was read the article
array:25 [ "pii" => "S2444440516300395" "issn" => "24444405" "doi" => "10.1016/j.rcreue.2016.09.002" "estado" => "S300" "fechaPublicacion" => "2016-07-01" "aid" => "82" "copyright" => "Asociación Colombiana de Reumatología" "copyrightAnyo" => "2016" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "crp" "cita" => "Rev Colomb Reumatol. 2016;23:213-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1965 "formatos" => array:3 [ "EPUB" => 50 "HTML" => 1500 "PDF" => 415 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0121812316300251" "issn" => "01218123" "doi" => "10.1016/j.rcreu.2016.04.002" "estado" => "S300" "fechaPublicacion" => "2016-07-01" "aid" => "82" "copyright" => "Asociación Colombiana de Reumatología" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Rev Colomb Reumatol. 2016;23:213-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 4962 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 4210 "PDF" => 742 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Informe de caso</span>" "titulo" => "Coexistencia de neuropatía periférica secundaria a intoxicación crónica por plomo y polimiositis: reporte de caso" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "213" "paginaFinal" => "217" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Co-existence of peripheral neuropathy secondary to lead poisoning and chronic polymyositis: Case report" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figura 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 717 "Ancho" => 900 "Tamanyo" => 99285 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Resonancia magnética nuclear de cintura pélvica con evidencia de atrofia grave, pero con hiperintensidad en secuencias STIR y poscontraste total del vasto lateral hasta formación del retináculo lateral (flechas).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Laura Becerra, Manuela Colorado, Juliana Molina, Angélica Rivera, Miguel Mesa, Carlos Jaime Velásquez-Franco, Carolina Muñoz-Grajales" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Laura" "apellidos" => "Becerra" ] 1 => array:2 [ "nombre" => "Manuela" "apellidos" => "Colorado" ] 2 => array:2 [ "nombre" => "Juliana" "apellidos" => "Molina" ] 3 => array:2 [ "nombre" => "Angélica" "apellidos" => "Rivera" ] 4 => array:2 [ "nombre" => "Miguel" "apellidos" => "Mesa" ] 5 => array:2 [ "nombre" => "Carlos Jaime" "apellidos" => "Velásquez-Franco" ] 6 => array:2 [ "nombre" => "Carolina" "apellidos" => "Muñoz-Grajales" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2444440516300395" "doi" => "10.1016/j.rcreue.2016.09.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444440516300395?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0121812316300251?idApp=UINPBA00004N" "url" => "/01218123/0000002300000003/v1_201609170050/S0121812316300251/v1_201609170050/es/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S2444440516300243" "issn" => "24444405" "doi" => "10.1016/j.rcreue.2016.06.004" "estado" => "S300" "fechaPublicacion" => "2016-07-01" "aid" => "78" "copyright" => "Asociación Colombiana de Reumatología" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "crp" "cita" => "Rev Colomb Reumatol. 2016;23:218-22" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2003 "formatos" => array:3 [ "EPUB" => 61 "HTML" => 1609 "PDF" => 333 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Camurati–Engelmann disease: case report and review of literature" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "218" "paginaFinal" => "222" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad de Camurati-Engelmann: reporte de un caso y revisión de la literatura" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1779 "Ancho" => 1333 "Tamanyo" => 228931 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">AP and lateral X-ray of the tibia and fibula showing a large sclerotic phenomenon in the diaphyses of both bones in a symmetrical manner.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Juan Pablo Restrepo, María del Pilar Molina" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Juan Pablo" "apellidos" => "Restrepo" ] 1 => array:2 [ "nombre" => "María del Pilar" "apellidos" => "Molina" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0121812316300214" "doi" => "10.1016/j.rcreu.2016.03.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0121812316300214?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444440516300243?idApp=UINPBA00004N" "url" => "/24444405/0000002300000003/v1_201701180108/S2444440516300243/v1_201701180108/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S2444440516300498" "issn" => "24444405" "doi" => "10.1016/j.rcreue.2016.12.004" "estado" => "S300" "fechaPublicacion" => "2016-07-01" "aid" => "81" "copyright" => "Asociación Colombiana de Reumatología" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "crp" "cita" => "Rev Colomb Reumatol. 