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Differences are determined in the organisation of collagen fibres, with less maturity in the distal segment than in the medial segment.</p> <p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">*<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.042.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "D. Figueroa, R. Martínez, R. Calvo, M. Scheu, M. Gallegos, A. Vaisman, C. Martínez, A. González" "autores" => array:8 [ 0 => array:2 [ "nombre" => "D." "apellidos" => "Figueroa" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Martínez" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Calvo" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Scheu" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "Gallegos" ] 5 => array:2 [ "nombre" => "A." "apellidos" => "Vaisman" ] 6 => array:2 [ "nombre" => "C." "apellidos" => "Martínez" ] 7 => array:2 [ "nombre" => "A." 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García-Jiménez, L. Trullols-Tarragó, A. Peiró-Ibáñez, I. Gracia-Alegría" "autores" => array:4 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "García-Jiménez" "email" => array:1 [ 0 => "agarciaji@santpau.cat" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "L." "apellidos" => "Trullols-Tarragó" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "Peiró-Ibáñez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "I." "apellidos" => "Gracia-Alegría" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Cirugía Ortopédica y Traumatología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Cirugía Oncológica Ortopédica, Servicio de Cirugía Ortopédica y Traumatología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Análisis de resultados en cirugía de revisión de márgenes de sarcomas de partes blandas" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1569 "Ancho" => 1569 "Tamanyo" => 83556 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Diagnostic findings in the revision of histological sample sections from the first operation by experienced pathologists in our hospital. CS: condrosarcoma; MFH: malign fibrohistiocytoma; LPS: liposarcoma.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Sarcomas are malign tumours which occur in tissue of mesenchymal origin, so that they may appear in bones as well as in soft tissues. Although they make up less than 1% of all malign tumours, they cause great morbidity and mortality at any age and in any location. Many of them present as a painless swelling which gradually grows in size.<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Given that soft tissue sarcomas are not very common and are far less frequent than benign tumours, it is possible that some of them go unnoticed, and that it would be inappropriate to resect them before establishing the correct histological diagnosis. It is calculated that centres specialising in sarcomas receive from 19% to 53% of patients referred from other hospitals after unplanned surgery. The risk of residual disease after unplanned resection stands at 24–60%.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">3</span></a> Tumour relapse is 2.2 times more common in these patients than it is in those who had received appropriate study prior to surgery.<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">To manage these patients the specialised centre has to gather the maximum amount of information about the case. The data supplied by the patient as well as the surgeon who first operated are therefore highly important. These include the results of any preoperative or postoperative study and the details of the surgery. It is also important to revise the histological samples from the tumour, not only to confirm the diagnosis, but also to discover the surgical margins, given that these are predictors of the risk of local relapse.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">4</span></a> The therapeutic options implemented in the reference centre often run from abstaining from therapy with regular checks on the patient, to revision surgery of the margins (“second-look surgery”), as well as the isolated or concomitant use of adjuvant therapies (radiotherapy and/or chemotherapy).<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">This study aims to describe the oncological evolution of a group of patients who were subjected to revision surgery of soft tissue sarcoma margins after they had previously been subjected to unplanned surgery for the resection of the same.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">We carried out a descriptive longitudinal observational and retrospective study of the relevant data in our database of patients with muscle or bone tumours. We included all of the patients aged 18 years old or above who had been sent to the orthopaedic oncology unit in our hospital after resection with positive margins of a soft tissue sarcoma located in the upper or lower limbs.