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Original Article
Arthroscopic hip surgery with a microfracture procedure of acetabular full-thickness chondral damage. Cohort study with a 3-year follow-up
Tratamiento artroscópico mediante microfracturas de la lesión cartilaginosa acetabular de espesor completo. Estudio de cohortes con seguimiento medio a 3 años
J. Más Martínez
Corresponding author
jmas@traumavist.com

Corresponding author.
, J. Sanz-Reig, C.M. Verdú Román, D. Bustamante Suárez de Puga, M. Morales Santías, E. Martínez Giménez
Traumatología Vistahermosa, Clínica Vistahermosa, Alicante, Spain
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regardless of whether damage is acute or chronic&#46; As there are no nociceptive receptors&#44; isolated chondral damage does not produce painful symptoms&#46; On occasion&#44; at diagnosis&#44; chondral damage is already at full thickness&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Arthroscopic hip surgery &#40;AHS&#41; has led to early diagnosis of acetabular chondral damage&#44; either through its indication in patients due to inexplicable inguinal pain and with normal diagnostic tests&#44; or in the context of intraarticular disease through loose bodies&#44; labrum damage or FAI&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">5&#44;6</span></a> A high percentage of patients who undergo FAI by AHS present with associated joint chondral damage&#44; although no degenerative signs appear in the preoperative radiologic study&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Outcomes with treatment for full thickness chondral damage using microfractures at knee level<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">8&#44;9</span></a> have extended their usage to the hip with favourable short term outcomes&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">10&#8211;15</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The aim of our study was to determine the clinical outcome of a cohort of patients with FAI diagnosis and treatment of full thickness acetabular chondral damage using arthroscopic microfracture hip surgery&#46; For greater awareness of the influence of acetabular chondral damage on functional outcome&#44; the results were compared with a cohort of patients with a diagnosis of FAI with no acetabular chondral damage&#46; Our working hypothesis was that the clinical outcome between both groups would be similar on termination of follow-up&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and method</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Patient selection</span><p id="par0030" class="elsevierStylePara elsevierViewall">During the period between January 2009 and January 2016 a cohort of patients were selected from our data base of prospective patients who had undergone AHS&#44; all of whom met with the following criteria&#58; aged under 50&#44; diagnosed with FAI&#44; T&#246;nnis 0-1 status&#44; articular height over 2<span class="elsevierStyleHsp" style=""></span>mm&#44; acetabular full-thickness chondral damage acetabular treated with microfractures&#44; and a minimum follow-up of one year&#46; Patients with hip dysplasia which was determined by a central-rim angle under 25&#176; were excluded&#44; as were those with Legg-Calve-Perthes disease&#44; previous hip surgery&#44; avascular necrosis and those under 18&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">For comparative effects&#44; a cohort of patients who met with the same inclusion and exclusion criteria but who did not present with any acetabular chondral damage were chosen&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">All the patients gave their informed consent for the inclusion in the study and this was approved by the Ethics Committee of the Clinical Research of our institution&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Clinical assessment</span><p id="par0045" class="elsevierStylePara elsevierViewall">Clinical assessment was made using 4 questionnaires&#58; the modified Harris scale &#40;mHHS&#41;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">16</span></a>&#59; hip assessment questionnaires with sections on daily life activities &#40;HOS-AVD&#41; and the practice of sports &#40;HOS-SSS&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">17</span></a> translated into Spanish and validated<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">18</span></a> and the iHOT-12<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">19</span></a> questionnaire&#46; The patient was asked how they thought the affected hip worked compared with the healthy one&#44; with 4 possible responses&#58; normal&#44; almost normal&#44; abnormal and severely abnormal&#46; If both hips of the patient were affected&#44; or the contralateral hip had been operated on previously&#44; they were asked to consider how the affected hip functioned compared with the previous situation&#44; when there were no limits to daily activities and&#47;or sports activities&#46; Clinical assessments were made preoperatively&#44; after 6 months&#44; after one year and subsequently on an annual basis&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Preoperative physical activity was recorded according to the Tegner scale&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">20</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Imaging studies</span><p id="par0055" class="elsevierStylePara elsevierViewall">Anteroposterior radiologic