Randomized, placebo-controlled, double-blind clinical trial to evaluate efficacy and safety of topical tranexamic acid in saving blood loss in patients undergoing prosthetic knee surgery | Revista Española de Cirugía Ortopédica y Traumatología

array:23 ["pii" => "S1888441522002223" "issn" => "18884415" "doi" => "10.1016/j.recot.2022.02.008" "estado" => "S300" "fechaPublicacion" => "2022-11-01" "aid" => "1116" "copyrightAnyo" => "2022" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Esp Cir Ortop Traumatol. 2022;66:T67-T72" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:18 [ "pii" => "S1888441522000182" "issn" => "18884415" "doi" => "10.1016/j.recot.2022.01.007" "estado" => "S300" "fechaPublicacion" => "2022-11-01" "aid" => "1041" "copyright" => "SECOT" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Esp Cir Ortop Traumatol. 2022;66:491-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "Original" "titulo" => "Ensayo clínico comparando el uso de tornillos y del sistema TighRope® Knotless en el tratamiento de las lesiones agudas de la sindesmosis" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "491" "paginaFinal" => "499" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "A randomized clinical trial comparing screws and the TighRope® Knotless system in the treatment of acute injuries of syndesmosis" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 493 "Ancho" => 1305 "Tamanyo" => 118877 ] ] "descripcion" => array:1 [ "es" => "Mediciones en proyección radiológica de mortaja y en estudio TAC. DSA: distancia sindesmosis anterior; DSP: distancia sindesmosis posterior; ECM: espacio claro medial; ECTF: espacio claro tibiofibular; Flecha: nivel de corte axial a 1cm de la línea articular; STF: solapamiento tibiofibular." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "P. Morales Muñoz, V. Barroso Gómez, R. de los Santos Real, M. de Dios Pérez, J. Escalera Alonso, J. Varas Navas" "autores" => array:6 [ 0 => array:2 [ "nombre" => "P." "apellidos" => "Morales Muñoz" ] 1 => array:2 [ "nombre" => "V." "apellidos" => "Barroso Gómez" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "de los Santos Real" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "de Dios Pérez" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Escalera Alonso" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Varas Navas" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1888441522000182?idApp=UINPBA00004N" "url" => "/18884415/0000006600000006/v3_202403210638/S1888441522000182/v3_202403210638/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1888441522000911" "issn" => "18884415" "doi" => "10.1016/j.recot.2022.02.007" "estado" => "S300" "fechaPublicacion" => "2022-11-01" "aid" => "1062" "copyright" => "SECOT" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Esp Cir Ortop Traumatol. 2022;66:485-90" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "es" => array:12 [ "idiomaDefecto" => true "cabecera" => "Original" "titulo" => "Ensayo clínico aleatorizado, controlado con placebo y doble ciego para evaluar la eficacia y la seguridad del ácido tranexámico tópico en el ahorro de pérdidas sanguíneas en pacientes tratados mediante cirugía protésica de rodilla" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "485" "paginaFinal" => "490" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Randomized, placebo-controlled, double-blind clinical trial to evaluate efficacy and safety of topical tranexamic acid in saving blood loss in patients undergoing prosthetic knee surgery" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "F. Oliva-Moya, I. Belloso-Moreno, J.M. Vilches-Fernández, M. Casas-Ruiz, J.A. Andrés-García" "autores" => array:5 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "Oliva-Moya" ] 1 => array:2 [ "nombre" => "I." "apellidos" => "Belloso-Moreno" ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Vilches-Fernández" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Casas-Ruiz" ] 4 => array:2 [ "nombre" => "J.A." "apellidos" => "Andrés-García" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1888441522000911?idApp=UINPBA00004N" "url" => "/18884415/0000006600000006/v3_202403210638/S1888441522000911/v3_202403210638/es/main.assets" ] "asociados" => array:1 [ 0 => array:18 [ "pii" => "S1888441522000911" "issn" => "18884415" "doi" => "10.1016/j.recot.2022.02.007" "estado" => "S300" "fechaPublicacion" => "2022-11-01" "aid" => "1062" "copyright" => "SECOT" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Esp Cir Ortop Traumatol. 2022;66:485-90" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "es" => array:12 [ "idiomaDefecto" => true "cabecera" => "Original" "titulo" => "Ensayo clínico aleatorizado, controlado con placebo y doble ciego para evaluar la eficacia y la seguridad del ácido tranexámico tópico en el ahorro de pérdidas sanguíneas en pacientes tratados mediante cirugía protésica de rodilla" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "485" "paginaFinal" => "490" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Randomized, placebo-controlled, double-blind clinical trial to evaluate efficacy and safety of topical tranexamic acid in saving blood loss in patients undergoing prosthetic knee surgery" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "F. Oliva-Moya, I. Belloso-Moreno, J.M. Vilches-Fernández, M. Casas-Ruiz, J.A. Andrés-García" "autores" => array:5 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "Oliva-Moya" ] 1 => array:2 [ "nombre" => "I." "apellidos" => "Belloso-Moreno" ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Vilches-Fernández" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Casas-Ruiz" ] 4 => array:2 [ "nombre" => "J.A." "apellidos" => "Andrés-García" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1888441522000911?idApp=UINPBA00004N" "url" => "/18884415/0000006600000006/v3_202403210638/S1888441522000911/v3_202403210638/es/main.assets" ] ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "Original Paper" "titulo" => " Randomized, placebo-controlled, double-blind clinical trial to evaluate efficacy and safety of topical tranexamic acid in saving blood loss in patients undergoing prosthetic knee surgery" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "T67" "paginaFinal" => "T72" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "F. Oliva-Moya, I. Belloso-Moreno, J.M. Vilches-Fernández, M. Casas-Ruiz, J.A. Andrés-García" "autores" => array:5 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "Oliva-Moya" ] 1 => array:4 [ "nombre" => "I." "apellidos" => "Belloso-Moreno" "email" => array:1 [ 0 => "isbemore@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Vilches-Fernández" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Casas-Ruiz" ] 4 => array:2 [ "nombre" => "J.A." "apellidos" => "Andrés-García" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Hospital Universitario Puerta del Mar, Cádiz, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Ensayo clínico aleatorizado, controlado con placebo y doble ciego para evaluar la eficacia y la seguridad del ácido tranexámico tópico en el ahorro de pérdidas sanguíneas en pacientes tratados mediante cirugía protésica de rodilla" ] ] "textoCompleto" => "IntroductionTotal knee replacement is a major surgical procedure that involves an array of complications, including blood loss and the consequent need for blood transfusion.<a class="elsevierStyleCrossRefs" href="#bib0135">1–3</a> In recent years, published studies have been focused on patient fast recovery and decreasing postoperative complications, in particular, those that have to do with blood transfusions, such as: higher costs, bacterial contamination, the transmission of viral infections, and reactions to the transfusion.<a class="elsevierStyleCrossRef" href="#bib0140">2</a>One of the drugs that has garnered interest recently is tranexamic acid (TXA). It is an anti-fibrinolytic agent that has been used for many years to control active bleeding and as a preventive measure in specialties such as ENT and gynaecology.<a class="elsevierStyleCrossRef" href="#bib0150">4</a> In the field of orthopaedic surgery, studies can be found on the use of intravenously administered TXA that evidence a reduction in post-surgical bleeding, as well as in the need for transfusion. Nevertheless, given the potential adverse effects of intravenous administration, the use of topical TXA was contemplated as an alternative.<a class="elsevierStyleCrossRef" href="#bib0155">5</a> The various studies published have shown that topical administration of TXA achieves high dose concentrations at the joint with low systemic distribution, thereby reducing adverse effects and achieving equal outcomes in terms of blood loss savings compared to intravenous administration.<a class="elsevierStyleCrossRefs" href="#bib0160">6–9</a>However, most of these studies are observational or reviews, and no experimental study based on a clinical trial of the topical administration of TXA in total knee arthroplasty surgery has been found in our setting.The main objective of our study is to compare both the efficacy and safety of topical TXA in terms of blood loss savings compared to placebo in individuals diagnosed with severe osteoarthritis who had been treated with prosthetic knee surgery.Materials and methodsAn independent, phase III, randomised, double-blind, placebo-controlled clinical trial was carried out from January 2018 to April 2019 at Hospital Puerta del Mar, Cádiz. This trial was authorised by the Spanish Agency of Medicines and Medical Devices and the Hospital Ethics Committee. The sample size was calculated for a power of 90%, beta 0.1, and alpha 0.05, resulting in the need for 66 patients per treatment group and an expected loss to follow-up rate of 5%. It was determined that 150 patients needed to be recruited, with 75 patients allocated to each treatment arm, in 15 blocks of 10 patients. Allocation was randomised using the free software application <a href="http://www.randomization.com/">www.randomization.com</a>. Study medication was masked by the hospital's Pharmacy Service, where 30ml pre-filled syringes with an odourless, transparent solution were prepared, containing either the study medication (3g of TXA) or placebo, with similar labelling. In this way, both patient and surgeon remain double-blinded.Inclusion criteria for participation in the study were: age between 18 and 80 years, with a visual analogue scale (VAS) score of seven or more, with a Kellgren's grade equal to or greater than II, and signed informed consent. Exclusion criteria were: severe heart disease, thromboembolic disease, prior hypersensitivity to TXA, severe systemic disease, history of seizures, severe mental disorder, taking anticoagulants, pregnancy or breastfeeding.The primary endpoint of the study was estimated total blood loss (TBL) according to the formula of Nadler et al.<a class="elsevierStyleCrossRef" href="#bib0180">10</a> Socio-demographic variables, anthropometric variables, need for blood transfusion, ambulation time, and time to hospital discharge were also examined. Safety variables were also analysed: adverse events of any kind, infection rate, need for haematoma evacuation, or surgical wound dehiscence. Patients were followed up for one month after the procedure in all cases.To estimate blood loss during surgery, two analytical determinations were performed: the first, 1h prior to surgery, and the second, 24h after surgery.All surgeries were performed by members of the Knee Unit of this hospital, using the internal parapatellar approach. Two prosthetic models were used: Sigma® by DePuy Synthes (DePuy-Synhes®, Johnson & Johnson®) and Triathlon® by Stryker (Stryker®). > [sic] After cemented placement of the prosthetic components and prior to closure of the capsule, the following drug protocol was followed: the knee was placed in extension, the contents of the syringes were administered and distributed over the entire joint. Subsequently, the edges of the surgical wound were approximated, covered with compresses, and a compressive bandage was applied. The ischaemia cuff was removed and the bandage was kept in place for 3min to allow the medication to take effect. After 3min, the compressive bandage was removed and the aqueous solution was aspirated. Finally, thorough local haemostasis was performed, closure by planes, and a cotton inguinopedic elastic bandage was applied. Drainage was not used in any case.SPSS v.21 for Macintosh (IBM Corp., Armonk, NY, USA) was used for data collection and processing. An intention-to-treat analysis was performed from the time of patient randomisation (following signature of informed consent). The normality of the distribution of all variables was assessed using the Kolmogorov–Smirnov and Shapiro–Wilk tests. To analyse baseline intergroup differences in quantitative variables, the Student's t-test and the chi-squared test for qualitative variables were used.ResultsOf the total of 150 patients recruited, 10 were excluded from the trial for the following reasons: three were over 80 years of age at the time of surgery; one patient had symptoms of urinary tract infection; another two patients were excluded for reasons related to the surgical technique (weakness of the patellar tendon and placement of a single compartment prosthesis), and, finally, the results of the post-operative analysis were lost in another of the patients. This left 69 patients in the TXA group and 71 in the placebo group.The descriptive demographic analysis of the sample is summarised in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>, with the percentage of males and females being 29.3% (n=44) and 70.7% (n=106), respectively, and adhering to a normal distribution.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>The type of prosthesis used was Sigma® (Depuy-Synthes) in 44.2% (n=65) and Triathlon® (Stryker) in 55.8% (n=82) of the cases, displaying similar distribution in both groups; 33 Sigma® and 40 Triathlon® prostheses for the TXA group, and 32 Sigma® and 42 Triathlon® prostheses for the placebo group. No statistically significant differences (p-value=0.94) were detected between the two groups.Regarding clinical and functional variables, no statistically significant differences were observed in both groups at the time when the patient began to stand upright (p value=NS), or for the total days of hospitalisation (p value=NS) or for the pain assessment based on the VAS score one month after surgery (p value=NS) (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>As regards efficacy variables, haemoglobin (Hb) and haematocrit (HCT) were measured and the data presented a normal distribution for Hb prior to surgery. In the case of prior HCT, the data followed a normal distribution for the TXA group, although not for the placebo group. No statistically significant differences were discovered between the two groups for either Hb or HCT. On the other hand, statistically significant differences were found in the differences between Hb and HCT pre- and post-surgery, the difference being greater for the placebo group (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>).<elsevierMultimedia ident="tbl0015"></elsevierMultimedia>The primary endpoint, TBL, had a mean of 662.30ml (95% confidence interval (CI), 600.8–723.7) for the TXA group and 831.5ml (5% CI, 752.8–910.2) for the placebo group; the difference between the two were 167.78ml in favour of the TXA group and was statistically significant, with a p value of 0.001, which corresponds to a savings of 20% with respect to the placebo group.In terms of safety analysis, there were no complications with the surgical wound; no patient required a repeat operation; there were no infections, and no blood transfusions were necessary in any case. The only adverse event unrelated to the use of TXA was one case of recurrent bladder ballooning.DiscussionIn the present study, a 20% decrease (an average of 167.78ml) in total blood loss was achieved by administering TXA in prosthetic knee surgery. In the literature, we found several studies with a methodology similar to ours. In 2010, Wong et al. analysed 3 treatment arms (in the first arm, 1.5g of TXA was administered; in the second, 3g, and in the third group, placebo) and observed a reduction of 315ml of blood loss on average in the first arm and 402ml in the second arm, compared to the control group.<a class="elsevierStyleCrossRef" href="#bib0185">11</a> Subsequently, Konig et al.<a class="elsevierStyleCrossRef" href="#bib0190">12</a> and Georgiadis et al.<a class="elsevierStyleCrossRef" href="#bib0195">13</a> reported a reduction in blood loss of 353 and 231ml on average, respectively. We believe that these results that are quantitatively greater compared to our study may be due to the methodology used in terms of surgical manoeuvres, which, given that they are not standardised, may lead to differences that are unrelated to the administration of the drug.<a class="elsevierStyleCrossRef" href="#bib0200">14</a>As for savings in blood loss, the main effect of administering TXA is that it reduces the rate of transfusion. Different studies indicate that patients undergoing knee arthroplasty who receive this drug do not require blood transfusion after surgery.<a class="elsevierStyleCrossRefs" href="#bib0205">15–17</a> In our case, the transfusion rate was zero for both TXA-treated patients and the control group.Regarding the analysis of functionality, the interest lies in the fact that, by decreasing blood loss-related complications, rehabilitation does not have to be delayed because of said complications. Therefore, in 2018, Grosso et al.<a class="elsevierStyleCrossRef" href="#bib0220">18</a> proposed to analyse functional outcomes and early recovery among the participants who received intravenous TXA. To do so, 560 patients were randomised into two treatment arms; the first group received TXA and the second group received placebo. The result was that the subjects who were given TXA were able to walk more from the second day on. However, there was no difference on the VAS score. On the other hand, Serrano et al.<a class="elsevierStyleCrossRef" href="#bib0225">19</a> analysed post-surgical functional outcomes with the Knee Society Score (KSS) and differences were observed at six weeks after drug administration, but not at four months. In 2019, Hirose et al.<a class="elsevierStyleCrossRef" href="#bib0230">20</a> conducted an analysis of joint balance (JB) after intra-articular TXA administration following surgical wound closure. They achieved an improvement in JB on the fourth, tenth, and fourteenth day. However, there was no difference in the 10m ambulation test, VAS, or muscle strength.Similar to Guerreiro et al.,<a class="elsevierStyleCrossRef" href="#bib0235">21</a> we found no significant differences in our study between the two groups with respect to time to onset of standing following surgery, VAS at one month postoperatively, and days of hospitalisation.In our opinion, these differences between the various studies in terms of functional outcomes are likely to be due to the analysis of multiple secondary variables. Therefore, a pre-study protocol is deemed fundamental to clearly define the primary endpoint, as well as the sample size.As for the possible adverse reactions of TXA administration, thromboembolic events are particularly relevant, as described in its technical data sheet.<a class="elsevierStyleCrossRef" href="#bib0240">22</a> However, in this clinical trial, no cases of thromboembolic events were reported in either of the two treatment arms. Other events related to the surgical technique, such as surgical wound dehiscence, haematoma requiring drainage, or bleeding that could not be controlled with conservative measures, were also not reported. Similar results were reached in studies by Konig et al.,<a class="elsevierStyleCrossRef" href="#bib0190">12</a> Wong et al.,<a class="elsevierStyleCrossRef" href="#bib0185">11</a> and Geordiadis et al.,<a class="elsevierStyleCrossRef" href="#bib0195">13</a> in which no increased incidence of thromboembolism or any other complication was observed when TXA was topically administered.A meta-analysis conducted in 2018<a class="elsevierStyleCrossRef" href="#bib0245">23</a> that included 73 clinical trials with a total of 6953 patients undergoing prosthetic knee surgery concluded that the overall incidence of venous thromboembolism was 2.1% in individuals who were given TXA versus 2% in the control group. However, these results should be taken with caution, inasmuch as clinical trials often select patients with strict inclusion criteria that do not reflect standard clinical practice, and exclude those who are at high surgical risk, as is the case in our study; this implies a lack of external validity. For this reason, Poeran et al.<a class="elsevierStyleCrossRef" href="#bib0250">24</a> conducted a retrospective analysis comparing the safety profile of TXA in 872,416 patients who underwent knee and hip replacement surgery in 510 hospitals in the United States. The study concluded that those who received TXA had a lower rate of thromboembolic complications (0.6% vs. 0.8%), as well as a decrease in acute renal failure (1.2% vs. 1.6%); the difference was significant. A similar result was obtained by Sabbag et al.<a class="elsevierStyleCrossRef" href="#bib0255">25</a> in their study, in which they observed that the administration of TXA in patients who had experienced an episode of thromboembolism did not increase the risk of recurrence of a new episode when they were treated with prosthetic knee surgery. In 2020, Porter et al.<a class="elsevierStyleCrossRef" href="#bib0260">26</a> also analysed the safety profile of the drug in 22,491 prosthetic knee surgery recipients. Of the total number of patients, 5501 were at high thromboembolic risk (deep vein thrombosis, pulmonary thromboembolism, myocardial infarction, stroke, atrial fibrillation, coronary artery bypass grafting, cardiac stents). TXA was administered to approximately 50% of these patients without finding an increased incidence of thromboembolic events. The importance of the latter article is greater, given that it reflects the results of routine clinical practice, thereby increasing its external validity.Among the limitations of our study, we found that the sample may not be representative of the general population as it was conducted under ideal conditions, which decreases its external validity. On the other hand, the participation of up to four surgeons may have affected the blood loss results. Finally, it is worth mentioning that subjects have benefited from closer monitoring, which may have had a bearing on initiation of standing and length of hospitalisation.ConclusionsTopical administration of 3g TXA in a single dose has proven to be safe and effective in our population.We believe that the rate of blood transfusion depends more on refined technique than on drug administration.Future lines of research could focus on clinical trials with greater external validity as more information becomes available about the safety profile of TXA. We also consider that future comparative studies could focus on functional variables as their primary endpoint.Protocol code: FPS-TRA-2017-02.EUDRACT NO.: 2017-002480-17.Clinicaltrials identifier: <a href="ctgov:NCT03386656">NCT03386656</a>.Level of evidenceLevel of evidence I.FundingThis research has not received any specific aid from any public, commercial, or non-profit entity.Conflict of interestsEach author certified that they have no commercial associations that might constitute a conflict of interest with respect to the document submitted." "textoCompletoSecciones" => array:1 [ "secciones" => array:13 [ 0 => array:3 [ "identificador" => "xres2111191" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background and objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Material and method" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1798468" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres2111192" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Antecedentes y objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Material y método" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1798467" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Materials and methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Conclusions" ] 9 => array:2 [ "identificador" => "sec0030" "titulo" => "Level of evidence" ] 10 => array:2 [ "identificador" => "sec0035" "titulo" => "Funding" ] 11 => array:2 [ "identificador" => "sec0040" "titulo" => "Conflict of interests" ] 12 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2021-11-11" "fechaAceptado" => "2022-02-28" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1798468" "palabras" => array:4 [ 0 => "Tranexamic acid" 1 => "Arthroplasty" 2 => "Knee replacement" 3 => "Tranexamic topic" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1798467" "palabras" => array:4 [ 0 => "Ácido tranexámico" 1 => "Artroplastia" 2 => "Prótesis de rodilla" 3 => "Tranexámico tópico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "Background and objectiveKnee arthroplasty is a major surgery with potential significant blood loss. Assess the efficacy and safety of topical administration of 3g of tranexamic acid (TXA) in terms of reducing blood loss in knee arthroplasty. Material and methodA randomized, phase III, double-blind, placebo-controlled clinical trial has been conducted. We included 150 patients in 2 parallel treatment groups (75 per arm). The solution was administered topically intra-articular after cementation and prior to capsular closure. Analytical determinations were made before and after surgery to quantify blood loss. ResultsTotal blood loss for the placebo group was 831.5ml and 662.3ml for the TXA group. The difference between the 2 groups was 169.2ml; which means a save of 20.4%; this difference being statistically significant (p<.001). There were no differences in terms of the onset of ambulation, days of admission or visual analogue scale at one month of surgery. Ten patients were rejected for presurgical urinary tract infection, metal allergy, selection failure, patellar weakening, prosthetic instability, intrasurgical tibial fracture, change of indication to unicompartimental prosthesis and a loss of follow-up. There was only one complication unrelated to the investigational drug (bladder balloon). ConclusionThe administration of TXA topically after cementation of the prosthetic components in total knee arthroplasty in a single dose has demonstrated being safe and effective." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background and objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Material and method" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "Antecedentes y objetivoDurante la artroplastia de rodilla se produce una pérdida sanguínea importante. El objetivo de nuestro estudio es valorar la eficacia y la seguridad de la administración tópica de 3g de ácido tranexámico (TXA) en cuanto a la reducción de pérdidas sanguíneas en artroplastia de rodilla. Material y métodoSe ha realizado un ensayo clínico aleatorizado, faseiii, doble ciego, controlado con placebo. Se incluyó a 150 pacientes en 2grupos paralelos de tratamiento (75 por brazo). La solución se administró de forma tópica intraarticular tras la cementación y previo al cierre capsular. Se realizaron determinaciones analíticas antes y después de la cirugía. ResultadosLa pérdida total de sangre media para el grupo placebo fue de 831,5ml, y de 662,3ml para el grupo TXA, con una diferencia entre ambos de 169,2ml, lo que supone un ahorro del 20,4%, siendo estadísticamente significativa (p<0,001). No se obtuvieron diferencias en el inicio de la deambulación, días de ingreso o escala visual analógica al mes de la cirugía. Se retiró a 10pacientes por infección del tracto urinario prequirúrgico, alergia a metales, fallo de selección, debilitamiento rotuliano, inestabilidad protésica, fractura tibial intraquirúrgica, cambio de indicación a prótesis unicompartimental y una pérdida de seguimiento. Hubo una única complicación no relacionada con el fármaco (globos vesicales de repetición). ConclusiónLa administración de TXA de forma tópica tras la cementación de los componentes protésicos en artroplastia de rodilla en una única dosis demuestra que es segura y eficaz." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Antecedentes y objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Material y método" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mean \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SD \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">69.17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.45 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Weight (kg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">82.88 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12.05 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Height (m) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.09 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BMI (kg/m2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">32.73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.23 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3491527.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Descriptive analysis of demographic variables." ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "RF: relative frequency." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">TXA group \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Placebo group \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Beginning of ambulation: days (RF) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">p value .55 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">First \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">41 (.28) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">39 (0.27) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Second \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25 (.17) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24 (0.17) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Third \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (.08) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 (0.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fourth \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (0.01) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Days of hospitalisation (RF) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">p value .14 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (.01) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (0.03) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">48 (.33) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38 (0.26) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 (.10) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23 (0.16) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 (.05) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (0.03) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (.01) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (0.01) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (.00) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (0.01) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">VAS at one month: score (RF) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">p value .82 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20 (.14) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20 (0.14) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1–3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 (.09) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16 (0.11) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4–6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25 (.17) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 (0.15) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7–9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 (.09) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16 (0.11) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3491528.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Descriptive analysis of functional variables: similar distribution in both groups." ] ] 2 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "The pre-Hb and pre-HCT variables are similar in both groups. The variables pre-post-surgery Hb difference and pre-post-surgery HTC show statistically significant intergroup differences, being higher in patients who did not receive tranexamic acid." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">TXA group \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Placebo group \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Previous haemoglobin (g/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.74(95% CI 13.41–14.07) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.59(95% CI 13.29–13.90) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.526 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Previous haematocrit (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">41.52(95% CI 40.64–42.79) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">40.65(95% CI 39.52–41.79) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.333 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Difference Hb pre-Hb post-surgery (g/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.785(95% CI 1.593–1.976) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.319(95% CI 2.046–2.591) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.004 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Difference HCT pre-HCT post-surgery (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.603(95% CI 5.012–6.194) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.683(95% CI 5.565–7.801) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.012 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3491526.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Statistical analysis of efficacy variables." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:26 [ 0 => array:3 [ "identificador" => "bib0135" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of low-dose intra-articular tranexamic acid in total knee replacement: a prospective triple-blinded randomized controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Sa-Ngasoongsong" 1 => "S. Wongsak" 2 => "P. Chanplakorn" 3 => "P. Woratanarat" 4 => "S. Wechmongkolgorn" 5 => "B. Wibulpolprasert" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1471-2474-14-340" "Revista" => array:5 [ "tituloSerie" => "BMC Musculoskelet Disord" "fecha" => "2013" "volumen" => "14" "paginaInicial" => "340" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24308672" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0140" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Conventional drainage versus four hour clamping drainage after total knee arthroplasty in severe osteoarthritis: a prospective, randomised trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Stucinskas" 1 => "S. Tarasevicius" 2 => "A. Cebatorius" 3 => "O. Robertsson" 4 => "A. Smailys" 5 => "H. Wingstrand" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00264-008-0662-4" "Revista" => array:6 [ "tituloSerie" => "Int Orthop" "fecha" => "2009" "volumen" => "33" "paginaInicial" => "1275" "paginaFinal" => "1278" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18925394" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0145" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K. Ker" 1 => "P. Edwards" 2 => "P. Perel" 3 => "H. Shakur" 4 => "I. Roberts" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/bmj.e3054" "Revista" => array:5 [ "tituloSerie" => "BMJ" "fecha" => "2012" "volumen" => "344" "paginaInicial" => "e3054" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22611164" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0150" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "2013 Documento «Sevilla» de Consenso sobre Alternativas a la Transfusión de Sangre Alogénica: Actualización del Documento «Sevilla»" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.R. Leal-Noval" 1 => "M. Muñoz" 2 => "M. Asuero" 3 => "E. Contreras" 4 => "J.A. García-Erce" 5 => "J.V. Llau" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.7399/FH.2013373.133" "Revista" => array:5 [ "tituloSerie" => "Farm Hosp" "fecha" => "2013" "volumen" => "37" "paginaInicial" => "209" "paginaFinal" => "235" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0155" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Topical administration of tranexamic acid in total hip arthroplasty: a meta-analysis of randomized controlled trials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "X. Xu" 1 => "S. Xiong" 2 => "Z. Wang" 3 => "X. Li" 4 => "W. Liu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5582/ddt.2015.01018" "Revista" => array:6 [ "tituloSerie" => "Drug Discov Ther" "fecha" => "2015" "volumen" => "9" "paginaInicial" => "173" "paginaFinal" => "177" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26193938" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0160" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of tranexamic acid on artificial joint materials: a biomechanical study (the bioTRANX study)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Alshryda" 1 => "J.M. Mason" 2 => "P. Sarda" 3 => "T. Lou" 4 => "M. Stanley" 5 => "J. Wu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10195-014-0312-0" "Revista" => array:6 [ "tituloSerie" => "J Orthop Traumatol" "fecha" => "2015" "volumen" => "16" "paginaInicial" => "27" "paginaFinal" => "34" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25091616" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0165" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Topical versus intravenous tranexamic acid as a blood conservation intervention for reduction of post-operative bleeding in hemiarthroplasty" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W.M. Emara" 1 => "K.K. Moez" 2 => "A.H. Elkhouly" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4103/0259-1162.128908" "Revista" => array:6 [ "tituloSerie" => "Anesth Essays Res" "fecha" => "2014" "volumen" => "8" "paginaInicial" => "48" "paginaFinal" => "53" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25886103" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0170" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Topical application of tranexamic acid in primary total hip arthroplasty: a randomized double-blind controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C. Yue" 1 => "P. Kang" 2 => "P. Yang" 3 => "J. Xie" 4 => "F. Pei" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arth.2014.03.032" "Revista" => array:6 [ "tituloSerie" => "J Arthroplasty" "fecha" => "2014" "volumen" => "29" "paginaInicial" => "2452" "paginaFinal" => "2456" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24793893" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0175" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Topical tranexamic acid reduces blood loss and transfusion rates associated with primary total hip arthroplasty" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.H. Chang" 1 => "Y. Chang" 2 => "D.W. Chen" 3 => "S.W. Ueng" 4 => "M.S. Lee" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11999-013-3446-0" "Revista" => array:6 [ "tituloSerie" => "Clin Orthop Relat Res" "fecha" => "2014" "volumen" => "472" "paginaInicial" => "1552" "paginaFinal" => "1557" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24385043" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0180" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prediction of blood volume in normal human adults" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.B. Nadler" 1 => "J.H. Hidalgo" 2 => "T. Bloch" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Surgery" "fecha" => "1962" "volumen" => "51" "paginaInicial" => "224" "paginaFinal" => "232" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21936146" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0185" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Wong" 1 => "A. Abrishami" 2 => "H. el Beheiry" 3 => "N. Mahomed" 4 => "J. Roderick Davey" 5 => "R. Ghandy" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2106/JBJS.I.01518" "Revista" => array:5 [ "tituloSerie" => "J Bone Joint Sur Am" "fecha" => "2010" "volumen" => "92" "paginaInicial" => "2503" "paginaFinal" => "2513" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0190" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Topical tranexamic acid reduces blood loss and transfusion rates in total hip and total knee arthroplasty" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Konig" 1 => "B.R. Hamlin" 2 => "J.H. Waters" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arth.2013.06.011" "Revista" => array:6 [ "tituloSerie" => "J Arthroplasty" "fecha" => "2013" "volumen" => "28" "paginaInicial" => "1473" "paginaFinal" => "1476" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23886406" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0195" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A prospective double-blind placebo-controlled trial of topical tranexamic acid in total knee arthroplasty" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Georgiadis" 1 => "S. Muh" 2 => "C. Silverton" 3 => "R. Weir" 4 => "M. Laker" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arth.2013.03.038" "Revista" => array:6 [ "tituloSerie" => "J Arthroplasty" "fecha" => "2013" "volumen" => "28" "paginaInicial" => "78" "paginaFinal" => "82" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23906869" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0200" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Blood transfusion after primary total knee arthroplasty can be significantly minimised through a multimodal blood-loss prevention approach" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Moráis" 1 => "M. Ortega-Andreu" 2 => "E.C. Rodríguez-Merchán" 3 => "N. Padilla-Eguiluz" 4 => "H. Pérez-Chrzanowska" 5 => "R. Figueredo-Zalve" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00264-013-2188-7" "Revista" => array:6 [ "tituloSerie" => "Int Orthop" "fecha" => "2014" "volumen" => "38" "paginaInicial" => "347" "paginaFinal" => "354" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24318318" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0205" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safety and efficacy of intra-articular tranexamic acid injection without drainage on blood loss in total knee arthroplasty: a randomized clinical trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C. Wang" 1 => "Z. Sun" 2 => "J. Liu" 3 => "J. Cao" 4 => "Z. Li" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijsu.2015.05.045" "Revista" => array:6 [ "tituloSerie" => "Int J Surg" "fecha" => "2015" "volumen" => "20" "paginaInicial" => "1" "paginaFinal" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26048730" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0210" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Topical tranexamic acid is effective in cementless total knee arthroplasty" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Chambers" 1 => "L. Tidwell" 2 => "A. Kerkhof" 3 => "R. Smith" 4 => "W. Mihalko" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ocl.2019.08.002" "Revista" => array:5 [ "tituloSerie" => "Orthop Clin N Am" "fecha" => "2020" "volumen" => "51" "paginaInicial" => "7" "paginaFinal" => "11" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0215" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intraarticular use of tranexamic acid reduces blood loss and transfusion rate after primary total knee arthroplasty" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E. Tille" 1 => "J. Mysliwietz" 2 => "F. Beyer" 3 => "A. Postler" 4 => "J. Lützner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s12891-019-2715-9" "Revista" => array:5 [ "tituloSerie" => "BMC Musculoskelet Disord" "fecha" => "2019" "volumen" => "20" "paginaInicial" => "341" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31351459" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0220" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tranexamic acid increases early perioperative functional outcomes after total knee arthroplasty" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Grosso" 1 => "D. Trofa" 2 => "J. Danoff" 3 => "T. Hickernell" 4 => "T. Murtaugh" 5 => "A. Lakra" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.artd.2017.05.009" "Revista" => array:6 [ "tituloSerie" => "Arthroplast Today" "fecha" => "2018" "volumen" => "4" "paginaInicial" => "74" "paginaFinal" => "77" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29560399" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0225" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Topical tranexamic acid may improve early functional outcomes of primary total knee arthroplasty" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Serrano" 1 => "K. Goudarz Mehdikhani" 2 => "L. Cáceres" 3 => "Y.Y. Lee" 4 => "A. Della Valle" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arth.2016.01.009" "Revista" => array:6 [ "tituloSerie" => "J Arthroplasty" "fecha" => "2016" "volumen" => "31" "paginaInicial" => "1449" "paginaFinal" => "1452" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26869064" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0230" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Periarticular injection of tranexamic acid promotes early recovery of the range of knee motion after total knee arthroplasty" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H. Hirose" 1 => "H. Ogawa" 2 => "K. Matsumoto" 3 => "H. Akiyama" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/2309499019864693" "Revista" => array:5 [ "tituloSerie" => "J Orthop Surg" "fecha" => "2019" "volumen" => "27" "paginaInicial" => "1" "paginaFinal" => "6" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0235" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Application of tranexamic acid in total knee arthroplasty – prospective randomized trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.P.F. Guerreiro" 1 => "B.S. Badaro" 2 => "J.R.M. Balbino" 3 => "M.V. Danieli" 4 => "A.O. Queiroz" 5 => "D.C. Cataneo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2174/1874325001711011049" "Revista" => array:5 [ "tituloSerie" => "Open Orthop J" "fecha" => "2017" "volumen" => "29" "paginaInicial" => "1049" "paginaFinal" => "1057" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0240" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Ficha técnica Amchafibrin 500mg solución inyectable. Available from: <a target="_blank" href="https://aemps.es/cima/pdfs/es/ft/53939/FT_53939.pdf">https://aemps.es/cima/pdfs/es/ft/53939/FT_53939.pdf</a> [consulted 2017]." ] ] ] 22 => array:3 [ "identificador" => "bib0245" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safety of intravenous tranexamic acid in patients undergoing major orthopaedic surgery: a meta-analysis of randomised controlled trials" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Franchini" 1 => "C. Mengoli" 2 => "M. Marietta" 3 => "G. Marano" 4 => "S. Vaglio" 5 => "S. Pupella" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2450//2017.0219-17" "Revista" => array:6 [ "tituloSerie" => "Blood Transfus" "fecha" => "2018" "volumen" => "16" "paginaInicial" => "36" "paginaFinal" => "43" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29337665" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0250" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States: retrospective analysis of effectiveness and safety" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Poeran" 1 => "R. Rasul" 2 => "S. Suzuki" 3 => "T. Danninger" 4 => "M. Mazumdar" 5 => "M. Opperer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/bmj.g4829" "Revista" => array:5 [ "tituloSerie" => "BMJ" "fecha" => "2014" "volumen" => "349" "paginaInicial" => "1" "paginaFinal" => "10" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0255" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tranexamic acid was safe in arthroplasty patients with a history of venous thromboembolism: a matched outcome study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "O. Sabbag" 1 => "M. Abdel" 2 => "A. Amundson" 3 => "D. Larson" 4 => "M. Pagnano" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arth.2017.02.008" "Revista" => array:6 [ "tituloSerie" => "J Arthroplasty" "fecha" => "2017" "volumen" => "32" "paginaInicial" => "246" "paginaFinal" => "250" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27480828" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0260" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tranexamic acid administration is not associated with an increase in complications in high-risk patients undergoing primary total knee or total hip arthroplasty: a retrospective case-control study of 38,220 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Porter" 1 => "L. White" 2 => "O. Osagiede" 3 => "C. Robards" 4 => "A. Spaulding" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arth.2019.08.015" "Revista" => array:6 [ "tituloSerie" => "J Arthroplasty" "fecha" => "2019" "volumen" => "35" "paginaInicial" => "45" "paginaFinal" => "51" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31522854" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/18884415/0000006600000006/v3_202403210638/S1888441522002223/v3_202403210638/en/main.assets" "Apartado" => array:4 [ "identificador" => "93617" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Originales / Original articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/18884415/0000006600000006/v3_202403210638/S1888441522002223/v3_202403210638/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1888441522002223?idApp=UINPBA00004N"]

Statistics

Original Paper

Randomized, placebo-controlled, double-blind clinical trial to evaluate efficacy and safety of topical tranexamic acid in saving blood loss in patients undergoing prosthetic knee surgery

Ensayo clínico aleatorizado, controlado con placebo y doble ciego para evaluar la eficacia y la seguridad del ácido tranexámico tópico en el ahorro de pérdidas sanguíneas en pacientes tratados mediante cirugía protésica de rodilla

F. Oliva-Moya, I. Belloso-Moreno

Corresponding author

isbemore@gmail.com

Corresponding author.

, J.M. Vilches-Fernández, M. Casas-Ruiz, J.A. Andrés-García

Hospital Universitario Puerta del Mar, Cádiz, Spain

Read

845

Times
was read the article

175

Total PDF

670

Total HTML

Share statistics

 array:23 [
  "pii" => "S1888441522002223"
  "issn" => "18884415"
  "doi" => "10.1016/j.recot.2022.02.008"
  "estado" => "S300"
  "fechaPublicacion" => "2022-11-01"
  "aid" => "1116"
  "copyrightAnyo" => "2022"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "fla"
  "cita" => "Rev Esp Cir Ortop Traumatol. 2022;66:T67-T72"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1888441522000182"
    "issn" => "18884415"
    "doi" => "10.1016/j.recot.2022.01.007"
    "estado" => "S300"
    "fechaPublicacion" => "2022-11-01"
    "aid" => "1041"
    "copyright" => "SECOT"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Rev Esp Cir Ortop Traumatol. 2022;66:491-9"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
      "titulo" => "Ensayo cl&#237;nico comparando el uso de tornillos y del sistema TighRope&#174; Knotless en el tratamiento de las lesiones agudas de la sindesmosis"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "491"
          "paginaFinal" => "499"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "A randomized clinical trial comparing screws and the TighRope&#174; Knotless system in the treatment of acute injuries of syndesmosis"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figura 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 493
              "Ancho" => 1305
              "Tamanyo" => 118877
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Mediciones en proyecci&#243;n radiol&#243;gica de mortaja y en estudio TAC&#46; DSA&#58; distancia sindesmosis anterior&#59; DSP&#58; distancia sindesmosis posterior&#59; ECM&#58; espacio claro medial&#59; ECTF&#58; espacio claro tibiofibular&#59; Flecha&#58; nivel de corte axial a 1<span class="elsevierStyleHsp" style=""></span>cm de la l&#237;nea articular&#59; STF&#58; solapamiento tibiofibular&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46; Morales Mu&#241;oz, V&#46; Barroso G&#243;mez, R&#46; de los Santos Real, M&#46; de Dios P&#233;rez, J&#46; Escalera Alonso, J&#46; Varas Navas"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Morales Mu&#241;oz"
            ]
            1 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Barroso G&#243;mez"
            ]
            2 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "de los Santos Real"
            ]
            3 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "de Dios P&#233;rez"
            ]
            4 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Escalera Alonso"
            ]
            5 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Varas Navas"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1888441522000182?idApp=UINPBA00004N"
    "url" => "/18884415/0000006600000006/v3_202403210638/S1888441522000182/v3_202403210638/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1888441522000911"
    "issn" => "18884415"
    "doi" => "10.1016/j.recot.2022.02.007"
    "estado" => "S300"
    "fechaPublicacion" => "2022-11-01"
    "aid" => "1062"
    "copyright" => "SECOT"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Rev Esp Cir Ortop Traumatol. 2022;66:485-90"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
      "titulo" => "Ensayo cl&#237;nico aleatorizado&#44; controlado con placebo y doble ciego para evaluar la eficacia y la seguridad del &#225;cido tranex&#225;mico t&#243;pico en el ahorro de p&#233;rdidas sangu&#237;neas en pacientes tratados mediante cirug&#237;a prot&#233;sica de rodilla"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "485"
          "paginaFinal" => "490"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Randomized&#44; placebo-controlled&#44; double-blind clinical trial to evaluate efficacy and safety of topical tranexamic acid in saving blood loss in patients undergoing prosthetic knee surgery"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "F&#46; Oliva-Moya, I&#46; Belloso-Moreno, J&#46;M&#46; Vilches-Fern&#225;ndez, M&#46; Casas-Ruiz, J&#46;A&#46; Andr&#233;s-Garc&#237;a"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Oliva-Moya"
            ]
            1 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Belloso-Moreno"
            ]
            2 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Vilches-Fern&#225;ndez"
            ]
            3 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Casas-Ruiz"
            ]
            4 => array:2 [
              "nombre" => "J&#46;A&#46;"
              "apellidos" => "Andr&#233;s-Garc&#237;a"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1888441522000911?idApp=UINPBA00004N"
    "url" => "/18884415/0000006600000006/v3_202403210638/S1888441522000911/v3_202403210638/es/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:18 [
      "pii" => "S1888441522000911"
      "issn" => "18884415"
      "doi" => "10.1016/j.recot.2022.02.007"
      "estado" => "S300"
      "fechaPublicacion" => "2022-11-01"
      "aid" => "1062"
      "copyright" => "SECOT"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "fla"
      "cita" => "Rev Esp Cir Ortop Traumatol. 2022;66:485-90"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:12 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
        "titulo" => "Ensayo cl&#237;nico aleatorizado&#44; controlado con placebo y doble ciego para evaluar la eficacia y la seguridad del &#225;cido tranex&#225;mico t&#243;pico en el ahorro de p&#233;rdidas sangu&#237;neas en pacientes tratados mediante cirug&#237;a prot&#233;sica de rodilla"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "485"
            "paginaFinal" => "490"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Randomized&#44; placebo-controlled&#44; double-blind clinical trial to evaluate efficacy and safety of topical tranexamic acid in saving blood loss in patients undergoing prosthetic knee surgery"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "F&#46; Oliva-Moya, I&#46; Belloso-Moreno, J&#46;M&#46; Vilches-Fern&#225;ndez, M&#46; Casas-Ruiz, J&#46;A&#46; Andr&#233;s-Garc&#237;a"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "F&#46;"
                "apellidos" => "Oliva-Moya"
              ]
              1 => array:2 [
                "nombre" => "I&#46;"
                "apellidos" => "Belloso-Moreno"
              ]
              2 => array:2 [
                "nombre" => "J&#46;M&#46;"
                "apellidos" => "Vilches-Fern&#225;ndez"
              ]
              3 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Casas-Ruiz"
              ]
              4 => array:2 [
                "nombre" => "J&#46;A&#46;"
                "apellidos" => "Andr&#233;s-Garc&#237;a"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1888441522000911?idApp=UINPBA00004N"
      "url" => "/18884415/0000006600000006/v3_202403210638/S1888441522000911/v3_202403210638/es/main.assets"
    ]
  ]
  "en" => array:18 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Paper</span>"
    "titulo" => " Randomized&#44; placebo-controlled&#44; double-blind clinical trial to evaluate efficacy and safety of topical tranexamic acid in saving blood loss in patients undergoing prosthetic knee surgery"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "T67"
        "paginaFinal" => "T72"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "F&#46; Oliva-Moya, I&#46; Belloso-Moreno, J&#46;M&#46; Vilches-Fern&#225;ndez, M&#46; Casas-Ruiz, J&#46;A&#46; Andr&#233;s-Garc&#237;a"
        "autores" => array:5 [
          0 => array:2 [
            "nombre" => "F&#46;"
            "apellidos" => "Oliva-Moya"
          ]
          1 => array:4 [
            "nombre" => "I&#46;"
            "apellidos" => "Belloso-Moreno"
            "email" => array:1 [
              0 => "isbemore@gmail.com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:2 [
            "nombre" => "J&#46;M&#46;"
            "apellidos" => "Vilches-Fern&#225;ndez"
          ]
          3 => array:2 [
            "nombre" => "M&#46;"
            "apellidos" => "Casas-Ruiz"
          ]
          4 => array:2 [
            "nombre" => "J&#46;A&#46;"
            "apellidos" => "Andr&#233;s-Garc&#237;a"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Hospital Universitario Puerta del Mar&#44; C&#225;diz&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Ensayo cl&#237;nico aleatorizado&#44; controlado con placebo y doble ciego para evaluar la eficacia y la seguridad del &#225;cido tranex&#225;mico t&#243;pico en el ahorro de p&#233;rdidas sangu&#237;neas en pacientes tratados mediante cirug&#237;a prot&#233;sica de rodilla"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Total knee replacement is a major surgical procedure that involves an array of complications&#44; including blood loss and the consequent need for blood transfusion&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">1&#8211;3</span></a> In recent years&#44; published studies have been focused on patient fast recovery and decreasing postoperative complications&#44; in particular&#44; those that have to do with blood transfusions&#44; such as&#58; higher costs&#44; bacterial contamination&#44; the transmission of viral infections&#44; and reactions to the transfusion&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">One of the drugs that has garnered interest recently is tranexamic acid &#40;TXA&#41;&#46; It is an anti-fibrinolytic agent that has been used for many years to control active bleeding and as a preventive measure in specialties such as ENT and gynaecology&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">4</span></a> In the field of orthopaedic surgery&#44; studies can be found on the use of intravenously administered TXA that evidence a reduction in post-surgical bleeding&#44; as well as in the need for transfusion&#46; Nevertheless&#44; given the potential adverse effects of intravenous administration&#44; the use of topical TXA was contemplated as an alternative&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">5</span></a> The various studies published have shown that topical administration of TXA achieves high dose concentrations at the joint with low systemic distribution&#44; thereby reducing adverse effects and achieving equal outcomes in terms of blood loss savings compared to intravenous administration&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">6&#8211;9</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">However&#44; most of these studies are observational or reviews&#44; and no experimental study based on a clinical trial of the topical administration of TXA in total knee arthroplasty surgery has been found in our setting&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The main objective of our study is to compare both the efficacy and safety of topical TXA in terms of blood loss savings compared to placebo in individuals diagnosed with severe osteoarthritis who had been treated with prosthetic knee surgery&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">An independent&#44; phase III&#44; randomised&#44; double-blind&#44; placebo-controlled clinical trial was carried out from January 2018 to April 2019 at Hospital Puerta del Mar&#44; C&#225;diz&#46; This trial was authorised by the Spanish Agency of Medicines and Medical Devices and the Hospital Ethics Committee&#46; The sample size was calculated for a power of 90&#37;&#44; beta 0&#46;1&#44; and alpha 0&#46;05&#44; resulting in the need for 66 patients per treatment group and an expected loss to follow-up rate of 5&#37;&#46; It was determined that 150 patients needed to be recruited&#44; with 75 patients allocated to each treatment arm&#44; in 15 blocks of 10 patients&#46; Allocation was randomised using the free software application <a href="http://www.randomization.com/">www&#46;randomization&#46;com</a>&#46; Study medication was masked by the hospital&#39;s Pharmacy Service&#44; where 30<span class="elsevierStyleHsp" style=""></span>ml pre-filled syringes with an odourless&#44; transparent solution were prepared&#44; containing either the study medication &#40;3<span class="elsevierStyleHsp" style=""></span>g of TXA&#41; or placebo&#44; with similar labelling&#46; In this way&#44; both patient and surgeon remain double-blinded&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Inclusion criteria for participation in the study were&#58; age between 18 and 80 years&#44; with a visual analogue scale &#40;VAS&#41; score of seven or more&#44; with a Kellgren&#39;s grade equal to or greater than II&#44; and signed informed consent&#46; Exclusion criteria were&#58; severe heart disease&#44; thromboembolic disease&#44; prior hypersensitivity to TXA&#44; severe systemic disease&#44; history of seizures&#44; severe mental disorder&#44; taking anticoagulants&#44; pregnancy or breastfeeding&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The primary endpoint of the study was estimated total blood loss &#40;TBL&#41; according to the formula of Nadler et al&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">10</span></a> Socio-demographic variables&#44; anthropometric variables&#44; need for blood transfusion&#44; ambulation time&#44; and time to hospital discharge were also examined&#46; Safety variables were also analysed&#58; adverse events of any kind&#44; infection rate&#44; need for haematoma evacuation&#44; or surgical wound dehiscence&#46; Patients were followed up for one month after the procedure in all cases&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">To estimate blood loss during surgery&#44; two analytical determinations were performed&#58; the first&#44; 1<span class="elsevierStyleHsp" style=""></span>h prior to surgery&#44; and the second&#44; 24<span class="elsevierStyleHsp" style=""></span>h after surgery&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">All surgeries were performed by members of the Knee Unit of this hospital&#44; using the internal parapatellar approach&#46; Two prosthetic models were used&#58; Sigma&#174; by DePuy Synthes &#40;DePuy-Synhes&#174;&#44; Johnson &#38; Johnson&#174;&#41; and Triathlon&#174; by Stryker &#40;Stryker&#174;&#41;&#46; &#62; &#91;<span class="elsevierStyleItalic">sic</span>&#93; After cemented placement of the prosthetic components and prior to closure of the capsule&#44; the following drug protocol was followed&#58; the knee was placed in extension&#44; the contents of the syringes were administered and distributed over the entire joint&#46; Subsequently&#44; the edges of the surgical wound were approximated&#44; covered with compresses&#44; and a compressive bandage was applied&#46; The ischaemia cuff was removed and the bandage was kept in place for 3<span class="elsevierStyleHsp" style=""></span>min to allow the medication to take effect&#46; After 3<span class="elsevierStyleHsp" style=""></span>min&#44; the compressive bandage was removed and the aqueous solution was aspirated&#46; Finally&#44; thorough local haemostasis was performed&#44; closure by planes&#44; and a cotton inguinopedic elastic bandage was applied&#46; Drainage was not used in any case&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">SPSS v&#46;21 for Macintosh &#40;IBM Corp&#46;&#44; Armonk&#44; NY&#44; USA&#41; was used for data collection and processing&#46; An intention-to-treat analysis was performed from the time of patient randomisation &#40;following signature of informed consent&#41;&#46; The normality of the distribution of all variables was assessed using the