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Firstly we gathered patient epidemiological data as well as data relating to certain aspects of the disease, such as location or the first symptom. We also recorded information about the first operation, such as additional testing beforehand (MRI, computerised tomography [CT], ultrasound scans and biopsies, etc.), the diagnosis of suspicion prior to surgery, the time lapse until surgery, the type of surgery (broad surgery or simple resection) and the result of the pathologic study of the samples obtained during the same. For the margins revision or second-look surgery we collected similar data, including the pathological diagnosis of the revision in our hospital of the histological sections from the first operation, imaging studies prior to the revision surgery, the time elapsed between the first and revision operations, and the classification of the residual disease based on the classification of the American Joint Commission on Cancer.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">5</span></a> Finally, we gathered information about adjuvant treatment and the clinical evolution of patients.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0035" class="elsevierStylePara elsevierViewall">From November 2001 to July 2013 35 patients who had been subjected to an unplanned resection of a soft tissue sarcoma were treated in our unit. They all fulfilled the inclusion criteria described. 18 of these patients were women (51.4%) and 17 were men (48.6%). Their average age was 48 years old (range from 17 to 29).</p><p id="par0040" class="elsevierStylePara elsevierViewall">The most common location of the disease was the thigh (42.9% of cases, 15 cases), followed by the foot (14.3%, 5 cases), the leg (8.6%, 3 cases), the groin (8.6%, 3 cases), at shoulder blade level (5.7%, 2 cases) and the knee (5.7%, 2 cases). The other cases were in the arm, elbow, hand, pelvic waist and the ankle (with one case in each location, 2.9%); 14 cases (40%) were in the right side and 21 cases (60%) were in the left side.</p><p id="par0045" class="elsevierStylePara elsevierViewall">The average duration of patient follow-up was 52 months (range from 5 to 128 months).</p><p id="par0050" class="elsevierStylePara elsevierViewall">The first symptom described by patients was the appearance of a painless swelling (85.7%, 30 cases), followed by a painful swelling (11.4%, 4 cases). Only one case (2.9%) presented isolated pain.</p><p id="par0055" class="elsevierStylePara elsevierViewall">97.1% of the patients (34 cases) were referred to the oncological orthopaedic unit from another centre. The remaining 2.9% (one case) were referred from the General Surgery department of our hospital with the definitive diagnosis of leiomyosarcoma in what had originally been suspected to be a groin adenopathy.</p><p id="par0060" class="elsevierStylePara elsevierViewall">76.4% (26 cases) of the patients from other centres were referred following a surprise diagnosis in the analysis of the intraoperative pathological samples obtained, which is known as “whoops surgery”. 17.6% (6 cases) were referred after positive tumour margins were found. The remaining 5.9% (2 cases) were referred when the tumour was found to persist by complementary imaging tests after surgery.</p><p id="par0065" class="elsevierStylePara elsevierViewall">54.3% of lesions were at the level of the fascia (19 patients), while in 45.7% (16 patients) they were superficial. The resected tumour was less than 8<span class="elsevierStyleHsp" style=""></span>cm in size in 91.4% of the patients (32 cases), i.e., T1 according to the American Joint Commission on Cancer (AJCC) staging system (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). The 3 remaining cases (8.6%) correspond to T2 tumours according to the same staging system.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Only one case (2.9%) presented close tumoral adenopathies, while only one case (2.9%) presented pulmonary metastasis in the diagnosis.</p><p id="par0075" class="elsevierStylePara elsevierViewall">The most common degree of tumour according to the AJCC classification was therefore II-A in 22 patients (62.9%), followed by II-B (5 cases, 14.3% of cases), I-B (2 cases, 5.7% of cases) and II-B, IV-A and IV-B (with one case each, 2.9% of cases each).</p><p id="par0080" class="elsevierStylePara elsevierViewall">The initial surgery had taken place without complementary tests in 10 cases (28.6%), while in 16 cases (45.7%) only one complementary test had been performed. Only 5 patients (14.3%) were subjected to biopsy beforehand, and 2 patients (5.7%) received fine needle aspiration biopsy (FNAB). A MRI technique was performed in 45.7% of cases (16 cases). Other imaging tests used were ultrasound scans (20%, 7 cases), CT (11.4%, 4 cases) and simple X-ray (5.7%, 2 cases).</p><p id="par0085" class="elsevierStylePara elsevierViewall">For the majority of patients (82.9% of cases, 29 patients) the samples obtained in the first operation were revised again by pathologists in our hospital with experience in tumours of this type. Samples were not revised in the other cases because of bureaucratic difficulties in obtaining the pathological sample sections. It may therefore be concluded that the most common diagnosis is synovial sarcoma (37.9%, 11 patients), followed by malign fibrohistiocytoma, high grade liposarcoma, extraskeletal condrosarcoma and malign schwannoma (6.9%, 2 patients each). Other diagnoses were pleomorphic sarcoma, extraskeletal osteosarcoma, leiomyosarcoma, fibrosarcoma, mesenchymal sarcoma, clear cell sarcoma and atypical fusocellular proliferation (3.4% and one patient each) (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">When patients arrived at our hospital a new MRI test was performed before revision surgery in 91.4% of cases (32 patients). 