metricas
covid
Buscar en
Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
Toda la web
Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) A rare case of clear cell carcinoma of the breast evaluated by 18F-FDG PET/CT
Journal Information

Statistics

Follow this link to access the full text of the article

Interesting image
A rare case of clear cell carcinoma of the breast evaluated by 18F-FDG PET/CT
Un caso poco frecuente de carcinoma de células claras de la mama evaluado con 18F-FDG PET/TC
G. Tregliaa,
Corresponding author
giorgiomednuc@libero.it

Corresponding author.
, U. Perriardb, L. Ceriania, L. Giovanellaa
a Department of Nuclear Medicine and PET/CT Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
b Institute of Pathology, Locarno, Switzerland
Read
59
Times
was read the article
17
Total PDF
42
Total HTML
Share statistics
 array:23 [
  "pii" => "S2253808915000592"
  "issn" => "22538089"
  "doi" => "10.1016/j.remnie.2015.05.006"
  "estado" => "S300"
  "fechaPublicacion" => "2015-07-01"
  "aid" => "659"
  "copyright" => "Elsevier España, S.L.U. and SEMNIM"
  "copyrightAnyo" => "2014"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "sco"
  "cita" => "Rev Esp Med Nucl Imagen Mol. 2015;34:264-5"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 59
    "formatos" => array:2 [
      "HTML" => 42
      "PDF" => 17
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2253808915000609"
    "issn" => "22538089"
    "doi" => "10.1016/j.remnie.2015.05.007"
    "estado" => "S300"
    "fechaPublicacion" => "2015-07-01"
    "aid" => "662"
    "copyright" => "Elsevier España, S.L.U. and SEMNIM"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "sco"
    "cita" => "Rev Esp Med Nucl Imagen Mol. 2015;34:266-7"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 80
      "formatos" => array:2 [
        "HTML" => 46
        "PDF" => 34
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Interesting image</span>"
      "titulo" => "Intestinal metastases as an unusual presentation of a burned-out testicular seminoma&#58; PET&#47;CT imaging"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "266"
          "paginaFinal" => "267"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Presentaci&#243;n inusual como met&#225;stasis intestinales de un seminoma testicular con regresi&#243;n espont&#225;nea"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1203
              "Ancho" => 950
              "Tamanyo" => 192147
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Coronal contrast-enhanced CT image showing the thickened proximal duodenum from presumed primary duodenal malignancy &#40;arrow&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "B&#46;D&#46; Nguyen, M&#46;C&#46; Roarke, M&#46; Yang"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "B&#46;D&#46;"
              "apellidos" => "Nguyen"
            ]
            1 => array:2 [
              "nombre" => "M&#46;C&#46;"
              "apellidos" => "Roarke"
            ]
            2 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Yang"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808915000609?idApp=UINPBA00004N"
    "url" => "/22538089/0000003400000004/v1_201506250030/S2253808915000609/v1_201506250030/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S2253808915000634"
    "issn" => "22538089"
    "doi" => "10.1016/j.remnie.2015.05.010"
    "estado" => "S300"
    "fechaPublicacion" => "2015-07-01"
    "aid" => "674"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and SEMNIM"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Rev Esp Med Nucl Imagen Mol. 2015;34:261-3"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 206
      "formatos" => array:2 [
        "HTML" => 56
        "PDF" => 150
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Clinical note</span>"
      "titulo" => "Platypnea-orthodeoxia syndrome&#58; Importance of patient position for correct diagnosis at the time of <span class="elsevierStyleSup">99m</span>Tc-MAA injection"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "261"
          "paginaFinal" => "263"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "S&#237;ndrome platipnea-ortodeoxia&#58; importancia de la posici&#243;n del paciente en el momento de la inyecci&#243;n de <span class="elsevierStyleSup">99m</span>Tc-MAA para un correcto diagn&#243;stico"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1440
              "Ancho" => 975
              "Tamanyo" => 199767
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Albumin macroaggregated&#39;s lung perfusion scan in posterior view&#46; The <span class="elsevierStyleSup">99m</span>Tc-macroaggregated albumin lung perfusion scan in the supine position shows only pulmonary activity &#40;A&#41;&#46; The <span class="elsevierStyleSup">99m</span>Tc-macroaggregated albumin injection in sitting position&#44; note the extrapulmonary accumulation of the radio-labeled albumin in the kidneys and the brain &#40;B&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46;P&#46; Fierro Alanis, I&#46; Bast&#243;n Rey, S&#46; Nieves-Maldonado, J&#46;A&#46; Torre Carballada, J&#46;E&#46; Dom&#237;nguez-Mu&#241;oz, &#193;&#46; Ruibal Morell"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "M&#46;P&#46;"
              "apellidos" => "Fierro Alanis"
            ]
            1 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Bast&#243;n Rey"
            ]