studies of the pelvis were requested of all patients in standing position and Dunn axial projection&#46; The presence of a cam and&#47;or pincer type lesion was determined&#44;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">2</span></a> together with the height of the joint space in the load region&#44;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">21</span></a> alpha angle&#44;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">2</span></a> acetabular angle&#44;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">2</span></a> T&#246;nnis angle<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">2</span></a> and degree of articular degeneration according to the T&#246;nnis scale&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">22</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The imaging study was completed with a conventional NMR in a Tesla 3 device&#44; to rule out the presence of avascular necrosis&#44; tendinopathies or intra-articular damage&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Surgical procedures</span><p id="par0065" class="elsevierStylePara elsevierViewall">Surgery was performed with spinal anaesthesia&#44; in accordance with the previously described surgical technique&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">23</span></a> The procedure commenced with examination of the central compartment&#46; The acetabular overcoverage or &#8220;pincer&#8221; type lesion was determined by the presence of diffuse equimosis of the labrum&#44; labral ossification&#44; intralabral cystic degeneration and&#47;or the extension of the acetabular bone ridge beyond the chondro-labral union&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">24</span></a> If a pincer type lesion presented&#44; the acetabular overcoverage anomalies were corrected by direct examination and radioscopic control&#46; Labral lesions were repaired with suturing whenever possible and particularly if they affected the chondro-labral union&#46; If not&#44; debridement was performed whilst maintaining the largest amount of chondro-labrum possible&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">25</span></a> The presence of tendon disease of the psoas with a base of inflammation or rupture of the labrum at psoas location level in the acetabular rim was determined&#44; and tenotomy of the psoas in the central compartment was performed when necessary&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">26</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Chondral damage of the acetabular rim was classified according to the recommendations of the Multicenter Arthroscopic Hip Outcome Research Network&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">27</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">When full thickness chondral damage was detected&#44; its location was determined according to the geographic zone method described by Ilizaliturri et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">28</span></a> and its size&#44; with the use of a measurement probe &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; For microfracture surgery&#44; the anterolateral portal vein was used as the viewing portal and the medioanterior portal as the working portal for insertion of material&#46; The microfracture technique was performed in accordance with the procedure described by Crawford et al&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">29</span></a> The first step of the process consisted in ensuring there was a stable chondral rim&#46; For this&#44; the loose delaminated cartilage was cleaned with pincers &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; and swing motor &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The acetabular labrum was accurately repaired to ensure that we finally had a full thickness chondral damage which was well defined geographically and able to contain the coagulation of pluripotent cells from the deep spongy bone which was reached with the microfractures&#46; The calcified tissue layer was resected with a curette &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#44; avoiding destructuring of the subchondral bone&#46; Once the stable chondral rim was ensured&#44; we proceeded to manually perforate with a 30 or 45&#176; spike&#44; always perpendicular to the subchondral bone&#44; from the periphery of the lesion&#46; The perforations were separated from one another by 3&#8211;4<span class="elsevierStyleHsp" style=""></span>mm and had a depth of 3&#8211;4<span class="elsevierStyleHsp" style=""></span>mm &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#41;&#46; Finally the intraarticular fluid flow was cut off to determine issue of blood or fat through the holes made &#40;<a class="elsevierStyleCrossRef" href="#fig0030">Fig&#46; 6</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia><elsevierMultimedia ident="fig0030"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">Following this&#44; the peripheral compartment was examined&#46; If full thickness chondral damage was detected at femoral head level&#44; microfractures were performed using the same technique as at acetabular level&#46; The cam type lesion was treated with direct low vision osteoplasty and fluoroscopy&#46; The joint capsule was systematically repaired with simple sutures&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Postoperative management</span><p id="par0085" class="elsevierStylePara elsevierViewall">The patients were