2016;23:210-2" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 4135 "formatos" => array:3 [ "EPUB" => 62 "HTML" => 3332 "PDF" => 741 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Pellegrini–Stieda syndrome: More than a radiological sign" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "210" "paginaFinal" => "212" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Síndrome de Pellegrini–Stieda: más allá que un signo radiológico" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1005 "Ancho" => 2500 "Tamanyo" => 318426 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">At the left side on the AP radiography of the knees is observed calcification of the medial collateral ligament in its proximal portion, in addition to a decrease in the medial femorotibial space. At the right side in the coronal acquisition with T1 information of the knee becomes evident an ossification in the proximal end of the medial collateral ligament, in relation with an old-injury, configuring a Pellegrini–Stieda lesion. Osteoarthritic changes with formation of marginal osteophytes in the medial compartment are also observed.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Juan Pablo Restrepo, María del Pilar Molina" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Juan Pablo" "apellidos" => "Restrepo" ] 1 => array:2 [ "nombre" => "María del Pilar" "apellidos" => "Molina" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S012181231630024X" "doi" => "10.1016/j.rcreu.2016.03.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S012181231630024X?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444440516300498?idApp=UINPBA00004N" "url" => "/24444405/0000002300000003/v1_201701180108/S2444440516300498/v1_201701180108/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Co-existence of peripheral neuropathy secondary to lead poisoning and chronic polymyositis: Case report" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "213" "paginaFinal" => "217" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Laura Becerra, Manuela Colorado, Juliana Molina, Angélica Rivera, Miguel Mesa, Carlos Jaime Velásquez-Franco, Carolina Muñoz-Grajales" "autores" => array:7 [ 0 => array:3 [ "nombre" => "Laura" "apellidos" => "Becerra" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Manuela" "apellidos" => "Colorado" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Juliana" "apellidos" => "Molina" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Angélica" "apellidos" => "Rivera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Miguel" "apellidos" => "Mesa" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 5 => array:4 [ "nombre" => "Carlos Jaime" "apellidos" => "Velásquez-Franco" "email" => array:1 [ 0 => "carjaivel@hotmail.com" ] "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 6 => array:3 [ "nombre" => "Carolina" "apellidos" => "Muñoz-Grajales" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Facultad de Medicina, Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana, Medellín, Colombia" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Reumatología, Clínica Universitaria Bolivariana, Medellín, Colombia" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana, Medellín, Colombia" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Reumatología, Hospital Pablo Tobón Uribe, Medellín, Colombia" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Coexistencia de neuropatía periférica secundaria a intoxicación crónica por plomo y polimiositis: Reporte de caso" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0030" "etiqueta" => "Fig. 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 776 "Ancho" => 932 "Tamanyo" => 96150 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Immunohistochemical study with presence of types 1 and 2 fibers with “chessboard” distribution. Fast myosin staining. 20× magnification.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Exposure to lead, as a result of the industrial activity and its massive use in household products, emerges as one of the problems of higher prevalence and impact on public health.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">1–4</span></a> Currently, the main sources of exposure are circumscribed to an occupational setting (manufacturing of paint, glass, ceramics, among others) and in the environment they are derived from the combustion of gasoline, industrial emissions and food contamination; both sources can generate toxicity in human beings.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">5</span></a> Patients with lead poisoning may have clinical manifestations of acute or late onset; in adults, the clinics becomes more evident when the lead serum levels are within moderate or high ranges (between 40 and 80<span class="elsevierStyleHsp" style=""></span>μg/dL), with gastrointestinal symptoms (abdominal pain, vomiting, constipation) being the most frequent.<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">6–8</span></a> In individuals with plumbemias exceeding 100<span class="elsevierStyleHsp" style=""></span>μg/dL, serious manifestations such as nephropathy, hepatic necrosis and anemia, and varied neurological manifestations such as peripheral neuropathy, carpal tunnel syndrome and encephalopathy occur.