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(A-C) images [maximum intensity projection (MIP), axial CT and axial PET/CT, respectively], show a large and hypermetabolic adenopathic mass in the right lateral cervical and supraclavicular region, of approximately 5<span class="elsevierStyleHsp" style=""></span>cm with a SUVmax of 18.6. No other pathological lesions were visualized.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A.M. García Vicente, G.A. Jiménez Londoño, B. Hernández Ruiz, Á. Soriano Castrejón" "autores" => array:4 [ 0 => array:2 [ "nombre" => "A.M." "apellidos" => "García Vicente" ] 1 => array:2 [ "nombre" => "G.A." "apellidos" => "Jiménez Londoño" ] 2 => array:2 [ "nombre" => "B." "apellidos" => "Hernández Ruiz" ] 3 => array:2 [ "nombre" => "Á." "apellidos" => "Soriano Castrejón" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808913000293?idApp=UINPBA00004N" "url" => "/22538089/0000003200000002/v1_201305061041/S2253808913000293/v1_201305061041/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2253808913000116" "issn" => "22538089" "doi" => "10.1016/j.remnie.2013.01.009" "estado" => "S300" "fechaPublicacion" => "2013-03-01" "aid" => "94" "copyright" => "Elsevier España, S.L. and SEMNIM" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Rev Esp Med Nucl Imagen Mol. 2013;32:92-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1689 "formatos" => array:2 [ "HTML" => 1367 "PDF" => 322 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Radiolabeling and biodistribution studies of polymeric nanoparticles as adjuvants for ocular vaccination against brucellosis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "92" "paginaFinal" => "97" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Radiomarcaje y estudios de biodistribución de nanopartículas poliméricas como adyuvantes para vacunación oftálmica frente a brucelosis" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0020" "etiqueta" => "Fig. 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1208 "Ancho" => 2167 "Tamanyo" => 138185 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Autoradiography images of 2 slices from the same animal at 2 different depths 4<span class="elsevierStyleHsp" style=""></span>h after the ophthalmic administration of <span class="elsevierStyleSup">99m</span>Tc-Man-NP-HS. Both slices show the biodistribution of the formulation in the ocular and nasal mucosa and in the gastrointestinal tract.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Sánchez-Martínez, R. Da Costa Martins, G. Quincoces, C. Gamazo, C. Caicedo, J.M. Irache, I. Peñuelas" "autores" => array:7 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Sánchez-Martínez" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Da Costa Martins" ] 2 => array:2 [ "nombre" => "G." "apellidos" => "Quincoces" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Gamazo" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Caicedo" ] 5 => array:2 [ "nombre" => "J.M." "apellidos" => "Irache" ] 6 => array:2 [ "nombre" => "I." "apellidos" => "Peñuelas" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S2253654X12002430" "doi" => "10.1016/j.remn.2012.11.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X12002430?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808913000116?idApp=UINPBA00004N" "url" => "/22538089/0000003200000002/v1_201305061041/S2253808913000116/v1_201305061041/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Clinical note</span>" "titulo" => "Lung ventilation/perfusion scintigraphy in pulmonary capillary hemangiomatosis: A pattern to consider" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "98" "paginaFinal" => "101" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "S. Carmona, M.J. Loureiro, J. Santos, A. Oliveira, R. Camacho, A.I. Santos" "autores" => array:6 [ 0 => array:4 [ "nombre" => "S." "apellidos" => "Carmona" "email" => array:1 [ 0 => "smmc24@yahoo.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M.J." "apellidos" => "Loureiro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Santos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "A." "apellidos" => "Oliveira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "R." "apellidos" => "Camacho" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 5 => array:3 [ "nombre" => "A.I." "apellidos" => "Santos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Servicio de Medicina Nuclear, Hospital Garcia de Orta, Almada, Portugal" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Cardiologia, Hospital Garcia de Orta, Almada, Portugal" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Anatomia Patológica, Hospital Garcia de Orta, Almada, Portugal" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Radiologia, Hospital Garcia de Orta, Almada, Portugal" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Gammagrafía pulmonar de ventilación/perfusión en la hemangiomatosis capilar pulmonar: un patrón a considerar" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1027 "Ancho" => 3155 "Tamanyo" => 235332 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Lung ventilation (upper row) and perfusion (lower row) scintigraphy show homogeneous ventilation in both lungs and augmented diffuse perfusion in both lung bases.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Pulmonary capillary hemangiomatosis (PCH) is a rare disease, first recognized in 1978 by Wagenvoort and colleagues and still of unknown aetiology. It is characterized by small capillaries proliferation, behaving like a very-low-grade vascular tumour leading to pulmonary arterial hypertension (PAH),<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3,4</span></a> although some authors defend this is not a neoplastic process.