discharged after 24<span class="elsevierStyleHsp" style=""></span>h&#46; Passive mobility was initiated on discharge&#44; with restrictions of hip rotations for 4 weeks&#46; The specific rehabilitationist protocol was identical in both cohorts&#46; No restrictive mobility orthetics were used&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">In all cases partial assisted weight bearing with 2 crutches was allowed&#44; in the microfractures cohort&#44; for 8 weeks&#44; and in the patients without chondral damage&#44; for 4 weeks&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Statistical analysis</span><p id="par0095" class="elsevierStylePara elsevierViewall">Statistical analysis was performed with the SPSS programme&#44; version 18&#46;0 &#40;SPSS Inc&#46;&#44; Chicago&#44; U&#46;S&#46;A&#46;&#41;&#46; <span class="elsevierStyleItalic">P</span> values equal to or lower than &#46;05 were considered significant&#46; To determine normal distribution the Kolmogorov&#8211;Smirnov test was used&#46; To compare continuous variables the Student&#39;s <span class="elsevierStyleItalic">t</span>-test and the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test were used&#44; and for categorical variables&#44; the chi-square test was used in those with normal distribution or the Mantel-Haenszel for non-parametric data&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Results</span><p id="par0100" class="elsevierStylePara elsevierViewall">The cohort of patients with full thickness chondral damage comprised 31 hips&#46; Mean age was 39 years &#40;SD 7&#46;2&#59; range 21&#8211;50&#41;&#46; Bilaterality was present in 12 patients&#46; By gender&#44; 16 were male and 3&#44; female&#46; In the cohort of 49 patients without chondral damage mean age was 38&#46;4 &#40;SD 7&#46;7&#59; range 18&#8211;50&#41;&#46; Bilaterality was present in 12 patients&#46; By gender&#44; 25 were male and 12 female&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">There were no significant differences between both cohorts with regard to age&#44; bilaterality&#44; gender&#44; side&#44; weight&#44; height&#44; body mass index&#44; symptom onset time&#44; level of physical activity and type of FAI&#46; Radiologic variables were similar with regard to articular height&#44; acetabular coverage angle and T&#246;nnis angle&#46; However&#44; the mean value of the alpha angle and the percentage of patients with T&#246;nnis 1 grade articular degeneration were higher in the cohort of patients with full thickness chondral damage with both differences being significant &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">During AHS&#44; in the cohort with full thickness chondral damage a cam type lesion was detected in all hips &#40;100&#37;&#41;&#44; a pincer type lesion in 15 hips &#40;48&#46;3&#37;&#41;&#44; labral rupture in 24 hips &#40;77&#46;4&#37;&#41;&#44; labral degeneration in 4 hips &#40;12&#46;9&#37;&#41; and tendon disorder of the psoas in 3 hips &#40;9&#46;6&#37;&#41;&#46; In the cohort without chondral damage&#44; cam type lesion presented in 46 hips &#40;93&#46;8&#37;&#41;&#44; pincer type lesion in 25 hips &#40;51&#46;0&#37;&#41;&#44; labral rupture in 36 hips &#40;73&#46;4&#37;&#41;&#44; labral degeneration in 7 hips &#40;14&#46;2&#37;&#41; and tendon disorder of the psoas in 6 hips &#40;12&#46;2&#37;&#41;&#46; Associated surgical procedures during AHS are described in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">The mean size of the full thickness chondral damage was 19&#46;4<span class="elsevierStyleHsp" style=""></span>mm in length &#40;SD 9&#59; range 11&#8211;30<span class="elsevierStyleHsp" style=""></span>mm&#41; and 12&#46;2<span class="elsevierStyleHsp" style=""></span>mm width &#40;SD 7&#59; range 10&#8211;30<span class="elsevierStyleHsp" style=""></span>mm&#41;&#46; Their location in 19 hips &#40;61&#46;3&#37;&#41; was in region 2 and 3&#44; in 8 hips &#40;25&#46;8&#37;&#41; in region 2&#44; in 3 hips &#40;9&#46;7&#37;&#41; in region 3 and one hip &#40;3&#46;2&#37;&#41; in region 1&#46; All lesions were located at chondrolabral union level&#46; The mean region of full thickness chondral damage was 222<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span> &#40;SD 75&#59; range 75&#8211;450<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span>&#41;&#46; In 9 hips &#40;29&#37;&#41; the region was greater than 400<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span>&#46; Only one patient presented with femoral head level chondral damage&#44; which was 5<span class="elsevierStyleHsp" style=""></span>mm wide by 10<span class="elsevierStyleHsp" style=""></span>mm long&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Mean follow-up was 36&#46;2 months &#40;SD 21&#46;3&#59; range 12&#8211;84 months&#41; in the cohort of patients with full thickness chondral damage and 36&#46;6 months &#40;SD 24&#46;5&#59; range 12&#8211;84 months&#41; in the cohort of patients without chondral damage&#44; differences which were not statistically significant &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;90&#41;&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">The mean score increased significantly in both cohorts in the clinical assessment questionnaires between preoperative and follow-up termination values&#46; When analysing these values in both cohorts&#44; the differences were not significant &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; There was no significant relationship between