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">9</span></a> Regarding other symptoms, for example musculoskeletal, those which have been more often mentioned in the different case series are: arthralgia (14–28%) and weakness of the extensor muscles of wrists and ankles (13%).<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">10</span></a> After an extensive literature search, as far as is known, no clinical articles reporting the simultaneous presence of inflammatory myopathy and peripheral neuropathy in patients with lead poisoning were found.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0010" class="elsevierStylePara elsevierViewall">A 47-year old-man with chronic lead poisoning secondary to occupational exposure for 5 years, with typical symptoms of saturnism: headache, hyporexia, diffuse abdominal pain and persistent decreased libido despite multiple treatments, among them: BAL dimercaprol, succimer and ethylenediaminetetraacetic acid. He consulted for generalized muscle weakness and paresthesias in upper and lower limbs, associated with high dysphagia for solids and liquids. On physical examination was found decreased muscle strength, symmetrical, with proximal predominance, accompanied by significant atrophy of the deltoid and vastus medialis muscles, as well as of the neck flexors and extensors, with secondary cephaloparesia.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The main findings in the laboratory tests carried out are in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. It drew the attention, clinically, the weakness as cardinal symptom, the inability of the patient to get up from sitting position, not being able to raise his arms above his head and the cephaloparesia; these characteristics compelled to explore causes of weakness of muscle origin. Toxic (no consumption of alcohol, glucocorticoids or lipid lowering agents), endocrine (hormonal and electrolytic profiles without alterations), malignant (normal thoracoabdominal CT scan, digestive endoscopy and colonoscopy; serum and urine immunofixation with no evidence of monoclonal gammopathy) and infectious (negative serologies for bacteria and fungi) causes were ruled out.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">An electromyography was performed as part of the diagnostic process, finding, in addition to the expected neuropathic pattern, polyphasic potentials, early recruitment and membrane irritability, findings highly suggestive of muscle fibers disease (<a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1 and 2</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">In order to define the degree of muscle atrophy, a nuclear magnetic resonance imaging of the girdle (scapular and pelvic) was performed to the patient, finding predominance of atrophy, but with areas of active myopathy (hyperintensity in the right lateralis vastus until the formation of the lateral retinaculum) (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). With these results, it was decided to take the patient to muscle biopsy, confirming the diagnosis of inflammatory myopathy (endomysial commitment and expression of HLA-1) (<a class="elsevierStyleCrossRefs" href="#fig0020">Figs. 4–6</a>).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia><elsevierMultimedia ident="fig0030"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">Lead poisoning can have a broad spectrum in its clinical presentation and a variable intensity, depending mainly on the serum levels of this metal. A case of concomitance of peripheral neuropathy and polymyositis is presented in this report. As mentioned above, in several series of cases have been reported neuromuscular symptoms such as: peripheral neuropathy, weakness of the extensor muscles, myalgias and arthralgias and carpal tunnel syndrome, among others.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">10</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">With regard to the peripheral neuropathy due to lead, it has been described classically as a pure motor disease, predominantly in the arms, especially in the wrist extensors; sensory involvement is very rare despite its predominance in other neuropathies due to heavy metals such as arsenic, mercury or thallium.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">11</span></a> These findings coincide with the reported case; minimal electromyographic changes such as slow motor conduction with slightly reduced compound muscle action potentials are reported in the literature. There are also series reporting findings of polyneuropathy (marginally prolonged distal motor and sensory latencies) and autonomic neuropathy. It is proposed that the traditional motor syndrome seems to be a lead-induced porphyria, and in individuals with chronic intoxication a mild sensory and autonomic polyneuropathy occurs due to a direct neurotoxic effect.