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Usefulness of 11C-Methionine PET in differential diagnosis of epileptogenic brain neoplasms
Utilidad de la PET con 11C-metionina en el diagnóstico diferencial de los tumores epileptógenos
J.R. García
Corresponding author
jrgarcia@cetir.es

Corresponding author.
, M. Baquero, E. Llinares, M. Soler, M. Moragas, E. Riera
Unidad PET/TC CETIR-ERESA,, Esplugues, Barcelona, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Brain tumors are associated to more than 50&#37; of patients with epilepsy&#44; of which about 30&#37; are drug-resistant&#46; Epilepsy associated with brain tumors is multifactorial&#44; but fundamentally depends on its location and histology&#46; So&#44; low-grade tumors are more epileptogenic than high-grade&#46; In high-grade tumors and adult epilepsy is associated with increased frequency of neurological deficits&#46; In low-grade tumors and infant-juvenile age&#44; epilepsy presents clinically isolated&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present two women of similar age &#40;27 and 25 years&#44; respectively&#41; following focal seizure who underwent Magnetic Resonance Imaging &#40;MRI&#41; that revealed similar findings&#58; hypointense on T1-weighted and high signal on T2-weighted and FLAIR images with areas of diffusion restriction and without contrast enhancement &#40;left frontal and parietal-temporal right&#44; respectively&#41;&#46; These features can be presented in different tumor types and in our case not allow the differential diagnosis between a low-grade glioma or ganglioneuronal tumor &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The Dysembryoplastic Neuroepithelial Tumor &#40;DNET&#41; was described by Daumas-Duport et al&#46; in 1988 as a mixed ganglioneuronal low-grade lesion &#40;WHO grade I&#41; containing oligodendrocytes&#44; astrocytes and neurons&#44; with colloid material&#44; which may be multifocal and coexist with regions of cortical dysgenesis&#46; It is manifested mainly by the presence of epilepsy with focal seizures with onset of symptoms between 1 and 30 years &#40;mean 9 years&#41;&#44; many times difficult to control&#44; usually without associated neurological deficit&#46; The DNET is mainly cortical&#44; but may show subcortical extension and sits mainly in the temporal lobe &#40;62&#37;&#41; and frontal &#40;31&#37;&#41;&#46; MRI typically shows hypointense lesions on T1-weighted and hyperintense on T2-weighted images without peri-lesional edema&#44; may submit gadolinium enhancement&#44; no specific characteristics of these tumors&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleSup">18</span>F-Fluorodeoxyglucose &#40;FDG&#41; Positron Emission Tomography &#40;PET&#41; has a recognized role in the localization of the seizure focus&#46; However&#44; in tumor metabolic assessment is known absence of uptake in low-grade gliomas&#46; However&#44; <span class="elsevierStyleSup">11</span>C-Methionine PET shows tracer uptake in all glial tumors&#44; although the degree of activity allows to differentiate between grades I&#8211;II of III&#8211;IV&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a> There are few references&#44; but has been described absence of abnormal uptake of <span class="elsevierStyleSup">11</span>C-Methionine in DNET&#44; in contrast to the tracer uptake in glial tumors&#44; even in low-grade gliomas&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">For these reasons we proceed to perform <span class="elsevierStyleSup">11</span>C-methionine PET in both cases&#46; After intravenous injection of 185<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#46;5<span class="elsevierStyleHsp" style=""></span>MBq of <span class="elsevierStyleSup">11</span>C-methionine&#44; patients were in 20<span class="elsevierStyleHsp" style=""></span>min resting sensory-motor period&#46; After performing a CT for attenuation correction PET brain images were acquired for 10<span class="elsevierStyleHsp" style=""></span>min&#46; At the same sesion&#44; we proceeded to study conducting 3D T1-weighted MRI for software fusion purpose &#40;SPM8&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The first patient shows a pathological <span class="elsevierStyleSup">11</span>C-Methionine uptake in cortical lesion on the upper-left frontal lobe &#40;ratio 1&#46;7&#47;0&#46;9&#58;1&#46;89&#41;&#46; However&#44; in the second patient the cortico-subcortical right parieto-temporal lesion shows no abnormal uptake of <span class="elsevierStyleSup">11</span>C-Methionine&#46; Quantifying more widely accepted in the evaluation of brain tumors with <span class="elsevierStyleSup">11</span>C-Methionine is the relationship between the degree of uptake of the lesion &#40;SUV max&#41; and the background calculating on gray matter of the healthy contralateral lobe &#40;medium SUV&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Given this different metabolic behavior differentiated therapeutic strategy is decided&#46; In the first patient&#44; due to suspected of glial tumor proceed to its removal&#44; confirming grade II glioma&#46; In the second patient&#44; performing a stereotactic biopsy is decided and confirmed suspected metabolic DNET&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Treatment of DNET&#44; even if it is a benign tumor&#44; requiring surgery in the case of drug-resistant epilepsies with frequent evolution of these patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">2&#44;3</span></a> In our case given the histological confirmation of DNET&#44; since it was the first epileptogenic episode was decided to initiate anticonvulsant treatment&#46; Due to medical control of seizures no tumor excision was performed&#44; avoiding the possible neurological deficit secondary intervention&#44; without new episodes epileptogenic&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">These results suggest that <span class="elsevierStyleSup">11</span>C-Methionine PET could be very useful in differentiating the various epileptogenic tumors&#44; especially in the characterization of DNET&#44; information that can influence the therapeutic decision of these patients&#46;</p></span>"
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es en pt

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