Kolmogorov&#8211;Smirnov and Shapiro&#8211;Wilk tests&#46; To analyse baseline intergroup differences in quantitative variables&#44; the Student&#39;s <span class="elsevierStyleItalic">t</span>-test and the chi-squared test for qualitative variables were used&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0055" class="elsevierStylePara elsevierViewall">Of the total of 150 patients recruited&#44; 10 were excluded from the trial for the following reasons&#58; three were over 80 years of age at the time of surgery&#59; one patient had symptoms of urinary tract infection&#59; another two patients were excluded for reasons related to the surgical technique &#40;weakness of the patellar tendon and placement of a single compartment prosthesis&#41;&#44; and&#44; finally&#44; the results of the post-operative analysis were lost in another of the patients&#46; This left 69 patients in the TXA group and 71 in the placebo group&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The descriptive demographic analysis of the sample is summarised in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#44; with the percentage of males and females being 29&#46;3&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>44&#41; and 70&#46;7&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>106&#41;&#44; respectively&#44; and adhering to a normal distribution&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">The type of prosthesis used was Sigma&#174; &#40;Depuy-Synthes&#41; in 44&#46;2&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>65&#41; and Triathlon&#174; &#40;Stryker&#41; in 55&#46;8&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>82&#41; of the cases&#44; displaying similar distribution in both groups&#59; 33 Sigma&#174; and 40 Triathlon&#174; prostheses for the TXA group&#44; and 32 Sigma&#174; and 42 Triathlon&#174; prostheses for the placebo group&#46; No statistically significant differences &#40;<span class="elsevierStyleItalic">p</span>-value<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;94&#41; were detected between the two groups&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Regarding clinical and functional variables&#44; no statistically significant differences were observed in both groups at the time when the patient began to stand upright &#40;<span class="elsevierStyleItalic">p</span> value<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>NS&#41;&#44; or for the total days of hospitalisation &#40;<span class="elsevierStyleItalic">p</span> value<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>NS&#41; or for the pain assessment based on the VAS score one month after surgery &#40;<span class="elsevierStyleItalic">p</span> value<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>NS&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">As regards efficacy variables&#44; haemoglobin &#40;Hb&#41; and haematocrit &#40;HCT&#41; were measured and the data presented a normal distribution for Hb prior to surgery&#46; In the case of prior HCT&#44; the data followed a normal distribution for the TXA group&#44; although not for the placebo group&#46; No statistically significant differences were discovered between the two groups for either Hb or HCT&#46; On the other hand&#44; statistically significant differences were found in the differences between Hb and HCT pre- and post-surgery&#44; the difference being greater for the placebo group &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">The primary endpoint&#44; TBL&#44; had a mean of 662&#46;30<span class="elsevierStyleHsp" style=""></span>ml &#40;95&#37; confidence interval &#40;CI&#41;&#44; 600&#46;8&#8211;723&#46;7&#41; for the TXA group and 831&#46;5<span class="elsevierStyleHsp" style=""></span>ml &#40;5&#37; CI&#44; 752&#46;8&#8211;910&#46;2&#41; for the placebo group&#59; the difference between the two were 167&#46;78<span class="elsevierStyleHsp" style=""></span>ml in favour of the TXA group and was statistically significant&#44; with a <span class="elsevierStyleItalic">p</span> value of 0&#46;001&#44; which corresponds to a savings of 20&#37; with respect to the placebo group&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">In terms of safety analysis&#44; there were no complications with the surgical wound&#59; no patient required a repeat operation&#59; there were no infections&#44; and no blood transfusions were necessary in any case&#46; The only adverse event unrelated to the use of TXA was one case of recurrent bladder ballooning&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">In the present study&#44; a 20&#37; decrease &#40;an average of 167&#46;78<span class="elsevierStyleHsp" style=""></span>ml&#41; in total blood loss was achieved by administering TXA in prosthetic knee surgery&#46; In the literature&#44; we found several studies with a methodology similar to ours&#46; In 2010&#44; Wong et al&#46; analysed 3 treatment arms &#40;in the first arm&#44; 1&#46;5<span class="elsevierStyleHsp" style=""></span>g of TXA was administered&#59; in the second&#44; 3<span class="elsevierStyleHsp" style=""></span>g&#44; and in the third group&#44; placebo&#41; and observed a reduction of 315<span class="elsevierStyleHsp" style=""></span>ml of blood loss on average in the first arm and 402<span class="elsevierStyleHsp" style=""></span>ml in the second arm&#44; compared to the control group&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">11</span></a> Subsequently&#44; Konig et al&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">12</span></a> and Georgiadis et al&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">13</span></a> reported a reduction in blood loss of 353 and 231<span class="elsevierStyleHsp" style=""></span>ml on average&#44; respectively&#46; We believe that these results that are quantitatively greater compared to our study may be due to the methodology used in terms of surgical manoeuvres&#44; which&#44; given that they are not standardised&#44; may lead to differences that are unrelated to the administration of the drug&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">14</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">As for savings in blood loss&#44; the main effect of administering TXA is that it reduces the rate of transfusion&#46; Different studies indicate that patients undergoing knee arthroplasty who receive this drug do not require blood transfusion after surgery&#46;<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">15&#8211;17</span></a> In our case&#44; the transfusion rate was zero for both TXA-treated patients and the control group&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Regarding the analysis of functionality&#44; the interest lies in the fact that&#44; by decreasing blood loss-related complications&#44; rehabilitation does not have to be delayed because of said complications&#46; Therefore&#44; in 2018&#44; Grosso et al&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">18</span></a> proposed to analyse functional outcomes and early recovery among the participants who received intravenous TXA&#46; To do so&#44; 560 patients were randomised into two treatment arms&#59; the first group received TXA and the second group received placebo&#46; The result was that the subjects who were given TXA were able to walk more from the second day on&#46; However&#44; there was no difference on the VAS score&#46; On the other hand&#44; Serrano et al&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">19</span></a> analysed post-surgical functional outcomes with the Knee Society Score &#40;KSS&#41; and differences were observed at six weeks after drug administration&#44; but not at four months&#46; In 2019&#44; Hirose et al&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">20</span></a> conducted an analysis of joint balance &#40;JB&#41; after intra-articular TXA administration following surgical wound closure&#46; They achieved an improvement in JB on the fourth&#44; tenth&#44; and fourteenth day&#46; However&#44; there was no difference in the 10<span class="elsevierStyleHsp" style=""></span>m ambulation test&#44; VAS&#44; or muscle strength&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Similar to Guerreiro et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">21</span></a> we found no significant differences in our study between the two groups with respect to time to onset of standing following surgery&#44; VAS at one month postoperatively&#44; and days of hospitalisation&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">In our opinion&#44; these differences between the various studies in terms of functional outcomes are likely to be due to the analysis of multiple secondary variables&#46; Therefore&#44; a pre-study protocol is deemed fundamental to clearly define the primary endpoint&#44; as well as the sample size&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">As for the possible adverse reactions of TXA administration&#44; thromboembolic events are particularly relevant&#44; as described in its technical data sheet&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">22</span></a> However&#44; in this clinical trial&#44; no cases of thromboembolic events were reported in either of the two treatment arms&#46; Other events related to the surgical technique&#44; such as surgical wound dehiscence&#44; haematoma requiring drainage&#44; or bleeding that could not be controlled with conservative measures&#44; were also not reported&#46; Similar results were reached in studies by Konig et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">12</span></a> Wong et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">11</span></a> and Geordiadis et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">13</span></a> in which no increased incidence of thromboembolism or any other complication was observed when TXA was topically administered&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">A meta-analysis conducted in 2018<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">23</span></a> that included 73 clinical trials with a total of 6953 patients undergoing prosthetic knee surgery concluded that the overall incidence of venous thromboembolism was 2&#46;1&#37; in individuals who were given TXA versus 2&#37; in the control group&#46; However&#44; these results should be taken with caution&#44; inasmuch as clinical trials often select patients with strict inclusion criteria that do not reflect standard clinical practice&#44; and exclude those who are at high surgical risk&#44; as is the case in our study&#59; this implies a lack of external validity&#46; For this reason&#44; Poeran et al&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">24</span></a> conducted a retrospective analysis comparing the safety profile of TXA in 872&#44;416 patients who underwent knee and hip replacement surgery in 510 hospitals in the United States&#46; The study concluded that those who received TXA had a lower rate of thromboembolic complications &#40;0&#46;6&#37; vs&#46; 0&#46;8&#37;&#41;&#44; as well as a decrease in acute renal failure &#40;1&#46;2&#37; vs&#46; 1&#46;6&#37;&#41;&#59; the difference was significant&#46; A similar result was obtained by Sabbag et al&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">25</span></a> in their study&#44; in which they observed that the administration of TXA in patients who had experienced an episode of thromboembolism did not increase the risk of recurrence of a new episode when they were treated with prosthetic knee surgery&#46; In 2020&#44; Porter et al&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">26</span></a> also analysed the safety profile of the drug in 22&#44;491 prosthetic knee surgery recipients&#46; Of the total number of patients&#44; 5501 were at high thromboembolic risk &#40;deep vein thrombosis&#44; pulmonary thromboembolism&#44; myocardial infarction&#44; stroke&#44; atrial fibrillation&#44; coronary artery bypass grafting&#44; cardiac stents&#41;&#46; TXA was administered to approximately 50&#37; of these patients without finding an increased incidence of thromboembolic events&#46; The importance of the latter article is greater&#44; given that it reflects the results of routine clinical practice&#44; thereby increasing its external validity&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Among the limitations of our study&#44; we found that the sample may not be representative of the general population as it was conducted under ideal conditions&#44; which decreases its external validity&#46; On the other hand&#44; the participation of up to four surgeons may have affected the blood loss results&#46; Finally&#44; it is worth mentioning that subjects have benefited from closer monitoring&#44; which may have had a bearing on initiation of standing and length of hospitalisation&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusions</span><p id="par0130" class="elsevierStylePara elsevierViewall">Topical administration of 3<span class="elsevierStyleHsp" style=""></span>g TXA in a single dose has proven to be safe and effective in our population&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">We believe that the rate of blood transfusion depends more on refined technique than on drug administration&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Future lines of research could focus on clinical trials with greater external validity as more information becomes available about the safety profile of TXA&#46; We also consider that future comparative studies could focus on functional variables as their primary endpoint&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Protocol code&#58; FPS-TRA-2017-02&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">EUDRACT NO&#46;&#58; 2017-002480-17&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Clinicaltrials identifier&#58; <a href="ctgov:NCT03386656">NCT03386656</a>&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Level of evidence</span><p id="par0160" class="elsevierStylePara elsevierViewall">Level of evidence I&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Funding</span><p id="par0165" class="elsevierStylePara elsevierViewall">This research has not received any specific aid from any public&#44; commercial&#44; or non-profit entity&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflict of interests</span><p id="par0170" class="elsevierStylePara elsevierViewall">Each author certified that they have no commercial associations that might constitute a conflict of interest with respect to the document submitted&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:13 [
        0 => array:3 [
          "identificador" => "xres2111191"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Background and objective"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Material and method"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusion"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1798468"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres2111192"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Antecedentes y objetivo"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Material y m&#233;todo"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusi&#243;n"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1798467"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Materials and methods"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Results"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conclusions"
        ]
        9 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Level of evidence"
        ]
        10 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Funding"
        ]
        11 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Conflict of interests"
        ]
        12 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2021-11-11"
    "fechaAceptado" => "2022-02-28"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1798468"
          "palabras" => array:4 [
            0 => "Tranexamic acid"
            1 => "Arthroplasty"
            2 => "Knee replacement"
