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Original Article
Screening with angiographic images prior to 99mTc-HMPAO labelled leukocyte scintigraphy in the diagnosis of periprosthetic infection
Cribado mediante angiogammagrafía previo a la realización de gammagrafía con leucocitos 99mTc-HMPAO en el diagnóstico de infección de prótesis articulares
U. Granadosa,
Corresponding author
ulgranad@clinic.ub.es

Corresponding author.
, D. Fustera, A. Sorianob, S. Garcíac, G. Boric, J.C. Martínezc, M. Mayorala, P. Perlazaa, X. Tomásd, F. Ponsa
a Servicio de Medicina Nuclear, Hospital Clínic, Barcelona, Spain
b Servicio de Enfermedades Infecciosas, Hospital Clínic, Barcelona, Spain
c Servicio de Traumatología y Ortopedia, Hospital Clínic, Barcelona, Spain
d Servicio de Radiodiagnóstico, Hospital Clínic, Barcelona, Spain
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they may involve multiple complications&#44; such as aseptic loosening or periprosthetic infection&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a> Infection is the most serious complication&#44; with an incidence of 0&#46;8&#8211;1&#46;9&#37; in knee replacements&#44; and between 0&#46;3&#37; and 1&#46;7&#37; with hip arthroplasty&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Patients with chronic diseases such as rheumatoid arthritis and diabetes&#44; obese patients and patients with multiple previous surgical interventions are particularly affected by infection&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> Up to about 70&#37; of all prosthetic infections occur within the first 2 years of surgery&#44;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">7</span></a> the most common microorganisms being <span class="elsevierStyleItalic">Staphylococcus epidermidis</span> &#40;31&#37;&#41; and <span class="elsevierStyleItalic">Staphylococcus aureus</span> &#40;20&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">A simple X-ray&#44; the initial step for the evaluation of a painful prosthesis&#44; is sufficient to identify the cause of pain in only 25&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> Therefore&#44; in most patients other imaging methods to discern etiology are usually required&#46; The presence of artifacts created by the metallic components of joint replacements limit the capabilities of CT and MRI scans&#46; Arthrocentesis is an invasive technique and the results are frequently inconclusive&#44; having a high false positive rate due to contamination and elevated false negative rate because of difficulties in obtaining a sufficient sample for diagnosis&#46; Markers of inflammation such as erythrocyte sedimentation rate &#40;ESR&#41; and C-reactive protein &#40;CRP&#41; have high sensitivity&#44; but low specificity&#44; and often cannot differentiate an aseptic loosening from an infection because levels may be elevated in both clinical situations&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Bone scintigraphy &#40;BS&#41; and scintigraphy with <span class="elsevierStyleSup">99m</span>Tc-HMPAO labeled leukocytes &#40;LS&#41; are the most widely used imaging techniques in the study of joint replacements for the differential diagnosis between aseptic loosening and infection&#46; The LS is highly sensitive and demonstrates specificity that can reach 80&#8211;100&#37; when analyzed by an expert specialist or evaluated in conjunction <span class="elsevierStyleSup">99m</span>Tc-colloid bone marrow scintigraphy which facilitates the differentiation between activation of bone marrow adjacent to the prosthesis from a true periprosthetic infection&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">11</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">It has been reported that the analysis of the three-phase BS has a high negative predictive value of 90&#8211;93&#37; in detecting periprosthetic infection&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">12&#44;13</span></a> However&#44; in most cases with aseptic loosening the blood pool phase and the bone phase in BS usually come up positive&#44; so that the overall performance as a screening test is low&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a> So far the different phases of BS as a possible screening method for the diagnosis of infection of joint replacements have not been studied independently&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The aim of this paper is to analyze whether angiographic images may be useful as a screening method for the diagnosis of prosthetic joint infection&#44; prior to LS&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Patients</span><p id="par0040" class="elsevierStylePara elsevierViewall">In this prospective study&#44; 120 patients were studied consecutively &#40;70 women and 50 men&#41; with a mean age of 71<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11 years&#44; with total hip &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>63&#41; or knee &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>57&#41; replacement&#46; The average time since the replacement surgery was 78<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>76 months&#46; The inclusion criterion was clinical suspicion of septic loosening of the prosthesis&#46; ESR and CRP were determined&#44; BS was performed in 3 phases and LS carried out in all patients&#46; Normal values were 1&#8211;20<span class="elsevierStyleHsp" style=""></span>mm&#47;h for ESR and 0&#8211;1<span class="elsevierStyleHsp" style=""></span>mg&#47;dl for CRP&#46; In patients undergoing replacement of the prosthesis&#44; the definitive diagnosis was performed by sampling and subsequent microbiological analysis&#46; In patients not undergoing surgery&#44; infection was excluded from diagnosis when&#44; during a clinical follow-up period of at least 12 