53.1% of these patients presented a residual tumour according to this complementary test (17 patients).</p><p id="par0095" class="elsevierStylePara elsevierViewall">Second look surgery was undertaken from 1 to 9 months after the first operation (with an average of 3 months). The most common diagnosis found was synovial sarcoma, in 25.7% of the patients (9 patients). In 31.4% of the patients (11 cases) no evidence of malignity was found. A total of 8 patients (22.8%) had positive tumour margins after resection (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">More than half of the patients (51.4%, 18 patients) also received adjuvant chemotherapy and radiotherapy. 25.7% (9 patients) only received radiotherapy after revision of the margins, while 8.6% (3 patients) only received adjuvant chemotherapy prior to the second look.</p><p id="par0105" class="elsevierStylePara elsevierViewall">At the end of follow-up a total of 4 patients (11.4%) had a local relapse. Two of them had positive margins in revision surgery histology. 4 other patients (11.4%) had systemic dissemination. One patient (2.9%) died due to pulmonary progression.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0110" class="elsevierStylePara elsevierViewall">The concept of the complete unplanned resection of soft tissue sarcomas was introduced for the first time by Giuliano and Eilber.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">6</span></a> It refers to the situation in which no previous type of diagnosis has taken place prior to surgery, which is performed without the intention of achieving free tumour margins.<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">7</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Given that there are a higher proportion of benign tumours in the soft tissues than malign ones, sometimes malign tumours may be resected in unplanned surgery. Several series in the literature show a significant number of patients were operated for tumours which unexpectedly proved to be malign.<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1,6–16</span></a> This may be due to a lack of knowledge about the management of soft tissue sarcomas and this may be problematic if their potential malignity is not considered.<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">14,15</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">To prevent the unplanned resection of soft tissue sarcomas a number of signs which may indicate malignity have to be taken into account. These include indurate consistency, a tumour size >5<span class="elsevierStyleHsp" style=""></span>cm, a rapid increase in size, the presence of the mass at the depth of the fascia, pain and recurrent swelling.<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">14,16</span></a> If there is a suspicion of malignity the relevant tests must be performed prior to the operation, including biopsy and imaging studies.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">3</span></a> In our series the initial surgery took place without previous complementary tests in 28.6% of cases. A biopsy was taken beforehand in only 14.3% of cases, while a MRI study was performed in 45.7% of cases. We found no similar data in the literature with which our results could be compared.</p><p id="par0125" class="elsevierStylePara elsevierViewall">Synovial sarcoma was the tumour found the most often in unplanned surgery (37.9%) in our series. This agrees with the results obtained by Chandrasekar et al.,<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a> although in their case this type of tumour represents 17% of the cases in their series. The most common tumour types found by Lewis et al.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">10</span></a> in their series were malign fibrohistiocytoma (MFH) and liposarcoma (LPS), at 28% and 26%, respectively. In the series of Fiore et al.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">13</span></a> they found the most common malign tumour to be liposarcoma, in 36% of cases. In our study malign fibrohistiocytoma and high grade liposarcoma are in second place, each with 6.9% of cases.</p><p id="par0130" class="elsevierStylePara elsevierViewall">The typical lesion found in our series would therefore be a synovial sarcoma smaller than 8<span class="elsevierStyleHsp" style=""></span>cm and located in the thigh. The typical patient, without adenopathies or metastasis, would be in AJCC stage II-A.</p><p id="par0135" class="elsevierStylePara elsevierViewall">As was observed in previous studies,<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1,6–10,12,13</span></a> the unplanned resection of a soft tissue sarcoma involves the incomplete cutting out of the same in the majority of cases (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). The incidence of residual tumour being found in revision margins surgery is similar to that in series such as that of Chandrasekar et al.,<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a> which stands at 60%. In our series we found residual tumour in 68.6% of patients (24 cases), although the actual figure is probably slightly higher, given that one patient (2.9%) without the finding of residual tumour in revision margin surgery went on to suffer a local relapse. We can therefore estimate that, in our series 71.4% of the patients subjected to an unplanned operation had residual tumour in the surgical site. It is due to this high number of patients with residual tumour after the unplanned resection of a soft tissue sarcoma that in our centre we routinely perform revision surgery of the margins in such cases.