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Metal-on-metal surface hip arthroplasties. Is annual monitoring of blood metal levels necessary?
Artroplastias de superficie metal-metal en cadera. ¿Es necesario realizar seguimiento anual mediante determinación de metales en sangre?
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"tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "436" "paginaFinal" => "441" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "D. Hernández-Vaquero, M. García-Pascual, S. Iglesias-Fernández, A. Escandon-Rodríguez" "autores" => array:4 [ 0 => array:4 [ "nombre" => "D." "apellidos" => "Hernández-Vaquero" "email" => array:1 [ 0 => "danielhvaquero@gmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M." "apellidos" => "García-Pascual" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "S." 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"apellidos" => "Escandon-Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Departamento de Cirugía, Facultad de Medicina, Universidad de Oviedo, Oviedo, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario San Agustín, Avilés, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Artroplastias de superficie metal-metal en cadera. ¿Es necesario realizar seguimiento anual mediante determinación de metales en sangre?" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 815 "Ancho" => 750 "Tamanyo" => 48543 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">MoM hip arthroplasty implanted 13 years previously. Normal blood metal levels. Asymptomatic patient.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The good results obtained at the end of the last century with metal-on-metal (MoM) hip arthroplasties were overshadowed by the appearance of high levels of metal ions in the blood and urine. Together with the formation of periarticular cysts and a high level of failures, this forced certain companies to withdraw some models of implants from the market in 2010. The presence of high levels of metals in the blood is a serious complication and its effects over the long-term are still unknown.<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">1</span></a> Due to this situation scientific societies (the Hip Society, BOA, AOA, EFORT, SECOT and SECCA), international agencies (the FDA) and health authorities (the Ministry of Health in Spain)<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">2</span></a> published monitoring protocols for patients who had been operated using these procedures, indicating when revision surgery should be recommended and how patients with these arthroplasties should be monitored. These protocols are based on the clinical situation of patients, radiographic findings, raised levels of chrome (Cr) and cobalt (Co) in the blood. They are also based on the presence, detected by imaging techniques, of periarticular cysts known as ALVAL (aseptic lymphocytic vasculitis associated lesions), the histology of which is dominated by B-lymphocytes and plasma cells, suggesting an immune response similar to a delayed hypersensitivity reaction. These complications deriving from high level of metal in the blood are grouped in the literature under the name ARMD (adverse reactions to metal debris).</p><p id="par0010" class="elsevierStylePara elsevierViewall">During the first years after the said alarm the necessary revision surgical operations were performed to remove MoM prostheses and implant conventional arthroplasties. The other patients have continued to regularly attend Hospital out-patient departments for evaluation using series of analytical checks. Although the literature states that MoM surface models have a shorter long-term lifespan than conventional arthroplasty models,<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">3</span></a> a good number of patients with MoM arthroplasty implants are asymptomatic and show excellent evolution over the medium term.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Although discrepancies exist regarding the usefulness of determining metal levels in the blood to indicate revision surgery,<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">4</span></a> this technique is still accepted as a means of evaluating whether these arthroplasties are functioning well or not in asymptomatic patients. It also supplies a criterion accepted by the majority to detect the presence of adverse reactions. The figure of 7<span class="elsevierStyleHsp" style=""></span>μg/L or ppb of Co or Cr in the blood is considered to mark the limit of normality.<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">1,5,6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The correct guideline for monitoring these patients is unknown, as is how often analysis should take place for metals in the blood and how long this should continue. The main question of our work is whether it is necessary to monitor levels analytically during the whole lifetime of asymptomatic patients who have MoM surface arthroplasties. We analysed blood levels of Cr and Co and how they evolved over the years in patients who have shown no clinical or radiographic alterations.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">A case study – monitoring diagnostic techniques. Our series is composed of 51 patients (52 arthroplasties, with one bilateral case) operated from 2005 to 2010 using the same type of arthroplasty (ASR, DePuy Orthopaedics, Inc., Warsaw, IN, U.S.A.), in the same hospital and by the same surgeons. The indication was highly selective, given that these cases amounted to only 4% of all the total hip arthroplasties (THA) implanted the 6 years in question in the Department.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The average age in the group of patients was 57.5<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>9.05 years old (35–76) and the average body mass index was 29.42<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>5.37 (19.48–43.58). Two patients were women and 49 were men. Sixteen revision surgeries were performed in as many patients. The causes were: 8 due to high levels of metals in the blood and the presence of ALVAL, 2 due to the presence of ALVAL with normal levels, 2 due to fracture of the neck of the femur, one due to osteolysis in the neck of the femur, one due to instability with repeated luxations, and 2 due to pain with an unexplained cause. 