months&#44; in the absence of specific antibiotic treatment&#44; no signs of active infection were found&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Microbiological analysis</span><p id="par0045" class="elsevierStylePara elsevierViewall">An average of 8 periprosthetic samples were taken&#44; if two or more samples were positive for the same organism results were considered positive for infection&#46; Samples were collected by joint fluid aspiration&#44; swab smears in standard culture medium and periprosthetic tissue biopsy&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Imaging techniques</span><p id="par0050" class="elsevierStylePara elsevierViewall">In order to carry out the BS&#44; an intravenous bolus injection 925<span class="elsevierStyleHsp" style=""></span>MBq of <span class="elsevierStyleSup">99m</span>Tc-HMDP was administered for study with the patient placed under the camera&#46; The blood flow phase consisted of a dynamic study in anterior and posterior projection obtaining 60<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>s images in word mode for 1<span class="elsevierStyleHsp" style=""></span>min with a 128<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>128 matrix and at zoom 1&#46; The detection field was focused on the prosthesis of study&#46; Next&#44; 2&#8211;4<span class="elsevierStyleHsp" style=""></span>min post-injection&#44; 90<span class="elsevierStyleHsp" style=""></span>s static images were acquired without changing the position of the patient &#40;blood pool phase&#41;&#46; Finally&#44; 2<span class="elsevierStyleHsp" style=""></span>h after injection&#44; images were taken of the area of study in word mode for 300<span class="elsevierStyleHsp" style=""></span>s with a matrix of 256<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>256 &#40;bone phase&#41;&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">For the LS autologous leukocytes were obtained from the patient for cell labeling with 185<span class="elsevierStyleHsp" style=""></span>MBq of <span class="elsevierStyleSup">99m</span>Tc-HMPAO&#46; Four hours after reinjection of the labeled leukocytes&#44; 600<span class="elsevierStyleHsp" style=""></span>s images were taken in anterior and posterior projection for hip prostheses&#44; and for knee replacements&#44; from the anterior&#44; posterior&#44; and both lateral aspects&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Image interpretation</span><p id="par0060" class="elsevierStylePara elsevierViewall">The evaluation of the BS and LS images was performed visually by 3 independent observers&#46; Analyzing images of each phase &#40;blood flow&#44; blood pool and bone phase&#41; of the BS independently&#44; 2 categories &#40;either positive or negative for periprosthetic infection&#41; were considered&#46; The GL was considered positive for infection when there was any extra-medullary periprosthetic uptake&#46; If the three observers did not agree on the same result&#44; either positive or negative for infection&#44; the result coinciding with two observers was selected&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Statistics</span><p id="par0065" class="elsevierStylePara elsevierViewall">Sensitivity&#44; specificity&#44; negative predictive value &#40;NPV&#41; and positive predictive value &#40;PPV&#41; were calculated using the standard methods&#46; The variables were compared using the Student&#39;s <span class="elsevierStyleItalic">t</span> test for ESR and CRP and were considered to be statistically significant when <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46; The kappa index was calculated to establish the degree of inter-observer concordance&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Results</span><p id="par0070" class="elsevierStylePara elsevierViewall">In 18 of the 120 patients included in the study &#40;15&#37;&#41;&#44; infection of the joint prosthesis was diagnosed&#58; 10&#47;63 &#40;16&#37;&#41; of patients with hip replacements and 8&#47;57 &#40;14&#37;&#41; patients with knee replacements&#46; The most common isolated microorganism was <span class="elsevierStyleItalic">Staphylococcus epidermidis</span> &#40;50&#37;&#41;&#46; In the other 102 of 120 cases&#44; infection was ruled out&#44; by negative cultures after surgical replacement of the prosthesis &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>42&#41; or by clinical observation &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>60&#41;&#46; The ESR and CRP in the group of patients with prosthesis infection were significantly higher than in the group of patients without infection &#40;51<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>44 vs 20<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22 for ESR and 2&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;86 vs 1&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;2 for CRP&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#46; The sensitivity and specificity of ESR were 58&#37; and 71&#37; and of CRP 75&#37; and 50&#37;&#44; respectively&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the main clinical and laboratory parameters of patients included in this study&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">The blood flow was positive in 15&#47;18 patients with infection of the prosthesis and in 21&#47;102 patients without infection&#44; showing a sensitivity and a specificity of 83&#37; and 79&#37; respectively&#44; and NPV and PPV of 97&#37; and 42&#37; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> and <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; In patients without infection vs patients with prosthesis infection&#44; results of the vascular or blood pool phase of the BS were positive in 56&#37; and 83&#37;&#44; and delayed &#40;bone phase&#41; images