Communication dimension after &#40;<a class="elsevierStyleCrossRef" href="#sec0090">Table 2 of the supplementary material</a>&#41;&#46;</p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Discussion</span><p id="par0160" class="elsevierStylePara elsevierViewall">This work explored the relationship between the HRQoL and the subjective cognitive and communicative complaints in PD patients with and without MCI&#46; Our results showed that subjective cognitive and communicative complaints are significantly correlated with the HRQoL in PD-MCI patients&#44; but not in the PD-nMCI group&#46; Therefore&#44; assessing the HRQoL and the subjective cognitive and communicative complaints might be useful to quantify important patient-reported outcomes in PD patients&#44;<a class="elsevierStyleCrossRefs" href="#bib0385"><span class="elsevierStyleSup">33&#44;34</span></a> especially those with MCI&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Cognitive decline has been recognized as an important factor that impacts negatively the HRQoL in PD patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">3&#44;35&#8211;37</span></a> We found a poorer HRQoL in the PD-MCI group with the largest effect size of the difference in the Cognition dimension of HRQoL&#46; One preliminary work has tried to determine what can be considered &#8220;minimally important differences in HRQoL&#8221; using the PDQ-39&#44; showing that those differences vary across the PDQ-39 dimensions&#46;<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">38</span></a> Thus&#44; in our study&#44; the observed differences between PD-MCI and PD-nMCI in the PDQ-39 SI&#44; the Cognition&#44; and the Communication dimensions seem to be considered important for the patients&#46;<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">38</span></a> Also&#44; in line with our findings&#44; preliminary reports have shown worse HRQoL in PD patients with an abnormal cognitive screening test&#44;<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">36</span></a> those with PD-amnestic MCI&#44;<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">37</span></a> as well as those with more severe MCI&#46;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">39</span></a> By contrast&#44; other studies found non-significant differences in the Cognition dimension or the global HRQoL when comparing PD patients with and without MCI&#46;<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">11&#44;28</span></a> However&#44; their conclusions only can be generalized to populations with a high level of education &#40;&#62;15 years&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">11</span></a> In our case&#44; the median years of education was below 15 years in both groups&#46; Therefore&#44; even if cross-sectional evidence suggests that low education level does not impact the HRQoL in PD patients&#44;<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">36</span></a> further research including larger and heterogeneous samples will elucidate the effect of education over subjective cognitive complaints and HRQoL in PD-MCI patients&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Beyond&#44; multiple factors can affect the scores of the Cognition dimension&#58; Lack of awareness of the cognitive deficits &#40;i&#46;e&#46; anosognosia&#41; that emerges in severe cognitive decline &#40;i&#46;e&#46; PD dementia&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">10</span></a> Other mental health factors such as anxiety&#44; depression&#44; and optimism seem to explain the worsening in the Cognition subscale and the HRQoL better than the neuropsychological performance&#46;<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">8&#44;28</span></a> Comparable results were described in PD patients with normal cognition&#58; the higher the depressive symptoms&#44; the higher the subjective cognitive complaints&#46;<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">35</span></a> However&#44; our results did not show significant correlations between depression or anxiety and the HRQoL nor the Cognition or Communication dimensions&#46; Also&#44; our findings regarding the relationship between HRQoL and subjective cognitive and communicative complaints were consistent in the PD-MCI group after controlling for depression&#44; anxiety&#44; and motor symptoms&#44; but the relationship of HRQoL and Communication dimension in the PD-nMCI group seems to be significant&#46; We are aware that these results should be interpreted with caution since the NPI is not a specific instrument for mood disorders&#44; and future studies with specific protocols will contribute to unveil the role of mood disorders as determinants of HRQoL in PD&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">It has been proposed that the Cognition dimension &#40;specifically the attention and memory items&#41; could be valuable measures of how the patients subjectively rate their cognitive performance and should be examined as an endpoint and predictor of cognitive decline in larger studies&#46;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">40</span></a> In addition to the Cognition dimension&#44; we have evaluated the Communication dimension &#40;i&#46;e&#46; phonetic and pragmatic level of language&#41;&#46; In line with our findings&#44; preliminary reports have suggested increased subjective communication difficulties in PD-MCI patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">11&#44;28</span></a> Also&#44; the prognostic impact of the subjective cognitive complaints has been recently evaluated in PD patients with normal cognition&#44; showing that subjective cognitive complaints have been associated with greater decline in cognition-related functional abilities&#44; suggesting that subjective cognitive complaints may be a sensitive indicator of the cognitive decline in PD&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">4</span></a> Therefore&#44; consider&#236;ng the subjective cognitive and communicative complaints as well as HRQoL in PD patients with and without MCI&#44; may lead the clinicians to a more comprehensive patient-centered approach with relevant prognostic implications&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">The PDQ-39 is an instrument that has been widely applied in clinical research to assess the HRQoL and the multiple dimensions of this construct&#44; demonstrating acceptability&#44; internal consistency&#44; and a holistic approach to both motor and non-motor symptoms of PD&#46;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">41</span></a> Nevertheless&#44; the validity of the Cognition dimension as a subjective measure of cognitive abilities has been questioned since some of the items are not directly related to cognition &#40;such as presence of hallucinations&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0420"><span class="elsevierStyleSup">40&#44;42</span></a> Further research analyzing the meaningful items of the Communication and Cognition dimensions as well as the PDQ-39 SI could represent an important patient-reported outcome measure&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Several limitations to this study should be considered when interpreting our results&#46; The small convenience sample size can affect the external validity of our results and the statistical power&#44; it also precluded us from the use of other statistical methods better suited for larger samples&#46; In order to get the external validity of our results&#44; the authors encourage future research to reproduce our exploratory findings&#46; Also&#44; the lack of follow-up reduces the