was read the article
array:25 [ "pii" => "S1988885621000018" "issn" => "19888856" "doi" => "10.1016/j.recote.2021.01.001" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "904" "copyright" => "SECOT" "copyrightAnyo" => "2020" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "rev" "cita" => "Rev Esp Cir Ortop Traumatol. 2021;65:138-51" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:20 [ "pii" => "S1888441520301223" "issn" => "18884415" "doi" => "10.1016/j.recot.2020.06.014" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "904" "copyright" => "SECOT" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "rev" "cita" => "Rev Esp Cir Ortop Traumatol. 2021;65:138-51" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">TEMA DE ACTUALIZACIÓN</span>" "titulo" => "Papel del cirujano ortopédico y traumatólogo en la impresión 3D: aplicaciones actuales y aspectos legales para una medicina personalizada" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "138" "paginaFinal" => "151" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Role of the orthopaedic surgeon in 3D printing: current applications and legal issues for a personalized medicine" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figura 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 1306 "Ancho" => 1740 "Tamanyo" => 287018 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Fases del proceso de impresión 3D médica.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "P. Andrés-Cano, J.A. Calvo-Haro, F. Fillat-Gomà, I. Andrés-Cano, R. Perez-Mañanes" "autores" => array:5 [ 0 => array:2 [ "nombre" => "P." "apellidos" => "Andrés-Cano" ] 1 => array:2 [ "nombre" => "J.A." "apellidos" => "Calvo-Haro" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "Fillat-Gomà" ] 3 => array:2 [ "nombre" => "I." "apellidos" => "Andrés-Cano" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Perez-Mañanes" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1988885621000018" "doi" => "10.1016/j.recote.2021.01.001" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1988885621000018?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1888441520301223?idApp=UINPBA00004N" "url" => "/18884415/0000006500000002/v1_202102140722/S1888441520301223/v1_202102140722/es/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S1988885621000109" "issn" => "19888856" "doi" => "10.1016/j.recote.2021.02.001" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "880" "copyright" => "SECOT" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Rev Esp Cir Ortop Traumatol. 2021;65:152-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Ossifying myositis in the infant. About a case" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "152" "paginaFinal" => "157" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Miositis osificante en el lactante. A propósito de un caso" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 990 "Ancho" => 1750 "Tamanyo" => 132248 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Series of X-ray images during follow-up. (a–c) Evolution of the calcification in the thickness of the gluteal muscles and morphological changes at the level of the proximal femur at one month, 2 and 9 months, respectively. (d) Complete remodelling of the proximal femur at 18 months. (e) 3 years: bilateral proximal derotatory and modifying femoral osteotomy. (f) 8 years: hips reduced without evidence of recurrence of the lesion.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L. Lanuza Lagunilla, A. Ramírez Barragán, C. Miranda Gorozarri" "autores" => array:3 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Lanuza Lagunilla" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Ramírez Barragán" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Miranda Gorozarri" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1888441520300692" "doi" => "10.1016/j.recot.2020.05.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1888441520300692?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1988885621000109?idApp=UINPBA00004N" "url" => "/19888856/0000006500000002/v1_202102230652/S1988885621000109/v1_202102230652/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S198888562100002X" "issn" => "19888856" "doi" => "10.1016/j.recote.2020.07.006" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "907" "copyright" => "SECOT" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Esp Cir Ortop Traumatol. 2021;65:132-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Prevalence of hypovitaminosis D in patients with juvenile osteochondritis dissecans" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "132" "paginaFinal" => "137" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Prevalencia de hipovitaminosis D en pacientes con osteocondritis disecante juvenil" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1143 "Ancho" => 1250 "Tamanyo" => 134701 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A) Magnetic resonance in coronal and saggital slices where an unstable lesion was observed in the medial femoral condyle in keeping with the criteria of Kijowski et al.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a>: a high T2 signal intensity rim which had the same signal intensity as the adjacent joint fluid; a secondary outer rim of low T2 signal intensity; multiple breaks in the subchondral bone plate, and the existence of multiple cysts or only one cyst above 5 mm in diameter. In addition to this, in this case, disruption of the joint cartilage was observed. B) Magnetic resonance in coronal and sagggital slices where we observed a stable lesion with osseous subchondral oedema in the medial femoral condyle but with none of the previously described features.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "V. Oberti, M. Sanchez Ortiz, V. Allende, J. Masquijo" "autores" => array:4 [ 0 => array:2 [ "nombre" => "V." "apellidos" => "Oberti" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Sanchez Ortiz" ] 2 => array:2 [ "nombre" => "V." "apellidos" => "Allende" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Masquijo" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1888441520301545" "doi" => "10.1016/j.recot.2020.07.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1888441520301545?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S198888562100002X?idApp=UINPBA00004N" "url" => "/19888856/0000006500000002/v1_202102230652/S198888562100002X/v1_202102230652/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review article</span>" "titulo" => "Role of the orthopaedic surgeon in 3D printing: current applications and legal issues for a personalized medicine" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "138" "paginaFinal" => "151" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "P. Andrés-Cano, J.A. Calvo-Haro, F. Fillat-Gomà, I. Andrés-Cano, R. Perez-Mañanes" "autores" => array:5 [ 0 => array:4 [ "nombre" => "P." "apellidos" => "Andrés-Cano" "email" => array:1 [ 0 => "pabloanca@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J.A." "apellidos" => "Calvo-Haro" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "F." "apellidos" => "Fillat-Gomà" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 3 => array:3 [ "nombre" => "I." "apellidos" => "Andrés-Cano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 4 => array:3 [ "nombre" => "R." "apellidos" => "Perez-Mañanes" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Departamento de Cirugía Ortopédica y Traumatología, Hospital Universitario Virgen del Rocío, Sevilla, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Cirugía Ortopédica y Traumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamento de Cirugía, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Unidad de Planificación Quirúrgica 3D, Departamento de Cirugía Ortopédica y Traumatología, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Barcelona, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Departamento de Radiodiagnóstico Hospital Universitario Puerta del Mar, Cádiz, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Papel del cirujano ortopédico y traumatólogo en la impresión 3D: aplicaciones actuales y aspectos legales para una medicina personalizada" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0030" "etiqueta" => "Figure 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 1182 "Ancho" => 2175 "Tamanyo" => 261766 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0030" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Segmentation tools at <span class="elsevierStyleItalic">Invesalius</span> (Centro de Tecnologia da Informação Renato Archer, Campinas, SP, Brazil). A): Paint brush-type manual. B) Automatic threshold type.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction: 3D printing</span><p id="par0005" class="elsevierStylePara elsevierViewall">3D printing (3DP) groups together a series of manufacturing technologies that, applied to the medical sector, bring many advantages, and represent a paradigm shift in health. Although 3DP is not a new technology (it dates from 1983), it has become popular in the last 10 years. This is due, on the one hand, to the release of patents on the main manufacturing technologies stereolithography (SLA) and fused deposition modelling (FDM)) and, on the other, to the advent of new materials and 3DP techniques. 3DP is a growing technology also used in many applications in the industrial, aeronautical, automotive, and architectural sectors.</p><p id="par0010" class="elsevierStylePara elsevierViewall">3DP is a type of additive manufacturing that allows a digital model to be transformed into a real and tangible three-dimensional object. Three-dimensional models are obtained by processing digital radiological imaging studies of patients, three-dimensional, external scanning techniques, computer-aided design (CAD) and reverse engineering techniques. Once the virtual model has been obtained, it can be printed. Objects are built layer-by-layer, using different technologies and materials depending on the final application. This layer-by-layer addition of material is what differentiates 3DP from other classical manufacturing technologies such as machining, casting, moulding, or forming.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Because 3DP enables manufacture by laying down successive layers of the object’s material, complex structures are created that could not be obtained with other technologies. This characteristic, together with the concept of personalised medicine, has resulted in the successful use of 3DP in medicine.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The possibility of obtaining short series in a shorter time and at a lower cost than other industrial manufacturing techniques and avoiding waste are other advantages.</p><p id="par0020" class="elsevierStylePara elsevierViewall">On the other hand, there are several disadvantages of the technology such as: 1) the need to use extra material as a support to prevent layers collapsing, 2) the low mechanical traction resistance of the part in the direction of the superimposed layers (Z axis) and 3) the time needed to print with certain technologies.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">There are many 3DP technologies, therefore, in 2015, the American Society for Testing and Materials (ASTM) developed the international standard ISO/ASTM 52900-2015 which classifies them into 7 processes which has resulted in 11 different technologies.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Each technology has its advantages, disadvantages and potential applications, therefore various techniques will be used in medicine according to the intended utility.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In any case, as with any recently introduced technology in the medical sector, caution is essential, since neither the regulations nor the legal regulation of the medical use of 3DP are fully in place and there are still numerous legal challenges that require further research and the development of specific medical regulations.</p><p id="par0035" class="elsevierStylePara elsevierViewall">This article reviews the current status of 3DP in medicine, its different practical uses in the speciality of orthopaedic surgery and traumatology (OST), the working process from image acquisition to manufacture using 3DP and, finally, the most relevant technical and legal details for successful implementation in a hospital’s OST department.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">3D printing in medicine</span><p id="par0040" class="elsevierStylePara elsevierViewall">Research on the utilities of medical 3DP has grown exponentially in recent years (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) and, although numerous, they can be grouped into the manufacture: 1) of biomodels or bioreplicas, 2) of custom-made tools, 3) of custom-made implants, 4) of drugs and 5) of biocompatible tissues, also known as bioprinting.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">The many utilities of 3DP are currently in different stages of maturity. The hype cycle of emerging technologies of the global consulting firm Gartner is a graphic representation of the maturity, adoption, and commercial application of specific technologies. It is published annually and establishes the key phases of a technology's life cycle: 1) the trigger, 2) the peak of inflated expectations, 3) the trough of disillusionment, 4) the slope of enlightenment, finally, 5) the plateau of productivity.