metricas
covid
Buscar en
Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
Toda la web
Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) Contribution of 18F-FDG PET/CT imaging in the diagnosis and management of HIV-po...
Journal Information
Vol. 41. Issue 5.
Pages 275-283 (September - October 2022)
Share
Share
Download PDF
More article options
Visits
6
Vol. 41. Issue 5.
Pages 275-283 (September - October 2022)
Original Article
Contribution of 18F-FDG PET/CT imaging in the diagnosis and management of HIV-positive patients
Contribución de las imágenes PET/TC con 18F-FDG en el diagnóstico y manejo de pacientes VIH-positivos
Visits
6
Gamze Tatara,
Corresponding author
gamze_tatar@hotmail.com

Corresponding author.
, Tevfik Fikret Çermikb, Göksel Alçınb, Ozge Erol Fenercioglub, Ayşe İncic, Ediz Beyhanb, Nurhan Ergülb
a University of Health Sciences, Istanbul Bagcılar Training and Research Hospital, Department of Nuclear Medicine, Istanbul, Turkey
b University of Health Sciences, Istanbul Training and Research Hospital, Department of Nuclear Medicine, Istanbul, Turkey
c University of Health Sciences, Istanbul Training and Research Hospital, Department of Infectious Disease, Istanbul, Turkey
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (5)
Show moreShow less
Abstract
Introduction and objectives

The human immunodeficiency virus [HIV] is a lentevirus, primarily infects certain cells of the immune system, thereby greatly weakens the body’s own defenses against diseases. This study was aimed to explore the value and significance of 18F-FDG PET/CT in the assessment of patients with HIV infection and to examine the presence of quantitative alterations in 18F-FDG uptake among patients with HIV-related infections or malignant diseases in HIV-positive patients.

Patients and methods

Forty patients with HIV infection were scanned on PET/CT system. The data were registered according to immune status, antiretroviral therapy, and definitive diagnosis. All pathologic lesions and disease related areas were described, 18F-FDG uptake patterns were evaluated. Semiquantitative analysis of 18F-FDG uptake was performed and SUVmax were calculated.

Results

Twenty-eight patients [70%] were diagnosed with HIV-related infection or malignant diseases. The sensitivity of PET/CT was shown to be 100% and the specificity 92% for concomitant diseases requiring additional treatment to antiretroviral therapy. The SUVmax and CD4 counts were not statistically different between HIV-related reactive lymphadenopathy, HIV-related malignancy, and HIV-related infections.

Conclusions

The pattern of distribution of nodal/extranodal uptake on 18F-FDG PET/CT may facilitate distinction between HIV-related generalized lymphadenopathies, HIV-related opportunistic infections, and malignancies. In this context, 18F-FDG PET/CT should be preferred for routine use in the management of patients infected with HIV.

Keywords:
18F-FDG PET/CT
HIV
Infection
Abstracto
Objetivo

El virus de la inmunodeficiencia humana [VIH] es un lentevirus, que infecta principalmente ciertas células del sistema inmunitario, por lo que debilita las defensas propias frente a las enfermedades. El objetivo de este estudio fue analizar el valor y significado de la PET/TC con 18F-FDG en la evaluación de pacientes con infección por VIH y determinar la presencia de diferencias cuantitativas de captación de 18F-FDG entre pacientes con infecciones relacionadas con el VIH o neoplasia maligna en pacientes VIH positivos.

Métodos

Se estudiaron cuarenta pacientes con infección por VIH mediante PET/TC con 18F-FDG. Se registró el estado inmunitario, el tratamiento antirretroviral y el diagnóstico definitivo de cada paciente. Se describieron todas las lesiones patológicas y áreas relacionadas con la enfermedad, se evaluaron los patrones de captación de 18F-FDG. Se realizó un análisis semicuantitativo de la captación de 18F-FDG mediante el calculó SUVmax.

Resultado

Veintiocho pacientes [70%] fueron diagnosticados con infección relacionada con el VIH o neoplasia maligna. La sensibilidad de la PET/TC con 18F-FDG fue del 100% y la especificidad del 92% para las enfermedades concomitantes que requerían tratamiento adicional a la terapia antirretroviral. El SUVmax y el recuento de CD4 no fueron estadísticamente diferentes entre la linfadenopatía reactiva relacionada con el VIH, la neoplasia maligna relacionada con el VIH y las infecciones relacionadas con el VIH.

Conclusion

El patrón de distribución de la captación ganglionar/extraganglionar en la PET/TC con 18F-FDG puede facilitar la distinción entre las adenopatías generalizadas relacionadas con el VIH, las infecciones oportunistas relacionadas con el VIH y las neoplasias malignas. En este contexto, se debe realizar el estudio PET/TC con 18F-FDG de forma rutinaria en el manejo de pacientes infectados por el VIH.

Palabras clave:
18F-FDG PET/TC
VIH
Infección

Article

These are the options to access the full texts of the publication Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos