array:23 [ "pii" => "S2253808912000729" "issn" => "22538089" "doi" => "10.1016/j.remnie.2012.06.004" "estado" => "S300" "fechaPublicacion" => "2012-05-01" "aid" => "342" "copyright" => "Elsevier España, S.L. and SEMNIM" "copyrightAnyo" => "2011" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Rev Esp Med Nucl Imagen Mol. 2012;31:142-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 987 "formatos" => array:2 [ "HTML" => 798 "PDF" => 189 ] ] "itemSiguiente" => array:19 [ "pii" => "S2253808912000432" "issn" => "22538089" "doi" => "10.1016/j.remnie.2012.03.005" "estado" => "S300" "fechaPublicacion" => "2012-05-01" "aid" => "329" "copyright" => "Elsevier España, S.L. and SEMNIM" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Rev Esp Med Nucl Imagen Mol. 2012;31:145-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1987 "formatos" => array:2 [ "HTML" => 1692 "PDF" => 295 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Clinical note</span>" "titulo" => "Morphological-metabolic evaluation of the urachal mucinous adenocarcinoma by positron emission tomography-computed tomography (PET-CT)" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "145" "paginaFinal" => "147" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Evaluación morfo-metabólica del adenocarcinoma mucinoso de uraco mediante tomografía por emisión de positrones-tomografía computarizada (PET-TC)" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1698 "Ancho" => 3327 "Tamanyo" => 449086 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">CT in reformated venous phase in a sagittal plane (a) and coronal planes in the venous phase (b) and in an excretory phase (c). A tumoral mass of 16.3<span class="elsevierStyleHsp" style=""></span>cm at its maximum axis is shown extending and invading the urinary bladder and the abdominal wall (a) associated with inguinal adenopathies (arrows in b) determining bilateral ureteropyelocalicial dilatation and a defect of vesical repletion (c).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A.E. Morató-López, M. Corres-Castillo, J. Isusi-Alcazar, N. Reyes-García, O. Quiroz-Castro, J. Serna-Macias" "autores" => array:6 [ 0 => array:2 [ "nombre" => "A.E." "apellidos" => "Morató-López" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Corres-Castillo" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Isusi-Alcazar" ] 3 => array:2 [ "nombre" => "N." "apellidos" => "Reyes-García" ] 4 => array:2 [ "nombre" => "O." "apellidos" => "Quiroz-Castro" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Serna-Macias" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S021269821100231X" "doi" => "10.1016/j.remn.2011.08.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021269821100231X?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808912000432?idApp=UINPBA00004N" "url" => "/22538089/0000003100000003/v1_201305061126/S2253808912000432/v1_201305061126/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2253808912000511" "issn" => "22538089" "doi" => "10.1016/j.remnie.2012.05.004" "estado" => "S300" "fechaPublicacion" => "2012-05-01" "aid" => "312" "copyright" => "Elsevier España, S.L. and SEMNIM" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Rev Esp Med Nucl Imagen Mol. 2012;31:135-41" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2357 "formatos" => array:2 [ "HTML" => 2133 "PDF" => 224 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Utility of the PET–CT in the evaluation of early response to treatment in the diffuse large B-cell lymphoma. Preliminary results" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "135" "paginaFinal" => "141" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Utilidad de la PET-TC en la valoración de la respuesta precoz al tratamiento en el linfoma B difuso de celula grande. Resultados preliminares" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1732 "Ancho" => 2325 "Tamanyo" => 336806 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">31-year-old male patient with diffuse large B-cell lymphoma. MIP (maximum intensity projection) images in the upper row. Axial thoracic slices of fusion PET/CT with FDG in the lower row. (1) Initial staging: stage IV. Bulky right mediastinal mass associated with pulmonary collapse and pleural involvement with effusion, thoracic and retroperitoneal abdominal adenopathies and hypermetabolic mass in left colon. Chemotherapy initiated (R-CHOP schedule) and three cycles received; (2) evaluation of early response (10 days after third cycle): disappearance of hypermetabolic lesions which translates in to favorable response. At the site of the mediastinal mass paramediastinal-cardiac cavitation is observed with herniation to the breast and subcutaneous emphysema. Continued with three cycles of chemotherapy; (3) evaluation of final response: complete metabolic response one month after completion of chemotherapy and (4) outcome control (at one year): no evidence of disease which continues to date.