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0140" class="elsevierStylePara elsevierViewall">Revision surgery has to include broader margins than those which would have been included in planned surgery for the resection of a soft tissue sarcoma. Imaging studies (CT or MRI) may be negative as they emphasise postoperative changes that prevent the correct visualisation of residual disease, while habitually unsuitable surgical incisions and approaches compromise and contaminate compartments adjacent to the tumour.<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">3,17</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">The value of adjuvant therapies following sarcoma margin revision surgery is unclear.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a> Chemotherapy, which was used alone in 8.6% of our patients and in 51.4% together with radiotherapy, plays a complementary role to margin revision surgery. Radiotherapy, which was used alone in 25.7% of our patients, is indicated routinely in many hospitals following the resection of a tumour.<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">10,13</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">According to the literature, local relapse and metastasis are greater in patients who receive second look surgery.<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1,10,14,18</span></a> The incidence of local relapse in our series was 11.4%. This is comparable to the rates observed in other series,<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1,6–10,12,13</span></a> in which the incidence stands at from 7% to 26%. In 50% of the patients who presented a relapse (2 patients, 5.7% of the total) margin positivity had been observed in the histology of the samples obtained during revision surgery in our hospital. 11.4% of the patients presented remote dissemination, a lower figure than that found in other series.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">The overall survival rate of the patients in our series was 97.1% at the end of follow-up. This survival rate is higher than those in other series, which stand at 77–88%.<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1,10,13</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">The results obtained in our series show no major differences from those of other published series in hospitals in other countries. We can conclude that the high rate of residual tumour identified in our series makes it recommendable to resect any soft tissue tumour in a sarcoma reference hospital.<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">19,20</span></a> In those cases in which the tumour was resected in an unplanned operation in another hospital, it is recommendable to refer the case to a reference hospital where a new revision of histology and MRI studies will be undertaken to detect residual disease, together with revision surgery of the tumour bed.</p><p id="par0165" class="elsevierStylePara elsevierViewall">This is why in our unit we currently systematically recommend broad revision of the surgical site following the unplanned resection of a sarcoma.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Level of evidence</span><p id="par0170" class="elsevierStylePara elsevierViewall">Level of evidence <span class="elsevierStyleSmallCaps">iii</span>.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Ethical responsibilities</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Protection of persons and animals</span><p id="par0175" class="elsevierStylePara elsevierViewall">The authors declare that no experiments in human beings or animals were performed for this research.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Data confidentiality</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors declare that they followed the protocols of their centre of work governing the publication of patient data.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Right to privacy and informed consent</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors declare that this paper contains no patient data.</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflict of interests</span><p id="par0190" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres755946" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Material and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec758087" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres755945" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Material y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec758086" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Material and methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Level of evidence" ] 9 => array:3 [ "identificador" => "sec0030" "titulo" => "Ethical responsibilities" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0035" "titulo" => "Protection of persons and animals" ] 1 => array:2 [ "identificador" => "sec0040" "titulo" => "Data