5 cases were lost: 2 whose evolution is unknown, and 3 patients died, 2 of them after the switch to a conventional THA (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). The bilateral case was excluded from this study because of the possibility of introducing distortions in blood metal levels.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Thus during all of the years in question we monitored 31 MoM arthroplasties implanted from 2005 to 2010 (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). At the time we undertook our work the arthroplasties had an age of from 7 to 13 years (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The patients attended the department clinic annually for analytical studies of the blood and 24 hour urine, a clinical examination (filling out the WOMAC, SF-12 and Oxford Hip questionnaires) and a standard radiographic study of the operated hip. Blood was extracted and transported to the laboratory under the conditions set for this process. Samples were analysed using mass spectrometry with an inductively coupled source (ICP-MS). Until the year 2013 molybdenum in blood and urine was also measured, together with detection of metals in the hair thanks to a SECOT research grant (results already published). Magnetic resonance (MR) imaging was indicated to rule out ALVAL or osteolysis if the patient showed functional reduction and pain, or when levels above 20<span class="elsevierStyleHsp" style=""></span>μg/L were detected in annual analysis. If levels of Co and Cr were from 7 to 19<span class="elsevierStyleHsp" style=""></span>μg/L and the patient was asymptomatic then they visited again after 6 months for another metal ion analysis. This work was approved by the Regional Ethics Committee (Reference 037/2011) and the patients signed an informed consent document prepared specifically for this study.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0040" class="elsevierStylePara elsevierViewall">The prosthesis sizes used in the series were above all those with a 58<span class="elsevierStyleHsp" style=""></span>mm diameter acetabular cup (19 cases) and 56<span class="elsevierStyleHsp" style=""></span>mm (12 cases). Taking into account that this model has a range of sizes from 50<span class="elsevierStyleHsp" style=""></span>mm to 64<span class="elsevierStyleHsp" style=""></span>mm in diameter, it can be said that medium sized were implanted above all.</p><p id="par0045" class="elsevierStylePara elsevierViewall">During the years in question Cr Levels in the blood remained at from .5 to 14<span class="elsevierStyleHsp" style=""></span>μg/L, with a median level from 1.3 to 5.4<span class="elsevierStyleHsp" style=""></span>μg/L (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>). Co levels were from .5 to 13.8<span class="elsevierStyleHsp" style=""></span>μg/L, with a median at from .5 to 1.2<span class="elsevierStyleHsp" style=""></span>μg/L (<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>). After 5 years a reduction in both metals was detected, although they increased during the sixth year before falling again. No changes were detected after 7 years (<a class="elsevierStyleCrossRefs" href="#fig0010">Figs. 2 and 3</a>).</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Under the circumstances described above (raised levels of Cr or Co in the blood or change in clinical and functional situation) MR imaging was performed with normal results in all cases, without detecting ALVAL-type periarticular cysts. The levels of both metals were not found to increase continuously in successive annual checks in any patient.</p><p id="par0055" class="elsevierStylePara elsevierViewall">One patient with high levels of Cr and Co in annual checks refused to undergo hip MR imaging to search for periarticular cysts; he remains asymptomatic and regularly attends for clinical, radiographic and analytical tests. In this case figures for Cr have evolved from 11.4 to 14<span class="elsevierStyleHsp" style=""></span>μg/L, while those for Co have evolved from 13.8 to 6.6<span class="elsevierStyleHsp" style=""></span>μg/L.</p><p id="par0060" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Data analysis and representation</span>. As there are a small number of highly variable data, the levels of Cr and Co per year are shown as their median together with their confidence interval at 95%. These figures were calculated using the binomial method that does not make suppositions on the underlying distribution of the variable. Box graphs were created according to the levels of Cr and Co for each year of monitoring. These graphs adjust data to a straight line, using the squared minimums method and a curve using the “lowess” command in STATA v.15 (STATA Corp., TX, U.S.A.).</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0065" class="elsevierStylePara elsevierViewall">After time the true scope of the failures of MoM surface arthroplasties is becoming clear. A period in which they were used for a wide range of indications has been followed by another period of almost complete restriction due to health alarms. As longer-term monitoring bears fruit we are able to learn the true place these models should occupy in the surgical arsenal for hips. They are less aggressive and offer better bone conservation, easier revision surgery and many patients describe their good evolution. In the future these factors will lead to the design of new types of surface once problems deriving from the materials used have been resolved.</p><p id="par0070" class="elsevierStylePara elsevierViewall">The percentage of failures of MoM arthroplasties in our series is similar to those published by other authors.