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Cortés Romera, C. Gámez Cenzano, A.P. Caresia Aróztegui, J. Martín-Comín, E. González-Barca, Y. Ricart Brulles, A. Palacios Abufón, J. Robles Barba, L. Rodríguez-Bel, S. Rossi Seoane, A. Fernández de Sevilla" "autores" => array:11 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Cortés Romera" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Gámez Cenzano" ] 2 => array:2 [ "nombre" => "A.P." "apellidos" => "Caresia Aróztegui" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Martín-Comín" ] 4 => array:2 [ "nombre" => "E." "apellidos" => "González-Barca" ] 5 => array:2 [ "nombre" => "Y." "apellidos" => "Ricart Brulles" ] 6 => array:2 [ "nombre" => "A." "apellidos" => "Palacios Abufón" ] 7 => array:2 [ "nombre" => "J." "apellidos" => "Robles Barba" ] 8 => array:2 [ "nombre" => "L." "apellidos" => "Rodríguez-Bel" ] 9 => array:2 [ "nombre" => "S." "apellidos" => "Rossi Seoane" ] 10 => array:2 [ "nombre" => "A." "apellidos" => "Fernández de Sevilla" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0212698211001819" "doi" => "10.1016/j.remn.2011.05.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0212698211001819?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808912000511?idApp=UINPBA00004N" "url" => "/22538089/0000003100000003/v1_201305061126/S2253808912000511/v1_201305061126/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Clinical note</span>" "titulo" => "FDG PET/CT appearance of multicentric Castleman's disease mimicking lymphoma" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "142" "paginaFinal" => "144" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "U. Elboga, Y. Narin, M. Urhan, E. Şahin" "autores" => array:4 [ 0 => array:4 [ "nombre" => "U." "apellidos" => "Elboga" "email" => array:1 [ 0 => "umutelboga@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Y." "apellidos" => "Narin" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Urhan" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Şahin" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "GATA Haydarpaşa Training Hospital, İstanbul, Turkey" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Distribución de la FDG PET/TAC en la enfermedad de Castleman simulando Linfoma" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1852 "Ancho" => 1894 "Tamanyo" => 98006 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Increased <span class="elsevierStyleSup">18</span>F-FDG accumulation was observed in bilateral cervical, axillary, multiple bilateral mediastinal, retroperitoneal, groin lymph nodes and crescent-shaped image in the right thorax related to pleural effusion on whole body <span class="elsevierStyleSup">18</span>F-FDG PET image (A), increased <span class="elsevierStyleSup">18</span>F-FDG accumulation was observed in bilateral cervical lymph nodes on transaxial <span class="elsevierStyleSup">18</span>F-FDG PET and PET/CT images (B).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Castleman's disease (CD) or angiofollicular lymph node hyperplasia is a rare benign lymphoproliferative disorder, which was first described in 1954.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The etiology of this disorder is unknown yet. Histologically, CD is classified into three subtypes: the hyaline vascular type, the plasma cell type and the intermediate (mixed) cell type.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">One of the critical issues in diagnosis is to differentiate between CD and Hodgkin's and non-Hodgkin's lymphoma. This is most challenging in multicentric plasma cell form of CD as involvement of multiple lymph nodes mimics lymphomas more than any other variants and forms of CD.</p><p id="par0015" class="elsevierStylePara elsevierViewall">It is therefore important to document the distribution of involved lymph nodes throughout the body. Whole body <span class="elsevierStyleSup">18</span>F-FDG PET/CT imaging is thus the right modality to investigate the distribution of the diseased lymph nodes. We report a patient with multicentric form of plasma cell variant CD showing a similar uptake pattern of non-Hodgkin's lymphoma on <span class="elsevierStyleSup">18</span>F-FDG PET/CT images, which caused a challenge in differential diagnosis.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case report</span><p id="par0020" class="elsevierStylePara elsevierViewall">A 73-year-old woman with anorexia, weight loss (7<span class="elsevierStyleHsp" style=""></span>kg in 3 months), fever and night sweats was admitted to the Hematology Department. Physical examination revealed slightly enlarged bilateral cervical lymph nodes. The initial laboratory findings showed hypochromic anemia with a hemoglobin level of 9.8<span class="elsevierStyleHsp" style=""></span>g/dL and 24.7% hematocrit, elevated erythrocyte sedimentation rate (69<span class="elsevierStyleHsp" style=""></span>mm/h), and serum C-reactive protein level of 18.32<span class="elsevierStyleHsp" style=""></span>mg/L. Chest X-ray showed multiple bilateral enlarged hilar and mediastinal lymph nodes, atelectasis in right lobe and pleural effusion in the right hemithorax. HIV antibody results were negative. Peripheral blood smear indicated leukocytosis with atypical lymphocytes.