confidentiality" ] 2 => array:2 [ "identificador" => "sec0045" "titulo" => "Right to privacy and informed consent" ] ] ] 10 => array:2 [ "identificador" => "sec0050" "titulo" => "Conflict of interests" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-07-22" "fechaAceptado" => "2016-06-25" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec758087" "palabras" => array:4 [ 0 => "Sarcoma" 1 => "Margins" 2 => "Unplanned surgery" 3 => "Margins revision" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec758086" "palabras" => array:4 [ 0 => "Sarcoma" 1 => "Márgenes" 2 => "Cirugía no planeada" 3 => "Revisión de márgenes" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Patients from other centres where they have had an unplanned surgical resection of a soft tissue sarcoma are often referred to hospitals specialised in sarcomas.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A study was conducted on 35 patients who required this type of surgery were referred to our centre between November 2001 and July 2013.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Surgery had been performed on 29% of the patients without any complementary tests being done. In 75% of cases, the sarcoma diagnosis was discovered in the post-surgical histological study. Synovial sarcoma was the most common, affecting 38% of the patients.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A surgical revision of the margins was performed on all of them, and adjuvant treatment was performed on 86% of them. The histopathology study found that 69% of the patients had residual disease.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">At the end of follow-up, 12% had a local recurrence, another 12% distant metastases, and 3% had died.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Given the results, it is concluded that any tumour of the soft tissues in which malignancy is suspected has to be resected in a reference centre. If an unplanned esection was performed in another centre, it should be referred immediately in order to perform an imaging study, revision surgery, and if required, adjuvant treatment.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Material and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducción</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">En ocasiones, a los hospitales especializados en sarcomas son derivados pacientes desde otros centros donde se les ha realizado una cirugía no planeada de resección de sarcoma de partes blandas.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y métodos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Entre noviembre del 2001 y julio del 2013, 35 pacientes de este tipo fueron derivados a nuestro centro.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">El 29% de los pacientes había sido intervenido sin pruebas complementarias previas. En el 76% el diagnóstico de sarcoma se descubrió en el estudio histológico postoperatorio. El sarcoma sinovial fue el más común encontrado, afectando el 38% de los pacientes.</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">A todos ellos se les realizó cirugía de revisión de márgenes y en el 86% se realizó terapia adyuvante. El 69% de los pacientes tenían enfermedad residual hallada en la anatomía patológica.</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Al final del seguimiento, el 12% había presentado recidiva local, otro 12% diseminación a distancia y el 3% había fallecido.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusión</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Dados los resultados, concluimos que cualquier tumoración de partes blandas de la que se sospeche malignidad ha de ser resecada en un centro de referencia, y si se ha producido una resección no planeada en otro centro tiene que ser derivado inmediatamente para la realización reglada de un estudio de imagen, cirugía de revisión y, si precisa, tratamiento adyuvante.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Material y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: García-Jiménez A, Trullols-Tarragó L, Peiró-Ibáñez A, Gracia-Alegría I. Análisis de resultados en cirugía de revisión de márgenes de sarcomas de partes blandas. Rev Esp Cir Ortop Traumatol. 2016;60:366–371.</p>" ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1569 "Ancho" => 1569 "Tamanyo" => 83556 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Diagnostic findings in the revision of histological sample sections from the first operation by experienced pathologists in our hospital. CS: condrosarcoma; MFH: malign fibrohistiocytoma; LPS: liposarcoma.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1564 "Ancho" => 1564 "Tamanyo" => 69594 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Diagnostic findings in the histology of margin revision surgery. MFH: malign fibrohistiocytoma.</p>" ] ] 2 => array:9 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "fuente" => "<span class="elsevierStyleItalic">Source</span>: Taken from the American Cancer Association.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">5</span></a>" "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Grades: I-A: T1, N0, M0, G1-2; I-B: T2-3, N0, M0, G1-2; II-A: T1, N0, M0, G3-4; II-B: T2, N0, M0, G3-4; III: T3, N0, M0, G3-4; IV-A: T1-3, N0, M1a, G0-3; IV-B: T1-3, N1, M0-1, G0-3/T1-3, N0-1, M1b, G0-3.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">0 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">1 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">2 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">3 \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No evidence of primary tumour \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Tumour <8<span class="elsevierStyleHsp" style=""></span>cm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Tumour >8<span class="elsevierStyleHsp" style=""></span>cm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Skip metastases \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">N \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No regional adenopathies \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">With regional adenopathies \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No metastasis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">a: only pulmonary<br>b: extrapulmonary dissemination \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " colspan="2" align="center" valign="top">Low grade</td><td class="td" title="table-entry " colspan="2" align="center" valign="top">High grade</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1249936.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">American Joint Commission on cancer staging.</p>" ] ] 3 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">RMS: revision margin surgery.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Noria et al.<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">7</span></a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Siebenrock et al.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Fiore et al.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">13</span></a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Chandrasekar et al.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Venkatesan et al.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">14</span></a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Umer et al.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">3</span></a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">García-Jiménez et al. \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total cases \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">65 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">597 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">363 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">51 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">35 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">RMS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">100% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">100% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">53% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">87% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">92,5% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">100% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">100% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Residual tumour \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">35% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">63% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">59% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">74% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">68.6% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">68.6% \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1249935.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Comparison of the number of cases with residual tumours in several studies.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:20 [ 0 => array:3 [ "identificador" => "bib0105" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of an unplanned excision of a soft-tissue sarcoma on prognosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.R. 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Year/Month | Html | Total | |
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2024 November | 3 | 0 | 3 |
2024 October | 19 | 1 | 20 |
2024 September | 26 | 2 | 28 |
2024 August | 25 | 3 | 28 |
2024 July | 20 | 8 | 28 |
2024 June | 20 | 3 | 23 |
2024 May | 20 | 6 | 26 |
2024 April | 22 | 5 | 27 |
2024 March | 27 | 7 | 34 |
2024 February | 24 | 11 | 35 |
2024 January | 21 | 7 | 28 |
2023 December | 24 | 9 | 33 |
2023 November | 29 | 5 | 34 |
2023 October | 23 | 7 | 30 |
2023 September | 13 | 6 | 19 |
2023 August | 25 | 3 | 28 |
2023 July | 11 | 9 | 20 |
2023 June | 13 | 7 | 20 |
2023 May | 37 | 0 | 37 |
2023 April | 54 | 4 | 58 |
2023 March | 11 | 2 | 13 |
2023 February | 10 | 6 | 16 |
2023 January | 10 | 9 | 19 |
2022 December | 14 | 6 | 20 |
2022 November | 26 | 11 | 37 |
2022 October | 21 | 10 | 31 |
2022 September | 17 | 20 | 37 |
2022 August | 16 | 17 | 33 |
2022 July | 12 | 12 | 24 |
2022 June | 16 | 8 | 24 |
2022 May | 21 | 8 | 29 |
2022 April | 20 | 11 | 31 |
2022 March | 30 | 5 | 35 |
2022 February | 16 | 5 | 21 |
2022 January | 12 | 6 | 18 |
2021 December | 18 | 6 | 24 |
2021 November | 22 | 9 | 31 |
2021 October | 19 | 15 | 34 |
2021 September | 15 | 10 | 25 |
2021 August | 14 | 9 | 23 |
2021 July | 18 | 7 | 25 |
2021 June | 24 | 7 | 31 |
2021 May | 10 | 6 | 16 |
2021 April | 28 | 15 | 43 |
2021 March | 16 | 13 | 29 |
2021 February | 10 | 8 | 18 |
2021 January | 5 | 3 | 8 |