            3 => "Tranexamic topic"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1798467"
          "palabras" => array:4 [
            0 => "&#193;cido tranex&#225;mico"
            1 => "Artroplastia"
            2 => "Pr&#243;tesis de rodilla"
            3 => "Tranex&#225;mico t&#243;pico"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background and objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Knee arthroplasty is a major surgery with potential significant blood loss&#46; Assess the efficacy and safety of topical administration of 3<span class="elsevierStyleHsp" style=""></span>g of tranexamic acid &#40;TXA&#41; in terms of reducing blood loss in knee arthroplasty&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material and method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A randomized&#44; phase III&#44; double-blind&#44; placebo-controlled clinical trial has been conducted&#46; We included 150 patients in 2 parallel treatment groups &#40;75 per arm&#41;&#46; The solution was administered topically intra-articular after cementation and prior to capsular closure&#46; Analytical determinations were made before and after surgery to quantify blood loss&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Total blood loss for the placebo group was 831&#46;5<span class="elsevierStyleHsp" style=""></span>ml and 662&#46;3<span class="elsevierStyleHsp" style=""></span>ml for the TXA group&#46; The difference between the 2 groups was 169&#46;2<span class="elsevierStyleHsp" style=""></span>ml&#59; which means a save of 20&#46;4&#37;&#59; this difference being statistically significant &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46; There were no differences in terms of the onset of ambulation&#44; days of admission or visual analogue scale at one month of surgery&#46; Ten patients were rejected for presurgical urinary tract infection&#44; metal allergy&#44; selection failure&#44; patellar weakening&#44; prosthetic instability&#44; intrasurgical tibial fracture&#44; change of indication to unicompartimental prosthesis and a loss of follow-up&#46; There was only one complication unrelated to the investigational drug &#40;bladder balloon&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The administration of TXA topically after cementation of the prosthetic components in total knee arthroplasty in a single dose has demonstrated being safe and effective&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background and objective"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Material and method"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusion"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antecedentes y objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Durante la artroplastia de rodilla se produce una p&#233;rdida sangu&#237;nea importante&#46; El objetivo de nuestro estudio es valorar la eficacia y la seguridad de la administraci&#243;n t&#243;pica de 3<span class="elsevierStyleHsp" style=""></span>g de &#225;cido tranex&#225;mico &#40;TXA&#41; en cuanto a la reducci&#243;n de p&#233;rdidas sangu&#237;neas en artroplastia de rodilla&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un ensayo cl&#237;nico aleatorizado&#44; fase<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleSmallCaps">iii</span>&#44; doble ciego&#44; controlado con placebo&#46; Se incluy&#243; a 150 pacientes en 2<span class="elsevierStyleHsp" style=""></span>grupos paralelos de tratamiento &#40;75 por brazo&#41;&#46; La soluci&#243;n se administr&#243; de forma t&#243;pica intraarticular tras la cementaci&#243;n y previo al cierre capsular&#46; Se realizaron determinaciones anal&#237;ticas antes y despu&#233;s de la cirug&#237;a&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">La p&#233;rdida total de sangre media para el grupo placebo fue de 831&#44;5<span class="elsevierStyleHsp" style=""></span>ml&#44; y de 662&#44;3<span class="elsevierStyleHsp" style=""></span>ml para el grupo TXA&#44; con una diferencia entre ambos de 169&#44;2<span class="elsevierStyleHsp" style=""></span>ml&#44; lo que supone un ahorro del 20&#44;4&#37;&#44; siendo estad&#237;sticamente significativa &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; No se obtuvieron diferencias en el inicio de la deambulaci&#243;n&#44; d&#237;as de ingreso o escala visual anal&#243;gica al mes de la cirug&#237;a&#46; Se retir&#243; a 10<span class="elsevierStyleHsp" style=""></span>pacientes por infecci&#243;n del tracto urinario prequir&#250;rgico&#44; alergia a metales&#44; fallo de selecci&#243;n&#44; debilitamiento rotuliano&#44; inestabilidad prot&#233;sica&#44; fractura tibial intraquir&#250;rgica&#44; cambio de indicaci&#243;n a pr&#243;tesis unicompartimental y una p&#233;rdida de seguimiento&#46; Hubo una &#250;nica complicaci&#243;n no relacionada con el f&#225;rmaco &#40;globos vesicales de repetici&#243;n&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La administraci&#243;n de TXA de forma t&#243;pica tras la cementaci&#243;n de los componentes prot&#233;sicos en artroplastia de rodilla en una &#250;nica dosis demuestra que es segura y eficaz&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Antecedentes y objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Material y m&#233;todo"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusi&#243;n"
          ]
        ]
      ]
    ]
    "multimedia" => array:3 [
      0 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mean&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69&#46;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Weight &#40;kg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">82&#46;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Height &#40;m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BMI &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#46;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3491527.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Descriptive analysis of demographic variables&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">RF&#58; relative frequency&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">TXA group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Placebo group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Beginning of ambulation&#58; days &#40;RF&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">p</span> value &#46;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>First&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41 &#40;&#46;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39 &#40;0&#46;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Second&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25 &#40;&#46;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24 &#40;0&#46;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Third&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;&#46;08&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;0&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fourth&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#46;01&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Days of hospitalisation &#40;RF&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">p</span> value &#46;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;&#46;01&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;0&#46;03&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48 &#40;&#46;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;0&#46;26&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;&#46;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;0&#46;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;0&#46;03&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;&#46;01&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#46;01&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;&#46;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#46;01&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">VAS at one month&#58; score &#40;RF&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">p</span> value &#46;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;&#46;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;0&#46;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1&#8211;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;&#46;09&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;0&#46;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>4&#8211;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25 &#40;&#46;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;0&#46;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>7&#8211;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;&#46;09&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;0&#46;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3491528.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Descriptive analysis of functional variables&#58; similar distribution in both groups&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">The pre-Hb and pre-HCT variables are similar in both groups&#46; The variables pre-post-surgery Hb difference and pre-post-surgery HTC show statistically significant intergroup differences&#44; being higher in patients who did not receive tranexamic acid&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">TXA group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Placebo group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Previous haemoglobin &#40;g&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;74&#40;95&#37; CI 13&#46;41&#8211;14&#46;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;59&#40;95&#37; CI 13&#46;29&#8211;13&#46;90&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;526&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Previous haematocrit &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&#46;52&#40;95&#37; CI 40&#46;64&#8211;42&#46;79&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&#46;65&#40;95&#37; CI 39&#46;52&#8211;41&#46;79&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;333&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Difference Hb pre-Hb post-surgery &#40;g&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;785&#40;95&#37; CI 1&#46;593&#8211;1&#46;976&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;319&#40;95&#37; CI 2&#46;046&#8211;2&#46;591&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Difference HCT pre-HCT post-surgery &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;603&#40;95&#37; CI 5&#46;012&#8211;6&#46;194&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;683&#40;95&#37; CI 5&#46;565&#8211;7&#46;801&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3491526.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Statistical analysis of efficacy variables&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:26 [
            0 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy of low-dose intra-articular tranexamic acid in total knee replacement&#58; a prospective triple-blinded randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Sa-Ngasoongsong"
                            1 => "S&#46; Wongsak"
                            2 => "P&#46; Chanplakorn"
                            3 => "P&#46; Woratanarat"
                            4 => "S&#46; Wechmongkolgorn"
                            5 => "B&#46; Wibulpolprasert"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2474-14-340"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Musculoskelet Disord"
                        "fecha" => "2013"
                        "volumen" => "14"
                        "paginaInicial" => "340"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24308672"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Conventional drainage versus four hour clamping drainage after total knee arthroplasty in severe osteoarthritis&#58; a prospective&#44; randomised trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Stucinskas"
                            1 => "S&#46; Tarasevicius"
                            2 => "A&#46; Cebatorius"
                            3 => "O&#46; Robertsson"
                            4 => "A&#46; Smailys"
                            5 => "H&#46; Wingstrand"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00264-008-0662-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int Orthop"
                        "fecha" => "2009"
                        "volumen" => "33"
                        "paginaInicial" => "1275"
                        "paginaFinal" => "1278"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18925394"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of tranexamic acid on surgical bleeding&#58; systematic review and cumulative meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "K&#46; Ker"
                            1 => "P&#46; Edwards"
                            2 => "P&#46; Perel"
                            3 => "H&#46; Shakur"
                            4 => "I&#46; Roberts"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bmj.e3054"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "2012"
                        "volumen" => "344"
                        "paginaInicial" => "e3054"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22611164"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "2013 Documento &#171;Sevilla&#187; de Consenso sobre Alternativas a la Transfusi&#243;n de Sangre Alog&#233;nica&#58; Actualizaci&#243;n del Documento &#171;Sevilla&#187;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;R&#46; Leal-Noval"
                            1 => "M&#46; Mu&#241;oz"
                            2 => "M&#46; Asuero"
                            3 => "E&#46; Contreras"
                            4 => "J&#46;A&#46; Garc&#237;a-Erce"
                            5 => "J&#46;V&#46; Llau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.7399/FH.2013373.133"
                      "Revista" => array:5 [
                        "tituloSerie" => "Farm Hosp"
                        "fecha" => "2013"
                        "volumen" => "37"
                        "paginaInicial" => "209"
                        "paginaFinal" => "235"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Topical administration of tranexamic acid in total hip arthroplasty&#58; a meta-analysis of randomized controlled trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "X&#46; Xu"
                            1 => "S&#46; Xiong"
                            2 => "Z&#46; Wang"
                            3 => "X&#46; Li"
                            4 => "W&#46; Liu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5582/ddt.2015.01018"
                      "Revista" => array:6 [
                        "tituloSerie" => "Drug Discov Ther"
                        "fecha" => "2015"
                        "volumen" => "9"
                        "paginaInicial" => "173"
                        "paginaFinal" => "177"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26193938"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of tranexamic acid on artificial joint materials&#58; a biomechanical study &#40;the bioTRANX study&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Alshryda"
                            1 => "J&#46;M&#46; Mason"
                            2 => "P&#46; Sarda"
                            3 => "T&#46; Lou"
                            4 => "M&#46; Stanley"
                            5 => "J&#46; Wu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10195-014-0312-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Orthop Traumatol"
                        "fecha" => "2015"
                        "volumen" => "16"
                        "paginaInicial" => "27"
                        "paginaFinal" => "34"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25091616"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Topical versus intravenous tranexamic acid as a blood conservation intervention for reduction of post-operative bleeding in hemiarthroplasty"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46;M&#46; Emara"
                            1 => "K&#46;K&#46; Moez"