possibility of establishing causal effects&#46; Besides&#44; given the retrospective nature of our study&#44; we did not use a specific measure for subjective cognitive and communicative complaints&#44; nor specific tests for anosognosia or mood symptoms&#46; Additionally&#44; the subtle nonsignificant age difference in our groups should be considered as a potential bias&#46; However&#44; few publications have evaluated the HRQoL in the Colombian population&#44;<a class="elsevierStyleCrossRefs" href="#bib0435"><span class="elsevierStyleSup">43&#44;44</span></a> and this is the first work examining the impact of subjective cognitive and communicative complaints on HRQoL in PD-MCI patients&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Conclusions</span><p id="par0190" class="elsevierStylePara elsevierViewall">HRQoL seems to be affected in PD-MCI patients&#44; and it might be influenced by greater subjective cognitive and communicative complaints&#46; Thus&#44; including patient-reported measures of HRQoL&#44; and providing cognitive and speech rehabilitation&#44; as well as psychotherapeutic strategies&#44; to face the cognitive and communicative deficits of the patients&#44; could enhance the patient-centered approach in PD&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Funding</span><p id="par0195" class="elsevierStylePara elsevierViewall">This work was supported by the Research Development Committee &#40;CODI&#41; - Universidad de Antioquia &#40;University of Antioquia&#41;&#44; Colombia&#44; under the research project&#58; <span class="elsevierStyleItalic">&#8220;Procesamiento del lenguaje de acci&#243;n en pacientes con enfermedad ganglio-basal desde una perspectiva neuropsicol&#243;gica y neurofisiol&#243;gica&#8221;</span> &#40;grant reference PRG-2014-768&#41;&#46; In addition&#44; this paper represents independent research supported by the Norwegian government&#44; through hospital owner Helse Vest &#40;Western Norway Regional Health Authority&#41;&#44; and was partly funded by the National Institute for Health Research &#40;NIHR&#41; Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King&#39;s College London&#46; The views expressed are those of the authors and not necessarily those of the NHS&#44; the NIHR or the Department of Health and Social Care&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Conflicts of interests</span><p id="par0200" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interests to declare&#46; The sponsor has no role in the collection&#44; analysis&#44; interpretation of the data&#44; and writing of the final manuscript&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:13 [
        0 => array:3 [
          "identificador" => "xres2042924"
          "titulo" => "Abstract"
          "secciones" => array:5 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Introduction"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Objective"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Methods"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Results"
            ]
            4 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1746752"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres2042923"
          "titulo" => "Resumen"
          "secciones" => array:5 [
            0 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Introducci&#243;n"
            ]
            1 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Objetivo"
            ]
            2 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "M&#233;todos"
            ]
            3 => array:2 [
              "identificador" => "abst0045"
              "titulo" => "Resultados"
            ]
            4 => array:2 [
              "identificador" => "abst0050"
              "titulo" => "Conclusiones"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1746751"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Materials and methods"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Sample selection"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Clinical assessment"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Health-related quality of life"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Statistical analysis"
            ]
          ]
        ]
        6 => array:3 [
          "identificador" => "sec0035"
          "titulo" => "Results"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Differences in global HRQoL"
            ]
            1 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Self-perceived cognition and its relation to HRQoL"
            ]
            2 => array:2 [
              "identificador" => "sec0050"
              "titulo" => "Self-perceived communication and its relation to HRQoL"
            ]
            3 => array:2 [
              "identificador" => "sec0055"
              "titulo" => "Effect of depression and anxiety symptoms over self-perceived cognition or communication difficulties and global HRQoL"
            ]
          ]
        ]
        7 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Conclusions"
        ]
        9 => array:2 [
          "identificador" => "sec0070"
          "titulo" => "Funding"
        ]
        10 => array:2 [
          "identificador" => "sec0080"
          "titulo" => "Conflicts of interests"
        ]
        11 => array:2 [
          "identificador" => "xack712065"
          "titulo" => "Acknowledgements"
        ]
        12 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2020-11-18"
    "fechaAceptado" => "2021-07-05"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1746752"
          "palabras" => array:5 [
            0 => "Parkinson&#39;s disease"
            1 => "Health-related quality of life"
            2 => "Quality of life"
            3 => "Cognitive decline"
            4 => "Mild cognitive impairment&#46;"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1746751"
          "palabras" => array:5 [
            0 => "Enfermedad de Parkinson"
            1 => "Calidad de vida relacionada con la salud"
            2 => "Calidad de vida"
            3 => "Deterioro cognitivo"
            4 => "Deterioro cognitivo leve"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Mild Cognitive Impairment &#40;MCI&#41; is common in Parkinson&#39;s Disease &#40;PD&#41;&#46; Few studies have compared the Health-Related Quality of Life &#40;HRQoL&#41; in patients with and without MCI due to PD &#40;PD-MCI&#41;&#44; and its correlation to patients&#8217; subjective cognitive and communicative difficulties has not been explored&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We aimed to compare HRQoL in PD-MCI and PD without MCI &#40;PD-nMCI&#41;&#44; and explore its possible relationship to subjective cognitive and communicative complaints&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We included 29 PD-nMCI and 11 PD-MCI patients&#46; The HRQoL was assessed with the Parkinson&#39;s Disease Questionnaire-39 &#40;PDQ-39&#41;&#58; its Cognition dimension was used as a measure of subjective cognitive complaints&#44; its Communication dimension for subjective communicative complaints&#44; and the summary index &#40;PDQ-39 SI&#41; as an indicator of HRQoL&#46; Non-parametric partial correlations between the Cognition and Communication dimensions&#44; and the adjusted PDQ-39 SI were conducted&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">PD-MCI patients had greater subjective cognitive and communicative complaints and worse HRQoL than PD-nMCI patients&#46; In the PD-MCI group&#44; both subjective cognitive and communicative complaints exhibited significant direct correlations with the adjusted HRQoL scores&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">HRQoL seems to be affected in PD-MCI&#44; and it might be influenced by greater subjective cognitive and communicative complaints&#46; Including patient-reported outcome measures of HRQoL&#44; and providing cognitive and speech rehabilitation&#44; as well as psychotherapeutic strategies to face these deficits can enhance the patient-centred approach in PD&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objective"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Methods"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Results"