<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">7,8</span></a> As is the case in other series, when revision surgery was carried out during the early years after implant, the most common cause was progressive pain together with high levels of metals in the blood and the finding of ALVAL in MR imaging. Other complications were less common and coincide with those published in broader series. We do not know the reason why patients progress in different ways. While in some patients failure occurs in the short term, in others the clinical result is excellent and patients request this same type of prosthesis for their other hip when an arthroplasty becomes necessary.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Although the presence of metals in other organic structures such as hair<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">9</span></a> has been analysed, as has the concentration of other metals like molibdenum,<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">10</span></a> the studies usually used to rule out metal intoxication after MoM arthroplasties centre on analysing blood Cr and Co. Although the literature on this respect is not fully in agreement, it is accepted that patients with low levels of metal ions in the blood are at low risk of ARMD following MoM hip arthroplasty.<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">11,12</span></a> Nevertheless, the decision to perform revision surgery must depend on individual factors and not exclusively on a certain specific analysis.<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">13</span></a> Several associated findings are considered to be necessary for this: clinical, imaging and analytical. For the latter, series of measurements and the tendency they display are considered to be more important than momentary values in predicting failure for arthroplasties of this type.</p><p id="par0080" class="elsevierStylePara elsevierViewall">There is no agreement in the literature on acceptable limits for blood metal levels; although some works do not accept that >7<span class="elsevierStyleHsp" style=""></span>μg/L indicates a potential soft tissue reaction,<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">14</span></a> this is the threshold recommended in monitoring protocols. Figures higher than 7<span class="elsevierStyleHsp" style=""></span>μg/L of Cr and Co in the blood after the implant of a MoM arthroplasty are considered to be raised and need special monitoring.<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">6</span></a> Levels up to 10<span class="elsevierStyleHsp" style=""></span>μg/L are considered to indicate risk and should be evaluated together with the results of other examinations. Co values ≥10<span class="elsevierStyleHsp" style=""></span>μg/L indicate an increase in joint wear, with a specificity of 100% and a sensitivity of 93%. A Co concentration of from 10 to 20<span class="elsevierStyleHsp" style=""></span>μg/L has to be considered highly abnormal, while above concentrations higher than 20<span class="elsevierStyleHsp" style=""></span>μg/L Co in repeated measurements are unacceptable due to the risk of systemic intoxication, and surgical treatment in the short term must be considered.<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">15</span></a> Intoxication by this metal is known as cobaltism, and it may also occur in the case of other types of prosthesis surfaces.<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">16</span></a> In our study we consider different alternatives depending on the levels found, considering 7 to 19<span class="elsevierStyleHsp" style=""></span>μg/L to be the range which demands careful monitoring.</p><p id="par0085" class="elsevierStylePara elsevierViewall">The cause of high blood levels of metals in cases of MoM arthroplasties has not been determined. It has been blamed on wear of the surfaces, an exaggerated acetabular angle, large cup size, gender, individual hypersensitivity, defective treatment of the metal surfaces or their corrosion.<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">17–19</span></a> Nor is it known why metal levels vary over time. Some studies<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">20</span></a> detect a fall in Cr but not in Co over the years. Other studies<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">21</span></a> detect raised levels of both metals in the first two years that then fall, although a rise in the level of Co was detected after 4 years together with a rise in Cr 6 years after the implant, followed by a fall. In our study we did not find such high levels in the first years, although there was an increase after 6–7 years which went on to normalise (<a class="elsevierStyleCrossRefs" href="#fig0010">Figs. 2 and 3</a>). We also found higher levels of Cr than Co throughout the follow-up, as well as a wider range between the upper and lower limits and less uniform data for Cr. As we pointed out above, the causes of these variations are unknown; it seems that they are not important if the curve remains flat or falls over time. Although our study is limited by its short duration, as are others,<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">21</span></a> it seems that after 7 years levels of these ions either stabilise or continue falling.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Although recommendations for monitoring these patients have changed over the years, they have not been agreed. Some scientific societies recommend increasing the time between analytical studies in asymptomatic patients 7 years after the implant. Given how these patients are observed to progress, annual analysis is not thought to be cost-effective if they have no pathological clinical data.<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">22,23</span></a> Other organisations recommend continuing regular checks only in certain cases, due to patient sex, cup size or the type of implant.