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The state of maturity of each application needs to be examined to make efficient use of medical 3DP. As an example, Gartner's 2018 emerging technologies hype cycle highlights that the 3D tools (where patient-specific surgical guides are included) are on the slope of enlightenment while the 3D anatomical models are about to start on it. By contrast, customised implants and human tissue obtained by bio-printing are in full disillusionment, and therefore they advise investing in research into them to establish their real usefulness and start their consolidation on the market.</p><p id="par0055" class="elsevierStylePara elsevierViewall">The use of this technology in the medical sector still has some disadvantages that need to be known. Depending on the use, the additional time required for manufacture, the extra cost involved, the need for technical staff, the mechanical properties or the precision of some technologies must be considered.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">3D biomodels</span><p id="par0060" class="elsevierStylePara elsevierViewall">3D biomodels or bioreplicas are physical reproductions of a patient’s specific organ or anatomical region. Using 3DP, any anatomical region visualised on medical imaging can be manufactured, in real scale, in various materials, and with millimetric accuracy depending on the quality of the image and the technology chosen. While it is possible to obtain data from any conventional imaging test, the most used are computed tomography (CT), magnetic resonance imaging (MRI) and even ultrasound.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Thanks to 3D biomodels, advance planning of certain medical procedures, such as surgical interventions, is possible.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> This enables the surgeon to make decisions or simulate surgery prior to the surgical act and facilitates communication with patients and teaching among professionals.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The use of 3D biomodels enables innovation and improvement in medical education. In addition to manufacturing highly detailed and realistic anatomical models, it is possible to manufacture, at very low cost, simulators of medical techniques such as orotracheal intubation,<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> sutures,<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> endoscopies,<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> endovascular<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> and surgical interventions, among others.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13–15</span></a> Furthermore, it is an alternative to the use of cadavers for university teaching of medicine in subjects such as anatomy.<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16–18</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Customised tools</span><p id="par0075" class="elsevierStylePara elsevierViewall">One of the main advantages of 3DP is the creation of customised products in small quantities, which facilitates personalised medicine, i.e., treatment tailored to each patient’s individual characteristics.</p><p id="par0080" class="elsevierStylePara elsevierViewall">Patient-specific guides are some of the most widely used tools manufactured by 3DP currently available. As they are exactly adapted to the patient’s specific location, they can be applied to a particular medical or surgical treatment such as an osteotomy, to insert an implant, to obtain grafts, to administer drugs or to use radiotherapy devices with exact dose control.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> These guides are manufactured with biocompatible material in the hospital itself, and therefore the entire process is under the permanent supervision of the surgeon or prescribing physician.</p><p id="par0085" class="elsevierStylePara elsevierViewall">Surgical instruments manufactured by 3DP are adapted not only to the size of the patient, but also to the surgeon and to a specific surgical technique.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> Most of the surgical instruments used today in interventions have not changed over the years and have structural characteristics that are not optimally adapted to new materials and manufacturing techniques. 3DP enables advanced rapid prototyping, reduces verification and validation times, improves the shape, weight, and strength of medical instruments, and gives them unique properties such as radio-translucence.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Customised implants</span><p id="par0090" class="elsevierStylePara elsevierViewall">3DP as a medical device manufacturing technique has many advantages over other traditional manufacturing techniques. It enables the creation of customised implants using the patient's own medical imaging data. These implants are manufactured with external and internal geometries that would probably not be possible with traditional methods.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Furthermore, with 3DP it is possible to manufacture customised implants at a significantly lower cost than other traditional techniques.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> Manufacturing technologies by means of selective laser sintering enable the creation of metal implants safely and very cost-effectively.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> This means that these customised implants are being used in more hospitals and in more surgical techniques.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Non-implantable medical devices, such as splints or corsets, are also manufactured using 3DP, which has many therapeutic advantages since, depending on the anatomical region, it is possible to manufacture them with improved characteristics and properties compared to traditional materials and techniques.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Drugs</span><p id="par0105" class="elsevierStylePara elsevierViewall">With 3DP it is possible to manufacture highly complex, customised drugs with enhanced pharmaceutical properties. There are currently several drugs on the market that are approved by the Food and Drug Administration (FDA) and produced using additive pharmaceutical manufacturing techniques.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> The FDA itself highlights the great potential of 3DP to create new therapies and improve the adherence, safety, and efficacy of existing ones. Therefore, 3DP for drugs is a utility that the pharmaceutical industry will continue to develop in coming years.<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">27,28</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Bioprinting</span><p id="par0110" class="elsevierStylePara elsevierViewall">Bioprinting is the manufacture of biological tissues by layer-by-layer printing of structures or scaffolds made of a biocompatible material and coated with the patient's own live cells obtained by means of tissue engineering techniques.<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">29,30</span></a> Cell coating is performed either a posteriori, using a bioreactor, or simultaneously with the manufacture of the scaffold, using bioinks.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">The possibilities of this technology have opened a wide range of research with countless potential applications. The manufacture of human tissues, using the patient's own living cells that can replace damaged ones, is a utility that is still in the early stages of research, but advancing rapidly.</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">3D printing in orthopaedic surgery and traumatology</span><p id="par0120" class="elsevierStylePara elsevierViewall">OST is possibly the area of medicine that can benefit most from the advantages of 3DP.<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">32,33</span></a> Almost all 3DP utilities are applicable to the various aspects of the specialty, from preoperative planning of orthopaedic interventions using 3D biomodels to the development of instruments, patient-specific surgical guides, or customised orthopaedic implants, among others.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a></p><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Preoperative planning in orthopaedic surgery and traumatology with 3D biomodels</span><p id="par0125" class="elsevierStylePara elsevierViewall">The use of 3D biomodels for preoperative planning in OST is one of the utilities where there has been most interest in recent years, since all subspecialties will be able to use it (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> The 3D Special Interest Group RSNA has reviewed and classified the clinical cases in which it is more efficient to use 3D biomodels in OST and concludes that in simple fractures, the role of 3D is not as useful (1/10) as in complex fractures, hip dysplasia or bone tumours with joint involvement (8/10).<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a></p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">Recently it has been demonstrated how the use of 3D biomodels reduces surgical time in certain interventions, with a saving in surgery costs of more than 3.700 $.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> It has also been shown that both the intraoperative radiation dose using 3D biomodels as support during surgery,<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a> and complications following the surgical intervention could be lower.<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Communication with patients is another advantage that has been studied and whose improvement using 3D biomodels has been quantified. Different studies have established that patients have a better understanding of their injury and planned surgery when the surgeon gives them information using 3D biomodels.<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">40,41</span></a></p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Patient-specific surgical guides in orthopaedics and traumatology</span><p id="par0140" class="elsevierStylePara elsevierViewall">Using patient-specific surgical guides manufactured by 3DP it is possible to perform osteotomies of the pelvis,<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a> hip<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">43,44</span></a> and knee,<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a> tumour resections,<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">46</span></a> correction of deformities,<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">47</span></a> pedicle screw insertion,<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">48</span></a> percutaneous trauma surgery<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a> and arthroplasties<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">50</span></a> with greater precision than with generic instruments (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0145" class="elsevierStylePara elsevierViewall">Many studies highlight that the use of patient-specific surgical guides reduces radiation and surgical time, and some studies even confirm a saving of $3500 in overall operating costs.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">The manufacture of customised surgical instruments for OST operations enables hybridisation with other technologies such as surgical navigation or augmented reality.<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">51,52</span></a></p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Orthoses and splints manufactured using 3D printing</span><p id="par0155" class="elsevierStylePara elsevierViewall">With 3D scanning technology, orthoses and splints are manufactured using 3DP (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>).<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">53</span></a> The main advantage is improved adaptation to the patient's anatomy.<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">54</span></a> This together with the use of different 3DP technologies and new materials has facilitated the design and approval of orthoses and splints for the treatment of diseases of the lower limb,<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">55,56</span></a> upper limb<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">57,58</span></a> and even spinal deformities, such as scoliosis.<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">59</span></a></p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0160" class="elsevierStylePara elsevierViewall">Orthoses manufactured by means of 3D technology are a valid alternative to the traditional that are manufactured by shaping thermoplastic materials. Although their use is not yet very widespread, this brings numerous advantages, such as a reduction in manufacturing times, lower costs, and greater patient satisfaction.<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">56</span></a> Recent papers have validated their biomechanical behaviour and confirmed them to be comparable to traditional orthoses.