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">11</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">As mentioned before, after an extensive search without restriction of terms in Scielo, Lilacs, PubMed and Academic Google databases, no association or coexistence between peripheral neuropathy and polymyositis was found in patients with lead poisoning.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Only one report was found in Rhesus monkeys that were exposed to lead acetate before and after birth during 9 years; in histological muscle studies were found signs of myopathy, with increased diameters of the muscle fibers, separated by copious endomysial connective tissue, in addition to hydropic mitochondria and a massively dilated sarcotubular system, with increased deposition of extracellular collagen and nuclear destruction.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">12</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">There is one case reported in the literature of a 31 year-old-patient with severe lead poisoning secondary to retained bullet fragments after a shootout, with impact on the left hemithorax and that appeared as proximal muscle weakness 6 weeks after the event, additional to classic symptoms of saturnism and deep tendon areflexia. In this case, the muscle enzymes were normal and the studies of motor nerve conduction revealed generalized compound muscle action potentials with no changes in the nerve conduction, compatible with axonopathy without demyelination. Similar cases of acute proximal muscle weakness due to this traumatic etiology, where abrupt and massive exposure to this metal prevails, have been described. The abnormal distribution and the loss of selectivity of lead deposition in the distal motor nerves, as well as the presence of a transient thyrotoxicosis, simulating a hyperthyroid myopathy, have been proposed as hypotheses for the genesis.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">13</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusion</span><p id="par0055" class="elsevierStylePara elsevierViewall">In a patient with lead poisoning, with moderate of high serum levels and weakness, the differential diagnosis must be broad, and neurological and muscular causes should be considered. As far as is known, this would be the first case report of concomitance of peripheral neuropathy and polymyositis in a patient with this condition.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethical responsibilities</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Protection of human and animal subjects</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Confidentiality of data</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Right to privacy and informed consent</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article. The corresponding author is in possession of this document.</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Funding</span><p id="par0075" class="elsevierStylePara elsevierViewall">Own resources.</p><p id="par0080" class="elsevierStylePara elsevierViewall">The work was not supported by any grant or funds from the pharmaceutical industry.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conflict of interest</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declare the absence of conflict of interest regarding the present case report.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres790704" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec789003" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres790705" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec789004" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conclusion" ] 8 => array:3 [ "identificador" => "sec0025" "titulo" => "Ethical responsibilities" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0030" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0035" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0040" "titulo" => "Right to privacy and informed consent" ] ] ] 9 => array:2 [ "identificador" => "sec0045" "titulo" => "Funding" ] 10 => array:2 [ "identificador" => "sec0050" "titulo" => "Conflict of interest" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-12-14" "fechaAceptado" => "2016-04-05" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec789003" "palabras" => array:3 [ 0 => "Lead poisoning" 1 => "Peripheral nervous system diseases" 2 => "Polymyositis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec789004" "palabras" => array:3 [ 0 => "Intoxicación por plomo" 1 => "Enfermedades del sistema nervioso periférico" 2 => "Polimiositis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A case is presented on a 47-year-old man with chronic lead poisoning with typical symptoms after 5 years of occupational exposure. He consulted for generalized muscle weakness, early dysphagia, cephaloparesia, and paresthesias in upper and lower limbs. He also had atrophy and decreased proximal muscle strength (deltoid and medial vast) and in both flexor and extensor muscles of the neck. He had a history of high blood lead levels and peripheral neuropathy documented by electromyography. In addition to the diagnosis of lead poisoning, inflammatory myopathy was confirmed based on muscle enzyme elevation, muscular inflammation in magnetic resonance imaging, and typical findings in a muscle biopsy. To the best of our knowledge, this is the first report where both conditions are documented in one patient.