<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">24,25</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Our work has limitations. Its greatest limitation is due to the small number of patients studied, as this also prevents appropriate statistical analysis and therefore may reduce the validity of the conclusions. Our patients have a limited follow-up. Nevertheless, the period studied is of similar length to those of other published studies.<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">21,26</span></a> Men predominate in our series, so this may lead to major distortion if the results are extrapolated to the general population. On the other hand, this work does not analyse how hip arthroplasties evolve over the years radiographically, clinically or functionally; our study is solely concerned with series of analytical determinations of blood Cr and Co.</p><p id="par0100" class="elsevierStylePara elsevierViewall">A slight rise in blood Cr and Co levels in a single annual evaluation should not lead to revision surgery in patients with MoM arthroplasties. On the other hand, it is more important to observe how levels change in a series of analyses over time than it is to base our decision on a single isolated high level of metals. It is also indispensible to evaluate other findings and most especially the clinical state of the patient.</p><p id="par0105" class="elsevierStylePara elsevierViewall">For asymptomatic patients blood metal levels remain stable over the medium term, so that it seems unnecessary to continue repeating annual determinations of the same.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Level of evidence</span><p id="par0110" class="elsevierStylePara elsevierViewall">Level of evidence IV.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflict of interests</span><p id="par0115" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres1112896" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Material and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1050668" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1112897" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Material y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1050667" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Material and methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Level of evidence" ] 9 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflict of interests" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-11-29" "fechaAceptado" => "2018-03-13" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1050668" "palabras" => array:3 [ 0 => "Total hip arthroplasty" 1 => "Surface arthroplasty" 2 => "Blood metals" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1050667" "palabras" => array:3 [ 0 => "Artroplastia total de cadera" 1 => "Artroplastias de superficie" 2 => "Metales en sangre" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Blood cobalt (Co) and chromium (Cr) ion levels have been used as surveillance tools for adverse reaction to metal debris in metal-on-metal (MoM) hip arthroplasty. The aim of our study was to present serial 7–13 year blood Co and Cr levels in a cohort of MoM total hip arthroplasties in asymptomatic patients.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A total of 52 MoM surface total hip arthroplasties were included in this study with data collected prospectively. Annual follow-up with blood Co and Cr measurements was performed. Revision surgery was necessary for 16 patients and therefore they dropped out of the study. The metal ion levels were analysed separately in 31 asymptomatic patients.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">High Cr or Co levels were not found continuously in any of the asymptomatic patients. The median Cr in blood was maintained between 1.3 and 5.4<span class="elsevierStyleHsp" style=""></span>μg/L and that of Co between 0.5 and 1.2<span class="elsevierStyleHsp" style=""></span>μg/L. After 7 years, there was no significant change in Co and Cr values.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In the medium term and in asymptomatic patients, the metallic blood levels remained unchanged; therefore, it does not seem appropriate to repeat these tests on a permanent basis in annual controls.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Material and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducción</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La determinación periódica de los niveles de cromo (Cr) y cobalto (Co) en sangre ha sido utilizada para evaluar las reacciones adversas secundarias al desgaste metal-metal en las artroplastias de superficie de cadera. El objetivo de nuestro estudio es evaluar los niveles de Cr y Co en sangre en una serie de pacientes asintomáticos con artroplastias de superficie con un seguimiento de 7 a 13 años.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Hemos analizado la evolución de los niveles metálicos en sangre en una serie de 52 artroplastias de superficie metal-metal. Se realizó un control anual de Co y Cr en sangre. En 16 pacientes fue preciso realizar una cirugía de revisión, por lo que salieron del estudio. Los niveles de iones metálicos en sangre fueron analizados en 31 pacientes asintomáticos.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">En ninguno de los pacientes asintomáticos aparecieron cifras elevadas de Cr o Co de manera continuada. La mediana de Cr en sangre se mantuvo entre 1,3 y 5,4<span class="elsevierStyleHsp" style=""></span>μg/L y la de Co entre 0,5 y 1,2<span class="elsevierStyleHsp" style=""></span>μg/L. Después de 7 años tras la cirugía no se han apreciado cambios en los niveles referidos.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusión</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A medio plazo y en pacientes asintomáticos, los niveles metálicos en sangre se mantienen sin cambios, por lo que no parece adecuado repetir anualmente estas determinaciones de manera permanente.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Material y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Please cite this article as: Hernández-Vaquero D, García-Pascual M, Iglesias-Fernández S, Escandon-Rodríguez A. Artroplastias de superficie metal-metal en cadera. ¿Es necesario realizar seguimiento anual mediante determinación de metales en sangre? Rev Esp Cir Ortop Traumatol. 