          ]
          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introducci&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">El deterioro cognitivo leve &#40;DCL&#41; es frecuente en la enfermedad de Parkinson &#40;EP&#41;&#46; Pocos estudios han comparado la calidad de vida relacionada con la salud &#40;CVRS&#41; en pacientes con DCL debido a EP &#40;EP-DCL&#41; sin explorar la relaci&#243;n entre la CVRS y las quejas subjetivas cognitivas y comunicativas de los pacientes&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Comparar la CVRS en EP-DCL y EP sin DCL &#40;EP-nDCL&#41; explorando sus posibles relaciones con las quejas subjetivas cognitivas y comunicativas&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">M&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; a 29 EP-DCL y 11 EP-nDCL&#46; La CVRS se evalu&#243; con el cuestionario PDQ-39&#58; su dimensi&#243;n Cognici&#243;n se us&#243; como medida de las quejas subjetivas cognitivas&#59; su dimensi&#243;n Comunicaci&#243;n&#44; como medida de las quejas subjetivas comunicativas y su puntuaci&#243;n resumen &#40;PDQ-39 SI&#41;&#44; como indicador de CVRS&#46; Se realizaron correlaciones parciales no param&#233;tricas entre el PDQ-39 SI ajustado y las dimensiones Cognici&#243;n y Comunicaci&#243;n&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Los pacientes EP-DCL presentaron una peor CVRS y mayores quejas subjetivas cognitivas y comunicativas&#46; En el grupo EP-DCL&#44; tanto las quejas subjetivas cognitivas como las comunicativas mostraron correlaciones directas significativas con la puntuaci&#243;n de CVRS ajustada&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La CVRS de los pacientes con EP-DCL parece estar afectada e influida por las quejas subjetivas en cognici&#243;n y comunicaci&#243;n&#46; Incluir los resultados de CVRS reportados por los pacientes&#44; proveer rehabilitaci&#243;n cognitiva y del lenguaje y estrategias de psicoterapia para afrontar dichos d&#233;ficit podr&#237;a mejorar el abordaje centrado en el paciente en la EP&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Objetivo"
          ]
          2 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "M&#233;todos"
          ]
          3 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Resultados"
          ]
          4 => array:2 [
            "identificador" => "abst0050"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:3 [
        "etiqueta" => "1"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0055">Authors contributed equally&#46;</p>"
        "identificador" => "fn0005"
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0215" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Supplementary data"
            "identificador" => "sec0090"
          ]
        ]
      ]
    ]
    "multimedia" => array:6 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1272
            "Ancho" => 1649
            "Tamanyo" => 111352
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Self-perception of HRQoL in PD-nMCI and PD-MCI&#46; PD-MCI&#58; Parkinson&#39;s disease with mild cognitive impairment&#59; PD-nMCI&#58; Parkinson&#39;s disease without mild cognitive impairment&#59; PDQ-39 SI&#58; Parkinson&#39;s Disease Questionnaire-39 Summary Index&#59; r&#58; effect size &#40;Wilcoxon&#41;&#59; P&#58; p-value&#59; S&#58; Shannon information-value&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 980
            "Ancho" => 2923
            "Tamanyo" => 176433
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Correlation between the global HRQoL and the Cognition and Communication dimensions&#46; 95&#37;CI&#58; 95&#37; confidence interval&#59; FDR&#58; false discovery ratio&#59; PD- nMCI&#58; Parkinson&#39;s disease without mild cognitive impairment&#59; PD-MCI&#58; Parkinson&#39;s disease with mild cognitive impairment&#59; PDQ-39&#58; Parkinson&#39;s Disease Questionnaire-39&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">F&#47;M&#58; female&#47;male&#59; LEDD&#58; levodopa equivalent daily dose&#59; MoCA&#58; Montreal Cognitive Assessment&#59; NPI&#58; neuropsychiatric inventory&#59; PD-MCI&#58; Parkinson&#39;s disease with mild cognitive impairment&#59; PD-nMCI&#58; Parkinson&#39;s disease without mild cognitive impairment&#59; UPDRS-III&#58; Unified Parkinson&#39;s Disease Rating Scale part III &#40;motor subscale&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">PD-nMCI&#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>29&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">PD-MCI&#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>-value<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Effect size<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63 &#91;54-66&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">65 &#91;60-69&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;225&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#46;192&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gender &#40;F&#47;M&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#47;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#47;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;528<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;115<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Education &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#91;8-16&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#91;5-16&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;693&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#46;063&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Years since diagnosis of PD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#91;3-8&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#91;3-8&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;394&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#46;135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LEDD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">600 &#91;350-800&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">750 &#91;300-1048&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;379&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#46;139&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hoehn &#38; Yahr&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#91;2-2&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#91;2-2&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;854&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#46;029&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">UPDRS-III score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#91;22-31&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35 &#91;28-41&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;030&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#46;343&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MoCA total score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#91;26-28&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22 &#91;19-23&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#46;771&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NPI total score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#91;1-9&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#91;0-19&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;428&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#46;126&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3387252.png"
              ]
            ]
          ]
          "notaPie" => array:4 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Mann-Whitney U test&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Effect size &#40;r&#41;&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Chi-squared test&#46;</p>"
            ]
            3 => array:3 [
              "identificador" => "tblfn0020"
              "etiqueta" => "d"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Effect size &#40;phi coefficient&#41;&#46;</p> <p class="elsevierStyleNotepara" id="npar0025">Values presented in the table are medians &#91;interquartile range&#93;&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Demographic and clinical characteristics of the sample&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">FDR&#58; false discovery ratio&#59; PD-MCI&#58; Parkinson&#39;s disease with mild cognitive impairment&#59; PD-nMCI&#58; Parkinson&#39;s disease without mild cognitive impairment&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">PD-nMCI &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>29&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">PD-MCI &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>-value &#40;FDR&#41;<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">S</span>-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Effect size<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mobility&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;5 &#91;5-30&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#91;15&#44;0-70&#44;0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;064 &#40;&#46;127&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#46;293&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Activities of Daily Living&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25 &#91;12&#44;5-37&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#46;3 &#91;16&#44;7-70&#44;8&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;167 &#40;&#46;268&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#46;218&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Emotional wellbeing&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;8 &#91;0-33&#44;3&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#46;3 &#91;4&#44;2-66&#44;7&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;179 &#40;&#46;205&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#46;213&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Stigma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#91;0-37&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;5 &#91;0-25&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;662 &#40;&#46;662&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#46;069&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Social support&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#91;0-0&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#91;0-8&#44;3&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;172 &#40;&#46;229&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#46;216&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cognition&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#91;12&#46;50-12&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#46;3 &#91;12&#44;5-43&#44;8&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;001 &#40;&#46;005&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#46;542&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Communication&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;3 &#91;0-16&#44;7&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25 &#91;16&#44;7-41&#44;7&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;007 &#40;&#46;029&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#46;424&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bodily discomfort&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;3 &#91;0-16&#44;7&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#46;3 &#91;16&#44;7-41&#44;7&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;017 &#40;&#46;046&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&#46;376&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3387250.png"
              ]
            ]
          ]
          "notaPie" => array:2 [
            0 => array:3 [
              "identificador" => "tblfn0025"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0030">Mann-Whitney&#39;s U test&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0030"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0035">Effect size &#40;r&#41;&#46;</p> <p class="elsevierStyleNotepara" id="npar0040">Values presented are median &#91;interquartile range&#93;&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Dimensions of the PDQ-39 in PD-nMCI and PD-MCI groups&#46;</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">FDR&#58; false discovery ratio&#59; PD-MCI&#58; Parkinson&#39;s disease with mild cognitive impairment&#59; PD-nMCI&#58; Parkinson&#39;s disease without mild cognitive impairment&#59; UPDRS-III&#58; Unified Parkinson&#39;s Disease Rating Scale part III &#40;motor subscale&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Dimension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Correlation with adjusted PDQ-39 Summary Index<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">a</span></a></th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Partial &#40;controlling for&#41; UPDRS-III</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Coefficient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>-value &#40;FDR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">S</span>-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cognition</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PD-MCI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;728&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;017 &#40;&#46;034&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PD-nMCI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;477 &#40;&#46;477&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Communication</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PD-MCI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;011 &#40;&#46;043&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PD-nMCI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;052 &#40;&#46;070&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3387251.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0035"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0045">For the correlations with the Cognition dimension&#44; the PDQ-39 Summary Index was calculated excluding the &#8220;Cognition&#8221; items&#46; For the correlations with the Communication dimension&#44; the PDQ-39 Summary Index was calculated excluding the &#8220;Communication&#8221; items&#46;</p> <p class="elsevierStyleNotepara" id="npar0050">Spearman partial correlations were adjusted for UPDRS-III to control the effect of motor symptoms in the model estimations&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Motor-adjusted partial correlations between the global HRQoL&#44; and the Cognition and Communication dimensions in PD-nMCI and PD-MCI groups&#46;</p>"
        ]
      ]
      5 => array:5 [
        "identificador" => "upi0005"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc1.pdf"