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se reporta el caso de un hombre de 47 años con intoxicación crónica por plomo, secundaria a exposición laboral de 5 años, con sintomatología típica de saturnismo. Consultó por debilidad muscular generalizada, disfagia y parestesias en extremidades. Se documentaron altos niveles de plomo en sangre, asociados a neuropatía periférica, confirmada por electromiografía, y disminución de la fuerza muscular en cintura escapular y pélvica (deltoides y vasto medial), así como atrofia de músculos del cuello (flexores y extensores) manifestada como cefaloparesia. Adicional al cuadro de saturnismo se diagnosticó miopatía inflamatoria con base en la elevación de enzimas musculares, miositis por resonancia magnética nuclear y biopsia muscular compatible, siendo, hasta donde se sabe, el primer reporte conocido de la coexistencia de estas 2 enfermedades.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Becerra L, Colorado M, Molina J, Rivera A, Mesa M, Velásquez-Franco CJ, et al. Coexistencia de neuropatía periférica secundaria a intoxicación crónica por plomo y polimiositis: Reporte de caso. Rev Colomb Reumatol. 2016;23:213–217.</p>" ] ] "multimedia" => array:7 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1234 "Ancho" => 1248 "Tamanyo" => 63188 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Analysis of motor units showing axonal motor polyneuropathy (upper tracing); increased insertional activity and polyphasic potentials of short duration (myopathic changes, lower tracing).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1578 "Ancho" => 1361 "Tamanyo" => 102592 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Automatic analysis of interference pattern compatible with inflammatory myopathy in the left vastus medialis.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 717 "Ancho" => 900 "Tamanyo" => 99689 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Nuclear magnetic resonance imaging of the pelvic girdle with evidence of severe atrophy, but with hyperintensity in STIR sequences and total postcontrast of the vastus lateralis until formation of the lateral retinaculum (arrows).</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Fig. 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 628 "Ancho" => 982 "Tamanyo" => 60597 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Presence of endomysial cells of lymphoid appearance (arrow). Hematoxylin–eosin staining. 40× magnification.</p>" ] ] 4 => array:7 [ "identificador" => "fig0025" "etiqueta" => "Fig. 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 641 "Ancho" => 950 "Tamanyo" => 48721 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Immunohistochemical study for HLA-1 with expression of muscle fibers (arrow).</p>" ] ] 5 => array:7 [ "identificador" => "fig0030" "etiqueta" => "Fig. 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 776 "Ancho" => 932 "Tamanyo" => 96150 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Immunohistochemical study with presence of types 1 and 2 fibers with “chessboard” distribution. Fast myosin staining. 20× magnification.</p>" ] ] 6 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Paraclinical \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Value \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Reference range \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Blood lead levels \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">97.61<span class="elsevierStyleHsp" style=""></span>μg/dL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0–10 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Creatine phosphokinase \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1000<span class="elsevierStyleHsp" style=""></span>U/L \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0–153 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Lactic dehydrogenase \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">556<span class="elsevierStyleHsp" style=""></span>U/L \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0–250 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Aldolase \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8.4<span class="elsevierStyleHsp" style=""></span>U/L \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0–6 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1321243.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Relevant results of paraclinical analyses in a patient with lead poisoning with muscle weakness and paresthesias.