the area of the chondral damage and the preoperative clinical assessment questionnaires nor those at the end of follow-up &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46; <a class="elsevierStyleCrossRef" href="#fig0035">Fig&#46; 7</a> shows the evolution of mean scores in the clinical assessment questionnaires during follow-up&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="fig0035"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">The function of the affected hip perceived by the patient in both cohorts is reflected in <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#46; Preoperatively&#44; the function of the hip was abnormal or severely abnormal in 27 hips &#40;87&#46;0&#37;&#41; in the cohort of patients with full thickness chondral damage&#44; compared to 39 hips &#40;79&#46;5&#37;&#41; in the cohort of patients without chondral damage&#46; At the end of follow-up&#44; the number of hips dropped to 5 &#40;16&#46;1&#37;&#41; in the cohort of patients with full thickness chondral damage&#44; and 8 &#40;16&#46;3&#37;&#41; in the cohort of patients without chondral damage&#46; The differences in both cohorts between the function of the preoperative hip and the end of follow-up were statistically significant &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46; The region of chondral damage was not significantly related to the function of the affected hip perceived by the patient preoperatively or at the end of follow-up &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0135" class="elsevierStylePara elsevierViewall">No complications were recorded relating to the microfracture technique&#46; In the cohort with full thickness chondral damage&#44; one patient required surgical reinvention 19 months after AHS with the implantation of a total hip replacement&#46; This was a 45-year-old male with full thickness chondral damage 12<span class="elsevierStyleHsp" style=""></span>mm wide by 40<span class="elsevierStyleHsp" style=""></span>mm long &#40;region 480<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span>&#41;&#44; and full thickness chondral damage in the femoral head 5<span class="elsevierStyleHsp" style=""></span>mm wide by 10<span class="elsevierStyleHsp" style=""></span>mm long&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discussion</span><p id="par0140" class="elsevierStylePara elsevierViewall">The most significant findings of our study were&#58; &#40;1&#41; full thickness chondral damage treatment with microfracture which led to significant improvement according to the assessment questionnaires used&#44; and this was maintained throughout study follow-up&#59; &#40;2&#41; no significant differences with a cohort of patients without chondral damage&#59; &#40;3&#41; the highest score increase in the assessment questionnaire occurred during the first 6 months&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Recommendation for microfractures referred to in the literature comprises focal and contained full thickness chondral damage&#44; at least 400<span class="elsevierStyleHsp" style=""></span>mm<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">2&#44;11&#44;13&#44;15</span></a> in size&#46; In the FAI context&#44; acetabular chondral damage starts at chondolabral level&#44; and prior repair of the labrum is therefore recommended as a contention method for coagulation which forms after performing microfractures&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">13</span></a> Different publications report favourable outcomes from microfracture treatment in full thickness chondral damage with short term follow-up&#46; Byrd and Jones report an increase of 20 points in the mHHS &#40;from 65 to 85&#41; in their series of 58 patients&#44; with a mean follow-up of 16 months &#40;range 12&#8211;24 months&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">30</span></a> Domb et al&#46; indicate a significant improvement in assessment questionnaires used &#40;mHHS&#44; NAHS&#44; HOS-ADL&#41; in 30 patients with mean follow-up of 35 months &#40;range 20&#8211;50 months&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">31</span></a> Later&#44; Domb et al&#46; compared the clinical outcomes of 79 patients with full thickness chondral damage treated with microfractures with 158 patients without chondral damage with a minimum follow-up of 2 years&#44; and no significant differences are found between the two groups&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">10</span></a> Lodhia et al&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">12</span></a> found no significant differences either between 35 patients with full thickness chondral damage treated with microfractures with 70 patients without chondral damage&#44; with a mean follow-up of 36 months &#40;range 24&#8211;55 months&#41;&#46; MacDonald et al&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">15</span></a> and Marquez-Lara et al&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">11</span></a> published systematic reviews of the outcome of microfractures in patients with full thickness chondral damage in the FAI&#46; 12 studies were selected which included 267 patients&#44; and in 11 of the 12 studies referred to satisfactory results with a mean follow-up of 29&#46;5 months &#40;range 4&#8211;60 months&#41;&#46; Fontana and de Girolamo<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">32</span></a> compared the results of 42 patients treated with microfractures with 55 patients treated with the autologous matrix-induced chondrogenesis technique&#44; with a 5-year follow-up&#46; Both groups significantly improved in the mHHS at 6 and 12 months&#44; but they refer to posterior worsening in patients treated with microfractures&#44; especially in lesions over 400<span class="elsevierStyleHsp" style=""></span>mm&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">2</span></a> In our series of comparative cohorts we have found significant differences in the clinical assessment questionnaires used&#44; with a mean follow-up of 36 months &#40;range 12&#8211;84 months&#41;&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Bleeding after microfractures enables pluripotent cells to be selected from deep spongy bone with the ability to differentiate into chondrocytes and regenerate chondral tissue&#44; repairing the articular defect&#46; Karthikeyan et al&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">33</span></a> performed a review AHS in 20 patients after a mean of 17 months after microfracture&#44; with a mean repair of the lesion of 93&#37;&#44; and defining the cartilage as microscopically stable&#46; In 2 patients repair tissue biopsies were taken which reported on fibrocartilage with collagen fibres distributed in an extracellular matrix&#46; Philippon et al&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">34</span></a> indicate similar results of repair in 8 patients with a damage coverage of between 95&#37; and 100&#37; after a mean 20-month follow up&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">The majority of studies recommend partial weight bearing with crutches after performance of microfractures&#46; The period of partial weight bearing was established between 4 and 16 weeks&#46; The protocols of rehabilitation are varied&#44; without determining which is the ideal for this group of patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">11&#44;15</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">Microfracture technique is a safe procedure&#46; MacDonald et al&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">15</span></a> refer in a systematic review to a &#46;7&#37; of complications in 297 patients&#46; In our series we did not record any complication associated with the procedure&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">The need for surgical reintervention after microfractures is 1&#46;1&#37; with a mean follow-up of 29 months in 267 patients&#44; according to the systematic review of MacDonald et al&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">15</span></a> However&#44; Domb<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">31</span></a> published a 6&#46;6&#37; conversion to total hip arthroplasty &#40;THA&#41; and a 6&#46;6&#37; of revision THA&#44; in 30 patients with a mean follow-up of 35 months&#46; Lodhia et al&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">12</span></a> refer to 8&#46;6&#37; conversion to THA and 20&#37; revision THA&#44; in 35 patients with a mean follow-up of 36 months&#46; Domb et al&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">10</span></a> indicate a 12&#46;6&#37; conversion to THA in 79 patients with a mean follow-up of 24 months&#46; Fontana and de Girolamo&#44;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">32</span></a> a 7&#46;8&#37; conversion to THA in 77 patients with a minimum follow-up of 36 months&#46; The risk factors relating to THA conversion described by Fontana and de Girolamo are the presence of cam type lesion&#44; the chondral defect larger than 400<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span>&#44; the association with chondral damage of the femoral head and a preoperative value in the mHHS under 50 points&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">32</span></a> In our series there was a 3&#46;2&#37; conversion to THA with a mean follow-up of 36 months&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Our study has several imitations&#46; Given that the patients with microfractures had also undergone other surgical procedures&#44; it is practically impossible to know the effect of the microfractures in the final clinical outcome&#46; The series is short in the number of cases and follow-up is short term&#46; The cohorts were not comparable with regard to the degree of articular degeneration according to the T&#246;nnis scale&#44; and in the cohort of patients with full thickness chondral damage there were 70&#37; of T&#246;nnis 1 patients&#44; compared with 34&#46;6&#37; in the cohort of patients without chondral damage&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">A strength to highlight is that this is a prospective cohort study in which 4 clinical assessment questionnaires were used&#44; aimed at increasing the scientific evidence in the final result of this patient group&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">35</span></a></p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conclusion</span><p id="par0180" class="elsevierStylePara elsevierViewall">Clinical results of a cohort of patients with full thickness chondral damage in the FAI treated with microfractures are similar to a cohort of patients without chondral damage after 36 months of mean follow up&#46; Greater follow-up of the cohort was needed to determine stability of clinical outcome obtained&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Level of evidence</span><p id="par0185" class="elsevierStylePara