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Since it is clinically unspecific and undistinguishable from other more frequent forms of PAH, it is frequently misdiagnosed as idiopathic pulmonary arterial hypertension (IPAH) or as pulmonary veno-occlusive disease (PVOD). Although PVOD differs pathologically from PCH, being characterized by small pulmonary veins and venules occlusion, these two entities are very similar on diagnostic and therapeutic features. PCH (or PVOD) diagnosis, which typically requires a lung biopsy,<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,5</span></a> is essential for selecting a correct treatment, since it is distinct from the therapeutic approaches for other forms of PAH.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Lung ventilation–perfusion scintigraphy (V/Q scan) is a simple and important exam on the evaluation of chronic pulmonary hypertension, permitting to differentiate embolic, from non-embolic aetiologies, with a reported 90–100% sensitivity and 94–100% specificity in 3 studies. False positive results are typically described in cases of vascular occlusion, other than embolic, as arterial sarcoma, vasculitis, extrinsic vascular compression and PVOD.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Although there are few published cases of V/Q scan in PCH, different patterns have been described, from normal scans to ventilation and/or perfusion defects.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–4,7–10</span></a> Some authors report the existence of enhanced perfusion to the hemangiomatous tissue and argue the existence of a characteristic V/Q scan pattern in PCH,<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9,10</span></a> but false positive results for pulmonary embolism or parenchyma disease have also been reported in this entity.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case report</span><p id="par0025" class="elsevierStylePara elsevierViewall">A 47-year-old man was referred to our institution complaining of a 2 years progressive chronic cough, accompanied by exertional syncope for the latter 2 months, without other relevant symptoms. Electrocardiogram revealed sinus rhythm (75 beats/min), frontal plane QRS right axis deviation (96°), P pulmonale (RA dilatation) and incomplete right bundle branch block (QRS – 100<span class="elsevierStyleHsp" style=""></span>ms). A transthoracic echocardiography showed a slight left ventricle hypertrophy with preserved function, paradoxical ventricular septum movement, left auricle and ventricle dilatation, right ventricle hypertrophy with systolic function commitment and PAH (systolic pulmonary arterial pressure<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>90–95<span class="elsevierStyleHsp" style=""></span>mmHg) with slight tricuspid insufficiency. Chest radiograph demonstrated cardiac and pulmonary arteries enlargement and vascular attenuation on the periphery.</p><p id="par0030" class="elsevierStylePara elsevierViewall">On a first impression, the V/Q scan was evaluated as a diffuse homogeneous decreased perfusion primary in the upper lobes, with preserved ventilation. After careful research, the perfusion study was considered as augmented perfusion on the bases of both lungs (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Thoracic CT demonstrated a micronodular centrilobular pattern with ground glass opacities, more prominent on the lower two-thirds of lungs, mediastinal lymphadenopathy and enlargement of the central and segmental pulmonary arteries (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). The thoracic CT pattern was considered suspected of PCH or eventually hypersensitivity pneumonitis.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Pulmonary function tests demonstrated reduced alveolocapillary diffusion. Right cardiac catheterization disclosed a right atrial pressure of 8<span class="elsevierStyleHsp" style=""></span>mmHg, pulmonary artery pressure of 101/43<span class="elsevierStyleHsp" style=""></span>mmHg (mean: 63<span class="elsevierStyleHsp" style=""></span>mmHg), pulmonary capillary wedge pressure of 8<span class="elsevierStyleHsp" style=""></span>mmHg, cardiac index of 1.49<span class="elsevierStyleHsp" style=""></span>L/min/m<span class="elsevierStyleSup">2</span>, pulmonary vascular resistance of 1692 dynes<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>s/m<span class="elsevierStyleSup">2</span> and trans-pulmonary pressure gradient of 55<span class="elsevierStyleHsp" style=""></span>mmHg.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Lung biopsy revealed pulmonary focus of alveolar wall thickening, due to capillary proliferation, expanding around vessel walls and bronchioles, hyperplasia of tunica media of small arteries and arterioles, venules dilatation extending to subpleural space and intra-alveolar haemorrhage (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). These findings were consistent with PCH.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0050" class="elsevierStylePara elsevierViewall">PCH is a rare and specific cause of PAH, characterized by diffuse capillary proliferation, in a vaguely lobular and patchy distribution, through the pulmonary interstitium and alveolar walls, also surrounding and invading small pulmonary vessels, small bronchi and the pleura.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2,7,9</span></a> Its aetiology remains uncertain, although a myriad of associated conditions as systemic lupus erythematosus, scleroderma, Takayasu arteritis, Kartagener syndrome or hypertrophic cardiomyopathy have been reported. It is recognized to occur in congenital, familial and sporadic forms, this last one being the most frequent. The congenital form is usually associated with other development abnormalities and the familiar form is very rare, with an autosomal recessive inherence documented only in one family.