gave positive results in 87&#37; of non-infected patients and 100&#37; of infected&#46; LS showed a sensitivity of 72&#37; and a specificity of 95&#37; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">The inter-observer concordance &#40;kappa index with a confidence interval of 95&#37;&#41; in assessing the results of the scintigraphic imaging was blood flow phase 0&#46;92 &#40;range 0&#46;85&#8211;1&#41;&#44; blood pool phase 0&#46;81 &#40;range 0&#46;81&#8211;0&#46;98&#41;&#44; bone phase 0&#46;8 &#40;range 0&#46;61&#8211;0&#46;99&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">In 3 of 10 patients with infected hip prostheses&#44; both the angiogram and the LS gave a negative diagnosis&#46; In all 3 cases the causative agent was <span class="elsevierStyleItalic">Staphylococcus epidermidis</span>&#44; and all cases showed a normal PCR&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">In 2 of 8 patients with infected &#40;coagulase negative staphylococcus&#41; knee replacements&#44; LS was negative and blood flow phase positive&#46; There were no cases found of periprosthetic infection with a positive LS and a false negative blood flow phase&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">In our study we have shown that if LS were performed exclusively on patients presenting positive blood flow phase&#44; the number of LS carried out could be reduced by 82&#37; in patients with hip replacements&#44; and by 56&#37; in patients with knee prosthesis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#59; an overall reduction of 70&#37; compared to the low reduction rate if we were to consider the other phases of the BS&#44; independently or combined &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discussion</span><p id="par0105" class="elsevierStylePara elsevierViewall">The treatment for mechanical loosening is an implant revision or prosthetic replacement&#46; However&#44; in cases where the cause of loosening corresponds to an infectious complication &#40;septic loosening&#41; a two-step removal and replacement procedure is necessary which may or may not involve local antibiotic administration and prolonged systemic antibiotherapy&#59; so prudent differential diagnosis is of great importance&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a> ESR and CRP&#44; with high levels of sensitivity and specificity&#44; have proven useful in ruling out of prosthetic joint infection&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a> Both tests have been used as a screening method in the diagnostic algorithms of the American Academy of Orthopedic Surgeons&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a> According to our data&#44; the ESR and CRP values were significantly higher in patients with periprosthetic infection&#59; however&#44; these parameters showed relatively low sensitivity &#40;ESR 58&#37; and CRP 71&#37;&#41; and specificity &#40;ESR 75&#37; and CRP 50&#37;&#41;&#46; Our results are consistent with studies by Nagoya et al&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a> who showed that although the elevated ESR and CRP are suggestive of infection&#44; some patients with prosthetic infection may show normal levels of these parameters and patients without infection may present abnormal levels&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Of the patients included in the study&#44; infection was diagnosed in 16&#37; of the hip replacements and in 14&#37; of the knee prosthesis&#46; The most common microorganism &#40;50&#37;&#41; was <span class="elsevierStyleItalic">Staphylococcus epidermidis</span>&#44; which follows the patterns of larger epidemiological studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">8&#44;10</span></a> In cases where infection was ruled out&#44; the most common diagnosis was mechanical loosening &#40;71&#37;&#41;&#44; followed by mechanical overload &#40;16&#37;&#41; which is probably identifying future loosening&#46; There were no significant differences in the average time from replacement surgery between the group of patients with prosthetic infection and patients without infection&#44; although it was slightly shorter time period when the prostheses were not infected&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The LS showed sensitivity of 72&#37; and a specificity of 95&#37;&#44; which when compared to previous studies&#44; are lower values&#46; In previous studies&#44; with a similar specificity&#44; sensibility reached values higher than 90&#37;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">9&#44;11</span></a> however&#44; these authors studied BS&#44; SL and bone marrow scintigraphy simultaneously&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">It has been widely reported in scientific literature that BS can detect persistent uptake up to 12 months after replacement surgery and in clinical practice even longer&#44; so it is of little use to differentiate between aseptic loosening and infection&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a> In our series of patients&#44; the bone phase of the BS was positive in 100&#37; of patients with infection and in 87&#37; of patients in the group without infection&#46; However&#44; a systematic review showed that diagnosis of periprosthetic infection using three-phase BS was highly useful&#44; with up to 80&#37; accuracy for hip and 81&#37; for knee replacements&#44; thus representing an effective detection method periprosthetic infection&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">Nagoya et al&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a> concluded that the three-phase BS could be useful for the detection of periprosthetic infection because serological tests such as ESR and CRP and radiological findings are not always