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Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) Radioguided surgery in neuroendocrine tumors. A review of the literature
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Vol. 33. Issue 6.
Pages 358-365 (November - December 2014)
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Vol. 33. Issue 6.
Pages 358-365 (November - December 2014)
Special collaboration
Radioguided surgery in neuroendocrine tumors. A review of the literature
Cirugía radioguiada de tumores neuroendocrinos. Revisión de la literatura
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601
P. García-Talaveraa,
Corresponding author
palomagtalavera@gmail.com

Corresponding author.
, R. Ruanob, M.E. Riojac, J.M. Corderod, P. Razolae, S. Vidal-Sicartf
a Servicio de Medicina Nuclear, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
b Servicio de Medicina Nuclear, Hospital Clínico Universitario de Salamanca, Salamanca, Spain
c Servicio de Medicina Nuclear, Hospital Universitario Ramón y Cajal, Madrid, Spain
d Servicio de Medicina Nuclear, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
e Servicio de Medicina Nuclear, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
f Servicio de Medicina Nuclear, Hospital Clínic de Barcelona, Barcelona, Spain
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Tables (6)
Table 1. Radioguided surgery with 111In-pentetreotide in pulmonary carcinoid tumors.
Table 2. Radioguided surgery with 111In-pentetreotide in gastroenteropancreatic tumors.
Table 3. Radioguided surgery with 99mTc-EDDA-HYNIC-TOC or Octreotate in gastroenteropancreatic neuroendocrine tumors.
Table 4. Sensitivity of the probe compared with palpation and imaging studies in gastroenteropancreatic tumors.
Table 5. Radioguided surgery in medullary thyroid carcinoma.
Table 6. Radioguided surgery in neuroblastoma, pheochromocytoma and ganglioneuroma.
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Abstract

Radioguided surgery can be a useful technique in the localization of neuroendocrine tumors. It detects more and smaller lesions compared to pre-surgical imaging and intraoperative digital palpation by the surgeon. It detects residual lesions and also indicates the shortest access route to the lesion. Nevertheless, its use has not become widespread because of technical difficulties. There is a limited number of published series, a lack of standardized protocol because of the great variability regarding type of radiopharmaceutical, dose of radiotracer, timing between injection and surgery. In this paper, we review these issues, describing the experience of different authors in diverse tumors.

Keywords:
Neuroendocrine tumors
Radioguided surgery
Gamma probe
Somatostatin analogs
Resumen

La cirugía radioguiada puede ser útil en la localización de tumores neuroendocrinos, detectando más lesiones y de menor tamaño que las pruebas de imagen prequirúrgicas y la palpación por el cirujano, detectando lesiones residuales e indicando una ruta más corta para acceder a la lesión. No obstante, su uso no se ha generalizado, ya que plantea dificultades técnicas, las series publicadas son limitadas, y no existe una uniformidad de criterios, debido a la gran variabilidad en cuanto al tipo de radiofármaco, dosis a emplear e intervalo entre la inyección del trazador y la cirugía. De estos aspectos nos ocupamos en esta revisión, describiendo la experiencia de distintos grupos, en los diversos tumores.

Palabras clave:
Tumores neuroendocrinos
Cirugía radioguiada
Sonda gammadetectora
Análogos de la somatostatina

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