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3,7,10</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">A correct diagnosis is of extreme importance, since in addition to the fact that PCH has a specific treatment, distinct from other forms of PAH. PCH patients can have their state aggravated if a standard and not specific IPAH therapeutic is established.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,4</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The new guidelines for the diagnosis and treatment of PAH, from the European Society of Cardiology and the European Respiratory Society, re-enforce the specificity of PCH and classify both PCH and PVOD on a separate subgroup within PAH, for its specific pathological, clinical and therapeutic issues.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Although the precise prevalence of PCH and PVOD is not known, they are thought to account for 5–10% of the forms of PAH initially considered idiopathic, with PCH being less prevalent than PVOD. We have found 63 published cases until September 2011. This research was based on MEDLINE database, using the key word pulmonary capillary hemangiomatosis; additional case reports were identified from the references of selected articles.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Patients with PCH usually present with unspecific symptoms of progressive dyspnoea and fatigue, and are frequently misdiagnosed as IPAH. They may also have chronic cough, chest pain, syncope, digital clubbing, haemoptysis and haemorrhagic pleural effusion. These last two, when present, should raise suspicion of the possibility of PCH. As the disease progresses right sided heart failure and its symptoms appear and a median survival of 3 years from the initial presentation is expected.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,4,9</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Electrocardiography typically demonstrates right axis deviation and right ventricular hypertrophy. Echocardiogram reveals PAH and excludes structural lesions and left ventricular dysfunction. Haemodynamic parameters present two distinct features: elevated pulmonary arterial pressure and normal or low pulmonary capillary wedge pressure. Chest radiograph demonstrates PAH (enlarged central pulmonary arteries and right sided prominence of the heart), and diffuse or bibasilar reticulonodular or micronodular areas of opacity; mediastinal lymphadenopathy may be reported. Chest CT shows pulmonary arterial enlargement and widespread centrilobular nodules, mixed with lobular ground-glass opacities; sporadically, septal thickening, lymphadenopathy, pleural effusion, enlargement of right heart chambers and pericardial effusion are seen.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,4,10</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">As advocated by this case, presently it is accepted that combining clinical suspicion and radiological findings, namely a high resolution CT, the diagnosis of PCH or PVOD can be established with almost certainty.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,5</span></a> This is an important feature since lung biopsies must be made with extreme care in these patients, especially in people with elevated PAH, due to the elevated risk of complications. More difficult is to differentiate PCH and PVOD, usually only provided by pathological examination.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Although few cases of V/Q scan on PCH have been published, this exam is usually considered of no use in the diagnosis of PCH since several patterns have been described, such as diffuse augmented perfusion on the bases, perfusion defects with preserved ventilation, matched ventilation and perfusion defects, ventilation defects with normal perfusion and even normal exams.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–4,7–10</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Augmented perfusion on the pulmonary bases is described by some authors as a typical pattern of PCH, since, in this condition, these are the regions of lung most affected by proliferating capillaries, as documented in our case. These authors defend that this pattern can help to distinguish PCH from other forms of PAH.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">In perfusion mismatched defects, two different patterns were described: diffuse defects in the upper lobes or focal defects. The former, when we look retrospectively, can in fact correspond to the pattern of augmented perfusion on the bases that gives the erroneous perception of decreased perfusion on upper lobes, as in our case.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> The focal defects mimic thromboembolism and can be attributed to the development of in situ thrombosis, as it has been reported in some autopsies, or small vessels compression by proliferating capillaries, that has also been described in PCH.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,7,8</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Perhaps the normal, augmented perfusion on bases and mismatched perfusion defects represent different phases of the disease or even different physiopathologic expressions of PCH.</p><p id="par0105" class="elsevierStylePara elsevierViewall">Ventilation defects with normal perfusion or perfusion and ventilation matched defects have been also described in this pathology, and although in some patients no concomitant disease was found in the lungs, perhaps this pattern was caused by other condition than PCH.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,4,9,10</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">Although the role of V/Q scan on PCH seems to be limited, among all the V/Q scan patterns reported, the authors consider the one of augmented perfusion on the lung bases emerge as a relevant one. In fact this pattern seems to help on the diagnosis of PCH, as supported by our case and other authors,<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> but can be misinterpreted as decreased perfusion on the upper lobes, leading to erroneous diagnostic hypotheses. Therefore, the authors conclude that awareness of this pattern is important, especially considering that, although PCH is a rare condition, the elevated number of V/Q scans performed on PAH patients, increases the possibility of coming across it.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:2 [ "identificador" => "xres119616" "titulo" => "Abstract" ] 1 => array:2 [ "identificador" => "xpalclavsec106896" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres119615" "titulo" => "Resumen" ] 3 => array:2 [ "identificador" => "xpalclavsec106895" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2012-01-12" "fechaAceptado" => "2012-06-30" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec106896" "palabras" => array:4 [ 0 => "Pulmonary hypertension" 1 => "Pulmonary capillary hemangiomatosis" 2 => "Ventilation/perfusion lung scintigraphy" 3 => "Thoracic CT" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec106895" "palabras" => array:4 [ 0 => "Hipertensión pulmonar" 1 => "Hemangiomatosis capilar pulmonar" 2 => "Gammagrafía pulmonar de ventilación/perfusión" 3 => "TC torácica" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Pulmonary capillary hemangiomatosis is a rare disease, characterized by small capillaries proliferation, leading to pulmonary hypertension. The authors report a case of pulmonary capillary hemangiomatosis, and discuss its diagnostic difficulties. Special attention is presented to ventilation/perfusion scintigraphy, given both its importance to the evaluation of pulmonary hypertension, and its referred limited usefulness in pulmonary capillary hemangiomatosis. The few published cases of ventilation/perfusion scintigraphy on this entity have showed different patterns, which are discussed. This case presents a pattern with augmented perfusion on lung bases and normal ventilation, which has been described by other authors as typical for pulmonary capillary hemangiomatosis. The authors consider important to retain this pattern, when evaluating pulmonary hypertensive patients, given not only its possible ability to help on pulmonary capillary hemangiomatosis diagnosis, but also mainly its risk of misinterpretation as a decreased perfusion on upper lung lobes, leading to erroneous diagnostic hypotheses.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La hemangiomatosis capilar pulmonar constituye una enfermedad rara, caracterizada por la proliferación de pequeños capilares que originan una hipertensión pulmonar. Los autores presentan un caso de hemangiomatosis capilar pulmonar, debatiendo sus dificultades diagnósticas. Se presta una atención especial a la gammagrafía de ventilación/perfusión, dada su importancia para la evaluación de la hipertensión pulmonar y su utilidad limitada en la hemangiomatosis capilar pulmonar. Se discuten los pocos casos publicados de gammagrafía de ventilación/perfusión en esta entidad crónica, que han mostrado diferentes patrones. Este caso presenta un patrón con incremento de perfusión en las bases pulmonares y ventilación pulmonar normal, que ha sido descrito por otros autores como típico en la hemangiomatosis capilar pulmonar. Los autores consideran importante la identificación de este patrón al evaluar a los pacientes con hipertensión pulmonar, dado que podría suponer una ayuda, no sólo para el diagnóstico de la hemangiomatosis capilar pulmonar, sino también por el riesgo de interpretar mal el descenso de perfusión en los lóbulos pulmonares superiores, que puede conducir a unas hipótesis diagnósticas erróneas.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1027 "Ancho" => 3155 "Tamanyo" => 235332 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Lung ventilation (upper row) and perfusion (lower row) scintigraphy show homogeneous ventilation in both lungs and augmented diffuse perfusion in both lung bases.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1230 "Ancho" => 1750 "Tamanyo" => 296385 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Thoracic CT scan shows (A) a micronodular centrilobular pattern with ground glass opacities, feature more prominent on the lower two-thirds of both lungs (lung window); (B) enlargement of the central and segmental pulmonary arteries (mediastinal window) and (C) mediastinal lymphadenopathy (mediastinal window).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1006 "Ancho" => 2710 "Tamanyo" => 872608 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Histology of resected lung tissue. (A) On lower magnification, a patchy alveolar wall thickening with extensive capillary proliferation, and intra-alveolar haemorrhage can be seen (hematoxilin–eosin stain). (B) On higher magnification, proliferating capillary channels within the septa, surrounding pulmonary vessels and muscular hyperplasia on small arteries are better demonstrated with this vascular endothelial marker (CD31 immunohistochemical stain).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.A. Frazier" 1 => "T.J. Franks" 2 => "T.H. Mohammed" 3 => "I.H. Ozbudak" 4 => "J.R. 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2023 March | 2 | 2 | 4 |
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2018 January | 9 | 0 | 9 |
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2017 May | 29 | 1 | 30 |
2017 April | 17 | 3 | 20 |
2017 March | 21 | 9 | 30 |
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2017 January | 17 | 0 | 17 |
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2016 November | 25 | 4 | 29 |
2016 October | 19 | 8 | 27 |
2016 September | 15 | 1 | 16 |
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2015 December | 7 | 3 | 10 |
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2015 July | 5 | 0 | 5 |
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