          "ficheroTamanyo" => 456911
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:44 [
            0 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lewy body dementias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46;J&#46; Armstrong"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Contin Lifelong Learn Neurol&#46;"
                        "fecha" => "2019"
                        "volumen" => "25"
                        "paginaInicial" => "128"
                        "paginaFinal" => "146"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognosis of mild cognitive impairment in early Parkinson disease&#58; The Norwegian ParkWest study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46;F&#46; Pedersen"
                            1 => "J&#46;P&#46; Larsen"
                            2 => "O&#46;B&#46; Tysnes"
                            3 => "G&#46; Alves"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jamaneurol.2013.2110"
                      "Revista" => array:7 [
                        "tituloSerie" => "JAMA Neurol&#46;"
                        "fecha" => "2013"
                        "volumen" => "70"
                        "paginaInicial" => "580"
                        "paginaFinal" => "586"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23529397"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1876285921001388"
                          "estado" => "S300"
                          "issn" => "18762859"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "D&#46; Aarsland"
                            1 => "B&#46; Creese"
                            2 => "M&#46; Politis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Cognitive decline in Parkinson disease&#46; Nature Publishing Group&#59;"
                        "fecha" => "2017"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32119429"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subjective cognitive complaint in Parkinson&#39;s disease patients with normal cognition&#58; canary in the coal mine&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46; Purri"
                            1 => "L&#46; Brennan"
                            2 => "J&#46; Rick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/mds.28115"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mov Disord&#46;"
                        "fecha" => "2020"
                        "volumen" => "35"
                        "paginaInicial" => "1618"
                        "paginaFinal" => "1625"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32520435"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Participant outcomes and preferences in Alzheimer&#39;s disease clinical trials&#58; The electronic Person-Specific Outcome Measure &#40;ePSOM&#41; development program"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Saunders"
                            1 => "G&#46; Muniz-Terrera"
                            2 => "J&#46; Watson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Alzheimer&#39;s Dement Transl Res Clin Interv&#46;"
                        "fecha" => "2018"
                        "volumen" => "4"
                        "paginaInicial" => "694"
                        "paginaFinal" => "702"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of a measurement strategy for Parkinson&#39;s disease&#58; Assessing patient health-related quality of life"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;M&#46; Damiano"
                            1 => "M&#46;M&#46; McGrath"
                            2 => "M&#46;K&#46; Willian"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1023/a:1008928321652"
                      "Revista" => array:6 [
                        "tituloSerie" => "Qual Life Res&#46;"
                        "fecha" => "2000"
                        "volumen" => "9"
                        "paginaInicial" => "87"
                        "paginaFinal" => "100"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10981209"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Quality of life in chronic disease patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "K&#46; Megari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Heal Psychol Res&#46;"
                        "fecha" => "2013"
                        "volumen" => "1"
                        "paginaInicial" => "27"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictors of quality of life in people with Parkinson&#39;s disease&#58; Evidence for both domain specific and general relationships"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Simpson"
                            1 => "G&#46; Lekwuwa"
                            2 => "T&#46; Crawford"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/09638288.2014.883442"
                      "Revista" => array:6 [
                        "tituloSerie" => "Disabil Rehabil&#46;"
                        "fecha" => "2014"
                        "volumen" => "36"
                        "paginaInicial" => "1964"
                        "paginaFinal" => "1970"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24499208"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patient perceptions and knowledge of Parkinson&#39;s disease and treatment &#40;KnowPD&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;R&#46; Salinas"
                            1 => "E&#46;J&#46; Chambers"
                            2 => "T&#46; Ho"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.prdoa.2020.100038"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Park Relat Disord&#46;"
                        "fecha" => "2020"
                        "volumen" => "3"
                        "paginaInicial" => "100038"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34316624"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0890856716000770"
                          "estado" => "S300"
                          "issn" => "08908567"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anosognosia for cognitive and behavioral symptoms in Parkinson&#39;s disease with mild dementia and mild cognitive impairment&#58; Frequency and neuropsychological&#47;neuropsychiatric correlates"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;D&#46; Orfei"
                            1 => "F&#46; Assogna"
                            2 => "C&#46; Pellicano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Park Relat Disord&#46;"
                        "fecha" => "2018"
                        "volumen" => "54"
                        "paginaInicial" => "62"
                        "paginaFinal" => "67"
                        "itemHostRev" => array:3 [
                          "pii" => "S0749379715000501"
                          "estado" => "S300"
                          "issn" => "07493797"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of mild cognitive impairment on health-related quality of life in Parkinson&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "W&#46; Reginold"
                            1 => "S&#46; Duff-Canning"
                            2 => "C&#46; Meaney"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000350032"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dement Geriatr Cogn Disord&#46;"
                        "fecha" => "2013"
                        "volumen" => "36"
                        "paginaInicial" => "67"
                        "paginaFinal" => "75"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23774742"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Resting functional connectivity and mild cognitive impairment in Parkinson&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;A&#46; Carmona Arroyave"
