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Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
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Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) Imaging of desmoplastic small round-cell tumor on 68Ga-FAPI PET/CT
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Vol. 43. Núm. 3.
(mayo - junio 2024)
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351
Vol. 43. Núm. 3.
(mayo - junio 2024)
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Imaging of desmoplastic small round-cell tumor on 68Ga-FAPI PET/CT
Valor diagnóstico de la imagen PET/TC con [68Ga]Ga-FAPI en el tumor de células redondas pequeñas desmoplásticas
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351
Yuhong Liua, Huipan Liub,c,d,
Autor para correspondencia
liuhuipan1573@163.com

Corresponding authors.
, Zibei Wanb,c,d, Yue Chenb,c,d, Jianwen Zhanga,
Autor para correspondencia
zhangjianwen66@126.com

Corresponding authors.
a Department of Oncology, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, Sichuan Province, China
b Department of Nuclear Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, Sichuan Province, China
c Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Southwest Medical University, Luzhou, 646000, Sichuan Province, China
d Institute of Nuclear Medicine, Southwest Medical University, Luzhou, 646000, Sichuan Province, China
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A 19-year-old man presented with abdominal pain for 6 months. Abdominal enhanced CT showed extensive irregular soft tissue masses in the pelvic cavity and thickening of the peritoneum, with inhomogeneous enhancement. Abdominal puncture biopsy revealed desmoplastic small round-cell tumor (DSRCT). Subsequently, four cycles of chemotherapy (cisplatin plus etoposide) were performed. However, the patient reported experiencing discomfort including thrombocytopenia, leukopenia, nausea, and vomiting after chemotherapy. Thus, chemotherapy was stopped. Then, the patient was admitted to our hospital. With the patient's informed consent, he was included in the clinical trial of 68Ga-FAPI-04 PET/CT in tumors. The MIP image of 68Ga-FAPI PET/CT (Fig. 1) revealed increased FAPI uptake in the pelvic cavity (solid arrow) and lower abdomen (dotted arrows), which showed the irregular soft tissue masses with intense uptake (SUVmax, 7.9) in the pelvic cavity (solid arrows). Diffuse thickening of the peritoneum (dotted arrows) with increased tracer uptake (SUVmax, 6.8) was also observed. The PET/CT finding were consistent with DSRCT. Subsequently, the patient received 177Lu-FAP2286 therapy (dose of 7.4 GBq, first cycle) with stable disease. Further follow-up is still under observation.

Figure 1.

The MIP (A) image of 68Ga-FAPI PET/CT revealed increased FAPI uptake in the pelvic cavity (solid arrow) and lower abdomen (dotted arrows). On the axial (B), coronal (C), and sagittal (D) images of PET/CT images showed the irregular soft tissue masses with intense uptake (SUVmax, 7.9) in the pelvic cavity (solid arrows). Diffuse thickening of the peritoneum (dotted arrows) with increased tracer uptake (SUVmax, 6.8) was also observed (upper row: PET; middle row: CT; lower row: fused PET/CT).

(0.51MB).

DSRCT is a rare, highly aggressive malignancy, that predominantly occurs in adolescents, and it often presents as multiple uneven density masses in the abdominal and pelvic cavities, involving the peritoneum and abdominal lymph nodes, lacking a definite organ origin.1 Thus, DSRCT is difficult to distinguish from other abdominal tumors. Furthermore, previous studies have preliminarily shown that 18F-FDG PET/CT is essential for the diagnosis, staging, and management of DSRCT.2 However, sometimes it cannot distinguish between certain infections and malignant tumors, and due to the physiological uptake of FDG in the gastrointestinal tract, this may limit its use in certain situations. 68Ga-FAPI is based on the molecular targeting of the FAP, known to be highly expressed in the major cell population in tumor stroma,3 which might be considered as the preferred imaging modality for monitoring DSRCT patients. Meanwhile, our case suggests that 68Ga-FAPI PET/CT may also be helpful in guiding the precise therapy of 177Lu-FAP2286 in DSRCT.

Ethical statement

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

Conflicts of interest

None declared.

Informed consent

Written informed consent for publication of this report was obtained from the patient.

References
[1]
Z. Zheng, P. Hu, Y. He, H. Shi.
Desmoplastic small round cell tumor with ovarian involvement on [(18)F]-FDG PET/CT.
Rev Esp Med Nucl Imagen Mol (Engl Ed), 43 (2024), pp. 55-56
[2]
H. Zhang, S. Dai.
Desmoplastic small round cell tumor of bone revealed by (18)F-FDG PET/CT: a case report with literature review.
[3]
A.P. Caresia, J. Jo Rosales, M. Rodriguez Fraile, A. Arcay Ozturk, C. Artigas, Oncology Task Force of Spanish Nuclear M, et al.
PET/CT FAPI: procedure and evidence review in oncology.
Rev Esp Med Nucl Imagen Mol (Engl Ed), 43 (2024), pp. 130-140
Copyright © 2024. The Author(s)
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