elsevierViewall">Level of evidence III&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Ethical disclosures</span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Protection of human and animal subjects</span><p id="par0190" class="elsevierStylePara elsevierViewall">The authors declare that no experiments have been conducted on humans or animals for this research study&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Confidentiality of data</span><p id="par0195" class="elsevierStylePara elsevierViewall">The authors declare that they have adhered to the protocols of their place or work on the publication of patient data&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Right to privacy and informed consent</span><p id="par0200" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Conflict of interest</span><p id="par0205" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare</p></span></span>"
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    "fechaRecibido" => "2017-08-20"
    "fechaAceptado" => "2018-02-01"
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          "palabras" => array:4 [
            0 => "Arthroscopy"
            1 => "Hip"
            2 => "Articular cartilage"
            3 => "Microfracture"
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            0 => "Artroscopia"
            1 => "Cadera"
            2 => "Cart&#237;lago articular"
            3 => "Microfracturas"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction and purpose</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Management of injuries to the articular cartilage is complex and challenging&#46; Our purpose was to assess outcomes of a cohort of patients who underwent hip arthroscopy with full-thickness chondral damage treated with microfracture and compare these outcomes with those from a similar cohort of patients who did not&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We prospectively gathered the data of 31 hips treated with microfracture from January 2009 to January 2016&#46; In the cohort of hips without chondral damage there were 49 hips&#46; All patients were assessed pre- and postoperatively with 4 patient-reported outcome instruments&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The mean follow-up was 36&#46;2 months in the cohort of patients with full-thickness chondral damage&#44; and 36&#46;6 months in the cohort of patients without chondral damage&#46; Both groups demonstrated significant improvement in all patient-reported outcome instruments between preoperative and final follow-up&#46; There was no statistically significant difference between both cohorts at final follow-up&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Discussion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">This study showed that patients undergoing microfracture during hip arthroscopy had significant improvement in all patient-reported outcome instruments during follow-up&#46; The greatest improvement was noted at 6 months postoperatively&#46; Both groups showed no significant difference in final patient-reported outcome instruments scores&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n y objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El tratamiento de las lesiones cartilaginosas de espesor completo constituyen un reto para el cirujano ortop&#233;dico&#46; Nuestro objetivo fue determinar los resultados cl&#237;nicos de una cohorte de pacientes con lesi&#243;n cartilaginosa acetabular de espesor completo tratados mediante microfracturas&#44; y comparar los resultados con una cohorte similar sin lesi&#243;n cartilaginosa acetabular&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo de 31 caderas con lesi&#243;n cartilaginosa acetabular de espesor completo intervenidas mediante microfracturas por cirug&#237;a artrosc&#243;pica entre enero de 2009 y enero de 2016&#46; La cohorte sin lesi&#243;n cartilaginosa constaba de 49 caderas&#46; Se utilizaron 4 cuestionarios de valoraci&#243;n cl&#237;nica&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El seguimiento medio fue de 36&#44;2 meses en la cohorte de pacientes con lesi&#243;n cartilaginosa de espesor completo y de 36&#44;6 meses en la cohorte de pacientes sin lesi&#243;n cartilaginosa&#46; La puntuaci&#243;n media se increment&#243; significativamente en ambas cohortes en los cuestionarios de valoraci&#243;n cl&#237;nica entre el valor preoperatorio y al final del seguimiento&#46; No hubo diferencias significativas entre ambas cohortes al final del seguimiento&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Discusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El estudio muestra que el tratamiento de la lesi&#243;n cartilaginosa de espesor completo mediante microfracturas permite una mejor&#237;a significativa en los cuestionarios de valoraci&#243;n utilizados&#44; que se mantiene durante el seguimiento del estudio&#46; El mayor incremento de la puntuaci&#243;n en los cuestionarios de valoraci&#243;n cl&#237;nica se produce en los 6 primeros meses&#46; Al comparar los resultados con una cohorte de pacientes sin lesi&#243;n cartilaginosa no hubo diferencias significativas al final del seguimiento&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; M&#225;s Mart&#237;nez J&#44; Sanz-Reig J&#44; Verd&#250; Rom&#225;n CM&#44; Bustamante Su&#225;rez de Puga D&#44; Morales Sant&#237;as M&#44; Mart&#237;nez Gim&#233;nez E&#46; Tratamiento artrosc&#243;pico mediante microfracturas de la lesi&#243;n cartilaginosa acetabular de espesor completo&#46; Estudio de cohortes con seguimiento medio a 3 a&#241;os&#46; Rev Esp Cir Ortop Traumatol&#46; 2018&#59;62&#58;248&#8211;256&#46;</p>"
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="char" valign="middle">&#46;30</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Females&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Weight &#40;kg&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">77&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Height &#40;m&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;70<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;75<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">BMI &#40;kg&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Time since onset &#40;months&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>19&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Tegner</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">6</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="char" valign="middle">&#46;19</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Type of impingement</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cam&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="3" align="char" valign="middle">&#46;37</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cam<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>pincer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pincer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Articular height &#40;mm&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Alpha angle &#40;&#176;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">59&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Acetabular coverage angle &#40;&#176;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">33&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">35&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">T&#246;nnis angle &#40;&#176;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">T&#246;nnis grade</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="char" valign="middle">&#46;006</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Cohort with full thickness chondral damage&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;16&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;11&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>End of follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">92&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">93&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">HOS-AVD</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Preoperative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>21&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">62&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>21&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>End of follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">85&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">78&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">HOS-SSS</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Preoperative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">35&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>27&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>End of follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>26&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">69&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>33&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">iHOT-12</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Preoperative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>19&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>End of follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">67&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">61&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>32&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Cohort with full thickness chondral damage&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Normal</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Preoperative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>6 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>12 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>24 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>End of follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Near normal</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Preoperative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>6 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>12 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>24 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>End of follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Abnormal</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Preoperative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>6 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>12 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>24 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>End of follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Severely abnormal</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Preoperative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>6 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>12 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>24 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
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