                            1 => "C&#46;A&#46; Tob&#243;n Quintero"
                            2 => "J&#46;J&#46; Su&#225;rez Revelo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "An electroencephalogram study&#46; Future Neurol&#46;"
                        "fecha" => "2019"
                        "volumen" => "14"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Emre M&#44; Aarsland D&#44; Brown R&#44; et al&#46; Clinical diagnostic criteria for dementia associated with Parkinson&#39;s disease&#46; Mov Disord&#46; 2007&#59;22&#58;1689-707"
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "MDS clinical diagnostic criteria for Parkinson&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46;B&#46; Postuma"
                            1 => "D&#46; Berg"
                            2 => "M&#46; Stern"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2015"
                        "editorial" => "John Wiley &#38; Sons"
                        "editorialLocalizacion" => "New York"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Hoehn and Yahr Rating Scale for Parkinson&#39;s disease&#46; In&#58; Instrumental Methods and Scoring in Extrapyramidal Disorders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;M&#46; Rabey"
                            1 => "A&#46;D&#46; Korczyn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:5 [
                        "fecha" => "1995"
                        "paginaInicial" => "7"
                        "paginaFinal" => "17"
                        "editorial" => "Springer"
                        "editorialLocalizacion" => "Berlin&#44; Heidelberg"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Unified Parkinson&#39;s Disease Rating Scale &#40;UPDRS&#41;&#58; Status and recommendations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "C&#46;C&#46; Goetz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2003"
                        "editorial" => "John Wiley &#38; Sons"
                        "editorialLocalizacion" => "New York"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validation of the Montreal Cognitive Assessment &#40;MoCA&#41; in Spanish as a screening tool for mild cognitive impairment and mild dementia in patients over 65 years old in Bogot&#225;&#44; Colombia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Gil"
                            1 => "C&#46; Ruiz De S&#225;nchez"
                            2 => "F&#46; Gil"
                            3 => "S&#46;J&#46; Romero"
                            4 => "F&#46; Pretelt Burgos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/gps.4199"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Geriatr Psychiatry&#46;"
                        "fecha" => "2015"
                        "volumen" => "30"
                        "paginaInicial" => "655"
                        "paginaFinal" => "662"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25320026"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Montreal Cognitive Assessment&#44; MoCA&#58; A brief screening tool for mild cognitive impairment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "Z&#46;S&#46; Nasreddine"
                            1 => "N&#46;A&#46; Phillips"
                            2 => "V&#46; B&#233;dirian"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1532-5415.2005.53221.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Geriatr Soc&#46;"
                        "fecha" => "2005"
                        "volumen" => "53"
                        "paginaInicial" => "695"
                        "paginaFinal" => "699"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15817019"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0890856713005947"
                          "estado" => "S300"
                          "issn" => "08908567"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnostic criteria for mild cognitive impairment in Parkinson&#39;s disease&#58; Movement Disorder Society Task Force guidelines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "I&#46; Litvan"
                            1 => "J&#46;G&#46; Goldman"
                            2 => "A&#46;I&#46; Tr&#246;ster"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Mov Disord&#46;"
                        "fecha" => "2012"
                        "volumen" => "27"
                        "paginaInicial" => "349"
                        "paginaFinal" => "356"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Functional evaluation&#58; the Barthel Index"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46;I&#46; Mahoney"
                            1 => "D&#46;W&#46; Barthel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Md State Med J&#46;"
                        "fecha" => "1965"
                        "volumen" => "14"
                        "paginaInicial" => "61"
                        "paginaFinal" => "65"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5832033"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0325"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of older people&#58; self-maintaining and instrumental activities of daily living"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;P&#46; Lawton"
                            1 => "E&#46;M&#46; Brody"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Gerontologist&#46;"
                        "fecha" => "1969"
                        "volumen" => "9"
                        "numero" => "3 Part 1"
                        "paginaInicial" => "179"
                        "paginaFinal" => "186"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5349366"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0330"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The development and validation of a short measure of functioning and well being for individuals with Parkinson&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "V&#46; Peto"
                            1 => "C&#46; Jenkinson"
                            2 => "R&#46; Fitzpatrick"
                            3 => "R&#46; Greenhall"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF02260863"
                      "Revista" => array:6 [
                        "tituloSerie" => "Qual Life Res&#46;"
                        "fecha" => "1995"
                        "volumen" => "4"
                        "paginaInicial" => "241"
                        "paginaFinal" => "248"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7613534"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0335"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictors of self-perceived stigma in Parkinson&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46;D&#46; Salazar"
                            1 => "E&#46; Weizenbaum"
                            2 => "T&#46;D&#46; Ellis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.parkreldis.2018.09.028"
                      "Revista" => array:6 [
                        "tituloSerie" => "Parkinsonism Relat Disord&#46;"
                        "fecha" => "2019"
                        "volumen" => "60"
                        "paginaInicial" => "76"
                        "paginaFinal" => "80"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30297211"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0340"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect size estimates&#58; Current use&#44; calculations&#44; and interpretation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46;O&#46; Fritz"
                            1 => "P&#46;E&#46; Morris"