            2 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Nieves-Maldonado"
            ]
            3 => array:2 [
              "nombre" => "J&#46;A&#46;"
              "apellidos" => "Torre Carballada"
            ]
            4 => array:2 [
              "nombre" => "J&#46;E&#46;"
              "apellidos" => "Dom&#237;nguez-Mu&#241;oz"
            ]
            5 => array:2 [
              "nombre" => "&#193;&#46;"
              "apellidos" => "Ruibal Morell"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808915000634?idApp=UINPBA00004N"
    "url" => "/22538089/0000003400000004/v1_201506250030/S2253808915000634/v1_201506250030/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Interesting image</span>"
    "titulo" => "A rare case of clear cell carcinoma of the breast evaluated by <span class="elsevierStyleSup">18</span>F-FDG PET&#47;CT"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "264"
        "paginaFinal" => "265"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "G&#46; Treglia, U&#46; Perriard, L&#46; Ceriani, L&#46; Giovanella"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "G&#46;"
            "apellidos" => "Treglia"
            "email" => array:1 [
              0 => "giorgiomednuc&#64;libero&#46;it"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "U&#46;"
            "apellidos" => "Perriard"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "L&#46;"
            "apellidos" => "Ceriani"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "L&#46;"
            "apellidos" => "Giovanella"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Department of Nuclear Medicine and PET&#47;CT Centre&#44; Oncology Institute of Southern Switzerland&#44; Bellinzona&#44; Switzerland"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Institute of Pathology&#44; Locarno&#44; Switzerland"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Un caso poco frecuente de carcinoma de c&#233;lulas claras de la mama evaluado con <span class="elsevierStyleSup">18</span>F-FDG PET&#47;TC"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1087
            "Ancho" => 1500
            "Tamanyo" => 348029
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Maximum-intensity-projection <span class="elsevierStyleSup">18</span>F-FDG PET image &#40;A&#41;&#44; axial non-enhanced CT &#40;B&#41; and fused PET&#47;CT image &#40;C&#41; showing increased tracer uptake corresponding to a 8<span class="elsevierStyleHsp" style=""></span>cm mass located in the left breast &#40;arrows&#41; with a SUV<span class="elsevierStyleInf">max</span> of 22&#46; At hematoxylin and eosin stain the breast mass was composed by large cells arranged into a solid pattern and characterized by abundant vacuolated clear cytoplasm&#44; marked nuclear pleomorphism and high number of mitoses &#40;D&#41;&#46; The proliferative index &#40;Ki67&#37;&#41; was 80&#37; &#40;E&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 53-year-old woman with a palpable mass in the left breast with coexisting skin ulceration at physical examination underwent breast ultrasonography &#40;US&#41; for staging&#46; US showed a large inhomogeneous and hypervascular mass in the left breast and enlarged lymph nodes in the left axilla&#46; US-guided biopsy demonstrated the presence of a clear cell carcinoma &#40;CCC&#41; of the breast&#46; The patient refused neoadjuvant chemotherapy and a <span class="elsevierStyleSup">18</span>F-FDG PET&#47;CT scan was performed for staging before surgical planning&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">PET&#47;CT images were acquired one hour after i&#46;v&#46; injection of 270<span class="elsevierStyleHsp" style=""></span>MBq of <span class="elsevierStyleSup">18</span>F-FDG&#46; Glucose blood levels corresponded to 92<span class="elsevierStyleHsp" style=""></span>mg&#47;dL before radiopharmaceutical injection&#46; PET&#47;CT showed an area of increased <span class="elsevierStyleSup">18</span>F-FDG uptake corresponding to a 8<span class="elsevierStyleHsp" style=""></span>cm mass in the left breast &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#8211;C&#41; with a maximum standardized uptake value &#40;SUV<span class="elsevierStyleInf">max</span>&#41; of 22&#46; No other areas of abnormal <span class="elsevierStyleSup">18</span>F-FDG uptake were detected in the rest of the body&#46; Negative results outside breast with <span class="elsevierStyleSup">18</span>F-FDG PET&#47;CT enhanced the surgical decision to perform left mastectomy and ipsilateral axillary lymph node dissection&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">At hematoxylin and eosin stain the breast mass was composed by large cells arranged into a solid pattern and characterized by abundant vacuolated clear cytoplasm&#44; marked nuclear pleomorphism and high number of mitoses &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#46; This tumor did not express estrogen receptor alpha&#44; progesterone receptor&#44; or human epidermal growth factor receptor 2 &#40;&#8220;triple-negative&#8221; feature&#41;&#46; The proliferative index &#40;Ki67&#37;&#41; was 80&#37;&#46; A final diagnosis of CCC of the left breast without metastatic spread was performed &#40;final stage after surgery&#58; T4N0M0&#41; and the patient was addressed to adjuvant radiation therapy&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">CCC is a rare malignant tumor of the breast&#44; accounting