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib0070" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A leading question" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Y. Beigel" 1 => "I. Ostfeld" 2 => "N. Schoenfeld" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199809173391208" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1998" "volumen" => "339" "paginaInicial" => "827" "paginaFinal" => "830" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9738092" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0075" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lead toxicity and chelation therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.C. Gracia" 1 => "W.R. Snodgrass" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2146/ajhp060175" "Revista" => array:6 [ "tituloSerie" => "Am J Health Syst Pharm" "fecha" => "2007" "volumen" => "64" "paginaInicial" => "45" "paginaFinal" => "53" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17189579" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0080" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathological effects of lead" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.A. Goyer" 1 => "B.C. Rhyne" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int Rev Exp Pathol" "fecha" => "1973" "volumen" => "12" "paginaInicial" => "1" "paginaFinal" => "77" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4349348" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0085" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Saturnismo, a propo¿sito de un caso" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.H. Labanda Urbano" 1 => "C. Fernández García" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Segur Trab (Internet)" "fecha" => "2012" "volumen" => "58" "paginaInicial" => "168" "paginaFinal" => "173" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0090" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intoxicación crónica por plomo" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F.J. Fernández" 1 => "C. Gonzáles" 2 => "E. Ameneiros-Lago" 3 => "F.S. Martínez-Debén" 4 => "G. Pía" 5 => "P. Sesma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "An Med Interna (Madrid)" "fecha" => "2002" "volumen" => "19" "paginaInicial" => "130" "paginaFinal" => "132" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0095" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of lead in the central nervous system: effect on electroencephlography, evoked potentials, electroretinography, and nerve conduction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "K.K. Sindhu" 1 => "W.W. Sutherling" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurodiagn J" "fecha" => "2015" "volumen" => "55" "paginaInicial" => "107" "paginaFinal" => "121" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26173349" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0100" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Environmental exposure to lead (Pb) and variations in its susceptibility" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Kim" 1 => "Y. Lee" 2 => "M. Yang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/10590501.2014.907461" "Revista" => array:7 [ "tituloSerie" => "J Environ Sci Health C Environ Carcinog Ecotoxicol Rev" "fecha" => "2014" "volumen" => "32" "paginaInicial" => "159" "paginaFinal" => "185" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24875442" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016508508021793" "estado" => "S300" "issn" => "00165085" ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0105" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pb neurotoxicity: neuropsychological effects of lead toxicity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.H. Mason" 1 => "J.P. Harp" 2 => "D.Y. Han" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1155/2014/840547" "Revista" => array:5 [ "tituloSerie" => "Biomed Res Int" "fecha" => "2014" "volumen" => "2014" "paginaInicial" => "840547" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24516855" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0110" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neurotoxicity and biomarkers of lead exposure: a review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K.S. Liu" 1 => "J.H. Hao" 2 => "Y. Zeng" 3 => "F.C. Dai" 4 => "P.Q. Gu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Chin Med Sci J" "fecha" => "2013" "volumen" => "28" "paginaInicial" => "178" "paginaFinal" => "188" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24074621" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S152169181400095X" "estado" => "S300" "issn" => "15216918" ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0115" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neurotoxicity of lead. hypothetical molecular mechanisms of synaptic function disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "I. Baranowska-Bosiacka" 1 => "I. Gutowska" 2 => "M. Rybicka" 3 => "P. Nowacki" 4 => "D. Chlubek" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurol Neurochir Pol" "fecha" => "2012" "volumen" => "46" "paginaInicial" => "569" "paginaFinal" => "578" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23319225" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0120" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Peripheral neuropathy in chronic occupational inorganic lead exposure: a clinical and electrophysiological study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "O. Rubens" 1 => "I. Logina" 2 => "I. Kravale" 3 => "M. Eglîte" 4 => "M. Donaghy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neurol Neurosurg Psychiatry" "fecha" => "2001" "volumen" => "71" "paginaInicial" => "200" "paginaFinal" => "204" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11459892" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0125" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Myopathy: a possible effect of chronic low level lead exposure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Buchheim" 1 => "G. Stoltenburg-Didinger" 2 => "H. Lilienthal" 3 => "G. Winneke" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurotoxicology" "fecha" => "1998" "volumen" => "19" "paginaInicial" => "539" "paginaFinal" => "545" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9745908" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0130" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proximal muscle weakness in severe lead poisoning from retained bullet fragments" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Srisuma" 1 => "E.J. Lavonas" 2 => "W. Wananukul" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Toxicol (Phila)" "fecha" => "2015" "volumen" => "53" "paginaInicial" => "586" "paginaFinal" => "587" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/24444405/0000002300000003/v1_201701180108/S2444440516300395/v1_201701180108/en/main.assets" "Apartado" => array:4 [ "identificador" => "53647" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case Reports" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/24444405/0000002300000003/v1_201701180108/S2444440516300395/v1_201701180108/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444440516300395?idApp=UINPBA00004N" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 4 | 0 | 4 |
2024 October | 30 | 15 | 45 |
2024 September | 39 | 23 | 62 |
2024 August | 34 | 17 | 51 |
2024 July | 28 | 7 | 35 |
2024 June | 24 | 8 | 32 |
2024 May | 18 | 10 | 28 |
2024 April | 32 | 8 | 40 |
2024 March | 39 | 10 | 49 |
2024 February | 28 | 5 | 33 |
2024 January | 22 | 5 | 27 |
2023 December | 29 | 11 | 40 |
2023 November | 45 | 12 | 57 |
2023 October | 56 | 11 | 67 |
2023 September | 18 | 3 | 21 |
2023 August | 15 | 3 | 18 |
2023 July | 63 | 6 | 69 |
2023 June | 59 | 5 | 64 |
2023 May | 85 | 8 | 93 |
2023 April | 78 | 4 | 82 |
2023 March | 63 | 5 | 68 |
2023 February | 55 | 5 | 60 |
2023 January | 61 | 4 | 65 |
2022 December | 64 | 14 | 78 |
2022 November | 52 | 10 | 62 |
2022 October | 52 | 14 | 66 |
2022 September | 48 | 16 | 64 |
2022 August | 49 | 28 | 77 |
2022 July | 21 | 13 | 34 |
2022 June | 38 | 7 | 45 |
2022 May | 32 | 12 | 44 |
2022 April | 61 | 5 | 66 |
2022 March | 74 | 15 | 89 |
2022 February | 38 | 4 | 42 |
2022 January | 80 | 12 | 92 |
2021 December | 66 | 9 | 75 |
2021 November | 64 | 9 | 73 |
2021 October | 80 | 14 | 94 |
2021 September | 47 | 7 | 54 |
2021 August | 64 | 8 | 72 |
2021 July | 72 | 10 | 82 |
2021 June | 45 | 9 | 54 |
2021 May | 78 | 15 | 93 |
2021 April | 252 | 33 | 285 |
2021 March | 75 | 11 | 86 |
2021 February | 79 | 12 | 91 |
2021 January | 64 | 17 | 81 |
2020 December | 64 | 14 | 78 |
2020 November | 149 | 15 | 164 |
2020 October | 72 | 14 | 86 |
2020 September | 88 | 11 | 99 |
2020 August | 67 | 8 | 75 |
2020 July | 52 | 8 | 60 |
2020 June | 31 | 6 | 37 |
2020 May | 60 | 14 | 74 |
2020 April | 42 | 8 | 50 |
2020 March | 65 | 4 | 69 |
2020 February | 53 | 11 | 64 |
2020 January | 75 | 8 | 83 |
2019 December | 69 | 7 | 76 |
2019 November | 56 | 15 | 71 |
2019 October | 90 | 12 | 102 |
2019 September | 60 | 4 | 64 |
2019 August | 63 | 4 | 67 |
2019 July | 51 | 13 | 64 |
2019 June | 131 | 23 | 154 |
2019 May | 259 | 53 | 312 |
2019 April | 106 | 20 | 126 |
2019 March | 28 | 13 | 41 |
2019 February | 34 | 12 | 46 |
2019 January | 30 | 3 | 33 |
2018 December | 14 | 7 | 21 |
2018 November | 19 | 7 | 26 |
2018 October | 32 | 11 | 43 |
2018 September | 34 | 5 | 39 |
2018 August | 16 | 10 | 26 |
2018 July | 16 | 7 | 23 |
2018 June | 9 | 4 | 13 |
2018 May | 19 | 14 | 33 |
2018 April | 15 | 10 | 25 |
2018 March | 11 | 3 | 14 |
2018 February | 14 | 0 | 14 |
2018 January | 23 | 1 | 24 |
2017 December | 18 | 0 | 18 |
2017 November | 21 | 3 | 24 |
2017 October | 12 | 2 | 14 |
2017 September | 15 | 7 | 22 |
2017 August | 9 | 8 | 17 |
2017 July | 20 | 6 | 26 |
2017 June | 22 | 16 | 38 |
2017 May | 21 | 19 | 40 |
2017 April | 20 | 6 | 26 |
2017 March | 9 | 48 | 57 |
2017 February | 13 | 10 | 23 |
2017 January | 2 | 2 | 4 |
2016 December | 3 | 7 | 10 |
2016 November | 4 | 7 | 11 |
2016 October | 3 | 4 | 7 |