                            2 => "J&#46;J&#46; Richler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1037/a0024338"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Psychol Gen&#46;"
                        "fecha" => "2012"
                        "volumen" => "141"
                        "paginaInicial" => "2"
                        "paginaFinal" => "18"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21823805"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0345"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Using the standardized difference to compare the prevalence of a binary variable between two groups in observational research"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;C&#46; Austin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Commun Stat Simul Comput&#46;"
                        "fecha" => "2009"
                        "volumen" => "38"
                        "paginaInicial" => "1228"
                        "paginaFinal" => "1234"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "King&#39;s College London&#44; IDIBAPS&#44; Karolinska Institutet&#44; NeuroImageN&#46; &#8216;Seed-based d Mapping - FDR online calculator&#8217; &#40;2010&#41;&#46; Available from&#58; https&#58;&#47;&#47;www&#46;sdmproject&#46;com&#47;utilities&#47;&#63;show&#61;FDR&#46;"
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0355"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Conover WJ&#46; Practical Nonparametric Statistics&#46; 3rd edition&#46; New York&#58; J&#46; Wiley &#38; Sons&#59; 1999"
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0360"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The cognition and emotional well-being indices of the Parkinson&#39;s Disease Questionnaire-39&#58; What do they really measure&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;D&#46; Jones"
                            1 => "C&#46; Hass"
                            2 => "P&#46; Mangal"
                            3 => "J&#46; Lafo"
                            4 => "M&#46;S&#46; Okun"
                            5 => "D&#46; Bowers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Park Relat Disord&#46;"
                        "fecha" => "2014"
                        "volumen" => "20"
                        "paginaInicial" => "1236"
                        "paginaFinal" => "1241"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0365"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The neuropsychiatric inventory&#58; Comprehensive assessment of psychopathology in dementia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;L&#46; Cummings"
                            1 => "M&#46; Mega"
                            2 => "K&#46; Gray"
                            3 => "S&#46; Rosenberg-Thompson"
                            4 => "D&#46;A&#46; Carusi"
                            5 => "J&#46; Gornbein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1212/wnl.44.12.2308"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurology&#46;"
                        "fecha" => "1994"
                        "volumen" => "44"
                        "paginaInicial" => "2308"
                        "paginaFinal" => "2314"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7991117"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Valid P-values behave exactly as they should&#58; some misleading criticisms of P-values and their resolution with S-values"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Greenland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Stat&#46;"
                        "fecha" => "2019"
                        "volumen" => "73"
                        "numero" => "Suppl 1"
                        "paginaInicial" => "106"
                        "paginaFinal" => "114"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "IBM Corp&#46; IBM SPSS Statistics for Windows&#46; 2017&#46;"
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "JASP Team&#46; JASP&#46; 2020&#46;"
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0385"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The 39-item Parkinson&#39;s Disease Questionnaire &#40;PDQ-39&#41;&#58; Is it a unidimensional construct&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46; Hagell"
                            1 => "M&#46;H&#46; Nilsson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/1756285609103726"
                      "Revista" => array:7 [
                        "tituloSerie" => "Ther Adv Neurol Disord&#46;"
                        "fecha" => "2009"
                        "volumen" => "2"
                        "paginaInicial" => "205"
                        "paginaFinal" => "214"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21179529"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1876285917304850"
                          "estado" => "S300"
                          "issn" => "18762859"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0390"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The 39 item Parkinson&#39;s disease questionnaire &#40;PDQ-39&#41; revisited&#58; Implications for evidence based medicine"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46; Hagell"
                            1 => "C&#46; Nygren"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/jnnp.2006.111161"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Neurosurg Psychiatry&#46;"
                        "fecha" => "2007"
                        "volumen" => "78"
                        "paginaInicial" => "1191"
                        "paginaFinal" => "1198"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17442762"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0395"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is quality of life in non-demented Parkinson&#39;s disease patients related to cognitive performance&#63;&#46; A clinic-based cross-sectional study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46; Klepac"
                            1 => "V&#46; Trkulja"
                            2 => "M&#46; Relja"
                            3 => "T&#46; Babi&#263;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J Neurol&#46;"
                        "fecha" => "2008"
                        "volumen" => "15"
                        "paginaInicial" => "128"
                        "paginaFinal" => "133"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0400"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Health-related quality of life in Parkinson&#39;s disease&#58; A cross-sectional study focusing on non-motor symptoms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Kadastik-Eerme"
                            1 => "M&#46; Rosenthal"
                            2 => "T&#46; Paju"
                            3 => "M&#46; Muldmaa"
                            4 => "P&#46; Taba"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Health Qual Life Outcomes&#46;"
                        "fecha" => "2015"
                        "paginaInicial" => "13"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0405"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mild cognitive impairment in Parkinson&#39;s disease&#58; Characterization and impact on quality of life according to subtype"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46;F&#46;R&#46; Vasconcellos"
                            1 => "J&#46;S&#46; Pereira"
                            2 => "H&#46; Charchat-Fichman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ggi.13649"
                      "Revista" => array:6 [
                        "tituloSerie" => "Geriatr Gerontol Int&#46;"
                        "fecha" => "2019"
                        "volumen" => "19"
                        "paginaInicial" => "497"