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The differential diagnosis included lymphoma, nonspecific reactive lymphoid hyperplasia, toxoplasmosis, tuberculosis, Epstein-Barr virus infection and Castleman's disease. Bone marrow biopsy was planned. The patient was referred to Nuclear Medicine Department for a PET/CT scan to document the distribution of the enlarged lymph nodes, and if the enlarged nodes were metabolically active. After 6<span class="elsevierStyleHsp" style=""></span>h fasting with a serum glucose 95<span class="elsevierStyleHsp" style=""></span>mg/dl, 447<span class="elsevierStyleHsp" style=""></span>MBq of <span class="elsevierStyleSup">18</span>F-FDG was injected intravenously. After 1<span class="elsevierStyleHsp" style=""></span>h of waiting for distribution and uptake of FDG in a semireclined relaxed chair in a quite booth, the patient was imaged in an integrated full-ring PET/CT (Discovery 600,General Electric Medical Systems, Waukesha, WI).</p><p id="par0030" class="elsevierStylePara elsevierViewall">The patient was not given any contrast agent for CT scan which was performed for attenuation correction and defining anatomical landmarks on PET images. Increased <span class="elsevierStyleSup">18</span>F-FDG accumulation was observed in bilateral cervical, axillary, multiple bilateral mediastinal, retroperitoneal, groin lymph nodes and crescent-shaped image in the right thorax related to pleural effusion on both PET images (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The areas of increased FDG uptake were well correlated with the enlarged lymph nodes detected on CT images. The maximum standardized uptake values (SUVmax) for the cervical, axillary and mediastinal, hilar, retroperitoneal, groin lymph nodes were 9.8, 12.3 and 14.7, 10.1, 12.2, respectively.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Bone marrow biopsy was performed, which revealed lymphoid aggregates, plasmacytosis but no malignant cells. Histopathological examination of an excised left cervical lymph node disclosed plasma cell variant of Castleman's disease. With the multiple nodes detected on <span class="elsevierStyleSup">18</span>F-FDG PET/CT images, the diagnosis was therefore multicentric plasma cell variant of Castleman's disease. The patient was informed about the expected benefits and complications of treatment options available and she preferred to be followed up without any treatment.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">Castleman's disease was first described by Benjamin Castleman in 1956, when he reported a series of patients with solitary hyperplastic mediastinal lymph nodes with small germinal centers.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> CD has many synonyms, including angiofollicular mediastinal lymph node hyperplasia, angiomatous lymphoid hamartoma, lymph nodal hamartoma, follicular lymphoreticuloma and benign giant lymphoma.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a> The etiology of CD is unknown, but there are several hypothetic mechanisms that have been proposed, such as chronic low-grade inflammation, a hamartomatous process, an immunodeficient state, and autoimmune disorders. CD has been linked to interleukin-6 (IL-6) overproduction. IL-6 is a major contributor to the systemic manifestations of CD.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Despite its high sensitivity <span class="elsevierStyleSup">18</span>F-FDG PET cannot differentiate between CD and other benign or malignant lymphoproliferative diseases. Active granulomatous and inflammatory disorders also show high accumulation of <span class="elsevierStyleSup">18</span>F-FDG mimicking malignant diseases including lymphoma.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Similar to our case, it was previously shown that slight to moderate <span class="elsevierStyleSup">18</span>F-FDG uptake was reported in enlarged lymph nodes in patients with CD.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,8</span></a> Furthermore, low and intermediate grade lymphomas also show low grade <span class="elsevierStyleSup">18</span>F-FDG uptake on PET scans,<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">9,10</span></a> while intense <span class="elsevierStyleSup">18</span>F-FDG uptake was seen in high grade lymphomas.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">10</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Although the enlarged lymph nodes in CD were benign, the high uptake suggests high metabolism in these nodes as seen in the lymphoma. The accumulation of <span class="elsevierStyleSup">18</span>F-FDG in our patient was high, but the appearance of diseased lymph nodes on <span class="elsevierStyleSup">18</span>F-FDG PET/CT images were not helpful to exclude Hodgkin's and non-Hodgkins lymphoma. It is therefore fair to conclude that whole body FDG PET/CT is effective in disclosing the involved lymph nodes and establishing new sites throughout the body, but it was not useful in differentiating CD from lymphoma.</p><p id="par0055" class="elsevierStylePara elsevierViewall">The <span class="elsevierStyleSup">18</span>F-FDG PET/CT appearance of Castleman's disease is similar to those of malignant diseases and benign lymphoproliferative disorders, and thus can offer little help in differential diagnosis of enlarged lymph nodes of multicentric distribution. It may be useful in mapping the involved lymph nodes throughout the body in patients with Castleman's disease and in disclosing new sites of enlarged lymph nodes which are otherwise difficult to document.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:2 [ "identificador" => "xres120325" "titulo" => "Abstract" ] 1 => array:2 [ "identificador" => "xpalclavsec107607" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres120326" "titulo" => "Resumen" ] 3 => array:2 [ "identificador" => "xpalclavsec107606" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2011-07-28" "fechaAceptado" => "2011-09-26" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec107607" "palabras" => array:3 [ 0 => "Castleman's disease" 1 => "Positron emission tomography/Computed tomography" 2 => "Angiofollicular lymphoid hyperplasia" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec107606" "palabras" => array:3 [ 0 => "Enfermedad de Castleman" 1 => "Tomografía por emisión de positrones/Tomografía computarizada" 2 => "Hiperplasia linfoide angiofolicular" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">We report a case of a multicentric form of Castleman's disease with multiple lymph nodes showing intense FDG uptake on whole body scan mimicking non-Hodgkin's lymphoma. In this report, the patient had multiple cervical, mediastinal, hilar, retroperitoneal and abnormal lymph nodes in the groin. <span class="elsevierStyleSup">18</span>F-fluorodeoxyglucose positron emission tomography/computed tomography was performed before tissue sampling. <span class="elsevierStyleSup">18</span>F-FDG/PET demonstrated multiple areas of increased uptake in cervical, mediastinal, hilar, retroperitoneal and groin lymph nodes, suggesting a generalized disease of the lymphatic system including non-Hodgkin's lymphoma. The final diagnosis is based on the histopathological findings of the material obtained from the cervical lymphadenectomy. The histological diagnosis was multicentric plasma cell variant of Castleman's disease. <span class="elsevierStyleSup">18</span>F fluorodeoxyglucose positron emission tomography/computed tomography scan helped to identify the lymph nodes involved throughout the whole body, but did not help to differentiate non-Hodgkin's lymphoma. The clinical conclusions and PET/CT findings are described in this report.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se presenta un caso de enfermedad de Castleman multicéntrica con múltiples ganglios linfáticos que muestran una intensa captación de FDG, imitando el linfoma no-Hodgkin. El paciente presenta múltiples nódulos linfáticos cervicales, mediastínicos, hiliares, retroperitonealeses, así como nódulos linfáticos anormales en la ingle.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La tomografía por emisión de positrones <span class="elsevierStyleSup">18</span>F fluorodeoxyglucosa/tomografía computarizada se realizó antes de obtener las muestras de tejido. La <span class="elsevierStyleSup">18</span>F FDG-PET mostró múltiples áreas de aumento de captación en ganglios linfáticos cervicaleses, mediastínicos, hiliares, retroperitoneales e inguinales, sugiriendo una enfermedad generalizada del sistema linfático, como el linfoma no-Hodgkin. El diagnóstico final se basó en los hallazgos histopatológicos obtenidos de la linfadenectomía cervical. El diagnóstico histológico fue el de enfermedad de Castleman multicéntrica variante de células plasmáticas. La <span class="elsevierStyleSup">18</span>F fluorodeoxyglucosa tomografía por emisión de positrones/tomografía computada ayudó a identificar la extensión corporal de la afectación ganglionar, pero no permitió un diagnóstico diferencial conel linfoma no Hodgkin. Se describen las conclusiones clínicas y los hallazgos de la PET/TAC.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1852 "Ancho" => 1894 "Tamanyo" => 98006 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Increased <span class="elsevierStyleSup">18</span>F-FDG accumulation was observed in bilateral cervical, axillary, multiple bilateral mediastinal, retroperitoneal, groin lymph nodes and crescent-shaped image in the right thorax related to pleural effusion on whole body <span class="elsevierStyleSup">18</span>F-FDG PET image (A), increased <span class="elsevierStyleSup">18</span>F-FDG accumulation was observed in bilateral cervical lymph nodes on transaxial <span class="elsevierStyleSup">18</span>F-FDG PET and PET/CT images (B).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Case records of the Massachusetts General Hospital: case 40011" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. 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Journal Information
Clinical note
FDG PET/CT appearance of multicentric Castleman's disease mimicking lymphoma
Distribución de la FDG PET/TAC en la enfermedad de Castleman simulando Linfoma
U. Elboga
, Y. Narin, M. Urhan, E. Şahin
Corresponding author
GATA Haydarpaşa Training Hospital, İstanbul, Turkey