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Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) Correlation between pre-radical prostatectomy standardized SUVmax ratios detecte...
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Vol. 43. Issue 2.
Pages 100-106 (March - April 2024)
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Vol. 43. Issue 2.
Pages 100-106 (March - April 2024)
Original Article
Correlation between pre-radical prostatectomy standardized SUVmax ratios detected on 68Ga-PSMA-I&T PET/CT and final histopathology outcomes: an in-depth analysis
Correlación entre los índices de SUVmáx estandarizados previos a la prostatectomía radical detectados en 68Ga-PSMA-PET/CT y los resultados histopatológicos finales: un análisis en profundidad
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M.G. Arıkana,
Corresponding author
mgarikan26@gmail.com

Corresponding author.
, S. Soyluoğlub, Ü. Korkmazb, E. Taştekinc, U. Elboğad, E. Ardae
a Hatay Dörtyol State Hospital, Urology Clinic, Hatay, Turkey
b Trakya University School of Medicine, Department of Nuclear Medicine, Edirne, Turkey
c Trakya University School of Medicine, Department of Pathology, Edirne, Turkey
d Gaziantep University School of Medicine, Department of Nuclear Medicine, Gaziantep, Turkey
e Trakya University School of Medicine, Department of Urology, Edirne, Turkey
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Tables (5)
Table 1. Demographic, clinical and histopathological characteristics of the patients.
Table 2. Clinical and Histopathological Characteristics of the Patients.
Table 3. Correlation of Clinical and Histopathological Data with 68Ga-PSMA-I&T PET/CT Data.
Table 4. Relation of preoperative data with histopathological results.
Table 5. 68Ga-PSMA-I&T PET/CT and histopathological results in terms of SVI.
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Abstract
Objective

To evaluate the predictive potential of the maximum standardized uptake value(SUVmax) value of intraprostatic tumors derived from preoperative 68Ga-PSMA-I&T PET/CT (SUVT), and its ratios to SUVmax in the liver (SUVTLR) and parotid gland (SUVTPR) with respect to histopathological findings.

Materials and methods

Data from patients who underwent radical prostatectomy (RP) for prostate cancer (PC) at our clinic between 2017 and 2020 were assessed. Patients with a secondary malignancy, a history of transurethral prostate resection, prior treatment for PC, or who received salvage RP were excluded. Whole-body images obtained using the same device, as per the guidelines, were reviewed by two nuclear medicine specialists with more than a decade of experience to reach a consensus for each lesion. The relationships between age, PSA, Prostate Volume, clinical T stage, biopsy International Society of Urological Pathology grade (ISUP), D’amico risk group, intraprostatic tumor volume (HPTV) identified in the final histopathological specimen review, HP-ISUP grade, seminal vesicle invasion (SVI), extracapsular invasion (ECI), positive surgical margine (PSM), SUVT, SUVTLR, and SUVTPR were analyzed.

Results

The mean age of the 64 included patients was 64.1 ± 5.3. A statistically significant correlation was found between SUVT, SUVTLR, SUVTPR values, and histopathologic stage parameters, such as biopsy ISUP, D'amico Risk Classification, HP-ISUP, HPTV (p < 0.05). PSMATV, SUVT, and SUVTLR were statistically significant predictors of extracapsular invasion, while PSA, PSMATV, and SUVTLR were significant predictors of SVI (p < 0.05).

Conclusion

The standardized SUVT, SUVTLR, and SUVTPR values could be employed as noninvasive markers to assist in predicting postoperative histopathological findings, particularly ECI, SVI, and PSM.

Keywords:
Prostate cancer
68Ga-PSMA-I&T PET/CT
SUVmax
Histopathology
Predictive potential
Intraprostatic tumor
Prostatectomy
Abbrevetions:
PCA
PSA
PSMA
68Ga-PSMA-I&T PET/CT
SUVT
SUVTLR
SUVTPR
RP
PV
ISUP
HPTV
SVI
ECI
PSM
LNM
LND
PSMATV
PSMALNV
Resumen
Objetivo

Evaluar el potencial predictivo del valor máximo de captación estandarizada (SUVmax) de tumores intraprostáticos derivados de PET/TC preoperatoria con 68Ga-PSMA-I&T (SUVT), y sus relaciones con el SUVmax en el hígado (SUVTLR) y la glándula parótida (SUVTPR) con respecto a los hallazgos histopatológicos.

Materiales y Métodos

Se evaluaron datos de pacientes sometidos a prostatectomía radical (PR) por cáncer de próstata (CP) en nuestra clínica entre 2017 and 2020. Se excluyeron los pacientes con una neoplasia maligna secundaria, antecedentes de resección transuretral de próstata, tratamiento previo para CP o que recibieron PR de rescate. Las imágenes de todo el cuerpo obtenidas con el mismo dispositivo, según las directrices, fueron revisadas por dos especialistas en medicina nuclear con más de una década de experiencia para llegar a un consenso para cada lesión. Las relaciones entre edad, PSA, volumen de próstata, estadio T clínico, grado de biopsia de la Sociedad Internacional de Patología Urológica (ISUP), grupo de riesgo D'amico, volumen de tumor intraprostático (HPTV) identificado en la revisión histopatológica final de la muestra, grado HP-ISUP, Se analizaron la invasión de la vesícula seminal (SVI), la invasión extracapsular (ECI), el margen quirúrgico positivo (PSM), SUVT, SUVTLR y SUVTPR.

Resultados

La edad media de los 64 pacientes incluidos fue 64,1 ± 5,3. Se encontró correlación estadísticamente significativa entre los valores de SUVT, SUVTLR, SUVTPR y los parámetros del estadio histopatológico, como ISUP de biopsia, Clasificación de Riesgo D'amico, HP-ISUP, HPTV (p < 0,05). PSMATV, SUVT y SUVTLR fueron predictores estadísticamente significativos de invasión extracapsular, mientras que PSA, PSMATV y SUVTLR fueron predictores significativos de SVI (p < 0,05).

Conclusión

Los valores estandarizados de SUVT, SUVTLR y SUVTPR podrían emplearse como marcadores no invasivos para ayudar a predecir los hallazgos histopatológicos posoperatorios, particularmente ECI, SVI y PSM.

Palabras clave:
Cáncer de próstata
PET/TC con 68Ga-PSMA-I&T
SUVmáx
Histopatología
Potencial predictivo
Tumor intraprostático
Prostatectomía

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