                        "paginaFinal" => "502"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30912284"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0410"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Determining minimally important differences for the PDQ-39 Parkinson&#39;s disease questionnaire"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "V&#46; Peto"
                            1 => "C&#46; Jenkinson"
                            2 => "R&#46;A&#46;Y&#46; Fitzpatrick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ageing/30.4.299"
                      "Revista" => array:6 [
                        "tituloSerie" => "Age Ageing&#46;"
                        "fecha" => "2001"
                        "volumen" => "30"
                        "paginaInicial" => "299"
                        "paginaFinal" => "302"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11509307"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0415"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Quality of life and mild cognitive impairment in early Parkinson&#39;s disease&#58; does subtype matter&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46;A&#46; Lawson"
                            1 => "A&#46;J&#46; Yarnall"
                            2 => "G&#46;W&#46; Duncan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Parkinsons Dis&#46;"
                        "fecha" => "2014"
                        "volumen" => "4"
                        "paginaInicial" => "331"
                        "paginaFinal" => "336"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0420"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The &#8216;cognitions&#8217; index of the Parkinson&#39;s disease questionnaire-39 relates to sleep disturbances and hallucinations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;D&#46; Jones"
                            1 => "C&#46; Hass"
                            2 => "M&#46;S&#46; Okun"
                            3 => "D&#46; Bowers"
                            4 => "Reply&#58;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.parkreldis.2014.12.002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Parkinsonism Relat Disord&#46;"
                        "fecha" => "2015"
                        "volumen" => "21"
                        "paginaInicial" => "351"
                        "paginaFinal" => "352"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25616693"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0425"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A review of health-related quality-of-life concepts and measures for Parkinson&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;M&#46; Damiano"
                            1 => "C&#46; Snyder"
                            2 => "B&#46; Strausser"
                            3 => "M&#46;K&#46; Willian"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1023/a:1008823222574"
                      "Revista" => array:7 [
                        "tituloSerie" => "Qual Life Res&#46;"
                        "fecha" => "1999"
                        "volumen" => "8"
                        "paginaInicial" => "235"
                        "paginaFinal" => "243"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10472154"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S109830151404621X"
                          "estado" => "S300"
                          "issn" => "10983015"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0430"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The &#8216;Cognitions&#8217; index of the Parkinson&#39;s Disease Questionnaire-39 relates to sleep disturbance and hallucinations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46;C&#46; Walton"
                            1 => "J&#46;Y&#46;Y&#46; Szeto"
                            2 => "J&#46;M&#46; Shine"
                            3 => "S&#46;J&#46;G&#46; Lewis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Parkinsonism Relat Disord&#46;"
                        "fecha" => "2015"
                        "paginaInicial" => "21"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0435"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Caracterizaci&#243;n funcional y calidad de vida en pacientes con enfermedad de Parkinson"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;B&#46; Avenda&#241;o-Avenda&#241;o"
                            1 => "O&#46; Bernal-Pacheco"
                            2 => "C&#46;T&#46; Esquivia-P&#225;jaro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Colomb Med Fis Rehabil&#46;"
                        "fecha" => "2019"
                        "volumen" => "29"
                        "paginaInicial" => "93"
                        "paginaFinal" => "102"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0440"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Calidad de vida en los pacientes con enfermedad de Parkinson valorados en un hospital universitario de Bogot&#225;&#44; Colombia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46; Palacios S&#225;nchez"
                            1 => "A&#46;V&#46; Gonz&#225;lez"
                            2 => "J&#46;A&#46; Vicu&#241;a"
                            3 => "L&#46; Villamizar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurol Argentina&#46;"
                        "fecha" => "2019"
                        "volumen" => "11"
                        "paginaInicial" => "151"
                        "paginaFinal" => "158"
                        "itemHostRev" => array:3 [
                          "pii" => "S1876285921003193"
                          "estado" => "S300"
                          "issn" => "18762859"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack712065"
        "titulo" => "Acknowledgements"
        "texto" => "<p id="par0205" class="elsevierStylePara elsevierViewall">We want to thank all the participants and their families&#44; researchers that collaborated&#44; the Research Development Committee &#40;CODI&#41; and Young Researchers program at Universidad de Antioquia&#44; as well as the staff and facilities provided by Grupo de Neurociencias de Antioquia &#40;GNA&#41;&#44; Grupo Neuropsicolog&#237;a y Conducta &#40;GRUNECO&#41;&#44; Semillero SINAPSIS &#40;research incubator program&#41; and the School of Medicine at the Universidad de Antioquia in Colombia&#44; as well to the Centre for age-related medicine &#40;SESAM&#41; in Norway&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/25303120/0000005200000004/v1_202312071909/S2530312023000814/v1_202312071909/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "65323"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/25303120/0000005200000004/v1_202312071909/S2530312023000814/v1_202312071909/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2530312023000814?idApp=UINPBA00004N"
]
Article information
ISSN: 25303120
Original language: English
DOI:10.1016/j.rcpeng.2023.11.004
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 4 3 7
2024 October 4 3 7

Follow this link to access the full text of the article

Subscribe to our newsletter

Publish in
Revista Colombiana de Psiquiatría
Revista Colombiana de Psiquiatría (English Edition) is a member and subscribes the principles of, the Committee on Publication Ethics (COPE)
www.publicationethics.org.
Free access articles
Psychiatric disorders in children and adolescents during...
Rev Colomb Psiquiatr. 2020;49:279-88
Mental health studies in medical students in the context of...
Rev Colomb Psiquiatr. 2020;49:223-4
Trends in Spanish-language Google searches on mental health...
Rev Colomb Psiquiatr. 2020;49:225-6