<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a></p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Customised implants in orthopaedic surgery and traumatology</span><p id="par0165" class="elsevierStylePara elsevierViewall">Customized implants manufactured by 3DP allow the reconstruction of bone defects after tumour resection operations,<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">61–66</span></a> or complex prosthetic revision surgeries (especially when it is not possible to use modular implants).<a class="elsevierStyleCrossRefs" href="#bib0335"><span class="elsevierStyleSup">67,68</span></a> The fixation and stability of customised implants is excellent, and therefore clinical outcomes, still in the short term, are very favourable.<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">69</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">Despite the numerous advantages of customised implants, most published papers refer to isolated clinical cases or case series, without the possibility of a comparative analysis with traditional implants.<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">70</span></a></p><p id="par0175" class="elsevierStylePara elsevierViewall">Most companies in the medical sector use direct metal laser sintering (DMLS) technology for the manufacture of customised orthopaedic implants. This, and because their design involves a more complex process than that of 3D biomodels and surgical guides, means that they are not yet widely used in the hospital setting and the participation of the medical industry is essential.</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">3D printing and tissue engineering in cartilage and bone</span><p id="par0180" class="elsevierStylePara elsevierViewall">Bioprinting in OST has revolutionised the field of cartilage and bone tissue engineering.<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">71</span></a> With respect to cartilage, bioprinting of mesenchymal stem cells in several layers has been performed in vivo together with an extracellular matrix formed by atelocollagen hydrogel and hyaluronic acid. The subsequent cell differentiation into mature chondrocytes allows the creation of personalised cartilage autografts for the reconstruction of chondral defects.<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">72</span></a></p><p id="par0185" class="elsevierStylePara elsevierViewall">Regarding the additive manufacture of bone tissue, thanks to bio-printing functional prototypes of clinically relevant bone tissue, mechanically resistant and with a functional bone marrow have been developed.<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">73</span></a> In the experimental field, synthetic polymer hydrogels have been successfully used to create an extracellular matrix to which mesenchymal stem cells are added. These differentiate into mature bone tissue when stimulated by ceramics, such as hydroxyapatite or bioactive crystals.<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">71</span></a> The main challenge at present is the vascularisation of bio-printed bone tissue.<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">74</span></a></p><p id="par0190" class="elsevierStylePara elsevierViewall">Combining and integrating imaging tests with bioprinting of cartilage and bone tissues will make it possible in the future to bioprint patient-specific autografts for the treatment of chondral and bone defects. Thanks to these bio-printed autografts, it will be possible to avoid both the problems of autografts (availability and morbidity) and those of allografts (compatibility and osteogenic capacity).<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">75</span></a></p></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Medical 3D printing process</span><p id="par0195" class="elsevierStylePara elsevierViewall">There are 4 well-differentiated phases in the medical 3DP process: 1) acquisition, 2) segmentation, 3) processing and 4) manufacturing by 3DP (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>).<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">76</span></a></p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Acquisition</span><p id="par0200" class="elsevierStylePara elsevierViewall">The medical 3DP process begins before the medical imaging treatment. Correct acquisition and optimisation of imaging studies is essential to create the CAD object that will later be printed. It is possible to use CT or MRI studies from routine clinical practice, but it must be borne in mind that these may not have been performed with optimised protocols for bone segmentation (<a class="elsevierStyleCrossRef" href="#fig0030">Fig. 6</a>).</p><elsevierMultimedia ident="fig0030"></elsevierMultimedia><p id="par0205" class="elsevierStylePara elsevierViewall">CT is the best study for 3DP of bone structures.<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">77</span></a> There are certain technical characteristics that can be modified at the time of the study that will facilitate the segmentation of fractures or orthopaedic deformities: 1) sections: slice thickness of 1<span class="elsevierStyleHsp" style=""></span>mm (or even less) with increments of .625–.75<span class="elsevierStyleHsp" style=""></span>mm (less than 1<span class="elsevierStyleHsp" style=""></span>mm); 2) Kernel filter: soft or moderate parts and 3) collimation: 1.25–1.50<span class="elsevierStyleHsp" style=""></span>mm.<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">78</span></a></p><p id="par0210" class="elsevierStylePara elsevierViewall">If the anatomical region presents metal elements, protocols for the reduction of metal artifacts are necessary. The new dual-energy tomographs, at the same dose, reduce brightness produced around the bone and that prevent the correct segmentation of the anatomical structures.<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">79</span></a></p><p id="par0215" class="elsevierStylePara elsevierViewall">Medical imaging is stored in DICOM (Digital Imaging and Communication on Medicine) format for subsequent processing.</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Segmenting</span><p id="par0220" class="elsevierStylePara elsevierViewall">The next stage is to process the medical image by selecting the regions or areas of the anatomy to be reconstructed in the CAD model, a process known as segmentation.</p><p id="par0225" class="elsevierStylePara elsevierViewall">Thanks to the development of commercial software tools such as Mimics (Materialise NV, Leuven, Belgium) and freely available tools such as Horos (Horos Project, Annapolis, MD, USA). Invesalius (Centro de Tecnologia da Informação Renato Archer, Campinas, SP, Brazil) and 3D-Slicer (BWH, Cambridge, MA, USA), the segmentation process has been simplified and, in certain situations, even automated.</p><p id="par0230" class="elsevierStylePara elsevierViewall">Segmentation can be carried out by 3 methods:<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1</span><p id="par0235" class="elsevierStylePara elsevierViewall">Manual: by selecting or painting pixel by pixel the regions of interest (ROI) in each layer of the imaging study.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2</span><p id="par0240" class="elsevierStylePara elsevierViewall">Automatic: using tools with algorithms to select regions of interest with similar characteristics for automatic segmentation in all the layers of the study.</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3</span><p id="par0245" class="elsevierStylePara elsevierViewall">Semi-automatic: combination of manual and automatic tools. The combination of the automatic tool for segmentation by grey intensity threshold of the Hounsfield scale together with the manual editing tool is one of the most widely used. This scale covers the different greys (from black to white) found in each pixel of a CT image, ranging from −1000 Hounsfield units (HU), which is equivalent to air density, to >1000 HU, which represent metal density.</p></li></ul></p><p id="par0250" class="elsevierStylePara elsevierViewall">The next step, once segmentation has been made and regardless of the method selected, is rendering to obtain a virtual 3D model. The visualisation and analysis of the virtual model are necessary to adjust those details of segmentation that may have gone unnoticed, such as areas of low contrast, artifacts or internal surfaces that do not require segmentation and that may compromise, as will be seen later, the result of 3DP.</p><p id="par0255" class="elsevierStylePara elsevierViewall">After segmentation and rendering of the virtual model, the model is exported to a digital CAD file. This file is made up of a three-dimensional mesh of triangles whose most widespread format is STL (stereolithography), a format which, despite being the most widely used and supported by most computer applications, does not provide information on colour, textures, or physical properties, although it does provide information on size or spatial location. It is possible that in years to come the format will evolve to include more information, which will give the models more useful clinical characteristics.</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Processing</span><p id="par0260" class="elsevierStylePara elsevierViewall">Depending on each case and the intended use, the CAD model usually requires further processing. Processing can range from slight smoothing of surface irregularities to the creation of additional elements such as surgical guides. In any case, it is essential not to vary the clinical information provided by the model.</p><p id="par0265" class="elsevierStylePara elsevierViewall">There are numerous computer applications for processing CAD models; some of the most used for medical models are free distribution applications such as <span class="elsevierStyleItalic">Meshmixer</span> (Autodesk Inc, San Rafael, CA, USA) and <span class="elsevierStyleItalic">MeshLab</span> (ISTI-CNR, Pisa, TO, Italy).</p><p id="par0270" class="elsevierStylePara elsevierViewall">The 5 key phases of processing are:<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">1</span><p id="par0275" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Mesh correction.</span> The conversion of the virtual model to the STL file usually causes the appearance of small defects (such as holes or lack of triangles in certain areas of the mesh) that require correction. Automatic correction tools are available in most applications for this purpose.</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">2</span><p id="par0280" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Close the ends of the model.</span> It is advisable to close open ends, such as the medullary cavity, to facilitate printing.</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">3</span><p id="par0285" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Optimise internal structures.</span> If the interior of the model is not going to provide clinical information, it is advisable to eliminate those layers or internal regions to improve the printing phase. A clean model without internal structures will be produced faster and with less chance of error.</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">4</span><p id="par0290" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Smooth out artifacts.</span> CT often produces a variety of artifacts that need to be smoothed, such as the steps between layers, brightness from metal artifacts or surface irregularities.</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">5</span><p id="par0295" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Modifications of the model.</span> Sometimes it is necessary to join elements that have become separated (for example, joints). To do this, it is possible to create connections to give the model stability. It is also advisable to add labels to classify them, highlight certain anatomical details, divide the model to improve visualisation and even add colours. In any case, it is essential not to make significant changes to the original anatomy.</p></li></ul></p><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Preoperative planning using computer-aided design models</span><p id="par0300" class="elsevierStylePara elsevierViewall">Digital 3D planning is a further step in the preoperative planning process. It provides the surgeon three-dimensional vision of the fundamental phases of the operation, since it allows the virtual simulation of the gestures that will be performed later during the surgery. It is particularly useful for preoperative planning of surgery on deformities, tumours or in complex locations, such as the pelvis or certain joints.</p><p id="par0305" class="elsevierStylePara elsevierViewall">The surgical intervention is planned once the CAD model has been reconstructed and repaired and prior to its manufacturing phase. The various tools of the computer applications allow rotating, cutting, measuring, and selecting and moving fragments, among other utilities. In addition, during this planning phase it is possible to design guides, instruments, or implants to achieve patient-specific CAD models.</p></span></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">3D printing manufacture</span><p id="par0310" class="elsevierStylePara elsevierViewall">The final step in the 3DP process is manufacturing. For this, depending on the intended use, it is essential to select the right 3DP technology and the most appropriate material (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0315" class="elsevierStylePara elsevierViewall">Regardless of the technology used, the manufacturing process will be similar. The CAD model in STL format will be imported into a laminating software that will convert it into orders to be interpreted by the printer, which will manufacture the product layer by layer (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0320" class="elsevierStylePara elsevierViewall">The technical printing settings will depend on the technology used: speed, resolution, fillers, or substrates are some of the basic features that will need to be adjusted before manufacturing begins. In addition, it is advisable to simulate the process using the different laminating applications to detect possible errors and determine those areas that require supports or those that can be optimised (such as fillers) to reduce the time and quantity of material required.</p><p id="par0325" class="elsevierStylePara elsevierViewall">Once manufactured, a more or less complex post-processing will be necessary depending on the technology, material, and product. A simple 3D biomodel manufactured by FDM will only require the removal of the supports, but an implant or surgical instrument manufactured by DMLS may require several complex treatments to improve its surface finish and mechanical characteristics.</p></span></span><span id="sec0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Implementation of 3D printing: 3D printing hospital units</span><span id="sec0105" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Creation of a digital hospital manufacturing workshop</span><p id="par0330" class="elsevierStylePara elsevierViewall">There is currently growing interest in the creation of digital manufacturing workshops or laboratories in the hospital itself. 3D printing means the emergence of new forms of production, such as point of care (POC) manufacturing, allowing hospitals to produce biomodels, patient-specific surgical guides, custom implants, and other 3D printed applications at the point of care. Thus, larger hospitals with more complex case histories can have their own 3D printing hospital units (3DP-HU), while smaller centres may network with those and the industry contracted, according to needs.<a class="elsevierStyleCrossRefs" href="#bib0400"><span class="elsevierStyleSup">80,81</span></a></p><p id="par0335" class="elsevierStylePara elsevierViewall">Many hospitals around the world already have 3DP-HUs, the OST speciality benefiting the most. Even some centres like the Hospital for Special Surgery in New York have a customised implant manufacturing workshop in the hospital itself thanks to collaboration with traditional orthopaedic implant manufacturers (<a href="https://trends.directindustry.es/project-190325.html">https://trends.directindustry.es/project-190325.html</a>).</p><p id="par0340" class="elsevierStylePara elsevierViewall">Traditional manufacturers, who often complement POC projects in hospitals, are valuable entities when integrated into the care flow working closely with hospital professionals. The creation of 3DP-HUs, the strengthening of collaborative work between the different actors involved, additional clinical studies and regulatory guidance will help to encourage innovation and ensure that in-hospital manufacturing becomes the standard of care.</p><span id="sec0110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Elements needed to start a hospital 3D printing unit</span><p id="par0345" class="elsevierStylePara elsevierViewall">The creation of a 3DP-HU begins with determining predicted utilities and coordinating the services involved. There are several human, technological, and material resources required to begin this activity:</p></span><span id="sec0115" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Human capital</span><p id="par0585" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">•</span><p id="par0350" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Clinical coordinator of the unit</span>: a doctor with a global vision of the process, which involves manufacturing at the point of care, from the acquisition of the virtual model from digital studies or computer design to the manufacture of biomodels, guides, instruments, and patient-specific implants</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">•</span><p id="par0355" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Medical specialists in radiodiagnosis</span>: experts in obtaining and processing medical images. In the 3D printing process, their role in validating both the digital model prior to manufacture and the biomodel is particularly relevant.</p></li><li class="elsevierStyleListItem" id="lsti0055"><span class="elsevierStyleLabel">•</span><p id="par0360" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Specialist radio-diagnostic technicians</span>: facilitate the acquisition and segmentation of imaging tests. As they are already present in most hospitals, this is a specialist profile to be considered to facilitate the creation of 3DP-HU.</p></li><li class="elsevierStyleListItem" id="lsti0060"><span class="elsevierStyleLabel">•</span><p id="par0365" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Bioengineers</span>: the applications of 3DP in areas of specific knowledge, such as medicine, require the creation of new competence models. Engineers with anatomical knowledge, training in medical imaging, experience in CAD design and in additive manufacturing technologies, are specialist profiles to consider when equipping a 3DP-HU.</p></li><li class="elsevierStyleListItem" id="lsti0065"><span class="elsevierStyleLabel">•</span><p id="par0370" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Medical specialists</span>: essential in cases where the utility is surgical planning and the need to manufacture patient-specific guides, instruments, or implants, which the legislation identifies as prescribing physicians responsible for the design.</p></li></ul></p></span><span id="sec0120" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Technological resources</span><p id="par0590" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0020"><li class="elsevierStyleListItem" id="lsti0070"><span class="elsevierStyleLabel">•</span><p id="par0375" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">3D printers</span>. In the initial stages, it may be sufficient to start with a semi-professional 3D printer using FDM technology that prints at an appropriate size (recommended print volume of 300<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>300<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>200<span class="elsevierStyleHsp" style=""></span>mm), with a double head, is reliable and minimal maintenance. The next entry technology can be 3D printing using SLA, which will allow the creation of biocompatible surgical guides for sterilisation later in the hospital itself, which will facilitate accessibility and reduce production time and costs. Other technologies such as MJF or DMLS may require more complex facilities and specialized manufacturing technicians, they will therefore not be widely used in most hospitals.</p></li><li class="elsevierStyleListItem" id="lsti0075"><span class="elsevierStyleLabel">•</span><p id="par0380" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Computer equipment</span>. Computer equipment of adequate power is essential to process the medical image smoothly. This equipment must be connected to the computer network and to the hospital PACS to import the patient's DICOM studies.</p></li><li class="elsevierStyleListItem" id="lsti0080"><span class="elsevierStyleLabel">•</span><p id="par0385" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Software.</span> Depending on the budget free distribution (Invesalius, Horos, Meshmixer, MeshLab) and commercial (Mimics) will be used.</p></li></ul></p></span><span id="sec0125" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Material resources</span><p id="par0595" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0025"><li class="elsevierStyleListItem" id="lsti0085"><span class="elsevierStyleLabel">•</span><p id="par0390" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Facility</span>. The location of the 3DP-HU is important so that professionals have access for supervision and communication tasks with the staff in charge. It also needs to be ventilated and have workstations for the staff.</p></li><li class="elsevierStyleListItem" id="lsti0090"><span class="elsevierStyleLabel">•</span><p id="par0395" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Computer equipment</span>. Computer equipment of adequate power is essential to process the medical image smoothly. This equipment must be connected to the computer network and to the hospital PACS to import the patient's DICOM studies.</p></li><li class="elsevierStyleListItem" id="lsti0095"><span class="elsevierStyleLabel">•</span><p id="par0400" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Post-processing tools.</span> Basic working tools are necessary such as pliers, tweezers, files, and saws to work and process the manufactured pieces. It is also interesting to provide the workshop with basic reused surgical instruments with which to simulate the techniques, such as screwdrivers, screws or osteosynthesis plates. Some technologies require advanced tools and even special post-processing machinery.</p></li></ul></p></span></span><span id="sec0130" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Medical 3D printing regulatory framework</span><p id="par0405" class="elsevierStylePara elsevierViewall">3DP is a tool within any doctor’s reach. The rapid growth of this technology has allowed new utilities to reach the health services. Although its use is gradually being regulated, there are currently certain aspects that are not completely legislated, and which are a barrier to definitive implementation in routine clinical practice.<a class="elsevierStyleCrossRefs" href="#bib0410"><span class="elsevierStyleSup">82,83</span></a></p><p id="par0410" class="elsevierStylePara elsevierViewall">The specific regulations according to the specific utility of the product manufactured by 3DP in a hospital should be checked. It can be considered a healthcare product and will therefore require specific regulation.</p><p id="par0415" class="elsevierStylePara elsevierViewall">The regulation of medical devices at European level requires a high level of control over the phases of the product cycle to guarantee patient and user safety. All aspects related to design and development, production, marketing, distribution, and installation, among others, are regulated by Regulation (EU) 2017/745 of the European Parliament and of the Council, of 5 April 2017.</p><span id="sec0135" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Medical device</span><p id="par0420" class="elsevierStylePara elsevierViewall">A medical device is any instrument or device intended to be used for human beings, which does not achieve its primary intended action by pharmacological, immunological, or metabolic means, used for:<ul class="elsevierStyleList" id="lis0030"><li class="elsevierStyleListItem" id="lsti0100"><span class="elsevierStyleLabel">•</span><p id="par0425" class="elsevierStylePara elsevierViewall">Diagnosis, prevention, monitoring, prediction, prognosis, treatment, or alleviation of disease.</p></li><li class="elsevierStyleListItem" id="lsti0105"><span class="elsevierStyleLabel">•</span><p id="par0430" class="elsevierStylePara elsevierViewall">Diagnosis, monitoring, treatment, alleviation of or compensation for an injury or disability.</p></li><li class="elsevierStyleListItem" id="lsti0110"><span class="elsevierStyleLabel">•</span><p id="par0435" class="elsevierStylePara elsevierViewall">Investigation, replacement, or modification of the anatomy or of a physiological or pathological process or state.</p></li><li class="elsevierStyleListItem" id="lsti0115"><span class="elsevierStyleLabel">•</span><p id="par0440" class="elsevierStylePara elsevierViewall">Providing information by means of in vitro examination of specimens derived from the human body, including organ, blood, and tissue donations.</p></li></ul></p><p id="par0445" class="elsevierStylePara elsevierViewall">Medical devices are classified into 4 classes according to their purpose and inherent risks: class I, class IIa, class IIb and class III; the lowest risk is class I and the maximum is class III.</p></span><span id="sec0140" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Customised medical device</span><p id="par0450" class="elsevierStylePara elsevierViewall">For products manufactured for a specific patient, such as a 3D biomodel to support planning, a patient-specific surgical guide or a customised implant, the concept of a customised medical device must be considered.</p><p id="par0455" class="elsevierStylePara elsevierViewall">A customised medical device is defined as any product specially made in accordance with a written prescription from any person authorised by national law by virtue of that person’s professional qualifications, which gives under that person’s responsibility, specific design characteristics, and is intended for the sole use of a particular patient exclusively to meet their individual conditions and needs.</p></span><span id="sec0145" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0165">Manufacturing hospital</span><p id="par0460" class="elsevierStylePara elsevierViewall">With reference to intra-hospital additive manufacture, the rules are that healthcare establishments must have the possibility of manufacturing, modifying, and using products internally and thus meet, on a non-industrial scale, the specific needs of the target patient groups which cannot be satisfied at the same level of performance by another equivalent product available on the market.</p></span><span id="sec0150" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0170">Legal recommendations in a 3D printing hospital unit</span><p id="par0465" class="elsevierStylePara elsevierViewall">For a healthcare facility to manufacture, it must be stated in the documentation that the specific needs of the group of patients for which the products are intended cannot be met or cannot be met at the appropriate level of performance, by another equivalent product on the market.</p><p id="par0470" class="elsevierStylePara elsevierViewall">Hospitals manufacturing any medical device must comply with the following requirements:<ul class="elsevierStyleList" id="lis0035"><li class="elsevierStyleListItem" id="lsti0120"><span class="elsevierStyleLabel">-</span><p id="par0475" class="elsevierStylePara elsevierViewall">Draw up a statement containing the following information:<ul class="elsevierStyleList" id="lis0040"><li class="elsevierStyleListItem" id="lsti0125"><span class="elsevierStyleLabel">o</span><p id="par0480" class="elsevierStylePara elsevierViewall">Name and address of the manufacturer and all manufacturing sites.</p></li><li class="elsevierStyleListItem" id="lsti0130"><span class="elsevierStyleLabel">o</span><p id="par0485" class="elsevierStylePara elsevierViewall">If applicable, the name and address of the authorised representative.</p></li><li class="elsevierStyleListItem" id="lsti0135"><span class="elsevierStyleLabel">o</span><p id="par0490" class="elsevierStylePara elsevierViewall">Data identifying the product in question.</p></li><li class="elsevierStyleListItem" id="lsti0140"><span class="elsevierStyleLabel">o</span><p id="par0495" class="elsevierStylePara elsevierViewall">Declaration that the product is intended for use only by a specific patient or user, identified by a name, an acronym, or a numerical code.</p></li><li class="elsevierStyleListItem" id="lsti0145"><span class="elsevierStyleLabel">o</span><p id="par0500" class="elsevierStylePara elsevierViewall">Name of the person issuing the prescription and who is authorised to do so by national law by virtue of their professional qualification and, if applicable, the name of the healthcare facility concerned.</p></li><li class="elsevierStyleListItem" id="lsti0150"><span class="elsevierStyleLabel">o</span><p id="par0505" class="elsevierStylePara elsevierViewall">Specific characteristics of the product indicated by the prescription.</p></li><li class="elsevierStyleListItem" id="lsti0155"><span class="elsevierStyleLabel">o</span><p id="par0510" class="elsevierStylePara elsevierViewall">Declaration that the product conforms to the general safety and performance requirements of Annex 1 and, where applicable, an indication of any general safety and performance requirements that it does not fully meet, with reasons.</p></li><li class="elsevierStyleListItem" id="lsti0160"><span class="elsevierStyleLabel">o</span><p id="par0515" class="elsevierStylePara elsevierViewall">If applicable, indication that the device contains or incorporates a medicinal substance, including a human blood or human plasma derivative, or cells or tissues of human or animal origin as covered in Regulation (EU) No 722/2012.</p></li></ul></p></li><li class="elsevierStyleListItem" id="lsti0165"><span class="elsevierStyleLabel">-</span><p id="par0520" class="elsevierStylePara elsevierViewall">Make the documentation available to the competent national authorities showing the place(s) of manufacture and allowing an understanding of the design, manufacture, and operation of the product, including the expected performance.</p></li><li class="elsevierStyleListItem" id="lsti0170"><span class="elsevierStyleLabel">-</span><p id="par0525" class="elsevierStylePara elsevierViewall">Take the necessary measures to ensure that the manufacturing process guarantees the conformity of the products manufactured.</p></li></ul></p><p id="par0530" class="elsevierStylePara elsevierViewall">Therefore, in view of current legislation, the following documentation is advisable for intrahospital additive manufacturing:<ul class="elsevierStyleList" id="lis0045"><li class="elsevierStyleListItem" id="lsti0175"><p id="par0535" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0050"><li class="elsevierStyleListItem" id="lsti0180"><span class="elsevierStyleLabel">o</span><p id="par0540" class="elsevierStylePara elsevierViewall">Technical documentation for each medical device.</p></li><li class="elsevierStyleListItem" id="lsti0185"><span class="elsevierStyleLabel">o</span><p id="par0545" class="elsevierStylePara elsevierViewall">Medical device manufacturer's licence.</p></li><li class="elsevierStyleListItem" id="lsti0190"><span class="elsevierStyleLabel">o</span><p id="par0550" class="elsevierStylePara elsevierViewall">Quality system ISO 13485:2016.</p></li></ul></p></li></ul></p><p id="par0555" class="elsevierStylePara elsevierViewall">In cases where required, POC manufacturing will allow networking with other health centres or manufacturing companies that are in possession of the above documentation.</p></span></span></span><span id="sec0155" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0175">Conclusions</span><p id="par0560" class="elsevierStylePara elsevierViewall">Medical 3DP in OST is an innovative and growing technology with many practical applications. The use of 3D biomodels for preoperative planning, surgeries assisted by patient-specific surgical guides, custom-made splints or implants and the application of bioengineering techniques are some of the utilities that will reduce costs and surgical times and will increase the safety of interventions and patient and doctor satisfaction.</p><p id="par0565" class="elsevierStylePara elsevierViewall">The current technological development enables the whole process of design, validation, and manufacturing of medical products to be integrated in the hospital itself. This requires the establishment of workflows and the implementation of existing legislation.</p><p id="par0570" class="elsevierStylePara elsevierViewall">It is essential that surgeons, as the medical specialists responsible for prescribing and delivering treatment, know this technology and its uses for the correct implementation of personalised medicine.</p></span><span id="sec0160" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0180">Level of evidence</span><p id="par0575" class="elsevierStylePara elsevierViewall">Level of evidence IV.</p></span><span id="sec0165" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0185">Conflicts of interest</span><p id="par0580" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:13 [ 0 => array:3 [ "identificador" => "xres1469348" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1338366" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1469349" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1338365" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction: 3D printing" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "3D printing in medicine" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "3D biomodels" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Customised tools" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Customised implants" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Drugs" ] 4 => array:2 [ "identificador" => "sec0035" "titulo" => "Bioprinting" ] ] ] 6 => array:3 [ "identificador" => "sec0040" "titulo" => "3D printing in orthopaedic surgery and traumatology" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0045" "titulo" => "Preoperative planning in orthopaedic surgery and traumatology with 3D biomodels" ] 1 => array:2 [ "identificador" => "sec0050" "titulo" => "Patient-specific surgical guides in orthopaedics and traumatology" ] 2 => array:2 [ "identificador" => "sec0055" "titulo" => "Orthoses and splints manufactured using 3D printing" ] 3 => array:2 [ "identificador" => "sec0060" "titulo" => "Customised implants in orthopaedic surgery and traumatology" ] 4 => array:2 [ "identificador" => "sec0065" "titulo" => "3D printing and tissue engineering in cartilage and bone" ] ] ] 7 => array:3 [ "identificador" => "sec0070" "titulo" => "Medical 3D printing process" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0075" "titulo" => "Acquisition" ] 1 => array:2 [ "identificador" => "sec0080" "titulo" => "Segmenting" ] 2 => array:3 [ "identificador" => "sec0085" "titulo" => "Processing" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0090" "titulo" => "Preoperative planning using computer-aided design models" ] ] ] 3 => array:2 [ "identificador" => "sec0095" "titulo" => "3D printing manufacture" ] ] ] 8 => array:3 [ "identificador" => "sec0100" "titulo" => "Implementation of 3D printing: 3D printing hospital units" "secciones" => array:2 [ 0 => array:3 [ "identificador" => "sec0105" "titulo" => "Creation of a digital hospital manufacturing workshop" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0110" "titulo" => "Elements needed to start a hospital 3D printing unit" ] 1 => array:2 [ "identificador" => "sec0115" "titulo" => "Human capital" ] 2 => array:2 [ "identificador" => "sec0120" "titulo" => "Technological resources" ] 3 => array:2 [ "identificador" => "sec0125" "titulo" => "Material resources" ] ] ] 1 => array:3 [ "identificador" => "sec0130" "titulo" => "Medical 3D printing regulatory framework" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0135" "titulo" => "Medical device" ] 1 => array:2 [ "identificador" => "sec0140" "titulo" => "Customised medical device" ] 2 => array:2 [ "identificador" => "sec0145" "titulo" => "Manufacturing hospital" ] 3 => array:2 [ "identificador" => "sec0150" "titulo" => "Legal recommendations in a 3D printing hospital unit" ] ] ] ] ] 9 => array:2 [ "identificador" => "sec0155" "titulo" => "Conclusions" ] 10 => array:2 [ "identificador" => "sec0160" "titulo" => "Level of evidence" ] 11 => array:2 [ "identificador" => "sec0165" "titulo" => "Conflicts of interest" ] 12 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-04-27" "fechaAceptado" => "2020-06-14" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1338366" "palabras" => array:5 [ 0 => "Additive manufacturing" 1 => "Patient-specific surgical guide" 2 => "Custom implants" 3 => "Bioprinting" 4 => "Medical 3d printing" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1338365" "palabras" => array:5 [ 0 => "Fabricación de aditivos" 1 => "Guía quirúrgica específica para el paciente" 2 => "Implantes personalizados" 3 => "Bioimpresión" 4 => "Impresión médica en 3D" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">3D printing (I3D) is an additive manufacturing technology with a growing interest in medicine and especially in the specialty of Orthopaedic Surgery and Traumatology. There are numerous applications that add value to the personalised treatment of patients: advanced preoperative planning, surgeries with specific tools for each patient, customised orthotic treatments, personalised implants or prostheses and innovative development in the field of bone and cartilage tissue engineering.</p><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">This paper provides an update on the role that the orthopaedic surgeon and traumatologist plays as a user and prescriber of this technology and a review of the stages required for the correct integration of I3D into the hospital care flow, from the necessary resources to the current legal recommendations.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">La impresión 3D (I3D) es una tecnología de fabricación aditiva con un creciente interés en medicina y sobre todo en la especialidad de Cirugía Ortopédica y Traumatología. Hay numerosas aplicaciones que aportan un valor añadido al tratamiento personalizado de los pacientes: planificación preoperatoria avanzada, cirugías con herramientas específicas para cada paciente, tratamientos ortésicos a medida, implantes o prótesis personalizadas y un desarrollo innovador en el campo de la ingeniería de tejidos óseos y cartilaginosos.</p><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">En el presente trabajo se realiza una actualización sobre el papel que el cirujano ortopédico y traumatólogo desempeña como usuario y como médico prescriptor de esta tecnología y un repaso a las etapas necesarias para una correcta integración de la I3D en el flujo asistencial hospitalario, desde los recursos necesarios hasta las recomendaciones legales actuales.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Andrés-Cano P, Calvo-Haro JA, Fillat-Gomà F, Andrés-Cano I, Perez-Mañanes R. Papel del cirujano ortopédico y traumatólogo en la impresión 3D: aplicaciones actuales y aspectos legales para una medicina personalizada. Rev Esp Cir Ortop Traumatol. 2021;65:138–151.</p>" ] ] "multimedia" => array:8 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1292 "Ancho" => 2338 "Tamanyo" => 129459 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Number of publications per year on 3D printing in medicine (Source: <span class="elsevierStyleInterRef" id="intr0005" href="http://pubmed.ncbi.nlm.nih.gov">pubmed.ncbi.nlm.nih.gov</span>).</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1079 "Ancho" => 1740 "Tamanyo" => 299859 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">3D biomodels in OST. A) Preoperative planning. B) Premoulding of plates. C) Intra-operative help. D) Sterilisation for surgical use. E) Doctor-patient communication. F) Medical training.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1090 "Ancho" => 1740 "Tamanyo" => 208617 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Example of a patient-specific surgical guide for the elevation of a sunken joint fragment in a tibial plateau fracture. A) CAD model and virtual planning of guide. B) CAD model of the surgical guide. C) Intervention with patient-specific surgical guide. D) Radioscopy prior to joint fragment elevation. E) Radioscopy during joint fragment elevation.</p>" ] ] 3 => array:8 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1010 "Ancho" => 1740 "Tamanyo" => 172651 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Example of a wrist orthosis made using 3D printing 3D. A) Virtual rendering after Surface scanning. B) CAD model of customised orthosis. C) 3D printing using FDM technology on PLA material. D) Correct application of the orthosis.</p>" ] ] 4 => array:8 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 1306 "Ancho" => 1740 "Tamanyo" => 288140 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0025" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Phases of the medical 3D printing process.</p>" ] ] 5 => array:8 [ "identificador" => "fig0030" "etiqueta" => "Figure 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 1182 "Ancho" => 2175 "Tamanyo" => 261766 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0030" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Segmentation tools at <span class="elsevierStyleItalic">Invesalius</span> (Centro de Tecnologia da Informação Renato Archer, Campinas, SP, Brazil). A): Paint brush-type manual. B) Automatic threshold type.</p>" ] ] 6 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0035" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">ABS: Acrylonitrile butadiene styrene; DMLS: Direct metal laser sintering; FDM: Fused deposition modelling; MJ: Material jetting or polyjet; MJF: Multijet fusion; PLA: Polylactic acid; SLA: Stereolithography; TPU 95A: Thermoplastic polyurethane.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Utility \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Technology \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Material \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3D planning biomodel \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FDM \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PLA/ABS/TPU 95A \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3D demonstration biomodel \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">MJ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Photopolymers \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Patient-specific guide \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SLA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sterilisable resin \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Orthesis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">MJF \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Nylon \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Surgical instruments \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">DMLS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Stainless steel \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Customised Implant \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">DMLS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Titanium (Ti-6Al-4V) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2528424.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Most frequently used technologies and materials for 3D printing in OST.</p>" ] ] 7 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0040" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Surgical instruments: reusable (class I<span class="elsevierStyleSmallCaps">)</span>, non-reusable (class IIa).</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Implants: osteosynthesis material: IIb.</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Total or partial joint prostheses III.</p><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Source: compiled by the authors.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Product \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Use \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Customised medical device \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Class \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3D biomodel \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Demonstration \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3D biomodel \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Surgical planning \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">I \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Patient-specific guide \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Surgical \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">IIa \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Orthesis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Therapeutic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">IIa \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Surgical instruments \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Surgical \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">I/IIa \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Implant \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Surgical \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">IIb/III \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2528425.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Classification of customised medical devices according to use and class.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:83 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The shape of things to come" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.2014.9542" "Revista" => array:5 [ "tituloSerie" => "JAMA." "fecha" => "2014" "volumen" => "312" "paginaInicial" => "2213" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Advantages and disadvantages of 3-dimensional printing in surgery: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.surg.2015.12.017" "Revista" => array:6 [ "tituloSerie" => "Surgery." "fecha" => "2016" "volumen" => "159" "paginaInicial" => "1485" "paginaFinal" => "1500" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fundamentals and applications of 3D printing for novel materials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.apmt.2017.02.004" "Revista" => array:5 [ "tituloSerie" => "Appl Mater Today." "fecha" => "2017" "volumen" => "7" "paginaInicial" => "120" "paginaFinal" => "133" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Progressive 3D printing technology and its application in medical materials" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3389/fphar.2020.00122" "Revista" => array:4 [ "tituloSerie" => "Front Pharmacol." "fecha" => "2020" "volumen" => "11" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3D printing: an industrial revolution" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/15424065.2014.877247" "Revista" => array:5 [ "tituloSerie" => "J Electron Resour Med Libr." "fecha" => "2014" "volumen" => "11" "paginaInicial" => "39" "paginaFinal" => "45" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of CT and MRI in the design and development of orthopaedic model using additive manufacturing" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jcot.2018.07.002" "Revista" => array:6 [ "tituloSerie" => "J Clin Orthop Trauma." "fecha" => "2018" "volumen" => "9" "paginaInicial" => "213" "paginaFinal" => "217" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3D printout models vs. 3D-rendered images: which is better for preoperative planning?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jsurg.2016.01.003" "Revista" => array:6 [ "tituloSerie" => "J Surg Educ." "fecha" => "2016" "volumen" => "73" "paginaInicial" => "518" "paginaFinal" => "523" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3D-printed model improves clinical assessment of surgeons on anatomy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11701-018-0809-2" "Revista" => array:6 [ "tituloSerie" => "J Robot Surg." "fecha" => "2018" "volumen" => "13" "paginaInicial" => "61" "paginaFinal" => "67" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increasing access to medical training with three-dimensional printing: creation of an endotracheal intubation model" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2196/12626" "Revista" => array:3 [ "tituloSerie" => "JMIR Med Educ." "fecha" => "2019" "volumen" => "5" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Investigating the perceived efficacy of a silicone suturing task trainer using input from novice medical trainees" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.7759/cureus.6612" "Revista" => array:2 [ "tituloSerie" => "Cureus." "fecha" => "2020" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multi-institutional evaluation of producing and testing a novel 3D-printed laparoscopic trainer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.urology.2018.06.034" "Revista" => array:6 [ "tituloSerie" => "Urology." "fecha" => "2019" "volumen" => "124" "paginaInicial" => "297" "paginaFinal" => "301" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Artificial vascular models for endovascular training (3D printing)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1515/iss-2018-0020" "Revista" => array:6 [ "tituloSerie" => "Innov Surg Sci." "fecha" => "2018" "volumen" => "3" "paginaInicial" => "225" "paginaFinal" => "234" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A practical 3D-printed model for training of endoscopic and exoscopic intracerebral hematoma surgery with a tubular retractor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1055/s-0039-1697023" "Revista" => array:2 [ "tituloSerie" => "J Neurol Surg Part A: Central Eur Neurosurg." "fecha" => "2020" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development and validation of a procedure-specific assessment tool for hands-on surgical training in congenital heart surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jtcvs.2019.11.130" "Revista" => array:3 [ "tituloSerie" => "J Thorac Cardiovasc Surg." "fecha" => "2019" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development of a high fidelity subglottic stenosis simulator for laryngotracheal reconstruction rehearsal using 3D printing" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijporl.2019.05.027" "Revista" => array:6 [ "tituloSerie" => "Int J Pediatr Otorhinolaryngol." "fecha" => "2019" "volumen" => "124" "paginaInicial" => "134" "paginaFinal" => "138" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The production of anatomical teaching resources using three-dimensional (3D) printing technology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ase.1475" "Revista" => array:5 [ "tituloSerie" => "Anatom Sci Educ." "fecha" => "2014" "volumen" => "7" "paginaInicial" => "479" "paginaFinal" => "486" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of 3D printed models in medical education: a randomized control trial comparing 3D prints versus cadaveric materials for learning external cardiac anatomy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ase.1573" "Revista" => array:5 [ "tituloSerie" => "Anatom Sci Educ." "fecha" => "2015" "volumen" => "9" "paginaInicial" => "213" "paginaFinal" => "221" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "What would you like to print? Students’ opinions on the use of 3D printing technology in medicine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0230851" "Revista" => array:4 [ "tituloSerie" => "PLOS ONE." "fecha" => "2020" "volumen" => "15" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3D-printing techniques in a medical setting: a systematic literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s12938-016-0236-4" "Revista" => array:4 [ "tituloSerie" => "BioMed Eng OnLine." "fecha" => "2016" "volumen" => "15" "itemHostRev" => array:3 [ "pii" => "S0165032714000214" "estado" => "S300" "issn" => "01650327" ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3D printer application for endoscope-assisted spine surgery instrument development: from prototype instruments to patient-specific 3D models" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3349/ymj.2020.61.1.94" "Revista" => array:5 [ "tituloSerie" => "Yonsei Med J." "fecha" => "2020" "volumen" => "61" "paginaInicial" => "94" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3D printed surgical instruments: the design and fabrication process" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00268-017-3946-2" "Revista" => array:3 [ "tituloSerie" => "World J Surg." "fecha" => "2017" "volumen" => "41" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current state of 3D-printed custom-made spinal implants" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s2589-7500(19)30081-0" "Revista" => array:5 [ "tituloSerie" => "Lancet Dig Health." "fecha" => "2019" "volumen" => "1" "paginaInicial" => "e149" "paginaFinal" => "50" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The lancet technology: 3D printing for instruments, models, and organs?