reliable&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The authors specified a diagnosis of infection when the 3 BS phases were positive&#44; 88&#37; of cases in the group of patients with a prosthetic infection were diagnosed correctly&#46; However&#44; the false positive rate reached 10&#37; in the group of patients not infected&#46; Interestingly&#44; in this series of patients&#44; the blood flow phase was found to successfully read negative in the group of patients without infection&#44; suggesting that the blood flow phase can rule out infection in aseptic cases&#46; In our series of patients&#44; the blood flow phase was positive in 83&#37; of patients with prosthesis infection and in 20&#37; of patients without infection&#44; showing sensitivity of 83&#37; and specificity of 79&#37;&#46; Of the 10 patients with an infected hip replacement&#44; there were 3 cases which came up negative both in the blood flow phase and the LS&#46; The bacterial agent was <span class="elsevierStyleItalic">Staphylococcus epidermidis</span> in all the cases&#46; The CRP results were all normal&#44; suggesting little inflammatory response&#44; and hence lower hyperemia&#44; which in turn would explain the negative blood flow phase&#46; In the 8 patients with infected knee prosthesis we did not find a single false negative in the blood flow phase&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">In our study with three-phase BS&#44; the high NPV of the blood flow phase stands out&#44; reaching up to 97&#37;&#44; suggesting that it could be a suitable screening technique for prosthetic joint infection&#46; We did not find any cases of an infected patient having positive LS and a false negative blood flow phase&#44; which would have invalidated its use as a screening technique&#46; The greatest advantage of a three-phase BS is that it would allow the use of LS to be reduced&#44; limiting it to patients with a positive blood flow phase&#44; without decreasing the LS sensitivity&#46; Routine practice of three-phase BS would lead to a reduction in the number of LS procedures carried out&#44; 82&#37; less in cases of hip prostheses and 56&#37; of cases of knee&#44; leading to an overall reduction of 70&#37;&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">In conclusion&#44; the blood flow phase has been shown to be an adequate and reliable screening technique in the diagnosis of suspected infection of hip and knee in this series of patients&#46; In carrying out a three phase BS in these patients&#44; a LS procedure can be avoided in a significant number of cases&#44; minimizing radiation dose&#44; lowering costs&#44; saving time dedicated to the cell labeling of the leukocytes&#44; and therefore speeding up the diagnosis process in these patients&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflict of interest</span><p id="par0145" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest&#46;</p></span></span>"
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          "titulo" => "Introduction"
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          "titulo" => "Material and methods"
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              "titulo" => "Microbiological analysis"
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              "titulo" => "Imaging techniques"
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    "fechaRecibido" => "2014-08-29"
    "fechaAceptado" => "2014-10-14"
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            0 => "Angioscintigraphy"
            1 => "Screening"
            2 => "Joint infection"
            3 => "<span class="elsevierStyleSup">99m</span>Tc-HMPAO-leukocyte"
            4 => "Joint prosthesis"
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            0 => "Angiogammagraf&#237;a"
            1 => "Cribado"
            2 => "Infecci&#243;n"
            3 => "<span class="elsevierStyleSup">99m</span>Tc-HMPAO-leucocitos"
            4 => "Pr&#243;tesis articulares"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Aim</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To evaluate the impact of the angioscintigrapy of the three phase bone scan as screening method to rule out infection of the hip and knee prosthesis prior to performing the <span class="elsevierStyleSup">99m</span>Tc-HMPAO leukocyte scintigraphy&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A total of 120 &#40;70 women&#44; 50 men&#59; mean age 71<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11<span class="elsevierStyleHsp" style=""></span>years&#41; with clinical suspicion of hip &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>63&#41; or knee &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>57&#41; infection of the prosthesis and clinical suspicion of infection were evaluated prospectively&#46; All patients underwent three-phase bone scan &#40;angioscintigraphy&#44; vascular and bone phase&#41; and <span class="elsevierStyleSup">99m</span>Tc-HMPAO-labeled white blood cell scintigraphy&#46; Final diagnosis of infection was made by microbiological documentation or clinical follow-up for at least 12 months&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Eighteen out of 120 patients were diagnosed of infection of hip prosthesis &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>10&#41; or knee prosthesis &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8&#41;&#46; The angioscintigraphy was positive in 15&#47;18 infected cases and in 21&#47;102 of the non-infected cases with a sensitivity of 83&#37;&#44; specificity of 79&#37; and negative predictive value of 97&#37;&#46; Sensitivity and specificity of <span class="elsevierStyleSup">99m</span>Tc-HMPAO leukocyte scintigraphy were 72&#37; and 95&#37;&#44; respectively&#46; If the leukocyte labeled scintigraphies had been used exclusively for patients with positive angioscintigraphy&#44; this would have saved up to 70&#37; of the <span class="elsevierStyleSup">99m</span>Tc-HMPAO leukocyte scintigraphies performed&#46; There were no cases of infection with positive labeled leukocyte scintigraphy and negative angioscintigraphy&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Angioscintigraphy &#40;blood flow phase of bone scan&#41; is a useful technique for screening for hip and knee joint prosthesis infection&#44; significantly reducing the need for <span class="elsevierStyleSup">99m</span>Tc-HMPAO leukocyte scintigraphy without affecting the sensitivity of the technique&#46;</p></span>"
