metricas
covid
Buscar en
Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
Toda la web
Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) Association between cardiovascular inflammation and alterations in immune system...
Journal Information
Vol. 43. Issue 5.
(September - October 2024)
Share
Share
Download PDF
More article options
Visits
3
Vol. 43. Issue 5.
(September - October 2024)
Original Article
Association between cardiovascular inflammation and alterations in immune system induced by HIV infection detected on [18F]FDG PET/MRI
Asociación entre la inflamación cardiovascular y los cambios del sistema inmune inducidos por la infección por VIH mediante PET/RM con [18F]FDG
Visits
3
J.R. Garciaa,
Corresponding author
jrgarcia@cetir.es

Corresponding author at: C/Viladomat 299, 08021 Barcelona, Spain. Tel.: 670677070
, R. Oliveroa, I. Arrieta-Aldeab, J.A. Romeroa, E. Rieraa, E. Cañas-Ruanob, N. Garridoa, J. Duc, R. Guerrib
a Unidad PET/RM, CETIR ASCIRES, Spain
b Servicio de Infecciosas, Hospital del Mar, Barcelona, Spain
c Instituto de Investigaciones Médicas, Hospital del Mar, Barcelona, Spain
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (7)
Show moreShow less
Tables (2)
Table 1. Cardiovascular biomarkers in the basal and one year control study.
Table 2. Inflammatory/immune biomarkers in the basal and one year control study.
Show moreShow less
Abstract
Objective

To assess by [18F]FDG PET/MR the biomarkers of HIV-induced inflammation at baseline and 1 year post-antiretroviral therapy (ART).

Methods

Prospective study, 14 patients, newly diagnosed HIV-positive, asymptomatic.

[18F]FDG PET/MRI (PET/MR-3.0T, Signa.GE) whole body and heart was performed, baseline and 1 year post-ART.

Qualitative vascular assessment (hepatic reference). Quantitative assessment (SUVmax) of the whole body. T1 and T2 value estimation in 16 myocardial segments.

Results

Baseline CMR showed in 3 (21.4%) a decreased LVEF, normalising post-TAR. Fibrosis was ruled out (T1), with no signs of myocardial oedema (T2) at baseline or post-TAR.

Four (28.6%) showed baseline vascular [18F]FDG uptake, two in ascending thoracic aorta and two in ascending and descending thoracic aorta, normalising post-TAR.

All (100%) showed basal lymph-nodes activity; supra (n:14) and infradiaphragmatic (n:13), laterocervical (n:14) and inguinal (n:13), with variable number of territories (9 patients >6;64.3%). Post-ART, 7 patients (50%) showed resolution and the other 7 reduction in extension (0 patients >5): 7 supra (100%) and 2 infradiaphragmatic (28.6%), 5 in the axilla and 2 in the groin.

All (100%) had persistent basal adenoid uptake post-ART, 9 (64.3%) splenic all resolved post-ART and 7 (50.5%) gastric, persistent 3 post-ART.

Conclusions

Cardiovascular biomarkers by [18F]FDG PET/MR have shown baseline 28.6% of patients with large vessel activity and 21.4% with low LVEF, normalising post-ART.

Inflammatory/immune biomarkers showed baseline activity in 100% of lymph-nodes, 100% adenoids, 64.3% splenic and 50.5% gastric. Post-TAR the reduction was 50% lymph-nodes, 0% adenoid, 100% splenic and 57.1% gastric.

Keywords:
Cardiovascular inflammation
Immune system
HIV infection
On [18F]FDG
PET/MRI
Resumen
Objetivo

Evaluar mediante [18F]FDG PET/RM los biomarcadores de inflamación inducidos por el VIH basal y 1 año post-tratamientos antirretrovirales (TAR).

Método

Estudio prospectivo, 14 pacientes, recién diagnosticados de VIH, asintomáticos.

Se realizó [18F]FDG PET/RM (PET/MR-3.0T, Signa.GE) de cuerpo completo y cardiaco, basal y 1 año post-TAR.

Valoración cualitativa vascular (referencia hepática). Valoración cuantitativa (SUVmax) de cuerpo completo. Estimación del valor T1 y T2 en 16 segmentos miocárdicos.

Resultado

La RMC basal mostró en 3 pacientes (21,4%) una FEVI disminuida, normalizándose post-TAR. Se descartó la presencia de fibrosis (T1), sin signos de edema miocárdico (T2) basal ni post-TAR.

En 4 (28,6%) se evidencio hipercaptación de [18F]FDG vascular basal, dos en aorta torácica ascendente y dos en aorta torácica ascendente y descendente, normalizándose post-TAR.

Todos (100%) mostraron actividad adenopática basal; supra (n:14) e infradiafragmática (n:13), laterocervical (n:14) e inguinal (n:13), variable el número de territorios (9 pacientes >6;64,3%). Post-TAR 7 pacientes (50%) mostraron su resolución y los otros 7 reducción en su extensión (0 pacientes >5): 7 supra (100%) y 2 infradiafragmáticos (28,6%), 5 en axila y 2 en ingle.

Todos (100%) presentaron captación adenoidea basal persistente post-TAR, 9 (64,3%) esplénica todas resueltas post-TAR y 7 (50,5%) gástrica, persistente 3 post-TAR.

Conclusiones

Los biomarcadores cardiovasculares mediante [18F]FDG PET/RM han mostrado basalmente un 28,6% de pacientes con actividad en grandes vasos y un 21,4% una baja FEVI, normalizándose post-TAR.

Los biomarcadores inflamatorios/inmunes han mostrado actividad basal en un 100% de adenopatías, 100% adenoides, 64,3% esplénica y 50,5% gástrica. Post-TAR la reducción fue del 50% adenopática, 0% adenoidea, 100% esplénica y 57,1% gástrica.

Palabras clave:
Inflamación cardiovascular
Sistema inmune
Infeccion por VIH
PET/RM con [18F]FDG

Article

These are the options to access the full texts of the publication Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

Quizás le interese:
10.1016/j.remnie.2021.10.005
No mostrar más