                            2 => "A&#46;H&#46; Elkhouly"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/0259-1162.128908"
                      "Revista" => array:6 [
                        "tituloSerie" => "Anesth Essays Res"
                        "fecha" => "2014"
                        "volumen" => "8"
                        "paginaInicial" => "48"
                        "paginaFinal" => "53"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25886103"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Topical application of tranexamic acid in primary total hip arthroplasty&#58; a randomized double-blind controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46; Yue"
                            1 => "P&#46; Kang"
                            2 => "P&#46; Yang"
                            3 => "J&#46; Xie"
                            4 => "F&#46; Pei"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arth.2014.03.032"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Arthroplasty"
                        "fecha" => "2014"
                        "volumen" => "29"
                        "paginaInicial" => "2452"
                        "paginaFinal" => "2456"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24793893"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Topical tranexamic acid reduces blood loss and transfusion rates associated with primary total hip arthroplasty"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;H&#46; Chang"
                            1 => "Y&#46; Chang"
                            2 => "D&#46;W&#46; Chen"
                            3 => "S&#46;W&#46; Ueng"
                            4 => "M&#46;S&#46; Lee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11999-013-3446-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Orthop Relat Res"
                        "fecha" => "2014"
                        "volumen" => "472"
                        "paginaInicial" => "1552"
                        "paginaFinal" => "1557"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24385043"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prediction of blood volume in normal human adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;B&#46; Nadler"
                            1 => "J&#46;H&#46; Hidalgo"
                            2 => "T&#46; Bloch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Surgery"
                        "fecha" => "1962"
                        "volumen" => "51"
                        "paginaInicial" => "224"
                        "paginaFinal" => "232"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21936146"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Wong"
                            1 => "A&#46; Abrishami"
                            2 => "H&#46; el Beheiry"
                            3 => "N&#46; Mahomed"
                            4 => "J&#46; Roderick Davey"
                            5 => "R&#46; Ghandy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2106/JBJS.I.01518"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Bone Joint Sur Am"
                        "fecha" => "2010"
                        "volumen" => "92"
                        "paginaInicial" => "2503"
                        "paginaFinal" => "2513"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Topical tranexamic acid reduces blood loss and transfusion rates in total hip and total knee arthroplasty"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Konig"
                            1 => "B&#46;R&#46; Hamlin"
                            2 => "J&#46;H&#46; Waters"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arth.2013.06.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Arthroplasty"
                        "fecha" => "2013"
                        "volumen" => "28"
                        "paginaInicial" => "1473"
                        "paginaFinal" => "1476"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23886406"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A prospective double-blind placebo-controlled trial of topical tranexamic acid in total knee arthroplasty"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Georgiadis"
                            1 => "S&#46; Muh"
                            2 => "C&#46; Silverton"
                            3 => "R&#46; Weir"
                            4 => "M&#46; Laker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arth.2013.03.038"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Arthroplasty"
                        "fecha" => "2013"
                        "volumen" => "28"
                        "paginaInicial" => "78"
                        "paginaFinal" => "82"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23906869"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Blood transfusion after primary total knee arthroplasty can be significantly minimised through a multimodal blood-loss prevention approach"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Mor&#225;is"
                            1 => "M&#46; Ortega-Andreu"
                            2 => "E&#46;C&#46; Rodr&#237;guez-Merch&#225;n"
                            3 => "N&#46; Padilla-Eguiluz"
                            4 => "H&#46; P&#233;rez-Chrzanowska"
                            5 => "R&#46; Figueredo-Zalve"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00264-013-2188-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int Orthop"
                        "fecha" => "2014"
                        "volumen" => "38"
                        "paginaInicial" => "347"
                        "paginaFinal" => "354"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24318318"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Safety and efficacy of intra-articular tranexamic acid injection without drainage on blood loss in total knee arthroplasty&#58; a randomized clinical trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46; Wang"
                            1 => "Z&#46; Sun"
                            2 => "J&#46; Liu"
                            3 => "J&#46; Cao"
                            4 => "Z&#46; Li"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijsu.2015.05.045"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Surg"
                        "fecha" => "2015"
                        "volumen" => "20"
                        "paginaInicial" => "1"
                        "paginaFinal" => "7"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26048730"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Topical tranexamic acid is effective in cementless total knee arthroplasty"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Chambers"
                            1 => "L&#46; Tidwell"
                            2 => "A&#46; Kerkhof"
                            3 => "R&#46; Smith"
                            4 => "W&#46; Mihalko"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ocl.2019.08.002"
                      "Revista" => array:5 [
                        "tituloSerie" => "Orthop Clin N Am"
                        "fecha" => "2020"
                        "volumen" => "51"
                        "paginaInicial" => "7"
                        "paginaFinal" => "11"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intraarticular use of tranexamic acid reduces blood loss and transfusion rate after primary total knee arthroplasty"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Tille"
                            1 => "J&#46; Mysliwietz"
                            2 => "F&#46; Beyer"
                            3 => "A&#46; Postler"
                            4 => "J&#46; L&#252;tzner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s12891-019-2715-9"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Musculoskelet Disord"
                        "fecha" => "2019"
                        "volumen" => "20"
                        "paginaInicial" => "341"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31351459"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tranexamic acid increases early perioperative functional outcomes after total knee arthroplasty"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Grosso"
                            1 => "D&#46; Trofa"
                            2 => "J&#46; Danoff"
                            3 => "T&#46; Hickernell"
                            4 => "T&#46; Murtaugh"
                            5 => "A&#46; Lakra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.artd.2017.05.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthroplast Today"
                        "fecha" => "2018"
                        "volumen" => "4"
                        "paginaInicial" => "74"
                        "paginaFinal" => "77"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29560399"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Topical tranexamic acid may improve early functional outcomes of primary total knee arthroplasty"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Serrano"
                            1 => "K&#46; Goudarz Mehdikhani"
                            2 => "L&#46; C&#225;ceres"
                            3 => "Y&#46;Y&#46; Lee"
                            4 => "A&#46; Della Valle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arth.2016.01.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Arthroplasty"
                        "fecha" => "2016"
                        "volumen" => "31"
                        "paginaInicial" => "1449"
                        "paginaFinal" => "1452"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26869064"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Periarticular injection of tranexamic acid promotes early recovery of the range of knee motion after total knee arthroplasty"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "H&#46; Hirose"
                            1 => "H&#46; Ogawa"
                            2 => "K&#46; Matsumoto"
                            3 => "H&#46; Akiyama"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/2309499019864693"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Orthop Surg"
                        "fecha" => "2019"
                        "volumen" => "27"
                        "paginaInicial" => "1"
                        "paginaFinal" => "6"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Application of tranexamic acid in total knee arthroplasty &#8211; prospective randomized trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;P&#46;F&#46; Guerreiro"
                            1 => "B&#46;S&#46; Badaro"
                            2 => "J&#46;R&#46;M&#46; Balbino"
                            3 => "M&#46;V&#46; Danieli"
                            4 => "A&#46;O&#46; Queiroz"
                            5 => "D&#46;C&#46; Cataneo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2174/1874325001711011049"
                      "Revista" => array:5 [
                        "tituloSerie" => "Open Orthop J"
                        "fecha" => "2017"
                        "volumen" => "29"
                        "paginaInicial" => "1049"
                        "paginaFinal" => "1057"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Ficha t&#233;cnica Amchafibrin 500<span class="elsevierStyleHsp" style=""></span>mg soluci&#243;n inyectable&#46; Available from&#58; <a target="_blank" href="https://aemps.es/cima/pdfs/es/ft/53939/FT_53939.pdf">https&#58;&#47;&#47;aemps&#46;es&#47;cima&#47;pdfs&#47;es&#47;ft&#47;53939&#47;FT&#95;53939&#46;pdf</a> &#91;consulted 2017&#93;&#46;"
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Safety of intravenous tranexamic acid in patients undergoing major orthopaedic surgery&#58; a meta-analysis of randomised controlled trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Franchini"
                            1 => "C&#46; Mengoli"
                            2 => "M&#46; Marietta"
                            3 => "G&#46; Marano"
                            4 => "S&#46; Vaglio"
                            5 => "S&#46; Pupella"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2450//2017.0219-17"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood Transfus"
                        "fecha" => "2018"
                        "volumen" => "16"
                        "paginaInicial" => "36"
                        "paginaFinal" => "43"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29337665"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States&#58; retrospective analysis of effectiveness and safety"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Poeran"
                            1 => "R&#46; Rasul"
                            2 => "S&#46; Suzuki"
                            3 => "T&#46; Danninger"
                            4 => "M&#46; Mazumdar"
                            5 => "M&#46; Opperer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bmj.g4829"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "2014"
                        "volumen" => "349"
                        "paginaInicial" => "1"
                        "paginaFinal" => "10"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tranexamic acid was safe in arthroplasty patients with a history of venous thromboembolism&#58; a matched outcome study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "O&#46; Sabbag"
                            1 => "M&#46; Abdel"
                            2 => "A&#46; Amundson"
                            3 => "D&#46; Larson"
                            4 => "M&#46; Pagnano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arth.2017.02.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Arthroplasty"
                        "fecha" => "2017"
                        "volumen" => "32"
                        "paginaInicial" => "246"
                        "paginaFinal" => "250"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27480828"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tranexamic acid administration is not associated with an increase in complications in high-risk patients undergoing primary total knee or total hip arthroplasty&#58; a retrospective case-control study of 38&#44;220 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Porter"
                            1 => "L&#46; White"
                            2 => "O&#46; Osagiede"
                            3 => "C&#46; Robards"
                            4 => "A&#46; Spaulding"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arth.2019.08.015"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Arthroplasty"
                        "fecha" => "2019"
                        "volumen" => "35"
                        "paginaInicial" => "45"
                        "paginaFinal" => "51"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31522854"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/18884415/0000006600000006/v3_202403210638/S1888441522002223/v3_202403210638/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "93617"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Originales &#47; Original articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/18884415/0000006600000006/v3_202403210638/S1888441522002223/v3_202403210638/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1888441522002223?idApp=UINPBA00004N"
]

Article information

ISSN: 18884415
Original language: English

DOI:10.1016/j.recot.2022.02.008

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	2	1	3
2024 October	23	6	29
2024 September	52	14	66
2024 August	45	11	56
2024 July	23	4	27
2024 June	30	2	32
2024 May	48	8	56
2024 April	31	7	38
2024 March	30	8	38
2024 February	21	9	30
2024 January	21	2	23
2023 December	9	9	18
2023 November	18	6	24
2023 October	26	5	31
2023 September	14	2	16
2023 August	18	5	23
2023 July	17	4	21
2023 June	25	5	30
2023 May	55	5	60
2023 April	24	3	27
2023 March	12	4	16
2023 February	11	3	14
2023 January	8	7	15
2022 December	19	8	27
2022 November	40	7	47
2022 October	48	11	59
2022 September	0	19	19

Show all

Indexed in:

Follow us:

Statistics

Indexed in:

Follow us:

Statistics

Subscribe to our newsletter