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          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusion"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Analizar la utilidad de la fase angiogammagr&#225;fica de la gammagraf&#237;a &#243;sea en 3<span class="elsevierStyleHsp" style=""></span>fases como posible m&#233;todo de cribado en el diagn&#243;stico de infecci&#243;n de pr&#243;tesis de cadera y de rodilla&#44; previa a la realizaci&#243;n de la gammagraf&#237;a con leucocitos marcados&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se analizaron prospectivamente 120 pacientes &#40;70 mujeres y 50 hombres&#41; con edad media de 71<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11<span class="elsevierStyleHsp" style=""></span>a&#241;os y sospecha cl&#237;nica de infecci&#243;n de pr&#243;tesis de cadera &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>63&#41; o rodilla &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>57&#41;&#44; a los que se realiz&#243; gammagraf&#237;a &#243;sea en 3<span class="elsevierStyleHsp" style=""></span>fases &#40;angiogammagraf&#237;a&#44; fase vascular y fase &#243;sea&#41; y gammagraf&#237;a con leucocitos marcados con <span class="elsevierStyleSup">99m</span>Tc-HMPAO&#46; El diagn&#243;stico definitivo se realiz&#243; mediante estudio microbiol&#243;gico o seguimiento cl&#237;nico m&#237;nimo de 12<span class="elsevierStyleHsp" style=""></span>meses&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se estableci&#243; el diagn&#243;stico de infecci&#243;n de la pr&#243;tesis articular en 18&#47;120 pacientes&#58; 10 pacientes con pr&#243;tesis de cadera y 8 pacientes con pr&#243;tesis de rodilla&#46; La angiogammagraf&#237;a fue positiva en 15&#47;18 pacientes infectados y en 21&#47;102 pacientes no infectados&#44; mostrando una sensibilidad del 83&#37;&#44; una especificidad del 79&#37; y un valor predictivo negativo del 97&#37;&#46; La gammagraf&#237;a con leucocitos marcados mostr&#243; una sensibilidad y una especificidad del 72 y del 95&#37;&#44; respectivamente&#46; Si se realizara la gammagraf&#237;a con leucocitos marcados exclusivamente a los pacientes con angiogammagraf&#237;a positiva&#44; se reducir&#237;a un 70&#37; de gammagraf&#237;as con leucocitos practicadas&#46; No hubo ning&#250;n caso de infecci&#243;n con gammagraf&#237;a con leucocitos marcados positiva y angiogammagraf&#237;a negativa&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La angiogammagraf&#237;a es una buena t&#233;cnica de cribado de infecci&#243;n de pr&#243;tesis articulares de cadera y rodilla&#44; disminuyendo significativamente el n&#250;mero de gammagraf&#237;as con leucocitos marcados&#44; sin afectar la sensibilidad de la t&#233;cnica&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Material y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Please cite this article as&#58; Granados U&#44; Fuster D&#44; Soriano A&#44; Garc&#237;a S&#44; Bori G&#44; Mart&#237;nez JC&#44; et al&#46; Cribado mediante angiogammagraf&#237;a previo a la realizaci&#243;n de gammagraf&#237;a con leucocitos <span class="elsevierStyleSup">99m</span>Tc-HMPAO en el diagn&#243;stico de infecci&#243;n de pr&#243;tesis articulares&#46; Rev Esp Med Nucl Imagen Mol&#46; 2015&#59;34&#58;219&#8211;224&#46;</p>"
      ]
    ]
    "multimedia" => array:6 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2167
            "Ancho" => 3002
            "Tamanyo" => 518948
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Patient with infection of the complete hip replacement secondary to <span class="elsevierStyleItalic">Staphyloccocus epidermidis</span> showing hyperemia in the angiogram &#40;A&#41; and increased blood pool activity &#40;B&#41;&#46; The delayed bone phase shows diffuse periprosthetic uptake predominantly around the tip of the prosthesis &#40;C&#41;&#46; In the LS there are foci in the left acetabulo-femoral joint with a fistulous route toward the external thigh &#40;D&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2208
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            "Tamanyo" => 531928
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Patient with complete left knee prosthesis with negative blood flow phase &#40;A&#41;&#44; hyperemia in the blood pool phase &#40;B&#41;&#44; periprosthetic uptake in the delayed bone phase&#44; predominantly on the tibial component&#44; suggesting loosening &#40;C&#41;&#46; The LS does not show leukocyte uptake which would suggest infection &#40;D&#41;&#46; 14 months follow up of this patient without antibiotic treatment&#44; did not produce clinical evidence of infection&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">N</span>&#58; Normal values&#59; ns&#58; nonsignificance&#46;</p>"
          "tablatextoimagen" => array:1 [
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Group with infection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Group without infection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Number</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">102&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Prosthesis type</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hip&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Knee&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Scintigraphic diagnosis</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Infection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Without abnormality &#40;BS &#38;LS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Aseptic loosening&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mechanical overload&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pelvic fracture&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Patellar chondropathy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Microorganism</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Staphylococcus epidermidis</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Coagulase-negative <span class="elsevierStyleItalic">Staphylococcus</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Staphylococcus aureus</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Polymicrobial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">ESR &#40;N&#58; 1&#8211;20</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">mm&#47;h&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">CRP &#40;N&#58; 0&#8211;1</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">mg&#47;dL&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;86&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Average time since replacement &#40;p</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">ns&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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            1 => array:3 [
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              "etiqueta" => "&#42;&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010"><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;061&#46;</p>"
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          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Clinical and laboratory parameters comparing the group of patients diagnosed as having of periprosthetic infection with the group of patients without infection&#46;</p>"
        ]
      ]
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        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
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        "mostrarDisplay" => false
        "tabla" => array:1 [
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Group with infection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Group without infection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Blood flow &#40;hip and knee&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Positive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Negative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top">Sensitivity<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>83&#37;&#47;specificity<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>79&#37;</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Blood flow &#40;hip&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Positive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Negative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top">Sensitivity<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>70&#37;&#47;specificity<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>93&#37;</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Blood flow &#40;knee&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Positive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Negative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&nbsp;\t\t\t\t\t\t\n
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                  """
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          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Angiogram results&#44; according to type of prosthesis and patient infection group&#46;</p>"
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                  <table border="0" frame="\n
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Group with infection&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">BS &#40;blood pool phase&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Positive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Negative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top">Sensitivity<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>83&#37;&#47;specificity<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>44&#37;</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">BS &#40;bone phase&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Positive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Negative&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Negative&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top">Sensitivity<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>72&#37;&#47;specificity<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>95&#37;</td></tr></tbody></table>
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&#37; &#40;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#37; &#40;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#37; &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&#37; &#40;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40&#37; &#40;48&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#37; &#40;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Reduction of scintigraphy with labeled leukocytes using the different phases of bone scintigraphy as screening&#46;</p>"
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    ]
    "bibliografia" => array:2 [
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                            1 => "R&#46; Estrada"
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