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0140-6736(16)31735-4" "Revista" => array:5 [ "tituloSerie" => "Lancet." "fecha" => "2016" "volumen" => "388" "paginaInicial" => "1368" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3D-printed spine surgery implants: a systematic review of the efficacy and clinical safety profile of patient-specific and off-the-shelf devices" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00586-019-06236-2" "Revista" => array:2 [ "tituloSerie" => "Eur Spine J." "fecha" => "2019" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Three-dimensional printing of metals for biomedical applications" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.mtbio.2019.100024" "Revista" => array:3 [ "tituloSerie" => "Mater Today Bio." "fecha" => "2019" "volumen" => "3" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "FDA approves first 3D-printed epilepsy drug experts assess the benefits and caveats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.nt.0000472137.66046.b5" "Revista" => array:5 [ "tituloSerie" => "Neurol Today" "fecha" => "2015" "volumen" => "15" "paginaInicial" => "26" "paginaFinal" => "27" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A new chapter in pharmaceutical manufacturing: 3D-printed drug products" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.addr.2016.03.001" "Revista" => array:5 [ "tituloSerie" => "Adv Drug Del Rev." "fecha" => "2017" "volumen" => "108" "paginaInicial" => "39" "paginaFinal" => "50" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3D printing technology: a new milestone in the development of pharmaceuticals" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2174/1381612825666190507115504" "Revista" => array:6 [ "tituloSerie" => "Curr Pharm Des." "fecha" => "2019" "volumen" => "25" "paginaInicial" => "937" "paginaFinal" => "945" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3D bioprinting for engineering complex tissues" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.biotechadv.2015.12.011" "Revista" => array:6 [ "tituloSerie" => "Biotechnol Adv." "fecha" => "2016" "volumen" => "34" "paginaInicial" => "422" "paginaFinal" => "434" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biofabrication" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/bto.0000000000000184" "Revista" => array:5 [ "tituloSerie" => "Techn Orthop." "fecha" => "2016" "volumen" => "31" "paginaInicial" => "190" "paginaFinal" => "203" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bioinks for 3D bioprinting: an overview" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1039/c7bm00765e" "Revista" => array:6 [ "tituloSerie" => "Biomater Sci." "fecha" => "2018" "volumen" => "6" "paginaInicial" => "915" "paginaFinal" => "946" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Publication trends and knowledge mapping in 3D printing in orthopaedics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jcot.2018.07.006" "Revista" => array:5 [ "tituloSerie" => "J Clin Orthop Trauma." "fecha" => "2018" "volumen" => "9" "paginaInicial" => "194" "paginaFinal" => "201" ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3D printing and its applications in orthopaedic trauma: a technological marvel" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jcot.2018.07.022" "Revista" => array:6 [ "tituloSerie" => "J Clin Orthop Trauma." "fecha" => "2018" "volumen" => "9" "paginaInicial" => "260" "paginaFinal" => "268" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3D printing: clinical applications in orthopaedics and traumatology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1302/2058-5241.1.000012" "Revista" => array:6 [ "tituloSerie" => "EFORT Open Rev." "fecha" => "2016" "volumen" => "1" "paginaInicial" => "121" "paginaFinal" => "127" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of three-dimensional printing in preoperative planning in orthopaedic trauma surgery: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5312/wjo.v11.i1.57" "Revista" => array:6 [ "tituloSerie" => "World J Orthop." "fecha" => "2019" "volumen" => "11" "paginaInicial" => "57" "paginaFinal" => "67" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radiological Society of North America (RSNA) 3D printing Special Interest Group (SIG): guidelines for medical 3D printing and appropriateness for clinical scenarios" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s41205-018-0030-y" "Revista" => array:3 [ "tituloSerie" => "3D Print Med." "fecha" => "2018" "volumen" => "4" ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Medical 3D printing cost-savings in orthopedic and maxillofacial surgery: cost analysis of operating room time saved with 3D printed anatomic models and surgical guides" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.acra.2019.08.011" "Revista" => array:2 [ "tituloSerie" => "Acad Radiol." "fecha" => "2019" ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Percutaneous pedicle screw placement aided by a new drill guide template combined with fluoroscopy: an accuracy study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/os.12642" "Revista" => array:2 [ "tituloSerie" => "Orthop Surg." "fecha" => "2020" ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3D printing utility for surgical treatment of acetabular fractures" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.recote.2018.05.002" "Revista" => array:5 [ "tituloSerie" => "Rev Esp Cir Ortop Traumatol (English Edition)." "fecha" => "2018" "volumen" => "62" "paginaInicial" => "231" "paginaFinal" => "239" ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3D printing technology for the classification of complex distal humerus fractures" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.21037/aoj.2018.10.05" "Revista" => array:3 [ "tituloSerie" => "Ann Joint." "fecha" => "2018" "volumen" => "3" ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0205" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Application of 3D printing in the surgical planning of trimalleolar fracture and doctor-patient communication" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1155/2016/2482086" "Revista" => array:5 [ "tituloSerie" => "BioMed Res Int." "fecha" => "2016" "volumen" => "2016" "paginaInicial" => "1" "paginaFinal" => "5" ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0210" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development of a novel customized cutting and rotating template for Bernese periacetabular osteotomy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s13018-019-1267-x" "Revista" => array:3 [ "tituloSerie" => "J Orthop Surg Res." "fecha" => "2019" "volumen" => "14" ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0215" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Three-dimensional-printing technology in hip and pelvic surgery: current landscape" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5371/hp.2020.32.1.1" "Revista" => array:5 [ "tituloSerie" => "Hip Pelvis." "fecha" => "2020" "volumen" => "32" "paginaInicial" => "1" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0220" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical applications of 3-dimensional printing technology in hip joint" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/os.12468" "Revista" => array:6 [ "tituloSerie" => "Orthop Surg." "fecha" => "2019" "volumen" => "11" "paginaInicial" => "533" "paginaFinal" => "544" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0225" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3D printing-assisted osteotomy treatment for the malunionof lateral tibial plateau fracture" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.injury.2016.09.025" "Revista" => array:6 [ "tituloSerie" => "Injury." "fecha" => "2016" "volumen" => "47" "paginaInicial" => "2816" "paginaFinal" => "2821" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0230" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bone tumor resection guide using three-dimensional printing for limb salvage surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/jso.25236" "Revista" => array:6 [ "tituloSerie" => "J Surg Oncol." "fecha" => "2018" "volumen" => "118" "paginaInicial" => "898" "paginaFinal" => "905" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0235" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy evaluation of three-dimensional printing assisted osteotomy guide plate in accurate osteotomy of adolescent cubitus varus deformity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s13018-019-1403-7" "Revista" => array:3 [ "tituloSerie" => "J Orthop Surg Res." "fecha" => "2019" "volumen" => "14" ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0240" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3D printing in spine surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.21037/atm.2019.08.88" "Revista" => array:4 [ "tituloSerie" => "Ann Trans Med." "fecha" => "2019" "volumen" => "7" "itemHostRev" => array:3 [ "pii" => "S0022395612001422" "estado" => "S300" "issn" => "00223956" ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0245" "etiqueta" => "49" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Experimental study and preliminary clinical application of mini-invasive percutaneous internal screw fixation for scaphoid fracture under the guidance of a 3D-printed guide plate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11596-019-2133-0" "Revista" => array:6 [ "tituloSerie" => "Curr Med Sci." "fecha" => "2019" "volumen" => "39" "paginaInicial" => "990" "paginaFinal" => "996" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0250" "etiqueta" => "50" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3D-printed patient-specific guides for hip arthroplasty" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5435/jaaos-d-16-00719" "Revista" => array:5 [ "tituloSerie" => "J Am Acad Orthop Surg." "fecha" => "2018" "volumen" => "26" "paginaInicial" => "e342" "paginaFinal" => "8" ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0255" "etiqueta" => "51" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Augmented reality in computer-assisted interventions based on patient-specific 3D printed reference" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1049/htl.2018.5072" "Revista" => array:6 [ "tituloSerie" => "Healthc Technol Lett." "fecha" => "2018" "volumen" => "5" "paginaInicial" => "162" "paginaFinal" => "166" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0260" "etiqueta" => "52" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combining augmented reality and 3D printing to display patient models on a smartphone" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3791/60618" "Revista" => array:3 [ "tituloSerie" => "J Vis Exp." "fecha" => "2020" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0265" "etiqueta" => "53" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The development of a wrist brace using 3D scanner and 3D printer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5805/sfti.2017.19.3.312" "Revista" => array:5 [ "tituloSerie" => "Fashion Text Res J." "fecha" => "2017" "volumen" => "19" "paginaInicial" => "312" "paginaFinal" => "319" ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0270" "etiqueta" => "54" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Advances in orthotic and prosthetic manufacturing: a technology review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3390/ma13020295" "Revista" => array:4 [ "tituloSerie" => "Materials." "fecha" => "2020" "volumen" => "13" "paginaInicial" => "295" ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0275" "etiqueta" => "55" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Feasibility of designing, manufacturing and delivering 3D printed ankle-foot orthoses: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s13047-019-0321-6" "Revista" => array:3 [ "tituloSerie" => "J Foot Ankle Res." "fecha" => "2019" "volumen" => "12" ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0280" "etiqueta" => "56" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ankle-foot orthosis made by 3D printing technique and automated design software" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1155/2017/9610468" "Revista" => array:5 [ "tituloSerie" => "Appl Bionics Biomech." "fecha" => "2017" "volumen" => "2017" "paginaInicial" => "1" "paginaFinal" => "6" ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib0285" "etiqueta" => "57" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of personalized wrist orthosis for wrist pain with three-dimensional scanning and printing technique: a preliminary, randomized, controlled, open-label study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/0309364618785725" "Revista" => array:6 [ "tituloSerie" => "Prosthet Orthot Int." "fecha" => "2018" "volumen" => "42" "paginaInicial" => "636" "paginaFinal" => "643" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib0290" "etiqueta" => "58" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proposal of custom made wrist orthoses based on 3D modelling and 3D printing" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1109/embc.2017.8037682" "LibroEditado" => array:3 [ "titulo" => "2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)" "conferencia" => "IEEE" "serieFecha" => "2017" ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib0295" "etiqueta" => "59" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Workflow of CAD / CAM scoliosis brace adjustment in preparation using 3D printing" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2174/1874431101711010044" "Revista" => array:6 [ "tituloSerie" => "Open Med Inform J." "fecha" => "2017" "volumen" => "11" "paginaInicial" => "44" "paginaFinal" => "51" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib0300" "etiqueta" => "60" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The biomechanical difference between running with traditional and 3D printed orthoses" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/02640414.2019.1626069" "Revista" => array:6 [ "tituloSerie" => "J Sports Sci." "fecha" => "2019" "volumen" => "37" "paginaInicial" => "2191" "paginaFinal" => "2197" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib0305" "etiqueta" => "61" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "One-step reconstruction with a 3D-printed, biomechanically evaluated custom implant after complex pelvic tumor resection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3109/10929088.2015.1076039" "Revista" => array:5 [ "tituloSerie" => "Computer Aided Surg." "fecha" => "2015" "volumen" => "20" "paginaInicial" => "14" "paginaFinal" => "23" ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib0310" "etiqueta" => "62" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Three-dimensional-printed intercalary prosthesis for the reconstruction of large bone defect after joint-preserving tumor resection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/jso.25826" "Revista" => array:6 [ "tituloSerie" => "J Surg Oncol." "fecha" => "2020" "volumen" => "121" "paginaInicial" => "570" "paginaFinal" => "577" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib0315" "etiqueta" => "63" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reconstruction with constrained scapular prosthesis after total scapulectomy for scapular malignant tumor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/jso.25118" "Revista" => array:6 [ "tituloSerie" => "J Surg Oncol." "fecha" => "2018" "volumen" => "118" "paginaInicial" => "177" "paginaFinal" => "183" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib0320" "etiqueta" => "64" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "One-step reconstruction with a 3D-printed, custom-made prosthesis after total en bloc sacrectomy: a technical note" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00586-016-4871-z" "Revista" => array:7 [ "tituloSerie" => "Eur Spine J." "fecha" => "2016" "volumen" => "26" "paginaInicial" => "1902" "paginaFinal" => "1909" "link" => array:1 [ 0 => array:2 [ …2] ] "itemHostRev" => array:3 [ "pii" => "S0022395614002386" "estado" => "S300" "issn" => "00223956" ] ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib0325" "etiqueta" => "65" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Three-dimension-printed custom-made prosthetic reconstructions: from revision surgery to oncologic reconstructions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00264-018-4232-0" "Revista" => array:7 [ "tituloSerie" => "Int Orthop." "fecha" => "2018" "volumen" => "43" "paginaInicial" => "123" "paginaFinal" => "132" "link" => array:1 [ 0 => array:2 [ …2] ] "itemHostRev" => array:3 [ "pii" => "S0165178116305649" "estado" => "S300" "issn" => "01651781" ] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib0330" "etiqueta" => "66" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3D printed custom made talus prosthesis coupled with total ankle artroplasty: a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.fas.2017.07.313" "Revista" => array:6 [ "tituloSerie" => "Foot Ankle Surg." "fecha" => "2017" "volumen" => "23" "paginaInicial" => "74" "paginaFinal" => "75" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib0335" "etiqueta" => "67" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The use of an Ossis custom 3D-printed tri-flanged acetabular implant for major bone loss: minimum 2-year follow-up" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/1120700018760817" "Revista" => array:6 [ "tituloSerie" => "HIP Int." "fecha" => "2018" "volumen" => "28" "paginaInicial" => "668" "paginaFinal" => "674" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 67 => array:3 [ "identificador" => "bib0340" "etiqueta" => "68" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Surgical applications of three-dimensional printing in the pelvis and acetabulum: from models and tools to implants" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00113-019-0626-8" "Revista" => array:6 [ "tituloSerie" => "Der Unfallchirurg." "fecha" => "2019" "volumen" => "122" "paginaInicial" => "278" "paginaFinal" => "285" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 68 => array:3 [ "identificador" => "bib0345" "etiqueta" => "69" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of principles inspiring design of three-dimensional-printed custom-made prostheses in two referral centres" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00264-020-04523-y" "Revista" => array:2 [ "tituloSerie" => "Int Orthop." "fecha" => "2020" ] ] ] ] ] ] 69 => array:3 [ "identificador" => "bib0350" "etiqueta" => "70" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The utility of 3D printing for surgical planning and patient-specific implant design for complex spinal pathologies: case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/2016.9.spine16371" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg Spine." "fecha" => "2017" "volumen" => "26" "paginaInicial" => "513" "paginaFinal" => "518" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 70 => array:3 [ "identificador" => "bib0355" "etiqueta" => "71" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Three-dimensional bioprinting for bone and cartilage restoration in orthopaedic surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5435/jaaos-d-17-00632" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Orthop Surg." "fecha" => "2019" "volumen" => "27" "paginaInicial" => "e215" "paginaFinal" => "26" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 71 => array:3 [ "identificador" => "bib0360" "etiqueta" => "72" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Three-dimensional bioprinting of multilayered constructs containing human mesenchymal stromal cells for osteochondral tissue regeneration in the rabbit knee joint" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1088/1758-5090/8/1/014102" "Revista" => array:3 [ "tituloSerie" => "Biofabrication." "fecha" => "2016" "volumen" => "8" ] ] ] ] ] ] 72 => array:3 [ "identificador" => "bib0365" "etiqueta" => "73" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Advances in three‐dimensional bioprinting of bone: progress and challenges" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/term.2847" "Revista" => array:2 [ "tituloSerie" => "J Tissue Eng Regen Med." "fecha" => "2019" ] ] ] ] ] ] 73 => array:3 [ "identificador" => "bib0370" "etiqueta" => "74" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Key components of engineering vascularized 3-dimensional bioprinted bone constructs" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.trsl.2019.08.010" "Revista" => array:5 [ "tituloSerie" => "Trans Res." "fecha" => "2020" "volumen" => "216" "paginaInicial" => "57" "paginaFinal" => "76" ] ] ] ] ] ] 74 => array:3 [ "identificador" => "bib0375" "etiqueta" => "75" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reconstruction of large skeletal defects: current clinical therapeutic strategies and future directions using 3D printing" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3389/fbioe.2020.00061" "Revista" => array:4 [ "tituloSerie" => "Front Bioeng Biotechnol." "fecha" => "2020" "volumen" => "8" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 75 => array:3 [ "identificador" => "bib0380" "etiqueta" => "76" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Maintaining safety and efficacy for 3D printing in medicine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s41205-016-0009-5" "Revista" => array:4 [ "tituloSerie" => "3D Print Med." "fecha" => "2017" "volumen" => "3" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 76 => array:3 [ "identificador" => "bib0385" "etiqueta" => "77" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A practical guide to image processing in the creation of 3D models for orthopedics" "autores" => array:1 [ 0 => array:2 [ "etal" => false …1 ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/bto.0000000000000181" "Revista" => array:5 [ "tituloSerie" => "Techn Orthop." "fecha" => "2016" "volumen" => "31" "paginaInicial" => "153" "paginaFinal" => "163" ] ] ] ] ] ] 77 => array:3 [ "identificador" => "bib0390" "etiqueta" => "78" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CT imaging parameters for precision models using additive manufacturing" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s41939-019-00046-1" "Revista" => array:5 [ "tituloSerie" => "Multiscale Multidiscip Model Exp Des." "fecha" => "2019" "volumen" => "2" "paginaInicial" => "209" "paginaFinal" => "220" ] ] ] ] ] ] 78 => array:3 [ "identificador" => "bib0395" "etiqueta" => "79" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dual-layer spectral computerized tomography for metal artifact reduction: small versus large orthopedic devices" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00256-019-03248-3" "Revista" => array:7 [ "tituloSerie" => "Skeletal Radiol." "fecha" => "2019" "volumen" => "48" "paginaInicial" => "1981" "paginaFinal" => "1990" "link" => array:1 [ …1] "itemHostRev" => array:3 [ …3] ] ] ] ] ] ] 79 => array:3 [ "identificador" => "bib0400" "etiqueta" => "80" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nuestra experiencia con impresión 3D doméstica en Cirugía Ortopédica y Traumatología. Hazlo tú mismo" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rslaot.2016.06.004" "Revista" => array:5 [ "tituloSerie" => "Rev Latinoam Cir Ortop." "fecha" => "2016" "volumen" => "1" "paginaInicial" => "47" "paginaFinal" => "53" ] ] ] ] ] ] 80 => array:3 [ "identificador" => "bib0405" "etiqueta" => "81" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3D printing in healthcare: emerging applications" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/15323269.2016.1188042" "Revista" => array:5 [ "tituloSerie" => "J Hosp Librariansh." "fecha" => "2016" "volumen" => "16" "paginaInicial" => "255" "paginaFinal" => "267" ] ] ] ] ] ] 81 => array:3 [ "identificador" => "bib0410" "etiqueta" => "82" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of fused deposit modeling for additive manufacturing in hospital facilities: European certification directives" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jcms.2017.06.018" "Revista" => array:5 [ "tituloSerie" => "J Cranio-Maxillofac Surg." "fecha" => "2017" "volumen" => "45" "paginaInicial" => "1542" "paginaFinal" => "1546" ] ] ] ] ] ] 82 => array:3 [ "identificador" => "bib0415" "etiqueta" => "83" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regulatory considerations in the design and manufacturing of implantable 3D-printed medical devices" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/cts.12315" "Revista" => array:5 [ "tituloSerie" => "Clin Trans Sci." "fecha" => "2015" "volumen" => "8" "paginaInicial" => "594" "paginaFinal" => "600" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/19888856/0000006500000002/v1_202102230652/S1988885621000018/v1_202102230652/en/main.assets" "Apartado" => array:4 [ "identificador" => "7579" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Review article" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/19888856/0000006500000002/v1_202102230652/S1988885621000018/v1_202102230652/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1988885621000018?idApp=UINPBA00004N" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 11 | 0 | 11 |
2024 October | 44 | 8 | 52 |
2024 September | 79 | 35 | 114 |
2024 August | 61 | 17 | 78 |
2024 July | 121 | 5 | 126 |
2024 June | 85 | 7 | 92 |
2024 May | 47 | 8 | 55 |
2024 April | 62 | 34 | 96 |
2024 March | 131 | 20 | 151 |
2024 February | 126 | 19 | 145 |
2024 January | 155 | 19 | 174 |
2023 December | 203 | 26 | 229 |
2023 November | 125 | 20 | 145 |
2023 October | 161 | 35 | 196 |
2023 September | 101 | 13 | 114 |
2023 August | 40 | 10 | 50 |
2023 July | 51 | 17 | 68 |
2023 June | 66 | 17 | 83 |
2023 May | 141 | 21 | 162 |
2023 April | 119 | 11 | 130 |
2023 March | 132 | 13 | 145 |
2023 February | 65 | 9 | 74 |
2023 January | 70 | 11 | 81 |
2022 December | 68 | 18 | 86 |
2022 November | 69 | 16 | 85 |
2022 October | 59 | 24 | 83 |
2022 September | 46 | 43 | 89 |
2022 August | 55 | 12 | 67 |
2022 July | 53 | 22 | 75 |
2022 June | 39 | 12 | 51 |
2022 May | 40 | 12 | 52 |
2022 April | 38 | 15 | 53 |
2022 March | 46 | 12 | 58 |
2022 February | 50 | 9 | 59 |
2022 January | 33 | 9 | 42 |
2021 December | 36 | 13 | 49 |
2021 November | 44 | 12 | 56 |
2021 October | 47 | 22 | 69 |
2021 September | 37 | 13 | 50 |
2021 August | 52 | 9 | 61 |
2021 July | 39 | 14 | 53 |
2021 June | 41 | 11 | 52 |
2021 May | 45 | 9 | 54 |
2021 April | 115 | 20 | 135 |
2021 March | 28 | 17 | 45 |
2021 February | 11 | 13 | 24 |
2021 January | 2 | 8 | 10 |