Article information
RESUMEN
La enfermedad de Alzheimer (EA) se caracteriza por la muerte neuronal asociada a la presencia de placas seniles y ovillos neurofibrilares. El componente principal de las placas seniles es el péptido β- amiloide (Aβ) el cual es considerado como un inductor de la neurodegeneración observada en el cerebro de individuos con EA. El objetivo del presente trabajo es revisar el estado actual de la investigación básica sobre los mecanismos de acción neurotóxicos del Aβ, así como el efecto neuroprotector de los estrógenos y de distintos antioxidantes como la vitamina E y la melatonina.
Palabras clave:
β-amiloide
Estrés oxidativo
Antioxidantes
Estrógenos
SUMMARY
The hallmarks of Alzheimer’s disease (AD) are neuronal death, senile plaques and neurofibrillary tangles. Senile plaques are mainly composed of amyloid β-peptide (Aβ) which is considered to trigger the neurodegeneration found in the brains of AD patients. The main goal of the present work is to review the proposed mechanisms which are involved in the Aβ-mediated cytotoxicity and the neuroprotective role of estrogens and antioxidants such as vitamin E and melatonin.
Key words:
β-amyloid
Oxidative stress
Antioxidants
Estrogens
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