Article information
Resumen
La demencia por cuerpos de Lewy es un tipo de demencia más frecuente de lo que se consideraba hasta hace poco, y que se caracteriza por la escasez de recursos terapéuticos y la dificultad de tratamiento por la sensibilidad a los neurolépticos presente en muchos de los pacientes que la sufren. Aunque es necesaria una mayor investigación en este campo, la estandarización de los criterios para su diagnóstico ha permitido mejorar los datos procedentes de la investigación. Actualmente, los anticolines terásicos son fármacos de valor probado en esta indicación y hay pruebas cada vez mayores de que la memantina también puede resultar útil. Es importante no utilizar nunca neurolépticos típicos, que revisten gran peligro y, de entre los atípicos, aún a falta de resultados concluyentes, la quetiapina se perfila como la mejor opción.
Palabras clave:
Demencia por cuerpos de Lewy
Memantina
Anticolinesterásicos
Parkinsonismo
Abstract
Lewy body dementia (LBD) is more frequent than previously considered and is characterized by the scarcity of therapeutic resources and the difficulty of treatment since many patients are hypersensitive to neuroleptics. Although further research is required in this field, standardization of the diagnostic criteria has improved the data obtained from research. Currently, anticholinesterase drugs have proven utility in LBD and there is increasing evidence that memantine can also be useful. Typical neuroleptics are dangerous in these patients and should never be used. Among atypical neuroleptics, quetiapine is the best option, although conclusive data are lacking.
Keywords:
Lewy body dementia
Memantine
Anticholinesterase drugs
Parkinsonism
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