2018;62:436–441.</p>" ] ] "multimedia" => array:7 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 815 "Ancho" => 750 "Tamanyo" => 48543 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">MoM hip arthroplasty implanted 13 years previously. Normal blood metal levels. Asymptomatic patient.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1030 "Ancho" => 1416 "Tamanyo" => 96403 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Blood Cr levels during follow-up.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1030 "Ancho" => 1416 "Tamanyo" => 82565 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Blood Co levels during follow-up.</p>" ] ] 3 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Number \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Revision surgery \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Unknown evolution \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Deaths \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Bilateral case \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Asymptomatic patients \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">31 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">52 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1902907.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Evolution of the series of MoM hip arthroplasties.</p>" ] ] 4 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Year \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Number of cases \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Asymptomatic \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">2005 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">2006 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">2007 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">2008 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">2009 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">2010 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1902906.png" ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">A lost case.</p>" ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Two lost cases.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Arthroplasties implanted per year that remain asymptomatic.</p>" ] ] 5 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Follow-up (years) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Median (μg/L) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">CI 95% \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">≤2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.6–2.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.2–5.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.5–6.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.4–6.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.6–7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.7–6.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.6–5.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.1–7.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">≥10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.1–3.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1902909.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Cr levels per year of follow-up. Median and confidence interval (CI).</p>" ] ] 6 => array:8 [ "identificador" => "tbl0020" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at4" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Follow-up (years) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Median (μg/L) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">CI 95% \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">≤2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.5–3.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.5–1.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.7–1.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.7–2.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.7–1.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.8–3.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.8–2.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.6–3.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">≥10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.6–2.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1902908.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Co levels per year of follow-up. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 9 | 0 | 9 |
| 2024 October | 13 | 2 | 15 |
| 2024 September | 10 | 1 | 11 |
| 2024 August | 13 | 3 | 16 |
| 2024 July | 13 | 4 | 17 |
| 2024 June | 14 | 0 | 14 |
| 2024 May | 13 | 0 | 13 |
| 2024 April | 37 | 7 | 44 |
| 2024 March | 59 | 1 | 60 |
| 2024 February | 42 | 6 | 48 |
| 2024 January | 28 | 4 | 32 |
| 2023 December | 47 | 9 | 56 |
| 2023 November | 23 | 3 | 26 |
| 2023 October | 35 | 4 | 39 |
| 2023 September | 9 | 3 | 12 |
| 2023 August | 16 | 4 | 20 |
| 2023 July | 8 | 3 | 11 |
| 2023 June | 23 | 8 | 31 |
| 2023 May | 37 | 2 | 39 |
| 2023 April | 38 | 0 | 38 |
| 2023 March | 19 | 6 | 25 |
| 2023 February | 27 | 2 | 29 |
| 2023 January | 10 | 2 | 12 |
| 2022 December | 28 | 5 | 33 |
| 2022 November | 16 | 8 | 24 |
| 2022 October | 25 | 11 | 36 |
| 2022 September | 19 | 8 | 27 |
| 2022 August | 21 | 5 | 26 |
| 2022 July | 20 | 7 | 27 |
| 2022 June | 15 | 5 | 20 |
| 2022 May | 16 | 5 | 21 |
| 2022 April | 23 | 8 | 31 |
| 2022 March | 22 | 7 | 29 |
| 2022 February | 21 | 4 | 25 |
| 2022 January | 10 | 7 | 17 |
| 2021 December | 29 | 8 | 37 |
| 2021 November | 34 | 9 | 43 |
| 2021 October | 22 | 16 | 38 |
| 2021 September | 13 | 9 | 22 |
| 2021 August | 13 | 3 | 16 |
| 2021 July | 20 | 7 | 27 |
| 2021 June | 16 | 3 | 19 |
| 2021 May | 16 | 5 | 21 |
| 2021 April | 42 | 4 | 46 |
| 2021 March | 11 | 6 | 17 |
| 2021 February | 16 | 4 | 20 |
| 2021 January | 16 | 5 | 21 |
| 2020 December | 1 | 0 | 1 |
| 2018 November | 1 | 2 | 3 |
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