for 0&#46;9&#37;-2&#46;8&#37; of all breast cancer cases&#46; Most of these tumors are invasive carcinomas with a poor prognosis&#46; The histology appearance of CCC is typical as these tumors are composed almost entirely of polygonal cells with clear cytoplasm&#46; The immunophenotype of CCC is not uniform&#44; but it is similar to that of conventional ductal carcinoma&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">To the best of our knowledge&#44; no cases describing <span class="elsevierStyleSup">18</span>F-FDG PET&#47;CT findings in this rare breast tumor are reported in the literature&#46; Conversely&#44; it was demonstrated that <span class="elsevierStyleSup">18</span>F-FDG PET&#47;CT may provide useful information in patients with locally advanced breast carcinoma&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">We have described an increased uptake of <span class="elsevierStyleSup">18</span>F-FDG in this rare malignancy&#46; Furthermore&#44; in our case&#44; <span class="elsevierStyleSup">18</span>F-FDG PET&#47;CT has been useful in staging before surgical planning&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2014-10-12"
    "fechaAceptado" => "2014-11-13"
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1087
            "Ancho" => 1500
            "Tamanyo" => 348029
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Maximum-intensity-projection <span class="elsevierStyleSup">18</span>F-FDG PET image &#40;A&#41;&#44; axial non-enhanced CT &#40;B&#41; and fused PET&#47;CT image &#40;C&#41; showing increased tracer uptake corresponding to a 8<span class="elsevierStyleHsp" style=""></span>cm mass located in the left breast &#40;arrows&#41; with a SUV<span class="elsevierStyleInf">max</span> of 22&#46; At hematoxylin and eosin stain the breast mass was composed by large cells arranged into a solid pattern and characterized by abundant vacuolated clear cytoplasm&#44; marked nuclear pleomorphism and high number of mitoses &#40;D&#41;&#46; The proliferative index &#40;Ki67&#37;&#41; was 80&#37; &#40;E&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:3 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinicopathologic characteristics and prognosis of glycogen-rich clear cell carcinoma of the breast"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "X&#46; Ma"
                            1 => "Y&#46; Han"
                            2 => "Y&#46; Fan"
                            3 => "X&#46; Cao"
                            4 => "X&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/tbj.12231"
                      "Revista" => array:6 [
                        "tituloSerie" => "Breast J"
                        "fecha" => "2014"
                        "volumen" => "20"
                        "paginaInicial" => "166"
                        "paginaFinal" => "173"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24400866"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intraductal glycogen-rich clear cell carcinoma of the breast&#58; a rare presentation and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "N&#46;S&#46; Salemis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000341393"
                      "Revista" => array:6 [
                        "tituloSerie" => "Breast Care"
                        "fecha" => "2012"
                        "volumen" => "7"
                        "paginaInicial" => "319"
                        "paginaFinal" => "321"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23904836"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleSup">18</span>F-FDG semi-quantitative parameters and biological prognostic factors in locally advanced breast cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;M&#46; Garc&#237;a Vicente"
                            1 => "A&#46; Soriano Castrej&#243;n"
                            2 => "F&#46; Relea Calatayud"
                            3 => "V&#46; Mu&#241;oz Madero"
                            4 => "M&#46;J&#46; Molina Garrido"
                            5 => "A&#46;A&#46; Le&#243;n Mart&#237;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.remn.2011.12.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Esp Med Nucl Imagen Mol"
                        "fecha" => "2012"
                        "volumen" => "31"
                        "paginaInicial" => "308"
                        "paginaFinal" => "314"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23084013"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/22538089/0000003400000004/v1_201506250030/S2253808915000592/v1_201506250030/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "7927"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Interesting images"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/22538089/0000003400000004/v1_201506250030/S2253808915000592/v1_201506250030/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808915000592?idApp=UINPBA00004N"
]
Article information
ISSN: 22538089
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2018 February 4 2 6
2018 January 4 1 5
2017 December 2 0 2
2017 November 4 1 5
2017 October 1 3 4
2017 September 7 1 8
2017 August 13 2 15
2017 July 6 1 7
2017 February 1 0 1
2016 June 0 1 1
2016 February 0 1 1
2016 January 0 1 1
2015 September 0 2 2
2015 July 0 1 1
Show all

Follow this link to access the full text of the article

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos