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The figure shows 68Ga PSMA-11 PET/CT scan prior to treatment, MIP (A), axial PET (B), axial CT (C), and axial fusion (D) images indicate multiple intense pathologic uptakes in lymph nodes (simple arrow), liver (dashed arrow) and bone (arrowhead)." ] ] ] "textoCompleto" => "Prostate cancer is the third highest cause of cancer deaths and the most commonly found malignancy in males within economically developed countries.<a class="elsevierStyleCrossRef" href="#bib0020">1</a>Prostate-specific membrane antigen (PSMA) is a unique target in metastatic castration resistant prostate carcinoma patients (mCRPC). PSMA is a good example of theranostic agent. Promising results obtained with Gallium-68 labelled PSMA Positron Emission Tomography/Computed Tomography (PET/CT) have been extensively studied for prostate cancer, particularly restaging in patients with biochemical relapse following treatment with curative intent.PSMA can also be used with therapy purposes. In particular, alpha-emitting radioisotope Actinium-225 is more effective than beta-emitting Lutetium-177, due to higher rates of double-strand DNA breaks in prostate cancer cells. It has less tissue penetration and minimal surrounded effects in PSMA-negative cells.<a class="elsevierStyleCrossRef" href="#bib0025">2</a>However, limited data are available on the clinical efficacy and side effects of 225Ac-PSMA targeted radionuclide treatment in mCRPC patients.<a class="elsevierStyleCrossRef" href="#bib0030">3</a>In our case, 225Ac-PSMA resulted in remarkable clinical and biochemical responses. It may be considered as a promising therapy and could improve the ECOG performance status of end-stage mCRPC patients.However, the results obtained do not allow to reach any conclusion since, unfortunately, due to the short follow up of the patient, the increase in the ECOG level could not be confirmed in a long period of time (<a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1–3</a>).<elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia>Source of foundationScience Development Foundation under the President of the Republic of Azerbaijan (Grant No. EIF-2014-9(24)-KETPL-14/13/3)." "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0010" "titulo" => "Source of foundation" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Novruzov F, Aliyev JA, Allahverdiyeva Z, Mehdi E, Giammarile F. Efecto positivo del tratamiento con Actinio 225-PSMA sobre el estado funcional ECOG: Informe del caso de un paciente con cáncer de próstata en estadio IV resistente a la castración. Rev Esp Med Nucl Imagen Mol. 2019;38:260–261." ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2292 "Ancho" => 1500 "Tamanyo" => 290954 ] ] "descripcion" => array:1 [ "en" => "74 y patient with metastatic prostate carcinoma, diagnosed 4 years before and treated with Docetaxel and hormonal therapy. The figure shows bone scan prior to treatment." ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1163 "Ancho" => 3167 "Tamanyo" => 438819 ] ] "descripcion" => array:1 [ "en" => "Due to progressive disease, the patient received 2 cycles of targeted treatment with 177Lu-PSMA, for a total of about 15GBq. The figure shows 68Ga PSMA-11 PET/CT scan prior to treatment, MIP (A), axial PET (B), axial CT (C), and axial fusion (D) images indicate multiple intense pathologic uptakes in lymph nodes (simple arrow), liver (dashed arrow) and bone (arrowhead)." ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1163 "Ancho" => 3167 "Tamanyo" => 401710 ] ] "descripcion" => array:1 [ "en" => "After the second cycle of 177Lu-PSMA, 68Ga-PSMA PET/CT control scan showed no response in lymph node lesions. Only one liver lesion disappeared, while the bone lesion increased. The patient was considered in stable disease after the treatment. MIP (A), axial PET (B), axial CT (C), and axial fusion (D) images indicate multiple intense pathologic uptakes in lymph nodes (simple arrow), liver (dashed arrow) and bone (arrowhead). In comparison with pre-treatment images only the liver lesion disappeared (dashed arrow), while the bone lesion increased (arrowhead). When 225Ac-PSMA treatment (8MBq) was administered (about one month after the decision to treat), the patient was in ECOG stage IV, with a PSA level of 623.8ng/mL. The thrombocyte count was 64,000 one day before treatment, after 5 days of the treatment the thrombocyte count has increased to 88,000. Fifteen days after the treatment, the PSA level got down to 476.3ng/mL and ECOG performance status rise to more favourable stage III. No treatment-related toxicity occurred, but the patient passed away 45 days after treatment because of heart failure (that was diagnosed 2 years before)." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0020" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinically localized prostate cancer: AUA/ASTRO/SUO Guideline. Part II: Recommended approaches and details of specific care options" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.G. Sanda" 1 => "J.A. Cadeddu" 2 => "E. Kirkby" 3 => "R.C. Chen" 4 => "T. Crispino" 5 => "J. Fontanarosa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.juro.2018.01.002" "Revista" => array:5 [ "tituloSerie" => "J Urol" "fecha" => "2018" "volumen" => "199" "paginaInicial" => "990" "paginaFinal" => "997" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0025" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prostate-specific membrane antigen for prostate cancer theranostics: from imaging to targeted therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "F. Arsenault" 1 => "J.M. Beauregard" 2 => "F. Pouliot" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/SPC.0000000000000357" "Revista" => array:7 [ "tituloSerie" => "Curr Opin Support Palliat Care" "fecha" => "2018" "volumen" => "12" "paginaInicial" => "359" "paginaFinal" => "365" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29939893" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1386505617300795" "estado" => "S300" "issn" => "13865056" ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0030" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "PSMA-PET based radiotherapy: a review of initial experiences, survey on current practice and future perspectives" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Zschaeck" 1 => "F. Lohaus" 2 => "M. Beck" 3 => "G. Habl" 4 => "S. Kroeze" 5 => "C. Zamboglou" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s13014-018-1047-5" "Revista" => array:5 [ "tituloSerie" => "Radiat Oncol" "fecha" => "2018" "volumen" => "13" "paginaInicial" => "90" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29751842" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/22538089/0000003800000004/v1_201907020628/S2253808918300764/v1_201907020628/en/main.assets" "Apartado" => array:4 [ "identificador" => "47121" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Interesting image" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/22538089/0000003800000004/v1_201907020628/S2253808918300764/v1_201907020628/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808918300764?idApp=UINPBA00004N"]

ISSN: 2253-8089

The Revista Española de Medicina Nuclear e Imagen Molecular (Spanish Journal of Nuclear Medicine and Molecular Imaging), was founded in 1982, and is the official journal of the Spanish Society of Nuclear Medicine and Molecular Imaging, which has more than 700 members. The Journal, which publishes 6 regular issues per year, has the promotion of research and continuing education in all fields of Nuclear Medicine as its main aim. For this, its principal sections are Originals, Clinical Notes, Images of Interest, and Special Collaboration articles. The works may be submitted in Spanish or English and are subjected to a peer review process. In 2009, it became the leading Spanish journal in the field of Medical Imaging on having an Impact Factor , awarded by the Journal Citation Reports.

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Impact factor

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Impact factor 2023

1.6

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1.1

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SJR 2023

0.208

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SNIP 2023

0.273

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