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The level of C-reactive protein (123.0mg/L; reference range, <5.0mg/L) was significantly elevated. Except for Epstein-Barr virus and cytomegalovirus infections, laboratory tests identifying co-existent opportunistic infections and autoimmune diseases were negative. The enlarged axillary and inguinal lymph nodes and lytic bone destruction of right wrist joint detected respectively by ultrasound and plain CT raised concern for malignant diseases. Thus, whole-body 18F-FDG PET/CT scan was performed. The MIP and axial images illustrated multifocal intense FDG accumulation mainly in skin and bony lesions (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>, <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A and B, <a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>A–C). Based on above findings in the AIDS setting, a malignant tumor was suspected. Eventually, pathological findings of acid-fast staining and quantitative polymerase chain reaction assay in a skin biopsy specimen proved non-tuberculous mycobacteria (NTM) infection. Symptoms were relieved after receiving anti-NTM therapy. NTM, typical environmental organisms, have been reported to cause pulmonary and extrapulmonary infections, with pulmonary infection being the most frequent.<a class="elsevierStyleCrossRef" href="#bib0005">1</a> As for extrapulmonary NTM infection, skin, soft tissues and lymph nodes are commonly involved sites, while musculoskeletal infection presenting as osteolysis is rare.<a class="elsevierStyleCrossRef" href="#bib0010">2</a> In addition, disseminated NTM infection is typically associated with severe immunosuppression and in AIDS patients just as our case, the disseminated lesions showing hypermetabolic activity can mimic imaging and clinical manifestations of malignancies.<a class="elsevierStyleCrossRef" href="#bib0005">1</a>. Our case presented FDG PET/CT features of disseminated NTM infection with skin and bone involvement in an AIDS patient, highlighting the role of PET/CT in assessing the exact extent and activity of disseminated lesions.<a class="elsevierStyleCrossRef" href="#bib0015">3</a><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia>FundingNone to declare by all authors.Conflict of interestThe authors have no conflicts of interest to declare." "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflict of interest" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:3 [ "etiqueta" => "1" "nota" => "Li Li and Haitao Wang contributed equally to this work and shared joint first authorship." "identificador" => "fn0005" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3442 "Ancho" => 2508 "Tamanyo" => 322794 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0040" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "The MIP images of whole-body 18F-FDG PET/CT showed multifocal intense FDG accumulation mainly in skin and bony lesions." ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1316 "Ancho" => 3008 "Tamanyo" => 268899 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0045" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Representative lesions in cutaneous and subcutaneous with focal FDG uptake were showed in the axial images. (A) Lesions in the abdominal wall with an SUVmax 2.23. (B) A lesion on right upper thigh with an SUVmax 5.44." ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 2031 "Ancho" => 3008 "Tamanyo" => 286999 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0050" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Representative bone lesions with intense FDG uptake were showed in the axial images. (A) Osteolytic lesions located in the right humerus with an SUVmax 8.74. (B) Osteolytic lesions and soft tissue swelling were observed at the right wrist joint, with an SUVmax 8.44. (C) Multiple osteolytic lesions involved the bilateral patella and the left femur with SUVmax 6.94." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Of tuberculosis and non-tuberculous mycobacterial infections - a comparative analysis of epidemiology, diagnosis and treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Gopalaswamy" 1 => "S. Shanmugam" 2 => "R. Mondal" 3 => "S. Subbian" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s12929-020-00667-6" "Revista" => array:5 [ "tituloSerie" => "J Biomed Sci" "fecha" => "2020" "volumen" => "27" "paginaInicial" => "74" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32552732" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Retrospective analysis of 10 cases of disseminated nontuberculous mycobacterial disease with osteolytic lesions" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Tang" 1 => "J. Huang" 2 => "W. Zeng" 3 => "Y. Huang" 4 => "Y. Lei" 5 => "Y. Qiu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2147/IDR.S337956" "Revista" => array:6 [ "tituloSerie" => "Infect Drug Resist" "fecha" => "2021" "volumen" => "14" "paginaInicial" => "4667" "paginaFinal" => "4679" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34785914" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Usefulness of F-18 FDG PET/CT in the assessment of disseminated Mycobacterium avium complex infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Sato" 1 => "T. Hiyama" 2 => "K. Kaito" 3 => "Y. Hayashi" 4 => "T. Okumura" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s12149-009-0298-5" "Revista" => array:6 [ "tituloSerie" => "Ann Nucl Med" "fecha" => "2009" "volumen" => "23" "paginaInicial" => "757" "paginaFinal" => "762" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19787313" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/22538089/0000004200000006/v1_202311030524/S225380892300068X/v1_202311030524/en/main.assets" "Apartado" => array:4 [ "identificador" => "7927" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Interesting images" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/22538089/0000004200000006/v1_202311030524/S225380892300068X/v1_202311030524/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S225380892300068X?idApp=UINPBA00004N"]

ISSN: 2253-8089

The Revista Española de Medicina Nuclear e Imagen Molecular (Spanish Journal of Nuclear Medicine and Molecular Imaging), was founded in 1982, and is the official journal of the Spanish Society of Nuclear Medicine and Molecular Imaging, which has more than 700 members. The Journal, which publishes 6 regular issues per year, has the promotion of research and continuing education in all fields of Nuclear Medicine as its main aim. For this, its principal sections are Originals, Clinical Notes, Images of Interest, and Special Collaboration articles. The works may be submitted in Spanish or English and are subjected to a peer review process. In 2009, it became the leading Spanish journal in the field of Medical Imaging on having an Impact Factor , awarded by the Journal Citation Reports.

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Impact factor

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Impact factor 2023

1.6

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Citescore 2023

1.1

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SJR 2023

0.208

SNIP

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SNIP 2023

0.273

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